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JOURNAL ARTICLE
Peter Preben Eggertsen, Johan Palmfeldt, Asger Roer Pedersen, Oana-Veronica Frederiksen, Rikke Katrine Jentoft Olsen, Jørgen Feldbæk Nielsen
BACKGROUND: Concussion leads to persistent post-concussion symptoms (PPCS) in up to one-third of those affected. While previous research has linked the initial trauma to elevated serum levels of neurofilament light chain (NFL), inflammatory markers, and neurotoxic metabolites within the kynurenine pathway, few studies have explored their relevance in PPCS. This study aims to investigate these biomarkers in PPCS patients, elucidating their relevance in the prolonged phase of concussion...
April 15, 2024: Journal of the Neurological Sciences
#22
JOURNAL ARTICLE
Tomohiko Nakata, Jun Natsume, Hiroyuki Yamamoto, Yuji Ito, Takeshi Suzuki, Masahiro Kawaguchi, Anna Shiraki, Sumire Kumai, Fumi Sawamura, Ryosuke Suzui, Takamasa Mitsumatsu, Hajime Narita, Takeshi Tsuji, Tetsuo Kubota, Shinji Saitoh, Akihisa Okumura, Hiroyuki Kidokoro
BACKGROUND: Various factors contribute to the development of infection-related acute encephalopathy (AE) in children, such as infectious agents and chronic underlying disorders. We studied underlying disorders in children with AE to identify predisposing factors of AE. METHODS: We investigated underlying disorders or past histories in patients with two types of AE from the database in the Tokai area of Japan between 2009 and 2022: 204 patients with AE with reduced subcortical diffusion (AED) and 137 with clinically mild encephalopathy with a reversible splenial lesion (MERS)...
March 22, 2024: Pediatric Neurology
#23
JOURNAL ARTICLE
Viktória Szabó-Műhelyi, Pál Tamás Szabó, Jeremy D Schmahmann, Tamás Káldi, Zoltán Bánréti, Katalin A Béres-Molnár, András Folyovich
Recent studies have reported that cerebellar lesions can cause cognitive, behavioral, and affective symptoms. This constellation is called the cerebellar cognitive affective syndrome (CCAS). A bedside instrument, the CCAS-Scale, has been developed to screen for this clinical presentation. The aim of this study is to adapt the CCAS-Scale to Hungarian according to international cross-cultural guidelines. In cooperation with the senior author of the original CCAS-Scale, we defined a five-step adaptation protocol (license number 6758-1/2021)...
April 18, 2024: Applied Neuropsychology. Adult
#24
REVIEW
Michelle C Welborn, Gregory Redding, Patrick Evers, Lindsey Nicol, David F Bauer, Rajiv R Iyer, Selina Poon, Steven Hwang
Scoliosis is a common complication of neuromuscular disorders. These patients are frequently recalcitrant to nonoperative treatment. When treated surgically, they have the highest risk of complications of all forms of scoliosis. While recent studies have shown an improvement in the rate of complications, they still remain high ranging from 6.3 to 75% depending upon the underlying etiology and the treatment center (Mohamad et al. in J Pediatr Orthop 27:392-397, 2007; McElroy et al. in Spine, 2012; Toll et al...
April 18, 2024: Spine Deformity
#25
JOURNAL ARTICLE
Cheng Zhang, Wenmiao Liu, Lulu Xu, Shiguo Liu, Fengyuan Che
ASH1L potentially contributes to Tourette syndrome (TS) and other neuropsychiatric disorders, as our previous studies have shown. It regulates essential developmental genes by counteracting polycomb-mediated transcriptional repression, which restricts chromatin accessibility at target genes. ASH1L is highly expressed in the adult brain, playing a crucial role in the early stage. However, it remains unclear how ASH1L mutations carried by patients with TS participate in regulating neuronal growth processes leading to TS traits...
April 18, 2024: European Child & Adolescent Psychiatry
#26
Ankita Sachdev, Sourya Acharya, Harshita J, Shreyash Huse
The Dyke-Davidoff-Masson syndrome (DDMS) is an uncommon neurological disorder whose prevalence is not yet known. There have only been 21 adult manifestations of this rare brain disorder, out of around 100 cases previously documented. Diagnosis is challenging because of the complexity of radiological findings and clinical symptoms, which include ventricle dilation, hypertrophy of the cranial bones, increased pneumatization of the sinuses, and cerebral hemisphere atrophy. It can be inherited or acquired from infections, brain hemorrhage, and hypoxia during pregnancy...
March 2024: Curēus
#27
Svetlana Tomic, Milorad Zjalic, Zvonimir Popovic, Zdravka Krivdic Dupan, Marija Heffer, Darija Snajder Mujkic, Dario Mandic, Silva Guljas, Igor N Petrovic
Neurological manifestations with basal ganglia involvement following Hymenoptera stings are rare and clinically ill-defined conditions. We present a patient with acute parkinsonism non-responsive to levodopa, who developed striatal lesions after a hornet sting. We report his response to immunomodulatory treatment and subsequent clinical and brain magnetic resonance imaging (MRI) follow-up. We also searched the literature for patients with acute extrapyramidal syndromes following an insect sting. Fourteen cases have been published; 12 of them are reviewed here...
2024: Frontiers in Neurology
#28
REVIEW
Erin D Wieruszewski, Mariam ElSaban, Patrick M Wieruszewski, Nathan J Smischney
The discovery and utilization of volatile anesthetics has significantly transformed surgical practices since their inception in the mid-19th century. Recently, a paradigm shift is observed as volatile anesthetics extend beyond traditional confines of the operating theatres, finding diverse applications in intensive care settings. In the dynamic landscape of intensive care, volatile anesthetics emerge as a promising avenue for addressing complex sedation requirements, managing refractory lung pathologies including acute respiratory distress syndrome and status asthmaticus, conditions of high sedative requirements including burns, high opioid or alcohol use and neurological conditions such as status epilepticus...
March 9, 2024: World Journal of Critical Care Medicine
#29
MULTICENTER STUDY
Xiaolan Chen, Hongning Shi, Jiaqi Chang, Wenjia Guo, Yuanhua Yang, Yong Wang, Lei Pan
To external validate the risk assessment model (RAM) of venous thromboembolism (VTE) in multicenter internal medicine inpatients. We prospectively collected 595 internal medical patients (310 with VTE patients, 285 non-VTE patients) were from Beijing Shijitan Hospital, Beijing Chaoyang Hospital, and the respiratory department of Beijing Tsinghua Changgeng Hospital from January 2022 to December 2022 for multicenter external validation. The prediction ability of Caprini RAM, Padua RAM, The International Medical Prevention Registry on Venous Thromboembolism (IMPROVE) RAM, and Shijitan (SJT) RAM were compared...
2024: Clinical and Applied Thrombosis/hemostasis
#30
Guilherme Diogo Silva, João Vitor Mahler, Sérgio Roberto Pereira da Silva Junior, Leonardo Oliveira Mendonça, Pedro Lucas Grangeiro de Sá Barreto Lima, Paulo Ribeiro Nóbrega, Fernando Kok, Fernando Freua
BACKGROUND: Monogenic autoinflammatory disorders result in a diverse range of neurological symptoms in adults, often leading to diagnostic delays. Despite the significance of early detection for effective treatment, the neurological manifestations of these disorders remain inadequately recognized. METHODS: We conducted a systematic review searching Pubmed, Embase and Scopus for case reports and case series related to neurological manifestations in adult-onset monogenic autoinflammatory diseases...
April 17, 2024: BMC Neurology
#31
JOURNAL ARTICLE
Jack A Black, Nha Trang Thu Pham, Farwa Ali, Mary M Machulda, Val J Lowe, Keith A Josephs, Jennifer L Whitwell
OBJECTIVE: Frontal hypometabolism on FDG-PET is observed in progressive supranuclear palsy (PSP), although it is unclear whether it is a feature of all PSP clinical variants and hence whether it is a useful diagnostic feature. We aimed to compare the frequency, severity, and pattern of frontal hypometabolism across PSP variants and determine whether frontal hypometabolism is related to clinical dysfunction. METHODS: Frontal hypometabolism in prefrontal, premotor, and sensorimotor cortices was visually graded on a 0-3 scale using CortexID Z-score images in 137 PSP patients...
April 17, 2024: Journal of Neurology
#32
EDITORIAL
Leighann Henehan, David Beeson, Jacqueline Palace
No abstract text is available yet for this article.
April 17, 2024: Practical Neurology
#33
JOURNAL ARTICLE
Mediha Annaç Asildağ, Gülden Sari, Adem Koyuncu, Ceprail Şimşek
Occupational exposure to manganese (Mn) primarily occurs through the inhalation of manganese-containing fumes and dust, with welding environments being significant sources of such exposure. Elevated levels of Mn in welding fumes can lead to a neurological syndrome known as manganism. A 28-yr-old male welder with 14 yr of experience, is presenting with complaints of forgetfulness, reasoning disorder, and decreased mental functions persisting for 10 yr. Three months ago, when he started working at the new workplace, he underwent employment screening conducted by the workplace physician...
April 16, 2024: Industrial Health
#34
REVIEW
Complex regional pain syndrome: advances in epidemiology, pathophysiology, diagnosis, and treatment.
Michael C Ferraro, Neil E O'Connell, Claudia Sommer, Andreas Goebel, Janet H Bultitude, Aidan G Cashin, G Lorimer Moseley, James H McAuley
Complex regional pain syndrome (CRPS) is a rare pain disorder that usually occurs in a limb after trauma. The features of this disorder include severe pain and sensory, autonomic, motor, and trophic abnormalities. Research from the past decade has offered new insights into CRPS epidemiology, pathophysiology, diagnosis, and treatment. Early identification of individuals at high risk of CRPS is improving, with several risk factors established and some others identified in prospective studies during the past 5 years...
May 2024: Lancet Neurology
#35
REVIEW
Jacob Pellinen, Emma C Foster, Jo M Wilmshurst, Sameer M Zuberi, Jacqueline French
Epilepsy diagnosis is often delayed or inaccurate, exposing people to ongoing seizures and their substantial consequences until effective treatment is initiated. Important factors contributing to this problem include delayed recognition of seizure symptoms by patients and eyewitnesses; cultural, geographical, and financial barriers to seeking health care; and missed or delayed diagnosis by health-care providers. Epilepsy diagnosis involves several steps. The first step is recognition of epileptic seizures; next is classification of epilepsy type and whether an epilepsy syndrome is present; finally, the underlying epilepsy-associated comorbidities and potential causes must be identified, which differ across the lifespan...
May 2024: Lancet Neurology
#36
JOURNAL ARTICLE
Julie K Wisch, Nicole S McKay, Anna H Boerwinkle, James Kennedy, Shaney Flores, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid E O'Bryant, Julie C Price, Charles M Laymon, Sharon J Krinsky-McHale, Florence Lai, H Diana Rosas, Sigan L Hartley, Shahid Zaman, Ira T Lott, Dana Tudorascu, Matthew Zammit, Adam M Brickman, Joseph H Lee, Thomas D Bird, Annie Cohen, Patricio Chrem, Alisha Daniels, Jasmeer P Chhatwal, Carlos Cruchaga, Laura Ibanez, Mathias Jucker, Celeste M Karch, Gregory S Day, Jae-Hong Lee, Johannes Levin, Jorge Llibre-Guerra, Yan Li, Francisco Lopera, Jee Hoon Roh, John M Ringman, Charlene Supnet-Bell, Christopher H van Dyck, Chengjie Xiong, Guoqiao Wang, John C Morris, Eric McDade, Randall J Bateman, Tammie L S Benzinger, Brian A Gordon, Beau M Ances
BACKGROUND: In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid and tau) occur in the brain at a young age, when comorbidities related to ageing are not present. Studies including these cohorts could, therefore, improve our understanding of the early pathogenesis of Alzheimer's disease and be useful when designing preventive interventions targeted at disease pathology or when planning clinical trials...
May 2024: Lancet Neurology
#37
JOURNAL ARTICLE
Lindsay McAlpine, Adeel S Zubair, Phillip Joseph, Serena Spudich
OBJECTIVES: To report a case-control study of new-onset small fiber neuropathy (SFN) after COVID-19 with invasive cardiopulmonary exercise testing (iCPET). SFN is a critical objective finding in long COVID and amenable to treatment. METHODS: A retrospective chart review was conducted on patients seen in the NeuroCOVID Clinic at Yale who developed new-onset SFN after a documented COVID-19 illness. We collected demographics, symptoms, skin biopsy, iCPET testing, treatments, and clinical response to treatment or no intervention...
May 2024: Neurology® Neuroimmunology & Neuroinflammation
#38
JOURNAL ARTICLE
Asena Gülçiçek, Elif Şanlı, Gülçin Benbir Şenel, Derya Karadeniz, Özlem Timirci-Kahraman, Cem İsmail Küçükali, Erdem Tüzün
OBJECTIVE: The main pathophysiological mechanisms in restless legs syndrome (RLS) are known as genetic predisposition, brain iron deficiency, and dopaminergic dysfunction. While some genetic variants and polymorphisms were defined, the genetic basis and etiopathogenesis of RLS remain unclear. We aimed to identify new candidate genes and/or potential biomarkers associated with increased RLS risk. METHODS: Twenty-three patients with RLS, 30 patients with Parkinson's disease (PD), and 27 healthy controls were enrolled...
April 17, 2024: Acta Neurologica Belgica
#39
JOURNAL ARTICLE
Claudia Pestchanker, Brenda Bertado Cortez, Marco A Lana Peixoto, José Ignacio Gortari, Sheila Castro Suarez, Cesar Caparo Zamalloa, Graciana Galiana, Francisco Peñalver, Vanesa Daccach Marques, Katharina Messias, Lorna Galleguillos, Fernando García, Juan I Rojas, Liliana Patrucco, Edgardo Cristiano, Verónica Tkachuk, Susana Liwacki, Jorge Correale, Mariano Marrodan, María C Ysraelit, Carlos Vrech, Norma Deri, Felisa Leguizamon, Darío Tavolini, Carolina Mainella, Gisela Zanga, Marina Alonso Serena, Ethel Ciampi, Herval Ribeiro Soares Neto, Pablo Lopez, Edgar Carnero Contentti
INTRODUCTION: We aimed to assess the frequency, duration, and severity of area postrema syndrome (APS) during follow-up in neuromyelitis optica spectrum disorder (NMOSD) patients, as well as its association with inflammatory activity and prognostic factors of APS severity in a real-world setting. METHODS: We conducted a retrospective study on a cohort of Latin American (LATAM) NMOSD patients who had experienced APS during their follow-up. Patients from Mexico, Peru, Brazil, Colombia, Panama, Chile and Argentina patients who met 2015 NMOSD criteria were included...
April 17, 2024: Journal of Neurology
#40
REVIEW
Inga Claus, Tobias Warnecke
Disorders of the gastrointestinal tract in patients suffering from hypokinetic movement disorders, and in particular Parkinson's disease, have increasingly been the subject of more intensive neuromedical research. So far, few data are available for patients with hyperkinetic movement disorders and ataxias. This review article summarizes the currently available and relevant publications on this topic. The particular focus is on essential tremor, restless legs syndrome, Huntington's disease and the group of hereditary ataxias...
April 17, 2024: Der Nervenarzt
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