Dong Woo Yeom, Bo Ram Chae, Jin Han Kim, Jun Soo Chae, Dong Jun Shin, Chang Hyun Kim, Sung Rae Kim, Ji Ho Choi, Seh Hyon Song, Dongho Oh, Se Il Sohn, Young Wook Choi
In order to improve the dissolution and oral bioavailability of valsartan (VST), and reduce the required volume for treatment, we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) composed of VST (80 mg), Capmul® MCM (13.2 mg), Tween® 80 (59.2 mg), Transcutol® P (59.2 mg), and Poloxamer 407 (13.2 mg). In the present study, by using Florite® PS-10 (119.1 mg) and Vivapur® 105 (105.6 mg) as solid carriers, VST-loaded solidified SuSMEDDS (S-SuSMEDDS) granules were successfully developed, which possessed good flow properties and rapid drug dissolution...
November 7, 2017: Oncotarget