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https://www.readbyqxmd.com/read/27812915/development-of-self-nanoemulsifying-drug-delivery-system-for-oral-bioavailability-enhancement-of-valsartan-in-beagle-dogs
#1
Zhenbao Li, Wenjuan Zhang, Yan Gao, Rongwu Xiang, Yan Liu, Mingming Hu, Mei Zhou, Xiaohong Liu, Yongjun Wang, Zhonggui He, Yinghua Sun, Jin Sun
Valsartan, an angiotensin II receptor antagonist, is widely used to treat high blood pressure in the clinical setting. However, its poor water solubility results in the low oral bioavailability. The aim of this study was to improve dissolution rate and oral bioavailability by developing a self-nanoemulsifying drug delivery system. Saturation solubility of valsartan in various oils, surfactants, and cosurfactants was investigated, and the optimized formulation was determined by central composite design-response surface methodology...
November 3, 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27753827/sy-02-3-resolving-ethical-problems-in-hypertension-treatment-trials
#2
Iwao Kuwajima
Since a concept of Evidence-based Medicine appeared in medical field in 1991, modern medical treatment have been remarkably changed.However, delusive belief of EBM without criticism has brought negative aspect, such as utilization of EBM by companies as a tool of promotion of drug or medical device.Although most of clinical trials were financially supported by drug companies. result of clinical trial does not always ended in favor of test drug or device. When negative results appeared, various way were taken by industry such as usage of SPIN, emphasizing secondary endpoint...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642880/sy-02-3-resolving-ethical-problems-in-hypertension-treatment-trials
#3
Iwao Kuwajima
Since a concept of Evidence-based Medicine appeared in medical field in 1991, modern medical treatment have been remarkably changed.However, delusive belief of EBM without criticism has brought negative aspect, such as utilization of EBM by companies as a tool of promotion of drug or medical device.Although most of clinical trials were financially supported by drug companies. result of clinical trial does not always ended in favor of test drug or device. When negative results appeared, various way were taken by industry such as usage of SPIN, emphasizing secondary endpoint...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27332366/classification-of-patient-care-complexity-cloud-technology
#4
Caren de Oliveira Riboldi, Andrea Barcellos Teixeira Macedo, Thiane Mergen, Vera Lúcia Mendes Dias, Diovane Ghignatti da Costa, Maria Luiza Falsarella Malvezzi, Ana Maria Muller Magalhães, Denise Tolfo Silveira
Presentation of the computerized structure to implement, in a university hospital in the South of Brazil, the Patients Classification System of Perroca, which categorizes patients according to the care complexity. This solution also aims to corroborate a recent study at the hospital, which evidenced that the increasing workload presents a direct relation with the institutional quality indicators. The tools used were the Google applications with high productivity interconnecting the topic knowledge on behalf of the nursing professionals and information technology professionals...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27220800/-national-strategic-promotion-for-large-scale-clinical-cancer-research
#5
Senya Toyama
The number of clinical research by clinical cancer study groups has been decreasing this year in Japan. They say the reason is the abolition of donations to the groups from the pharmaceutical companies after the Diovan scandal. But I suppose fundamental problem is that government-supported large-scale clinical cancer study system for evidence based medicine (EBM) has not been fully established. An urgent establishment of the system based on the national strategy is needed for the cancer patients and the public health promotion...
April 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26961969/chronotherapeutically-modulated-pulsatile-system-of-valsartan-nanocrystals-an-in-vitro-and-in-vivo-evaluation
#6
Nikhil Biswas, Ketousetuo Kuotsu
The objective was to improve the dissolution of valsartan by developing valsartan nanocrystals and design a pulsed release system for the chronotherapy of hypertension. Valsartan nanocrystals were prepared by sonication-anti-solvent precipitation method and lyophilized to obtain dry powder. Nanocrystals were directly compressed to minitablets and coated to achieve pulsatile valsartan release. Pharmacokinetic profiles of optimized and commercial formulations were compared in rabbit model. The mean particle size and PDI of the optimized nanocrystal batch V4 was reported as 211 nm and 0...
March 9, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/26171023/non-functioning-paraganglioma-occurring-in-the-urinary-bladder-a-case-report-and-review-of-the-literature
#7
Chuandu Peng, Siyuan Bu, Shenghua Xiong, Kunjie Wang, Hong Li
Paraganglioma, also termed extra-adrenal pheochromocytoma, may be observed at the base of the skull and neck as well as within the mediastinum and periaortic region. The clinical symptoms of paraganglioma of the urinary bladder include intermittent hypertensive attacks, micturition, headaches and palpitations due to high catecholamine levels; these types of paragangliomas are extremely rare. However, certain bladder paragangliomas do not present with any of these symptoms; thus, surgeons are not pre-warned on how to prepare for their resection...
July 2015: Oncology Letters
https://www.readbyqxmd.com/read/25531786/use-of-compounded-dispersing-media-for-extemporaneous-pediatric-syrups-with-candesartan-cilexetil-and-valsartan
#8
Monika Musko, Malgorzata Sznitowska
Available tablets or capsules for adults are often used to prepare extemporaneously formulated medicines appropriate for children. The most acceptable drug forms in pediatric population are oral liquids and pharmacists use commercial dispersing media to compound syrups from an active substance or from tablets available on the market. In many countries ready-to-use dispersing media are not available or refunded, but pharmacists can use other compounded media, providing their compatibility and stability are proven...
December 2014: Acta Pharmaceutica
https://www.readbyqxmd.com/read/23539423/pharmacokinetics-of-angiotensin-ii-receptor-blockers-in-the-dog-following-a-single-oral-administration
#9
COMPARATIVE STUDY
I-H Baek, B-Y Lee, E-S Lee, K-I Kwon
Angiotensin II receptor blockers (ARBs) are effective and well-tolerated orally active anti-hypertensive agents. The purpose of this study was to investigate the pharmacokinetic properties of typical ARBs in the dog. 60 beagles were administered a single oral dose of Micardis® 80 mg (telmisartan), Cozaar® 50 mg (losartan), or Diovan® 80- and 160-mg (valsartan). The plasma concentrations of these ARBs were measured using liquid chromatography/tandem mass spectrometry and their pharmacokinetic properties were analyzed using both non-compartmental and compartmental approaches...
July 2013: Drug Research
https://www.readbyqxmd.com/read/23227577/the-ceo-of-novartis-on-growing-after-a-patent-cliff
#10
Joseph Jimenez
When Joseph Jimenez joined Novartis, in 2007, the company was facing a big challenge: Its blockbuster drug Diovan, which accounted for more than 20% of the pharmaceutical division's revenue, would lose its U.S. patent in 2012. His senior executives had some ideas for offsetting the loss-about 100 of them. From that list they chose three on which to focus: (1) The division invested significantly in testing Afinitor (a treatment for renal cell carcinoma that was nearly ready for market) in breast cancer. (2) It set up Novartis China Commercial University to screen, hire, and train several hundred salespeople for rapid expansion in high-growth markets...
December 2012: Harvard Business Review
https://www.readbyqxmd.com/read/22891149/the-effects-of-blocking-angiotensin-receptors-on-early-stages-of-diabetic-nephropathy
#11
Alaleh Gheissari, Shaghayegh H Javanmard, Roohollah Shirzadi, Masood Amini, Nooshin Khalili
BACKGROUND: This study aimed to investigate the beneficial effects of angiotensin receptor blockers (ARBs) on markers of endothelial function in patients with early stage of diabetic nephropathy (DN). METHODS: This cross-sectional study was conducted on 32 participants with IDDM from January 2010 until May 2011 in Isfahan, Iran. The participants were candidate for receiving ARBs or angiotensin-converting enzyme inhibitors (ACEIs) to decrease microalbuminuria. The inclusion criteria were as follows: the age of onset of insulin-dependent diabetes mellitus (IDDM)less than 15 years; normal glomerular filtration rate (GFR); normal blood pressure; normal cardiovascular examination; negative urine culture, receiving no medications except insulin...
July 2012: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/22249663/participative-leadership-in-the-management-process-of-nightshift-nursing
#12
Diovane Ghignatti da Costa, Clarice Maria Dall'Agnol
This is a qualitative, exploratory, descriptive study, aiming to identify the perceptions of nurses regarding the leadership process and to analyze how this process takes place on the nightshift. Data collection was performed through the Focus Groups Technique, with 13 nightshift nurses of a public teaching hospital. Two categories that resulted from the thematic analysis are the focus of this article: the context of nightshift nursing work and leadership from the perception of the nightshift nurses. Teamwork is an important condition to vitalize the participatory perspective of the leadership process, given the necessary relationship of support and integration, above all in the nightshift nursing work...
November 2011: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/22125946/identification-and-determination-of-selected-angiotensin-ii-receptor-antagonist-group-drugs-by-hplc-method
#13
Krystyna Czerwińska, Aleksander P Mazurek
Losartan potassium, valsartan, telmisartan, irbesartan, eprosartan mesylate and candesartan cilexitil, the angiotensin II receptor antagonists, were analyzed in bulk substances and in tablets: Lorista tablets 50 mg, Diovan tablets 160 mg, Micardis tablets 20 mg, Aprovel tablets 300 mg, Teveten tablets 600 mg and Blopress tablets 16 mg. The conditions for identification by HPLC method in a gradient system and for determination of those compounds in isocratic systems were developed. The determination was carried out using Zorbax SB-Phenyl column with UV-VIS detector set at 230 nm and the following mobile phases: 0...
November 2011: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/22085435/novel-valsartan-loaded-solid-dispersion-with-enhanced-bioavailability-and-no-crystalline-changes
#14
Yi-Dong Yan, Jun Ho Sung, Kun Kook Kim, Dong Wuk Kim, Jong Oh Kim, Beom-Jin Lee, Chul Soon Yong, Han-Gon Choi
With the aim of developing a novel valsartan-loaded solid dispersion with enhanced bioavailability and no crystalline changes, various valsartan-loaded solid dispersions were prepared with water, hydroxypropyl methylcellulose (HPMC) and sodium lauryl sulphate (SLS). Effects of the weight ratios of SLS/HPMC and carrier/drug on both the aqueous solubility of valsartan and the drug-release profiles of solid dispersions were investigated. The physicochemical properties of solid dispersions were characterized using scanning electron microscope (SEM), differential scanning calorimetry (DSC) and X-ray diffraction (XRD)...
January 17, 2012: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/21617777/formulation-and-bioequivalence-of-two-valsartan-tablets-after-a-single-oral-administration
#15
Abdel Naser Zaid, Rita Cortesi, Aiman Qaddomi, Saed Khammash
The aim of this study is to assess the quality of Valzan(®) tablet (160 mg, valsartan immediate release test formulation) by comparing its pharmacokinetic parameters with Diovan(®) tablet (160 mg, valsartan reference formulation). Valzan(®) tablets were prepared according to a dry granulation method (roll compaction). To assess the bioequivalence of Valzan(®) tablets a randomized, two-way, crossover, bioequivalence study was performed in 24 healthy male volunteers. The selected volunteers were divided into two groups of 12 subjects...
March 2011: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/21375023/-observation-on-therapeutic-effect-of-acupuncture-in-the-treatment-of-german-hypertension-patients
#16
RANDOMIZED CONTROLLED TRIAL
Ning-yong Chen, Ying Zhou, Qin Dong, Chun-xiang Zhou
OBJECTIVE: To observe the clinical efficacy of acupuncture in the treatment of hypertension patients. METHODS: A total of 80 out-patients and in-patients with primary hypertension were randomly and equally divided into acupuncture group and medication group. Patients of the acupuncture group were treated with acupuncture stimulation of Fengchi (GB20), Qu-chi (LI 11), Taichong (LR 3), etc. for 30 min, combined with Xingjian (LR 2), Xiaxi (GB43) for hyperactivity of the liver-yang, with Ganshu (BL 18) and Fuliu (KI 7) for severe phlegm-damp, and with Guanyuan (CV 4) and Shenshu (BL23) for deficiency of both yin and yang, once per day, continuously for one month except weekends...
December 2010: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/21218537/ask-the-doctor-i-read-that-angiotensin-receptor-blockers-cause-cancer-i-take-one-diovan-for-my-blood-pressure-should-i-stop
#17
Thomas Lee
No abstract text is available yet for this article.
December 2010: Harvard Heart Letter: From Harvard Medical School
https://www.readbyqxmd.com/read/20502651/a-short-and-efficient-synthesis-of-valsartan-via-a-negishi-reaction
#18
Samir Ghosh, A Sanjeev Kumar, G N Mehta
An efficient synthesis of the angiotensin-II inhibitor valsartan (Diovan®) is presented. Directed ortho-metalation of 5-phenyl-1-trityl-1H-tetrazole (6) and its Negishi coupling with aryl bromide 5 are the key steps of the synthesis. This method overcomes many of the drawbacks associated with previously reported syntheses.
2010: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/19804097/valsartan-the-past-present-and-future
#19
Lars Køber, Christian Torp-Pedersen
Valsartan (Diovan) is a widely use angiotensin receptor blocker that prevents angiotensin II from binding to the subtype 1 receptor. Stimulation of the subtype 1 receptor is believed to mediate many of the deleterious effects accompanied by increased angiotensin II levels. Valsartan is effective in the treatment of hypertension, alone and in combination with hydrochlorothiazide. Valsartan is similarly as effective as angiotensin-converting enzyme (ACE) blockers following myocardial infarction accompanied with left ventricular dysfunction, and/or heart failure...
September 2005: Future Cardiology
https://www.readbyqxmd.com/read/19579313/ask-the-doctor-can-muscle-damage-from-a-statin-or-from-strenuous-exercise-elevate-creatinine-even-after-i-stopped-taking-the-statin-and-exercising-but-continue-to-take-zetia-and-diovan-hct
#20
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