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hepatitis b phases

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https://www.readbyqxmd.com/read/29142236/circulating-mir-210-and-mir-22-combined-with-alt-predict-the-virological-response-to-interferon-alpha-therapy-of-chb-patients
#1
Jin Li, Xiaonan Zhang, Liang Chen, Zhanqing Zhang, Jiming Zhang, Weixia Wang, Min Wu, Bisheng Shi, Xinxin Zhang, Maya Kozlowski, Yunwen Hu, Zhenghong Yuan
Interferon-alpha (IFN-α) therapy of chronic hepatitis B (CHB) patients is constrained by limited response and side effects. We described a panel of circulating microRNAs (miRNAs) which could potentially predict outcome of IFN-α therapy. Here, we report development of a simplified scoring model for personalized treatment of CHB patients. 112 CHB patients receiving IFN-α treatment were randomly divided into a training (n = 75) or a validation group (n = 37). The expression of 15 candidate miRNAs was detected in training group with 5 miRNAs exhibiting significantly different levels (p < 0...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127460/hepatic-metabolism-of-licochalcone-a-a-potential-chemopreventive-chalcone-from-licorice-glycyrrhiza-inflata-determined-using-liquid-chromatography-tandem-mass-spectrometry
#2
Lingyi Huang, Dejan Nikolic, Richard B van Breemen
The metabolism of the chemoprevention agent licochalcone A, which is a chemopreventive chalcone found in abundance in the licorice species Glycyrrhiza inflata, was investigated using human liver microsomes and human hepatocytes combined with analysis using high performance liquid chromatography-mass spectrometry (LC-MS). Five oxygenated phase I metabolites of licochalcone A were formed by human liver microsomes, including a catechol on the A-ring, two intramolecular cyclization products following epoxidation of the exocyclic alkene at position 5 of the B-ring, and two dioxygenated products...
November 10, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29127350/memory-regulatory-t-cells-increase-only-in-inflammatory-phase-of-chronic-hepatitis-b-infection-and-related-to-galectin-9-tim-3-interaction
#3
Ching-Chih Hu, Wen-Juei Jeng, Yi-Cheng Chen, Jian-He Fang, Chien-Hao Huang, Wei Teng, Yi-Chung Hsieh, Yung-Chang Lin, Rong-Nan Chien, I-Shyan Sheen, Chun-Yen Lin
CD4(+)Foxp3(+) regulatory T cells (Tregs) are the main immune suppressors with subpopulation of inflamed-tissue related memory Tregs (mTregs) and non-related resting Treg (rTregs). Previously, Treg was proposed to be the cause of chronicity of hepatitis B virus (HBV) infection but with controversies. We then investigated the role of mTregs in distinct immune phases of chronic HBV infection, especially the non-inflammatory versus inflammatory phases. It was found mTregs but not rTregs increased only in the inflammatory phase and correlated with serum alanine aminotransferase (ALT) level...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29125756/hepatitis-b-virus-capsid-completion-occurs-through-error-correction
#4
Corinne A Lutomski, Nicholas A Lyktey, Zhongchao Zhao, Elizabeth E Pierson, Adam Zlotnick, Martin F Jarrold
Understanding capsid assembly is important because of its role in virus lifecycles and in applications to drug discovery and nanomaterial development. Many virus capsids are icosahedral, and assembly is thought to occur by the sequential addition of capsid protein subunits to a nucleus, with the final step completing the icosahedron. Almost nothing is known about the final (completion) step because the techniques usually used to study capsid assembly lack the resolution. In this work, charge detection mass spectrometry (CDMS) has been used to track the assembly of the T = 4 hepatitis B virus (HBV) capsid in real time...
November 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29120380/in-vitro-phase-i-metabolism-of-crv431-a-novel-oral-drug-candidate-for-chronic-hepatitis-b
#5
Daniel J Trepanier, Daren R Ure, Robert T Foster
The cytochrome P450-mediated Phase I in vitro metabolism of CRV431 was studied using selective chemical inhibition and recombinant human enzymes. Additionally, the metabolic profile of CRV431 in human, rat, and monkey liver microsomes was investigated. Liver microsomes were incubated for 0-80 min with CRV431, and the metabolite profile was assessed by electrospray ionization liquid chromatography mass spectrometry (ESI-LCMS). CRV431 was extensively metabolized through oxidation to produce various hydroxylated and demethylated species...
November 9, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/29111237/imaging-findings-of-primary-hepatic-angiosarcoma-on-gadoxetate-disodium-enhanced-liver-mri-comparison-with-hepatic-haemangiomas-of-similar-size
#6
B Kim, J H Byun, J H Lee, B J Park, H-J Kwon, J H Lee, S J Lee, H J Won, Y M Shin, P N Kim
AIM: To describe imaging characteristics of primary hepatic angiosarcoma on gadoxetate disodium-enhanced dynamic magnetic resonance imaging (MRI) and to determine features that differentiate angiosarcomas from similar-sized haemangiomas. MATERIALS AND METHODS: The study included 15 patients with hepatic angiosarcomas and 35 patients with size-matched hepatic haemangiomas who underwent gadoxetate disodium-enhanced liver MRI. The number, size, growth pattern, signal intensity (SI) characteristics, and SI changes on dynamic scans were evaluated and compared between the two entities...
October 27, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29106740/pharmacokinetics-of-nintedanib-in-subjects-with-hepatic-impairment
#7
Kristell Marzin, Gunther Kretschmar, Doreen Luedtke, Sandrine Kraemer, Raimund Kuelzer, Rozsa Schlenker-Herceg, Ulrike Schmid, David Schnell, Claudia Dallinger
Nintedanib is an intracellular inhibitor of tyrosine kinases used in the treatment of non-small cell lung cancer and idiopathic pulmonary fibrosis (IPF). This phase 1 open-label study investigated the influence of mild and moderate hepatic impairment on the pharmacokinetics (PK), safety, and tolerability of nintedanib following oral administration of a single 100-mg dose. Subjects with hepatic impairment classified as Child-Pugh A (mild hepatic impairment) or Child-Pugh B (moderate hepatic impairment) were eligible...
November 6, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29104490/transarterial-chemoembolization-a-favorable-postoperative-management-to-improve-prognosis-of-hepatitis-b-virus-associated-intrahepatic-cholangiocarcinoma-after-surgical-resection
#8
Seogsong Jeong, Bo Zheng, Jian Wang, Jiachang Chi, Ying Tong, Lei Xia, Ning Xu, Jianjun Zhang, Xiaoni Kong, Jinyang Gu, Qiang Xia
Background: There is no information regarding transarterial chemoembolization (TACE) as a postoperative management after hepatic resection for patients with hepatitis B virus (HBV)-associated intrahepatic cholangiocarcinoma (ICC). Methods: Forty-two patients with pathological confirmation of HBV-associated ICC were enrolled. Prognostic impact of the clinicopathological factors as well as postoperative TACE were evaluated. Computed tomography findings of HBV-associated ICC were assessed. Results: Tumor size of larger than 5 cm (hazard ratio [HR], 5...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29104121/safety-efficacy-and-pharmacodynamics-of-vesatolimod-gs-9620-in-virally-suppressed-patients-with-chronic-hepatitis-b
#9
Harry L A Janssen, Maurizia R Brunetto, Yoon Jun Kim, Carlo Ferrari, Benedetta Massetto, Anh-Hoa Nguyen, Adarsh Joshi, Jacky Woo, Audrey H Lau, Anuj Gaggar, G Mani Subramanian, Eric M Yoshida, Sang Hoon Ahn, Naoky C S Tsai, Scott Fung, Edward J Gane
BACKGROUND & AIMS: Vesatolimod (GS-9620) is an oral agonist of toll-like receptor 7, an activator of innate and adaptive immune responses. Here the safety and efficacy of vesatolimod is assessed after once-weekly treatment in chronic hepatitis B (CHB) infected patients suppressed on oral antiviral treatment. METHODS: In a Phase 2, double-blind, randomized, placebo (PBO)-controlled study, 162 patients stratified by hepatitis B surface antigen (HBsAg) levels and serum HBeAg status were randomized 1:3:3:3 to once-weekly oral PBO or vesatolimod (1-, 2-, or 4-mg doses) for 4, 8 or 12 weeks per cohort and efficacy assessed by change in baseline HBsAg (log10 IU/mL) at the primary endpoint (Week 24)...
November 2, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29103340/immunogenicity-of-branched-polyethylene-glycol-modified-interferon-alpha
#10
Weidong Zhou, Daru Lu, Xiaojin Liao, Lu Zhuang, Li Sun
AIM: To assess the immunogenicity of Peginterferon alpha-2 b(Pegberon) and its effect on the efficacy and safety in phase III clinical trial, by comparing it with the control drug Pegasys. METHODS: 770 patients were recruited in total. 509 were treated with Pegberon plus ribavirin and 261 were treated with Pegasys plus ribavirin. After treatment of 12 and 24 weeks, plasma samples were collected from individual patients for detecting the anti-therapeutic antibodies (ATA) and hepatitis C RNA(HCV RNA), to evaluate the production of antibodies and their adverse effect on the efficacy and safety of the treatments...
November 6, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29099040/assessment-of-hepatitis-b-viral-infection-as-a-predictor-of-hepatic-enzymes-and-compounds-alteration-among-antenatal-patients
#11
Olatunji Ayodeji Abulude, Ismai'la Ahmed, Farouk Umar Sadisu
Worldwide, hepatitis B viral (HBV) infection continues to be a major public health issue. The study was aimed at assessing HBV infection as a predictor of hepatic enzymes and compounds alteration among antenatal patients in Kano State, Nigeria. Sera were screened for HBV markers using immunochromatograhy and ELISA. Serum levels of alkaline phosphatase (ALP), asphatate aminotransferase (AST), alanine aminotransferase (ALT), albumin and bilirubin were also determined. Out of the 160 patients, 6.9% and 31.3% tested positive for HBsAg and HBcAb, respectively...
October 18, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29089040/veritable-antiviral-capacity-of-natural-killer-cells-in-chronic-hbv-infection-an-argument-for-an-earlier-anti-virus-treatment
#12
Xiaoyan Li, Liang Zhou, Lin Gu, Yurong Gu, Lubiao Chen, Yifan Lian, Yuehua Huang
BACKGROUND: There is limited information on innate immunity, especially natural killer (NK) cell function, in different chronic hepatitis B (CHB) stages. Therefore, we examined whether the clinical staging strategy accurately reflects veritable NK cell immunity. METHODS: A total of 237 eligible CHB patients and 22 healthy controls were enrolled in our study. Demographic and clinical data were collected, and the CHB phases (immune active-IA, immune tolerant phase-IT, inactive CHB-IC, and grey zone-GZ) were classified according to the latest American Association for the Study of Liver Disease guidelines...
October 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29076364/evaluation-of-canine-hepatic-masses-by-use-of-triphasic-computed-tomography-and-b-mode-color-flow-power-and-pulsed-wave-doppler-ultrasonography-and-correlation-with-histopathologic-classification
#13
Erin R Griebie, Frederic H David, Christopher P Ober, Daniel A Feeney, Kari L Anderson, Arno Wuenschmann, Carl R Jessen
OBJECTIVE To determine clinical relevance for quantitative and qualitative features of canine hepatic masses evaluated by use of triphasic CT and B-mode, color flow, power, and pulsed-wave Doppler ultrasonography and to compare diagnostic accuracy of these modalities for predicting mass type on the basis of histopathologic classification. ANIMALS 44 client-owned dogs. PROCEDURES Dogs with histopathologic confirmation (needle core, punch, or excisional biopsy) of a hepatic mass were enrolled. Triphasic CT and B-mode, color flow, power, and pulsed-wave Doppler ultrasonography of each hepatic mass were performed...
November 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29069498/transient-changes-in-hepatic-physiology-that-alter-bilirubin-and-bile-acid-transport-may-explain-elevations-in-liver-chemistries-observed-in-clinical-trials-of-ggf2-cimaglermin-alfa
#14
Merrie Mosedale, Donald Button, Jonathan P Jackson, Kimberly M Freeman, Kenneth R Brouwer, Anthony O Caggiano, Andrew Eisen, Jennifer F Iaci, Tom J Parry, Ric Stanulis, Maya Srinivas, Paul B Watkins
GGF2 is a recombinant human neuregulin-1β in development for chronic heart failure. Phase 1 clinical trials of GGF2 were put on hold when transient elevations in serum aminotransferases and total bilirubin were observed in 2 of 43 subjects who received single doses of GGF2 at 1.5 or 0.378 mg/kg. However, aminotransferase elevations were modest and not typical of liver injury sufficient to result in elevated serum bilirubin. Cynomolgus monkeys administered a single 15 mg/kg dose of GGF2 had similar transient elevations in serum aminotransferases and bilirubin as well as transient elevations in serum bile acids...
October 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29062901/new-directions-in-hepatitis-b-therapy-research
#15
REVIEW
Marta Lewandowska, Anna Piekarska
Chronic hepatitis B treatment is available for a long period, allowing disease control and infection suppression, but it is rarely responsible for HBsAg clearance. None of the drugs available aim at cccDNA, the obstacle in HBV infection eradication. Complications related to CHB, such as liver insufficiency, cirrhosis, and hepatocellular carcinoma are reduced in conditions of good viremia suppression, but still exist even after HBsAg seroclearance, what makes a need for urgent forthcoming of new therapeutics...
September 2017: Clin Exp Hepatol
https://www.readbyqxmd.com/read/29061175/hepatic-artery-infusion-chemotherapy-using-mfolfox-versus-transarterial-chemoembolization-for-massive-unresectable-hepatocellular-carcinoma-a-prospective-non-randomized-study
#16
Min-Ke He, Yong Le, Qi-Jiong Li, Zi-Shan Yu, Shao-Hua Li, Wei Wei, Rong-Ping Guo, Ming Shi
BACKGROUND: Transarterial chemoembolization (TACE) is recommended as the standard care for unresectable hepatocellular carcinoma (HCC) at Barcelona Clinic Liver Cancer (BCLC) stage A-B. However, the efficacy of TACE on large (≥ 10 cm) stage A-B HCC is far from satisfactory, and it is proposed that hepatic artery infusion chemotherapy (HAIC) might be a better first-line treatment of this disease. Hence, we compared the safety and efficacy of HAIC with the modified FOLFOX (mFOLFOX) regimen and those of TACE in patients with massive unresectable HCC...
October 23, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29056075/an-updated-review-of-the-jak1-2-inhibitor-ruxolitininb-in-the-philadelphia-negative-myeloproliferative-neoplasms
#17
Natalia Curto-Garcia, Claire N Harrison
Ruxolitinib (Rux), a JAK1/2 inhibitor, has been approved for patients with myelofibrosis and in polycythemia vera with inadequate response/intolerance to hydroxycarbamide. Studies have demonstrated that Rux improves disease-related symptoms and splenomegaly. A late emerging observation from two Phase III trials was that Rux was associated with survival advantage in comparison with placebo or other available therapies in myelofibrosis. Important data suggest that for polycythemia vera Rux improved control of blood counts...
October 23, 2017: Future Oncology
https://www.readbyqxmd.com/read/29056008/-clinical-effect-and-safety-of-pegylated-interferon-%C3%AE-2b-injection-y-shape-40-kd-in-treatment-of-hbeag-positive-chronic-hepatitis-b-patients
#18
F Q Hou, Y L Yin, L Y Zeng, J Shang, G Z Gong, C Pan, M X Zhang, C B Yin, Q Xie, Y Z Peng, S J Chen, Q Mao, Y P Chen, Q G Mao, D Z Zhang, T Han, M R Wang, W Zhao, J J Liu, Y Han, L F Zhao, G H Luo, J M Zhang, J Peng, D M Tan, Z W Li, H Tang, H Wang, Y X Zhang, J Li, L L Zhang, L Chen, J D Jia, C W Chen, Z Zhen, B S Li, J Q Niu, Q H Meng, H Yuan, Y T Sun, S C Li, J F Sheng, J Cheng, L Sun, G Q Wang
Objective: To investigate the clinical effect and safety of long-acting pegylated interferon-α-2b (Peg-IFN-α-2b) (Y shape, 40 kD) injection (180 μg/week) in the treatment of HBeAg-positive chronic hepatitis B (CHB) patients, with standard-dose Peg-IFN-α-2a as positive control. Methods: This study was a multicenter, randomized, open-label, and positive-controlled phase III clinical trial. Eligible HBeAg-positive CHB patients were screened out and randomized to Peg-IFN-α-2b (Y shape, 40 kD) trial group and Peg-IFN-α-2a control group at a ratio of 2:1...
August 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29055988/-association-of-hla-dq-and-ifnl4-polymorphisms-with-hepatitis-b-virus-infection-and-clearance
#19
H Chen, J H Fan, W X Chen, J J Guo, Y Huang
Objective: To confirmed the polymorphisms of HLA-DQ and IFNL4 were associated with HBV infection and clearance in a Chinese population. Methods: The Sequenom MassARRAY MALDI-TOF system was used to genotype the HLA-DQrs9275319 and IFNL4rs368234815, rs12971396, rs12979860, and rs8099917. A binary logistic regression test was conducted to estimate the relative risk of these SNPs with HBV infection and clearance. Haploview4.2 software and PHASE software (v2.0.2) were employed to analyze linkage disequilibrium (LD) and haplotype frequencies...
July 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29055908/high-risk-of-hepatocellular-carcinoma-and-death-in-patients-with-immune-tolerant-phase-chronic-hepatitis-b
#20
Gi-Ae Kim, Young-Suk Lim, Seungbong Han, Jonggi Choi, Ju Hyun Shim, Kang Mo Kim, Han Chu Lee, Yung Sang Lee
OBJECTIVE: High serum HBV DNA levels are associated with high risks of hepatocellular carcinoma (HCC) and cirrhosis in patients with chronic hepatitis B (CHB). Although the immune-tolerant (IT) phase is characterised by high circulating HBV DNA levels, it remains unknown whether antiviral treatment reduces risks of HCC and mortality. DESIGN: This historical cohort study included HBeAg-positive patients with CHB with high HBV DNA levels (≥20 000 IU/mL) and no evidence of cirrhosis at a tertiary referral hospital in Korea from 2000 to 2013...
October 21, 2017: Gut
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