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Residual curarization

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https://www.readbyqxmd.com/read/27871583/sugammadex-given-for-rocuronium-induced-neuromuscular-blockade-in-infants-a-retrospect%C3%A4-ve-study
#1
Ozlem Ozmete, Cagla Bali, Oya Yalcin Cok, Hatice Evren Eker Turk, Nesrın Bozdogan Ozyilkan, Soner Civi, Anıs Aribogan
STUDY OBJECTIVE: To evaluate the efficacy and safety of sugammadex in reversing profound neuromuscular block induced by rocuronium in infant patients. DESIGN: Retrospective observational study. SETTING: University teaching hospital. PATIENTS: Twenty-six infants (2-12 months of age; 3-11 kg) with an American Society of Anesthesiologists classification I, II, or III who were scheduled to undergo neurosurgical procedures were included in the study...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27871504/efficacy-and-safety-of-sugammadex-compared-to-neostigmine-for-reversal-of-neuromuscular-blockade-a-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Michele Carron, Francesco Zarantonello, Paola Tellaroli, Carlo Ori
BACKGROUND AND OBJECTIVE: Sugammadex has been introduced for reversal of rocuronium (or vecuronium)-induced neuromuscular blockade (NMB). Although its efficacy has been established, data are conflicting whether it is safer than neostigmine traditionally used for reversing NMB. DESIGN: Meta-analysis of data about effectiveness and safety of sugammadex compared to neostigmine for reversing NMB in adults was performed using the PRISMA methodology. SETTING: University medical hospital...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27797097/neuromuscular-blockade-in-the-elderly
#3
Michał Stankiewicz-Rudnicki
The aim of the presented review is to highlight the clinical problem of postoperative residual curarization (PORC) following general anaesthesia in the elderly. Possible complications of PORC are described along with age-induced changes in pharmacokinetics of long and intermediate-acting neuromuscular blocking agents. This is intended to facilitate the selection and to promote appropriate intraoperative use of muscle relaxants in patients over the age of 65 years.
2016: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/27555126/recovery-of-laryngeal-nerve-function-with-sugammadex-after-rocuronium-induced-profound-neuromuscular-block
#4
Vittorio Pavoni, Lara Gianesello, Cristiana Martinelli, Andrew Horton, Alessandra Nella, Gabriele Gori, Martina Simonelli, Giuseppe De Scisciolo
STUDY OBJECTIVE: The aim of this study was to evaluate the efficacy of sugammadex in reversing profound rocuronium-induced neuromuscular block at the laryngeal adductor muscles using motor-evoked potentials (mMEPs). DESIGN: A prospective observational study. SETTING: University surgical center. PATIENTS: Twenty patients with American Society of Anesthesiologists physical class I-II status who underwent propofol-remifentanil anesthesia for the surgery of the thyroid gland...
September 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27403387/a-comparision-of-the-effect-of-sugammadex-on-the-recovery-period-and-postoperative-residual-block-in-young-elderly-and-middle-aged-elderly-patients
#5
Emine Yazar, Canan Yılmaz, Hülya Bilgin, Derya Karasu, Selcan Bayraktar, Yılmaz Apaydın, Halil Erkan Sayan
BACKGROUND: The importance of the characteristics of anesthesia and postoperative residual curarization (PORC) in the elderly population should be a growing concern in this century. AIMS: To investigate the effect of sugammadex on the duration of the recovery from neuromuscular blocking agents and postoperative residual curarization in the young elderly and middle-aged elderly patients who underwent elective laparoscopic cholecystectomy, followed by a train of four (TOF) watch monitorization...
March 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27232277/residual-neuromuscular-blockade-in-the-postanesthesia-care-unit-observational-cross-sectional-study-of-a-multicenter-cohort
#6
Carlos L Errando, Ignacio Garutti, Guido Mazzinari, Oscar Diaz-Cambronero, John F Bebawy
BACKGROUND: Residual neuromuscular blockade after general anesthesia using nondepolarizing neuromuscular blocking agents has pathophysiological, clinical, and economic consequences. A significant number of patients under muscle relaxation sustain residual curarization. METHODS: Observational, prospective, multicenter study of a cohort of patients (Residual Curarization in Spain Study, ReCuSS). Residual blockade was defined as TOFr<0.9. Patients >18 years-old under general anesthesia, including at least one dose of non-depolarizing neuromuscular blocking agents, and transferred extubated and spontaneously ventilating to the postanesthesia care unit were included...
May 27, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/26937203/sugammadex-for-reversal-of-neuromuscular-blockade-a-retrospective-analysis-of-clinical-outcomes-and-cost-effectiveness-in-a-single-center
#7
Michele Carron, Fabio Baratto, Francesco Zarantonello, Carlo Ori
OBJECTIVE: The aim of the study is to evaluate the clinical and economic impact of introducing a rocuronium-neostigmine-sugammadex strategy into a cisatracurium-neostigmine regimen for neuromuscular block (NMB) management. METHODS: We conducted a retrospective analysis of clinical outcomes and cost-effectiveness in five operating rooms at University Hospital of Padova. A clinical outcome evaluation after sugammadex administration as first-choice reversal drug in selected patients (rocuronium-sugammadex) and as rescue therapy after neostigmine reversal (rocuronium-neostigmine-sugammadex) compared to control was performed...
2016: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/26768931/survey-of-postoperative-residual-curarization-acute-respiratory-events-and-approach-of-anesthesiologists
#8
Ismail Aytac, Aysun Postaci, Betul Aytac, Ozlem Sacan, Gulcin Hilal Alay, Bulent Celik, Kadriye Kahveci, Bayazit Dikmen
BACKGROUND AND OBJECTIVES: residual paralysis following the use of neuromuscular blocking drugs (NMBDs) without neuromuscular monitoring remains a clinical problem, even when NMBDs are used. This study surveys postoperative residual curarization and critical respiratory events in the recovery room, as well as the clinical approach to PORC of anesthesiologists in our institution. METHODS: This observational study included 415 patients who received general anesthesia with intermediate-acting NMBDs...
January 2016: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/26508869/feasibility-of-full-and-rapid-neuromuscular-blockade-recovery-with-sugammadex-in-myasthenia-gravis-patients-undergoing-surgery-a-series-of-117-cases
#9
Tomas Vymazal, Martina Krecmerova, Vladimír Bicek, Robert Lischke
PURPOSE: Myasthenia gravis (MG) is an autoimmune disease interfering with neuromuscular transmission. Patients are at risk of postoperative residual curarization (PORC) if nondepolarizing muscle relaxants are used. Clinically inapparent insufficient muscle strength may result in hypoventilation and postoperative bronchopneumonia. We describe a cohort of 117 cases in which sugammadex was used in MG patients undergoing surgery with muscle relaxation with rocuronium. METHODS AND PATIENTS: We anesthetized 117 patients with MG using rocuronium and sugammadex as neuromuscular blockade reversal agent...
2015: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/26472231/prospective-study-of-residual-neuromuscular-block-and-postoperative-respiratory-complications-in-patients-reversed-with-neostigmine-versus-sugammadex
#10
Javier Martinez-Ubieto, Sonia Ortega-Lucea, Ana Pascual-Bellosta, Ivan Arazo-Iglesias, Jesús Gil-Bona, Teresa Jimenez-Bernardó, Luis Muñoz-Rodriguez
BACKGROUND: Postoperative residual curarization (PORC) is an important complication of neuromuscular blocking drug (NMBD) use. This study evaluates the incidence of PORC in the Postanesthesia Care Unit (PACU), its relation to the type of muscle relaxant and reversal agent used, and its implication in the development of postoperative respiratory complications. METHODS: A prospective observational study of cohorts was made with 558 patients operated under general anesthesia...
July 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/26323727/use-of-neuromuscular-blockers-in-brazil
#11
Giovani de Figueiredo Locks, Ismar Lima Cavalcanti, Nadia Maria Conceição Duarte, Rafael Martins da Cunha, Maria Cristina Simões de Almeida
The objective of this study was to evaluate how Brazilian anesthesiologists are using neuromuscular blockers, focusing on how they establish the diagnosis of postoperative residual curarization and the incidence of complications associated with the use of neuromuscular blockers. A questionnaire was sent to anesthesiologists inviting them to participate in the study. The online data collection remained open from March 2012 to June 2013. During the study period, 1296 responses were collected. Rocuronium, atracurium, and cisatracurium were the main neuromuscular blockers used in cases of elective surgery...
September 2015: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/26160168/-use-of-neuromuscular-blockers-in-brazil
#12
Giovani de Figueiredo Locks, Ismar Lima Cavalcanti, Nadia Maria Conceição Duarte, Rafael Martins da Cunha, Maria Cristina Simões de Almeida
The objective of this study was to evaluate how Brazilian anesthesiologists are using neuromuscular blockers (NMB), focusing on how they establish the diagnosis of postoperative residual curarization and the incidence of complications associated with the use of NMB. A questionnaire was sent to anesthesiologists inviting them to participate in the study. The online data collection remained open from March 2012 to June 2013. During the study period, 1296 responses were collected. Rocuronium, atracurium, and cisatracurium were the main neuromuscular blockers used in cases of elective surgery...
September 2015: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/26022912/target-controlled-infusion-of-remifentanil-without-muscle-relaxants-allows-acceptable-surgical-conditions-during-thoracotomy-performed-under-sevoflurane-anesthesia
#13
RANDOMIZED CONTROLLED TRIAL
Mohamed R El-Tahan, Mohamed Regal
OBJECTIVES: To test the hypothesis that the use of a nonmuscle relaxant anesthetic technique (NMRT) during thoracotomy would be associated with comparable surgical conditions with the standard use of neuromuscular blocking drugs. DESIGN: A prospective, randomized, single-blind, controlled study. SETTING: A single university hospital. PARTICIPANTS: Sixty-six patients scheduled for open thoracotomy under sevoflurane anesthesia with a target-controlled infusion (TCI) of remifentanil...
December 2015: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/25902322/the-recite-study-a-canadian-prospective-multicenter-study-of-the-incidence-and-severity-of-residual-neuromuscular-blockade
#14
MULTICENTER STUDY
Louis-Philippe Fortier, Dolores McKeen, Kim Turner, Étienne de Médicis, Brian Warriner, Philip M Jones, Alan Chaput, Jean-François Pouliot, André Galarneau
BACKGROUND: Postoperative residual neuromuscular blockade (NMB), defined as a train-of-four (TOF) ratio of <0.9, is an established risk factor for critical postoperative respiratory events and increased morbidity. At present, little is known about the occurrence of residual NMB in Canada. The RECITE (Residual Curarization and its Incidence at Tracheal Extubation) study was a prospective observational study at 8 hospitals in Canada investigating the incidence and severity of residual NMB...
August 2015: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/25789175/bp-13-pla2-purification-and-neuromuscular-activity-of-a-new-asp49-toxin-isolated-from-bothrops-pauloensis-snake-venom
#15
Georgina Sucasaca-Monzón, Priscila Randazzo-Moura, Thalita Rocha, Frank Denis Torres-Huaco, Augusto Vilca-Quispe, Luis Alberto Ponce-Soto, Sérgio Marangoni, Maria Alice da Cruz-Höfling, Léa Rodrigues-Simioni
A new PLA2 (Bp-13) was purified from Bothrops pauloensis snake venom after a single chromatographic step of RP-HPLC on μ-Bondapak C-18. Amino acid analysis showed a high content of hydrophobic and basic amino acids and 14 half-cysteine residues. The N-terminal sequence showed a high degree of homology with basic Asp49 PLA2 myotoxins from other Bothrops venoms. Bp-13 showed allosteric enzymatic behavior and maximal activity at pH 8.1, 36°-45°C. Full Bp-13 PLA2 activity required Ca(2+); its PLA2 activity was inhibited by Mg(2+), Mn(2+), Sr(2+), and Cd(2+) in the presence and absence of 1 mM Ca(2+)...
2015: Biochemistry Research International
https://www.readbyqxmd.com/read/25751174/the-facilitatory-effect-of-casearia-sylvestris-sw-gua%C3%A3-atonga-fractions-on-the-contractile-activity-of-mammalian-and-avian-neuromuscular-apparatus
#16
Adriana C Werner, Miriele C Ferraz, Edson H Yoshida, Natalia Tribuiani, Jean A A Gautuz, Monique N Santana, Bruna A Dezzotti, Vanessa G de Miranda, Ameris L Foramiglio, Sandro Rostelato-Ferreira, Renata V da Silva Tavares, Stephen Hyslop, Yoko Oshima-Franco
Many natural products influence neurotransmission and are used clinically. In particular, facilitatory agents can enhance neurotransmission and are potentially useful for treating neuromuscular diseases in which muscular weakness is the major symptom. In this work, we investigated the facilitatory effect of apolar to polar fractions of Casearia sylvestris Sw. (guaçatonga) on contractility in mouse phrenic nerve-diaphragm (PND) and chick biventer cervicis (BC) neuromuscular preparations exposed to indirect (via the nerve; 3 V stimuli) and direct (30 V stimuli) muscle stimulation in the absence and presence of pharmacological antagonists...
2015: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/25738388/the-facilitatory-effect-of-casearia-sylvestris-sw-gua%C3%A3-atonga-fractions-on-the-contractile-activity-of-mammalian-and-avian-neuromuscular-apparatus
#17
Adriana C Werner, Miriéle C Ferraz, Edson H Yoshida, Natalia Tribuiani, Jean A A Gautuz, Monique N Santana, Bruna A Dezzotti, Vanessa G de Miranda, Améris L Foramiglio, Sandro Rostelato-Ferreira, Renata V da Silva Tavares, Stephen Hyslop, Yoko Oshima-Franco
Many natural products influence neurotransmission and are used clinically. In particular, facilitatory agents can enhance neurotransmission and are potentially useful for treating neuromuscular diseases in which muscular weakness is the major symptom. In this work, we investigated the facilitatory effect of apolar to polar fractions of Casearia sylvestris Sw. (guaçatonga) on contractility in mouse phrenic nerve-diaphragm (PND) and chick biventer cervicis (BC) neuromuscular preparations exposed to indirect (via the nerve; 3 V stimuli) and direct (30 V stimuli) muscle stimulation in the absence and presence of pharmacological antagonists...
March 3, 2015: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/25693333/-efficacy-and-safety-of-sugammadex-org-25969-in-reversing-deep-neuromuscular-block-induced-by-rocuronium-or-vecuronium-in-japanese-patients
#18
RANDOMIZED CONTROLLED TRIAL
Junzo Takeda, Hiroshi Iwasaki, Tetsutaro Otagiri, Takasumi Katoh, Koh Shingu, Hidefumi Obara, Hideki Nakatsuka, Yoshinobu Tomiyama, Toshiharu Kasaba
BACKGROUND: Efficacy and safety of sugammadex in reversing neuromuscular block induced by rocuronium or vecuronium were investgated in Japanese patients. METHODS: We studied 99 Japanese patients undergoing surgery requiring general anesthesia. Patients were allocated randomly to receive intubation dose of rocuronium or vecuronium. During surgery, patients received additional dose of rocuronium or vecuronium for maintenance of deep block. At 1-2 PTC, 0.5-8.0 mg ...
October 2014: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/25693332/-efficacy-and-safety-of-sugammadex-org-25969-in-reversing-moderate-neuromuscular-block-induced-by-rocuronium-or-vecuronium-in-japanese-patients
#19
RANDOMIZED CONTROLLED TRIAL
Junzo Takeda, Hiroshi Iwasaki, Michiaki Yamakage, Makoto Ozaki, Miwako Kawamata, Yoshio Hatano, Toshihiro Yorozuya, Hiroshi Miyakawa, Yuichi Kanmura
BACKGROUND: Efficacy and safety of sugammadex in reversing neuromuscular block induced by rocuronium or vecuronium were investgated in Japanese patients. METHODS: We studied 98 Japanese patients undergoing surgery requiring general anesthesia. Patients were allocated randomly to receive intubation dose of rocuronium or vecuronium. During surgery, patients received additional doses of rocuronium or vecuronium for maintenance of moderate block. At T2 reappearance sugammadex 0-4...
October 2014: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/25669002/the-incidence-of-postoperative-residual-curarization-following-the-use-of-intermediate-acting-muscle-relaxants-and-related-factors
#20
Ozlem Kocaturk, Nil Kaan, Nurten Kayacan, Fatma Ertugrul
PURPOSE: To evaluate the incidence of residual curarization (RC) and related risk factors in the early and late postoperative periods in patients receiving general anesthesia with intermediate-acting muscle relaxants. METHODS: Two-hundred and eight American Society of Anesthesiologists class I and II patients, aged 18-70 years, who underwent general anesthesia with intermediate-acting muscle relaxants, were included. Heart rate, blood pressure, oxygen saturation, tympanic temperature were recorded for each patient who was transported to the recovery room, every 10 minutes by a trained nurse...
October 2014: Middle East Journal of Anesthesiology
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