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Post Burn Scars

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https://www.readbyqxmd.com/read/29887351/the-recovery-of-post-burn-hypertrophic-scar-in-a-monitored-pressure-therapy-intervention-programme-and-the-timing-of-intervention
#1
Pan Li, Cecilia Wai Ping Li-Tsang, Xue Deng, Xiaoyun Wang, Hanjie Wang, Yuting Zhang, Ziming Tan, Chengqi He
INTRODUCTION: Pressure therapy used to be considered as the mainstay non-invasive treatment of hypertrophic scar. However, the maturation process of hypertrophic scar during pressure therapy process has seldom be reported. Moreover, although early application of pressure therapy after burn injuries is reco6mmended, minimal evidence exists to support it. This study aimed to examine the maturation trajectory of post-burn hypertrophic scars in a 6-month monitored pressure therapy intervention programme and investigate the difference in the trajectory between patients receiving early intervention and patients receiving late intervention...
June 7, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29805934/medical-needling-effect-on-moisture-and-transepidermal-water-loss-of-mature-hypertrophic-burn-scars
#2
Kay-Hendrik Busch, Antigona Aliu, Nicole Walezko, Matthias Aust
BACKGROUND: Burn scars remain a serious psychological and physiological problem for affected people. Clinical studies and scientific research have already shown that medical needling improves the scar quality in terms of skin elasticity and erythema. At the same time, patients are confronted with a low-risk therapy and face comparatively less postoperative complications. OBJECTIVE: The goal of our study was to examine the influence of medical needling on the skin moisture and transepidermal water loss (TEWL) of hypertrophic dry scars...
March 26, 2018: Curēus
https://www.readbyqxmd.com/read/29799583/treatment-of-burn-scars-in-fitzpatrick-phototype-iii-patients-with-a-combination-of-pulsed-dye-laser-and-non-ablative-fractional-resurfacing-1550-nm-erbium-glass-1927-nm-thulium-laser-devices
#3
Joy Tao, Amanda Champlain, Charles Weddington, Lauren Moy, Rebecca Tung
Introduction: Burn scars cause cosmetic disfigurement and psychosocial distress. We present two Fitzpatrick phototype (FP) III patients with burn scars successfully treated with combination pulsed dye laser (PDL) and non-ablative fractional lasers (NAFL). Case 1: A 30-year-old, FP III woman with a history of a second-degree burn injury to the bilateral arms and legs affecting 30% body surface area (BSA) presented for cosmetic treatment. The patient received three treatments with 595 nm PDL (7 mm, 8 J, 6 ms), six with the 1550 nm erbium:glass laser (30 mJ, 14% density, 4-8 passes) and five with the 1927 nm thulium laser (10 mJ, 30% density, 4-8 passes)...
January 2018: Scars, burns & healing
https://www.readbyqxmd.com/read/29792359/adverse-effect-analysis-of-high-intensity-focused-ultrasound-in-the-treatment-of-benign-uterine-diseases
#4
Yunchang Liu, Wendy Wenyi Zhang, Min He, Chunmei Gong, Bin Xie, Xiangxia Wen, Dandan Li, Lian Zhang
OBJECTIVE: To retrospectively analyze the adverse effects of high-intensity focused ultrasound (HIFU) in management of benign uterine diseases. MATERIALS AND METHODS: From 2011 to 2017, 27,053 patients with benign uterine diseases were treated with HIFU in 19 centers in China. Among them, 17,402 patients had uterine fibroids, 8434 had adenomyosis, 876 had caesarean scar pregnancies, and 341 had placenta accreta. RESULTS: The median age, height, weight, BMI of the patients was 42 years, 158 mm, 56 kg, 22...
May 24, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29719102/risk-factors-for-hypertrophic-burn-scar-pain-pruritus-and-paresthesia-development
#5
Yongqiang Xiao, Yu Sun, Banghui Zhu, Kangan Wang, Pengfei Liang, Wenjun Liu, Jinfeng Fu, Shiqing Zheng, Shichu Xiao, Zhaofan Xia
Hypertrophic scar pain, pruritus, and paresthesia symptoms are major and particular concerns for burn patients. However, because no effective and satisfactory methods exist for their alleviation, the clinical treatment for these symptoms is generally considered unsatisfactory. Therefore, their risk factors should be identified and prevented during management. We reviewed the medical records of 129 post-burn hypertrophy scar patients and divided them into two groups for each of three different symptoms based on the University of North Carolina "4P" Scar Scale: patients with scar pain requiring occasional or continuous pharmacological intervention (HSc pain, n=75) vs...
May 2, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29698995/-burn-wound-treatment-through-enzymatic-debridement-first-experience-in-switzerland
#6
Rik Osinga, Peter Steiger, Pietro Giovanoli, Jan A Plock, Lijo Mannil
INTRODUCTION: Thermal injuries are frequent and can be associated with relevant morbidity and mortality in severe cases. Excisional debridement followed by autografting is the standard of care for deep burns, but is associated with serious potential complications. Clinical results of a novel enzymatic debridement based on Bromelain raw material extracted from the pineapple plant (Nexobrid™) were published in 2014. At the Center for Burns at the University Hospital Zürich enzymatic debridement was introduced in 2016...
April 26, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29684639/use-of-autologous-fat-graft-and-fractiononal-co-2-laser-to-optimize-the-aesthetic-and-functional-results-in-patients-with-severe-burn-outcomes-of-the-face
#7
S La Padula, B Hersant, J P Meningaud, F D'Andrea
BACKGROUND: Facial burn outcomes are often difficult to treat. Residual scars represent a problem for aesthetic and functional concerns as well as for patient's social and psychological life. Autologous fat graft can be used in the treatment of burn outcomes, providing a sensitive improvement in the quality of the burned areas. The aim of our report is the discussion of the value of lipofilling and fractional CO2 laser in optimizing aesthetic and functional results of burn sequelae. METHODS: We treated twenty four patients with post burns scars who underwent to autologous fat graft followed by CO2 fractional laser treatment...
April 21, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29665489/management-impacts-on-fire-occurrence-a-comparison-of-fire-regimes-of-african-and-south-american-tropical-savannas-in-different-protected-areas
#8
Swanni T Alvarado, Thiago Sanna Freire Silva, Sally Archibald
Humans can alter fire dynamics in grassland systems by changing fire frequency, fire seasonality and fuel conditions. These changes have effects on vegetation structure and recovery, species composition, and ecosystem function. Understanding how human management can affect fire regimes is vital to detect potential changes in the resilience of plant communities, and to predict vegetation responses to human interventions. We evaluated the fire regimes of two recently protected areas in Madagascar (Ibity and Itremo NPA) and one in Brazil (Serra do Cipó NP) before and after livestock exclusion and fire suppression policies...
July 15, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29596600/burn-scar-evaluation-using-the-cutometer%C3%A2-mpa-580-in-comparison-to-patient-and-observer-scar-assessment-scale-and-vancouver-scar-scale
#9
Marc Nicolai Busche, Alice-Caroline Johanna Thraen, Andreas Gohritz, Hans-Oliver Rennekampff, Peter Maria Vogt
The effect of the "Patient and Observer Scar Assessment Scale" (POSAS) and "Vancouver Scar Scale" (VSS) on patients' quality of life and their correlation with objective scar assessment tools, such as the Cutometer®, is not fully elucidated. In addition, long-term results of the dermal substitute Matriderm® used in combination with split-thickness skin grafting (STSG) remain unclear. We evaluated burn scars of 45 patients at least 2 years postburn injury using the Cutometer® MPA 580, the VSS, and the POSAS with three additional questions regarding quality of life and correlated the results...
December 4, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29529861/3d-protein-based-bilayer-artificial-skin-for-the-guided-scarless-healing-of-third-degree-burn-wounds-in-vivo
#10
Mazaher Gholipourmalekabadi, Alexander M Seifalian, Aleksandra M Urbanska, Mir Davood Omrani, John G Hardy, Zahra Madjd, Seyed Mahmoud Hashemi, Hossein Ghanbarian, Peiman Brouki Milan, Masoud Mozafari, Rui L Reis, Subhas C Kundu, Ali Samadikuchaksaraei
Severe burn injuries can lead to delays in healing and devastating scar formation. Attempts have been made to develop a suitable skin substitute for the scarless healing of such skin wounds. Currently, there is no effective strategy for completely scarless healing after the thermal injuries. In our recent work, we fabricated and evaluated a 3D protein-based artificial skin made from decellularized human amniotic membrane (AM) and electrospun nanofibrous silk fibroin (ESF) in vitro. We also characterized both biophysical and cell culture investigation to establish in vitro performance of the developed bilayer scaffolds...
April 18, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29510800/microneedles-as-enhancer-of-drug-absorption-through-the-skin-and-applications-in-medicine-and-cosmetology
#11
Pablo Serrano-Castañeda, Jose Juan Escobar-Chavez, Isabel Marlen Rodriguez-Cruz, Luz Maria Melgoza, Jessica Martinez-Hernandez
The microneedles technology has found applications in many health-related fields. For example, their application in drugs and vaccines delivery as well, as the determination of biomarkers, has been reported. They also have a place in the dermatology and cosmetic areas such as the treatment of wounds from burns, scars, acne, depigmentation, and alopecia will be shown. Microneedles are used in therapeutic applications and are manufactured using materials such as metal (steel, titanium, nickel), polymer (oly-glycolic acid (PGA), poly-lactide-co-glycolide acid (PLGA), poly-L-lactic acid (PLA), chitosan), glass, silicon, ceramic, carbohydrates (trehalose, sucrose, mannitol)...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29473114/treatment-of-post-burn-and-post-traumatic-atrophic-scars-with-fractional-co-2-laser-experience-at-a-tertiary-care-centre
#12
Abid Keen, Gousia Sheikh, Iffat Hassan, Yasmeen Jabeen, Shagufta Rather, Syed Mubashir, Insha Latif, Sumaya Zeerak, Muzafar Ahmad, Aqib Hassan, Peerzada Ashraf, Faizan Younis, Najamul Saqib
Scars are abnormal wound responses in predisposed individuals. They occur after any kind of wound and skin inflammation in predisposed individuals. Despite their benign nature, they can be aesthetically disabling. Although several approaches have been tried in their management, most of them have produced poor results. This study aims to assess the efficacy and safety of fractional CO2 laser treatment in the management of post-burn and post-traumatic scars. One hundred consecutive patients (77 females and 23 males) affected by post-burn scars as well as post-traumatic atrophic scars were treated with monthly sessions of fractional CO2 laser treatment...
February 23, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29457376/delivery-of-allogeneic-adipose-stem-cells-in-polyethylene-glycol-fibrin-hydrogels-as-an-adjunct-to-meshed-autografts-after-sharp-debridement-of-deep-partial-thickness-burns
#13
David M Burmeister, Randolph Stone, Nicole Wrice, Alfred Laborde, Sandra C Becerra, Shanmugasundaram Natesan, Robert J Christy
Harvesting of autografts results in donor site morbidities and is limited in scenarios such as large total body surface area burns. In these instances, coverage is increased by meshing grafts at the expense of delayed biologic closure. Moreover, graft meshing increases the likelihood of contraction and hypertrophic scarring, limits range of motion, and worsens cosmesis. Many tissue engineering technologies have touted the promise of adipose-derived stem cells (ASCs) for burn wounds. The primary objective of the current study was to determine feasibility and efficacy of in situ ASC delivery via PEGylated fibrin (FPEG) hydrogels as adjuncts to meshed split thickness skin grafts in a porcine model...
April 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29438815/new-onset-squamous-cell-carcinoma-in-previous-split-thickness-skin-graft-donor-site
#14
Vincent J Noori, Kanika Trehan, Alisa Savetamal, Damien W Carter
INTRODUCTION: Marjolin' s ulcer, an aggressive ulcerating squamous cell carcinoma, is a well-known phenomenon that occurs in chronically inflamed or scarred tissue; however, squamous cell carcinoma arising in the acute setting after tissue trauma - specifically autograft donor harvest sites for burns - is a rare, but notable event. METHODS: This case series describes three instances of squamous cell carcinoma diagnosed in split-thickness skin graft donor sites in the immediate post-operative period...
April 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29428585/distally-based-anteromedial-thigh-flaps-pedicled-on-the-rectus-femoris-branch-of-the-lateral-circumflex-femoral-artery-for-reconstruction-of-soft-tissue-defect-of-the-knee
#15
Shan Zhu, Mengqing Zang, Shengji Yu, Boyang Xu, Yuanbo Liu
BACKGROUND: Anteromedial thigh flaps are far less clinically appealing than their anterolateral counterparts, and are occasionally considered as an alternative to the anterolateral thigh flap. Herein, we report the study of soft-tissue defects reconstruction in the knee using a distally based anteromedial thigh flap pedicled on the rectus femoris branch of the descending branch of the lateral circumflex femoral artery. PATIENTS AND METHODS: Between July 2008 and September 2016, a distally based anteromedial thigh flap was used to reconstruct soft-tissue defects of the knee in 5 patients (3 males, 2 females; age range at surgery 4-55 years old)...
May 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29423280/biomaterials-enabled-cornea-regeneration-in-patients-at-high-risk-for-rejection-of-donor-tissue-transplantation
#16
M Mirazul Islam, Oleksiy Buznyk, Jagadesh C Reddy, Nataliya Pasyechnikova, Emilio I Alarcon, Sally Hayes, Philip Lewis, Per Fagerholm, Chaoliang He, Stanislav Iakymenko, Wenguang Liu, Keith M Meek, Virender S Sangwan, May Griffith
The severe worldwide shortage of donor organs, and severe pathologies placing patients at high risk for rejecting conventional cornea transplantation, have left many corneal blind patients untreated. Following successful pre-clinical evaluation in mini-pigs, we tested a biomaterials-enabled pro-regeneration strategy to restore corneal integrity in an open-label observational study of six patients. Cell-free corneal implants comprising recombinant human collagen and phosphorylcholine were grafted by anterior lamellar keratoplasty into corneas of unilaterally blind patients diagnosed at high-risk for rejecting donor allografts...
2018: NPJ Regenerative Medicine
https://www.readbyqxmd.com/read/29422437/effect-of-cold-pack-therapy-for-management-of-burn-scar-pruritus-a-pilot-study
#17
So Young Joo, June-Bum Kim, Yoon Soo Cho, Yong Suk Cho, Cheong Hoon Seo
PURPOSE: Pruritus, a common, chronically disabling condition is often refractory to treatment. The pruritus sensation is mediated in the spinal cord and post-burn pruritus is considered a form of neuropathic pain. We investigated cold pack therapy as a treatment modality for post-burn pruritus. METHODS: We studied 23 patients with severe pruritus scoring at least 5 on the visual analogue scale (VAS) and refractory to antihistamine and gabapentin administration. Each cold pack therapy lasted more than 20min...
February 5, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29369171/microdissected-thin-anterolateral-thigh-perforator-flaps-with-multiple-perforators-a-series-of-case-reports
#18
Jiu-Long Liang, Xiao-Yan Liu, Tao Qiu, Zhi-Qiang Fu, Hong-Yi Wang, Xu Kong, Kai Tao
INTRODUCTION: The study aimed to explore the effect of microdissected thin anterolateral thigh (MTALT) perforator flap with multiple perforators on patients with complex defects on the hand, elbow, heel, or knee. METHODS: From March 2012 to February 2013, 5 patients with complex defects on the hand, elbow, heel, or knee were included. During the flap preparation, 2 to 3 perforators penetrating the fascia of the anterolateral femoral area were initially detected, and the deep fascia was incised...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29301325/extracorporeal-shock-wave-therapy-alters-the-expression-of-fibrosis-related-molecules-in-fibroblast-derived-from-human-hypertrophic-scar
#19
Hui Song Cui, A Ram Hong, June-Bum Kim, Joo Hyang Yu, Yoon Soo Cho, So Young Joo, Cheong Hoon Seo
Extracorporeal shock wave therapy (ESWT) considerably improves the appearance and symptoms of post-burn hypertrophic scars (HTS). However, the mechanism underlying the observed beneficial effects is not well understood. The objective of this study was to elucidate the mechanism underlying changes in cellular and molecular biology that is induced by ESWT of fibroblasts derived from scar tissue (HTSFs). We cultured primary dermal fibroblasts derived from human HTS and exposed these cells to 1000 impulses of 0...
January 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29249978/prediction-of-scar-size-in-rats-six-months-after-burns-based-on-early-post-injury-polarization-sensitive-optical-frequency-domain-imaging
#20
Eli Kravez, Martin Villiger, Brett Bouma, Martin Yarmush, Zohar Yakhini, Alexander Golberg
Hypertrophic scars remain a major clinical problem in the rehabilitation of burn survivors and lead to physical, aesthetic, functional, psychological, and social stresses. Prediction of healing outcome and scar formation is critical for deciding on the best treatment plan. Both subjective and objective scales have been devised to assess scar severity. Whereas scales of the first type preclude cross-comparison between observers, those of the second type are based on imaging modalities that either lack the ability to image individual layers of the scar or only provide very limited fields of view...
2017: Frontiers in Physiology
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