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Christopher Mascio

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https://www.readbyqxmd.com/read/29769202/predictors-of-length-of-hospital-stay-after-complete-repair-for-tetralogy-of-fallot-a-prospective-cohort-study
#1
Laura Mercer-Rosa, Okan U Elci, Grace DeCost, Stacy Woyciechowski, Sharon M Edman, Chitra Ravishankar, Christopher E Mascio, Steven M Kawut, Elizabeth Goldmuntz
BACKGROUND: We sought to identify patient and surgical factors associated with time to hospital discharge in patients undergoing complete repair for tetralogy of Fallot. METHODS AND RESULTS: We performed a prospective cohort study of patients with tetralogy of Fallot admitted for complete repair between May 1, 2012 and June 2, 2017 at Children's Hospital of Philadelphia with detailed demographic, clinical, and operative characteristics. The primary outcome was time to hospital discharge...
May 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29684375/cumulative-effect-of-preoperative-risk-factors-on-mortality-after-pediatric-heart-transplantation
#2
Matthew J O'Connor, Andrew C Glatz, Joseph W Rossano, Robert E Shaddy, Rachel Ryan, Chitra Ravishankar, Stephanie Fuller, Christopher E Mascio, J William Gaynor, Kimberly Y Lin
BACKGROUND: Risk assessment in heart transplantation is critical for candidate selection, but current models inadequately assess individual risk of postoperative mortality. We sought to identify risk factors and develop a scoring system to predict mortality following heart transplantation in children. METHODS: The records of patients undergoing heart transplantation at our institution from 2010 - 2016 were reviewed. Clinical characteristics were recorded and compared between survivors and non-survivors...
April 20, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29655537/ambulatory-extracorporeal-membrane-oxygenation-as-a-bridge-to-cardiac-transplant-a-step-in-the-right-direction
#3
EDITORIAL
Harold M Burkhart, Jess L Thompson, Christopher E Mascio
No abstract text is available yet for this article.
March 26, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29603626/pulmonary-hypertension-barrier-or-just-a-bump-in-the-road-in-transplanting-adults-with-congenital-heart-disease
#4
Jonathan N Menachem, Edo Y Birati, Payman Zamani, Anjali T Owens, Pavan Atluri, Christian A Bermudez, David Drajpuch, Stephanie Fuller, Yuli Y Kim, Christopher E Mascio, Vikram Palanivel, J Eduardo Rame, Joyce Wald, Michael A Acker, Jeremy A Mazurek
BACKGROUND: Heart failure (HF) is the leading cause of death in adults with congenital heart disease (ACHD). Identification of disease progression and timing of referral for advanced therapies is often delayed. However, increased awareness and understanding of ACHD and improvements in the approach to treatment have led to improved outcomes. Pulmonary hypertension (PH) is a common barrier to HT. In ACHD, the approach to PH and HT is quite complicated, given the anatomic heterogeneity and lower prevalence and experience...
March 30, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29221691/characteristics-and-outcomes-of-pediatric-heart-failure-related-emergency-department-visits-in-the-united-states-a-population-based-study
#5
Erika J Mejia, Matthew J O'Connor, Kimberly Y Lin, Lihai Song, Heather Griffis, Christopher E Mascio, Pirouz Shamszad, Aaron Donoghue, Chitra Ravishankar, Robert E Shaddy, Joseph W Rossano
OBJECTIVES: To describe the frequency, characteristics, and outcomes of heart failure-related emergency department (ED) visits in pediatric patients. We aimed to test the hypothesis that these visits are associated with higher admission rates, mortality, and resource utilization. STUDY DESIGN: A retrospective analysis of the Nationwide Emergency Department Sample for 2010 of patients ≤18 years of age was performed to describe ED visits with and without heart failure...
February 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29181795/comparison-of-3d-echocardiogram-derived-3d-printed-valve-models-to-molded-models-for-simulated-repair-of-pediatric-atrioventricular-valves
#6
Adam B Scanlan, Alex V Nguyen, Anna Ilina, Andras Lasso, Linnea Cripe, Anusha Jegatheeswaran, Elizabeth Silvestro, Francis X McGowan, Christopher E Mascio, Stephanie Fuller, Thomas L Spray, Meryl S Cohen, Gabor Fichtinger, Matthew A Jolley
Mastering the technical skills required to perform pediatric cardiac valve surgery is challenging in part due to limited opportunity for practice. Transformation of 3D echocardiographic (echo) images of congenitally abnormal heart valves to realistic physical models could allow patient-specific simulation of surgical valve repair. We compared materials, processes, and costs for 3D printing and molding of patient-specific models for visualization and surgical simulation of congenitally abnormal heart valves...
March 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29098350/reintervention-burden-and-vessel-growth-after-surgical-reimplantation-of-a-pulmonary-artery-during-childhood
#7
Stephan J Wu, Tacy Downing, Christopher Mascio, Matthew J Gillespie, Yoav Dori, Jonathan J Rome, Andrew C Glatz
Children requiring reimplantation of a branch pulmonary artery (PA) are at risk for postoperative stenosis and impaired growth of the reimplanted PA. Outcomes and risk factors for reintervention and impaired growth are incompletely described. We reviewed data on patients who underwent reimplantation of a branch PA between 1/1/99 and 5/1/15 at a single center. The primary outcome was reintervention to treat postoperative stenosis. The secondary outcome was "catch-up" growth (faster diameter growth of the affected PA compared with the unaffected PA from the preoperative to follow-up measurements...
February 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29042354/comparison-between-patent-ductus-arteriosus-stent-and-modified-blalock-taussig-shunt-as-palliation-for-infants-with-ductal-dependent-pulmonary-blood-flow-insights-from-the-congenital-catheterization-research-collaborative
#8
Andrew C Glatz, Christopher J Petit, Bryan H Goldstein, Michael S Kelleman, Courtney E McCracken, Alicia McDonnell, Timothy Buckey, Christopher E Mascio, Subi Shashidharan, R Allen Ligon, Jingning Ao, Wendy Whiteside, W Jack Wallen, Christina M Metcalf, Varun Aggarwal, Hitesh Agrawal, Athar M Qureshi
BACKGROUND: Infants with ductal-dependent pulmonary blood flow may undergo palliation with either a patent ductus arteriosus (PDA) stent or a modified Blalock-Taussig (BT) shunt. A balanced multicenter comparison of these 2 approaches is lacking. METHODS: Infants with ductal-dependent pulmonary blood flow palliated with either a PDA stent or a BT shunt from January 2008 to November 2015 were reviewed from the 4 member centers of the Congenital Catheterization Research Collaborative...
February 6, 2018: Circulation
https://www.readbyqxmd.com/read/28821330/systemic-atrioventricular-valve-excision-and-ventricular-assist-devices-in-pediatric-patients
#9
Deipanjan Nandi, Kelley D Miller, Carley M Bober, Tami M Rosenthal, Lisa M Montenegro, Joseph W Rossano, J William Gaynor, Christopher E Mascio
BACKGROUND: Continuous-flow ventricular assist devices (CF VADs) designed for adults are increasingly used in pediatric patients. However, there is greater risk of device inflow obstruction as a result of size and anatomy. METHODS: We reviewed all cases of systemic atrioventricular valve (AVV) excision with HeartWare HVAD (HeartWare, Framingham, MA) implantation in the systemic ventricle performed at our institution from November 2015 to May 2016. RESULTS: AVV excision with CF VAD implantation was undertaken in 3 patients...
January 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28766759/value-of-a-flow-cytometry-cross-match-in-the-setting-of-a-negative-complement-dependent-cytotoxicity-cross-match-in-heart-transplant-recipients
#10
Britton C Keeshan, Matthew J O'Connor, Kimberly Y Lin, Dimitrios Monos, Curt Lind, Christopher E Mascio, Jesus Eduardo Rame, Thomas L Spray, Robert E Shaddy, Joseph W Rossano
Complement-dependent cytotoxicity cross-match (CDCXM) is used for evaluation of preformed HLA-specific antibodies in patients undergoing heart transplantation. Flow cytometry cross-match (FCXM) is a more sensitive assay and used with increasing frequency. To determine the clinical relevance of a positive FCXM in the context of negative CDCXM in heart transplantation, the United Network for Organ Sharing (UNOS) database was analyzed. Kaplan-Meier analysis and Cox proportional hazard modeling were used to assess graft survival for three different patient cohorts defined by cross-match results: T-cell and B-cell CDCXM+ ("CDCXM+" cohort), CDCXM- but T-cell and/or B-cell FCXM+ ("FCXM+" cohort), and T-cell/B-cell CDCXM- and FCXM- ("XM-" cohort)...
August 2, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28746082/heartware-ventricular-assist-device-as-a-bridge-to-transplant-in-a-small-boy-with-complicated-kawasaki-disease
#11
Christopher E Mascio, Dhananjay P Malankar, Jonathan J Rome
We report a case of HeartWare ventricular assist device (HVAD) implant as a Bridge-to-Transplant in the smallest and the youngest known patient, a 32-month-old boy (body surface area of 0.66 m2) with known Kawasaki disease and giant coronary artery aneurysms. The disease course was complicated by coronary thromboembolism resulting in acute myocardial infarction, ventricular fibrillation, and cardiac arrest. After short-term support with extracorporeal membrane oxygenation for 7 days and long-term support with an HVAD for 5 months, he underwent heart transplantation and is doing well 2 months after the transplant...
July 25, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28455909/emergency-department-utilization-in-pediatric-heart-transplant-recipients
#12
Carol A Wittlieb-Weber, Joseph W Rossano, David R Weber, Kimberly Y Lin, Chitra Ravishankar, Christopher E Mascio, Robert E Shaddy, Matthew J O'Connor
We used the NEDS database (2010) to evaluate ED utilization in PED HT recipients compared to other patient populations with focus on characteristics of ED visits, risk factors for admission, and charges. We analyzed 433 ED visits by PED HT recipients (median age 8 [range: 0-18] years). The most common primary diagnosis category was infectious (n=163, 37.6%), with pneumonia being the most common infectious etiology. When compared to all PED visits, HT visits were more likely to result in hospital admission (32...
June 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28287055/congenital-pulmonary-lymphangiectasia-and-early-mortality-after-stage-1-reconstruction-procedures
#13
Jeremy L Herrmann, Mallory L Irons, Christopher E Mascio, Jack Rychik, Thomas L Spray, J William Gaynor, Jennifer E Pogoriler
OBJECTIVES: Pulmonary lymphangiectasia associated with hypoplastic left heart syndrome with an intact or restrictive atrial septum may result from increased left atrial pressure, and is associated with worse outcomes following staged reconstruction due to lung dysfunction and significant hypoxaemia. Our objective was to characterise the incidence of pulmonary lymphangiectasia in cases of early mortality following stage 1 reconstructions. METHODS: An institutional cardiac surgical database was retrospectively searched for patients who died within 30 days following a stage 1 reconstruction between 1 January, 1984 and 31 December, 2013...
September 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28283942/comparison-of-blood-viscoelasticity-in-pediatric-and-adult-cardiac-patients
#14
COMPARATIVE STUDY
M Keith Sharp, Mary Gregg, Guy Brock, Neema Nair, Sarina Sahetya, Erle H Austin, Christopher Mascio, Mark D Slaughter, George M Pantalos
Evidence is accumulating that blood flow patterns in the cardiovascular system and in cardiovascular devices do, in some instances, depend on blood viscoelasticity. Thus, to better understand the challenges to providing circulatory support and surgical therapies for pediatric and adult patients, viscous and elastic components of complex blood viscoelasticity of 31 pediatric patients were compared to those of 29 adult patients with a Vilastic-3 rheometer. A random effects model with categorical age covariates found statistically significant differences between pediatric and adult patients for log viscosity (p = 0...
June 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28096041/advance-care-planning-in-adults-with-congenital-heart-disease-a-patient-priority
#15
Lisa X Deng, Lacey P Gleason, Abigail M Khan, David Drajpuch, Stephanie Fuller, Leah A Goldberg, Christopher E Mascio, Sara L Partington, Lynda Tobin, Yuli Y Kim, Adrienne H Kovacs
BACKGROUND: Adult congenital heart disease (ACHD) patients with moderate or great defect complexity are at risk for premature death. Although early engagement in advance care planning (ACP) is recommended, previous research suggests that it seldom occurs. METHODS: This study investigated ACHD patient preferences for ACP and factors that impact preferences. ACHD patients completed an ACP preferences questionnaire, the Hospital Anxiety and Depression Scale and a measure of attachment styles...
March 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28031423/neurological-injury-and-cerebral-blood-flow-in-single-ventricles-throughout-staged-surgical-reconstruction
#16
Mark A Fogel, Christine Li, Okan U Elci, Tom Pawlowski, Peter J Schwab, Felice Wilson, Susan C Nicolson, Lisa M Montenegro, Laura Diaz, Thomas L Spray, J William Gaynor, Stephanie Fuller, Christopher Mascio, Marc S Keller, Matthew A Harris, Kevin K Whitehead, Jim Bethel, Arastoo Vossough, Daniel J Licht
BACKGROUND: Patients with a single ventricle experience a high rate of brain injury and adverse neurodevelopmental outcome; however, the incidence of brain abnormalities throughout surgical reconstruction and their relationship with cerebral blood flow, oxygen delivery, and carbon dioxide reactivity remain unknown. METHODS: Patients with a single ventricle were studied with magnetic resonance imaging scans immediately prior to bidirectional Glenn (pre-BDG), before Fontan (BDG), and then 3 to 9 months after Fontan reconstruction...
February 14, 2017: Circulation
https://www.readbyqxmd.com/read/27834765/a-comparison-of-perioperative-management-of-anomalous-aortic-origin-of-a-coronary-artery-between-an-adult-and-pediatric-cardiac-center
#17
MULTICENTER STUDY
Jeremy L Herrmann, Leah A Goldberg, Abigail M Khan, Sara L Partington, Julie A Brothers, Christopher E Mascio, Thomas L Spray, Yuli Y Kim, Stephanie Fuller
BACKGROUND: Anomalous aortic origin of a coronary artery (AAOCA) presents in varying age-groups. Assuming management algorithms differ between pediatric and adult institutions, we compared the perioperative management of patients with AAOCA at two such centers. METHODS: A retrospective review was conducted at a pediatric and an adult institution of patients 14 years or older who underwent surgical repair of AAOCA between January 2000 and May 2014. RESULTS: Twenty patients from the pediatric center (median age: 16...
November 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27183884/accuracy-of-transesophageal-echocardiography-in-the-identification-of-postoperative-intramural-ventricular-septal-defects
#18
Jyoti K Patel, Andrew C Glatz, Reena M Ghosh, Shannon M Jones, Chitra Ravishankar, Christopher Mascio, Meryl S Cohen
BACKGROUND: Intramural ventricular septal defects (VSDs), residual interventricular communications occurring after repair of conotruncal defects, are associated with poor postoperative outcomes. The ability of intraoperative transesophageal echocardiography (TEE) to identify intramural VSDs has not yet been evaluated. METHODS: Intraoperative TEE and postoperative transthoracic echocardiography (TTE) data in all patients undergoing all biventricular repair of conotruncal anomalies in our hospital between January 1, 2006, and June 30, 2013, were reviewed...
September 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27154145/seminal-postoperative-complications-and-mode-of-death-after-pediatric-cardiac-surgical-procedures
#19
MULTICENTER STUDY
Michael Gaies, Sara K Pasquali, Janet E Donohue, Justin B Dimick, Sarah Limbach, Nancy Burnham, Chitra Ravishankar, Richard G Ohye, J William Gaynor, Christopher E Mascio
BACKGROUND: Understanding the seminal complications leading to death after pediatric cardiac surgical procedures may provide opportunities to reduce mortality. This study analyzed all deaths at two pediatric cardiac surgical programs and developed a method to identify the seminal complications and modes of death. METHODS: Trained nurses abstracted all cases of in-hospital mortality meeting inclusion criteria from each site over 5 years (2008 to 2012). Complication definitions were consistent with those of a multicenter clinical registry...
August 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26808622/outcomes-of-single-ventricle-patients-supported-with-extracorporeal-membrane-oxygenation
#20
Andrew M Misfeldt, Roxanne E Kirsch, David J Goldberg, Christopher E Mascio, Maryam Y Naim, Xumei Zhang, Antonio R Mott, Chitra Ravishankar, Joseph W Rossano
OBJECTIVES: Extracorporeal membrane oxygenation is often used in children with single-ventricle anomalies. We aimed to describe extracorporeal membrane oxygenation use in single-ventricle patients to test the hypothesis that despite increasing prevalence, mortality has not improved and overall burden measure by hospital charges and length of stay have increased. DESIGN: Retrospective analysis of the Healthcare Cost and Utilization Project Kids' Inpatient Database was performed with sample weighting to generate national estimates...
March 2016: Pediatric Critical Care Medicine
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