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https://www.readbyqxmd.com/read/28790805/bilateral-implantation-of-3-0-d-multifocal-toric-intraocular-lenses-results-of-a-us-food-and-drug-administration-clinical-trial
#1
Robert Lehmann, Satish Modi, Bret Fisher, Magda Michna, Michael Snyder
PURPOSE: The purpose of this study was to evaluate the clinical outcomes of apodized diffractive +3.0 D multifocal toric intraocular lens (IOL) implantations in subjects with preoperative corneal astigmatism. PATIENTS AND METHODS: This was a prospective cohort study conducted at 21 US sites. The study population consisted of 574 subjects, aged ≥21 years, with preoperative astigmatism 0.75-2.82 D, and potential postoperative visual acuity (VA) ≥0.2 logMAR, undergoing bilateral cataract removal by phacoemulsification...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28695482/role-of-apolipoproteins-and-%C3%AE-synuclein-in-parkinson-s-disease
#2
REVIEW
Fatemeh Nouri Emamzadeh
Parkinson's disease (PD) is a progressive brain disorder that interferes with activities of normal life. The main pathological feature of this disease is the loss of more than 80% of dopamine-producing neurons in the substantia nigra (SN). Dopaminergic neuronal cell death occurs when intraneuronal, insoluble, aggregated proteins start to form Lewy bodies (LBs), the most important component of which is a protein called α-synuclein (α-syn). α-Syn structurally contains hexameric repeats of 11 amino acids, which are characteristic of apolipoproteins and thus α-syn can also be considered an apolipoprotein...
August 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28636792/mtf-and-dqe-enhancement-using-an-apodized-aperture-x-ray-detector-design
#3
Tomi F Nano, Terenz Escartin, Elina Ismailova, Karim S Karim, Jan Lindstrȍm, Ho Kyung Kim, Ian A Cunningham
PURPOSE: Acquisition of high-quality x-ray images using low patient exposures requires detectors with high detective quantum efficiency (DQE). We describe a novel apodized-aperture pixel (AAP) design that increases high-frequency modulation transfer function (MTF) and DQE values. The AAP design makes a separation of physical sensor elements from image pixels by using very small sensor elements (e.g. 0.010-0.025 mm) to synthesize desired larger image pixels (e.g. 0.1-0.2 mm). METHODS: A cascaded systems model of signal and noise propagation is developed to describe the benefits of the AAP approach in terms of the MTF, Wiener noise power spectrum (NPS) and DQE...
June 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28626289/comparison-of-high-resolution-x-ray-detectors-with-conventional-fpds-using-experimental-mtfs-and-apodized-aperture-pixel-design-for-reduced-aliasing
#4
A Shankar, M Russ, S Vijayan, D R Bednarek, S Rudin
Apodized Aperture Pixel (AAP) design, proposed by Ismailova et. al, is an alternative to the conventional pixel design(1). The advantages of AAP processing with a sinc filter in comparison with using other filters include non-degradation of MTF values and elimination of signal and noise aliasing, resulting in an increased performance at higher frequencies, approaching the Nyquist frequency(3). If high resolution small field-of-view (FOV) detectors with small pixels used during critical stages of Endovascular Image Guided Interventions (EIGIs) could also be extended to cover a full field-of-view typical of flat panel detectors (FPDs) and made to have larger effective pixels, then methods must be used to preserve the MTF over the frequency range up to the Nyquist frequency of the FPD while minimizing aliasing...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28599255/research-on-two-port-network-of-wavelet-transform-processor-using-surface-acoustic-wavelet-devices-and-its-application
#5
Shoubing Liu, Wenke Lu, Changchun Zhu
The goal of this research is to study two-port network of wavelet transform processor (WTP) using surface acoustic wave (SAW) devices and its application. The motive was prompted by the inconvenience of the long research and design cycle and the huge research funding involved with traditional method in this field, which were caused by the lack of the simulation and emulation method of WTP using SAW devices. For this reason, we introduce the two-port network analysis tool, which has been widely used in the design and analysis of SAW devices with uniform interdigital transducers (IDTs)...
November 2017: Ultrasonics
https://www.readbyqxmd.com/read/28505094/antigiardial-activity-of-podophyllotoxin-type-lignans-from-bursera-fagaroides-var-fagaroides
#6
Filiberto Gutiérrez-Gutiérrez, Ana María Puebla-Pérez, Sirenia González-Pozos, José Manuel Hernández-Hernández, Armando Pérez-Rangel, Laura Patricia Alvarez, Gabriela Tapia-Pastrana, Araceli Castillo-Romero
Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects. Bursera fagaroides has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from Bursera fagaroides var. fagaroides, namely, 5'-desmethoxy-β-peltatin-A-methylether (5-DES), acetylpodophyllotoxin (APOD), burseranin (BUR), and podophyllotoxin (POD)...
May 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28485374/serum-glycopattern-and-maackia-amurensis-lectin-ii-binding-glycoproteins-in-autism-spectrum-disorder
#7
Yannan Qin, Yanni Chen, Juan Yang, Fei Wu, Lingyu Zhao, Fuquan Yang, Peng Xue, Zhuoyue Shi, Tusheng Song, Chen Huang
The pathophysiology of autistic spectrum disorder (ASD) is not fully understood and there are no diagnostic or predictive biomarkers. Glycosylation modified as many as 70% of all human proteins can sensitively reflect various pathological changes. However, little is known about the alterations of glycosylation and glycoproteins in ASD. In this study, serum glycopattern and the maackia amurensis lectin-II binding glycoproteins (MBGs) in 65 children with ASD and 65 age-matched typically developing (TD) children were compared by using lectin microarrays and lectin-magnetic particle conjugate-assisted LC-MS/MS analyses...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28463340/relating-wavefront-error-apodization-and-the-optical-transfer-function-general-case
#8
Jim Schwiegerling
In a previous paper, a technique was developed for decomposing the incoherent optical transfer function (OTF) into a linear combination of basis functions [J. Opt. Soc. Am. A31, 2476 (2014)JOAOD60740-323210.1364/JOSAA.31.002476]. The expansion coefficients for the OTF are directly related to wavefront error coefficients and apodization factors. This earlier work assumed rotational symmetry, so that only the on-axis wavefront error components, defocus and various orders of spherical aberration, and rotationally symmetric apodization were handled...
May 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/28452749/fresnel-zone-plate-with-apodized-aperture-for-hard-x-ray-gaussian-beam-optics
#9
Akihisa Takeuchi, Kentaro Uesugi, Yoshio Suzuki, Seiichi Itabashi, Masatoshi Oda
Fresnel zone plates with apodized apertures [apodization FZPs (A-FZPs)] have been developed to realise Gaussian beam optics in the hard X-ray region. The designed zone depth of A-FZPs gradually decreases from the center to peripheral regions. Such a zone structure forms a Gaussian-like smooth-shouldered aperture function which optically behaves as an apodization filter and produces a Gaussian-like focusing spot profile. Optical properties of two types of A-FZP, i.e. a circular type and a one-dimensional type, have been evaluated by using a microbeam knife-edge scan test, and have been carefully compared with those of normal FZP optics...
May 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28410681/simulation-of-scanner-and-patient-specific-low-dose-ct-imaging-from-existing-ct-images
#10
Robiël E Naziroglu, Vincent F van Ravesteijn, Lucas J van Vliet, Geert J Streekstra, Frans M Vos
PURPOSE: Simulating low-dose Computed Tomography (CT) facilitates in-silico studies into the required dose for a diagnostic task. Conventionally, low-dose CT images are created by adding noise to the projection data. However, in practice the raw data is often simply not available. This paper presents a new method for simulating patient-specific, low-dose CT images without the need of the original projection data. METHODS: The low-dose CT simulation method included the following: (1) computation of a virtual sinogram from a high dose CT image through a radon transform; (2) simulation of a 'reduced'-dose sinogram with appropriate amounts of noise; (3) subtraction of the high-dose virtual sinogram from the reduced-dose sinogram; (4) reconstruction of a noise volume via filtered back-projection; (5) addition of the noise image to the original high-dose image...
April 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28410283/postoperative-evaluation-of-bilateral-reading-performance-with-two-intraocular-lenses-twelve-month-results
#11
Semra Akkaya Turhan, Ebru Toker
PURPOSE: The aim of this study was to compare the bilateral reading performances within the first 12 months after the implantation of two intraocular lens (IOL) models. METHODS: The patients involved in this research had bilateral phacoemulsification and implantation of the Acriva Reviol MFM 613 IOL (group 1) or AcrySof ReSTOR SN6AD1 apodized multifocal IOL (group 2). The bilateral reading performance was evaluated preoperatively and postoperatively using the MNREAD acuity charts...
April 12, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28380916/simply-integrated-dual-comb-spectrometer-via-tunable-repetition-rates-and-avoiding-self-referencing
#12
Honglei Yang, Haoyun Wei, Kun Chen, Shengkang Zhang, Yan Li
Dual-comb system with simplified integration acts a crucial role in the next stage of field-deployable application. Here we demonstrate a home-made dual-comb spectrometer that meets this requirement based on optically stabilized erbium-fiber frequency combs. The simplified integration and operability are highlighted by the embedded large motion-span automatic optical delay line that resulted in 1.7 MHz of continuous repetition rate tuning range and avoid multiple fiber cutbacks. This relaxes the second similar frequency comb duplication, therefore simplifies dual-comb system integration...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28375280/strehl-ratio-and-amplitude-weighted-generalized-orthonormal-zernike-based-polynomials
#13
Cosmas Mafusire, Tjaart P J Krüger
The concept of orthonormal polynomials is revisited by developing a Zernike-based orthonormal set for a non-circular pupil that is transmitting an aberrated, non-uniform field. We refer to this pupil as a general pupil. The process is achieved by using the matrix form of the Gram-Schmidt procedure on Zernike circle polynomials and is interpreted as a process of balancing each Zernike circle polynomial by adding those of lower order in the general pupil, a procedure which was previously performed using classical aberrations...
March 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/28355223/pre-control-relationship-of-onchocercal-skin-disease-with-onchocercal-infection-in-guinea-savanna-northern-nigeria
#14
Michele E Murdoch, Ian E Murdoch, Jennifer Evans, Haliru Yahaya, Ngozi Njepuome, Simon Cousens, Barrie R Jones, Adenike Abiose
BACKGROUND: Onchocerca volvulus infection can result in blindness, itching and skin lesions. Previous research concentrated on blindness. METHODS: A clinical classification system of the cutaneous changes in onchocerciasis was used for the first time in this study within the context of an early ivermectin drug trial in the savanna region of Kaduna State, northern Nigeria. Skin examinations were performed in 6,790 individuals aged 5+ years in endemic communities and 1,343 individuals in nonendemic communities...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28330926/a-new-crustacean-from-the-herefordshire-silurian-lagerst%C3%A3-tte-uk-and-its-significance-in-malacostracan-evolution
#15
David J Siveter, Derek E G Briggs, Derek J Siveter, Mark D Sutton, David Legg
Cascolus ravitis gen. et sp. nov. is a three-dimensionally preserved fossil crustacean with soft parts from the Herefordshire (Silurian) Lagerstätte, UK. It is characterized by a head with a head shield and five limb pairs, and a thorax (pereon) with nine appendage-bearing segments followed by an apodous abdomen (pleon). All the appendages except the first are biramous and have a gnathobase. The post-mandibular appendages are similar one to another, and bear petal-shaped epipods that probably functioned as a part of the respiratory-circulatory system...
March 29, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28301514/apolipoprotein-d-expression-does-not-predict-breast-cancer-recurrence-among-tamoxifen-treated-patients
#16
Daniella Klebaner, Stephen Hamilton-Dutoit, Thomas Ahern, Anatasha Crawford, Thomas Jakobsen, Deirdre P Cronin-Fenton, Per Damkier, Emiel Janssen, Anders Kjaersgaard, Anne Gulbech Ording, Håvard Søiland, Henrik Toft Sørensen, Timothy L Lash, Ylva Hellberg
BACKGROUND: Apolipoprotein D (ApoD) has been proposed as a predictor of breast cancer recurrence among estrogen receptor-positive (ER+), tamoxifen-treated patients. METHODS: We conducted a population-based case-control study nested in a population of 11,251 women aged 35-69 years at diagnosis with Stage I-III breast cancer between 1985 and 2001 on Denmark's Jutland Peninsula and registered with the Danish Breast Cancer Cooperative Group. We identified 541 recurrent or contralateral breast cancers cases among women with ER+ disease treated with tamoxifen for at least 1 year and 300 cases in women with ER- disease never treated with tamoxifen...
2017: PloS One
https://www.readbyqxmd.com/read/28287573/fabrication-of-1-d-photonic-crystal-cavity-on-a-nanofiber-using-femtosecond-laser-induced-ablation
#17
Kali Prasanna Nayak, Jameesh Keloth, Kohzo Hakuta
We present a protocol for fabricating 1-D Photonic Crystal (PhC) cavities on subwavelength-diameter tapered optical fibers, optical nanofibers, using femtosecond laser-induced ablation. We show that thousands of periodic nano-craters are fabricated on an optical nanofiber by irradiating with just a single femtosecond laser pulse. For a typical sample, periodic nano-craters with a period of 350 nm and with diameter gradually varying from 50 - 250 nm over a length of 1 mm are fabricated on a nanofiber with diameter around 450 - 550 nm...
February 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28182653/protecting-cells-by-protecting-their-vulnerable-lysosomes-identification-of-a-new-mechanism-for-preserving-lysosomal-functional-integrity-upon-oxidative-stress
#18
Raquel Pascua-Maestro, Sergio Diez-Hermano, Concepción Lillo, Maria D Ganfornina, Diego Sanchez
Environmental insults such as oxidative stress can damage cell membranes. Lysosomes are particularly sensitive to membrane permeabilization since their function depends on intraluminal acidic pH and requires stable membrane-dependent proton gradients. Among the catalog of oxidative stress-responsive genes is the Lipocalin Apolipoprotein D (ApoD), an extracellular lipid binding protein endowed with antioxidant capacity. Within the nervous system, cell types in the defense frontline, such as astrocytes, secrete ApoD to help neurons cope with the challenge...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28113577/ultrasonic-reverberation-clutter-suppression-using-multi-phase-apodization-with-cross-correlation
#19
Junseob Shin, Yu Chen, Harshawn Malhi, Jesse Yen
Despite numerous recent advances in medical ultrasound imaging, reverberation clutter from near-field anatomical structures, such as the abdominal wall, ribs, and tissue layers, is one of the major sources of ultrasound image quality degradation. Reverberation clutter signals are undesirable echoes, which arise as a result of multiple reflections of acoustic waves between the boundaries of these structures, and cause fill-in to lower image contrast. In order to mitigate the undesirable reverberation clutter effects, we present in this paper a new beamforming technique called multi-phase apodization with cross-correlation (MPAX), which is an improved version of our previous technique, DAX...
August 2, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28113492/high-frame-rate-high-resolution-ultrasound-imaging-with-multi-line-transmission-and-filtered-delay-multiply-and-sum-beamforming
#20
Giulia Matrone, Alessandro Ramalli, Alessandro Savoia, Piero Tortoli, Giovanni Magenes
Multi-Line Transmission (MLT) was recently demonstrated as a valuable tool to increase the frame rate of ultrasound images. In this approach, the multiple beams that are simultaneously transmitted may determine cross-talk artifacts that are typically reduced, although not eliminated, by the use of Tukey apodization on both transmission and reception apertures, which unfortunately worsens the image lateral resolution. In this paper we investigate the combination, and related performance, of Filtered-Delay Multiply And Sum (F-DMAS) beamforming with MLT for high frame-rate ultrasound imaging...
October 4, 2016: IEEE Transactions on Medical Imaging
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