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Angiopoietin

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https://www.readbyqxmd.com/read/28720059/cervical-cancer-cell-derived-angiopoietins-promote-tumor-progression
#1
Ping Yang, Na Chen, Dongyun Yang, Janet Crane, Bangxing Huang, Ruiqing Dong, Xiaoqing Yi, Jing Guo, Jing Cai, Zehua Wang
Metastatic or recurrent cervical cancer has limited treatment options and a high rate of mortality. Although anti-vascular endothelial growth factor drugs have shown great promise as a therapeutic target for treatment of advanced cervical cancer, drug resistance and class-specific side effects negate long-term benefits. The identification of alternative anti-angiogenic factors will be critical for future drug development for advanced or recurrent cervical cancer. In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28719646/a-synergistic-negative-effect-of-gestational-smoke-exposure-and-small-litter-size-on-rat-placental-efficiency-vascularisation-and-angiogenic-factors-mrna-expression
#2
Zhen-Yan Chen, Ying Yao
Smoking increases the risk of pregnancy complications such as spontaneous abortion and low birth weight (LBW). By cigarette smoke exposure (gestational day, GD3-17), normal-litter-size pregnancy with low birth weight (NP-LBW) and small-litter-size pregnancy with normal birth weight (SP-NBW) in rats were induced. The placental weight in SP-NBW was twice the weight of the normal in contrast with the smaller placenta in NP-LBW. Compared with the normal, placental efficiency (expressed as fetus-to-placenta weight ratio) and placental vascularisation were significantly decreased in smoke exposed placentas with more obvious decrease in SP-NBW...
2017: PloS One
https://www.readbyqxmd.com/read/28719590/pericyte-expressed-tie2-controls-angiogenesis-and-vessel-maturation
#3
Martin Teichert, Laura Milde, Annegret Holm, Laura Stanicek, Nicolas Gengenbacher, Soniya Savant, Tina Ruckdeschel, Zulfiyya Hasanov, Kshitij Srivastava, Junhao Hu, Stella Hertel, Arne Bartol, Katharina Schlereth, Hellmut G Augustin
The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expressed at lower levels by pericytes and it has not been unravelled through which mechanisms pericyte Angiopoietin/Tie signalling affects angiogenesis. Here we show that human and murine pericytes express functional Tie2 receptor. Silencing of Tie2 in pericytes results in a pro-migratory phenotype. Pericyte Tie2 controls sprouting angiogenesis in in vitro sprouting and in vivo spheroid assays...
July 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28717903/high-expression-of-angiopoietin-1-is-associated-with-lymph-node-metastasis-and-invasiveness-of-papillary-thyroid-carcinoma
#4
Yea Eun Kang, Koon Soon Kim, Sung Jae Park, Seung-Nam Jung, Jae Won Chang, Shinae Yi, Min Gyu Jung, Jin-Man Kim, Bon Seok Koo
BACKGROUND: We investigated the expression of angiopoietins in patients with papillary thyroid carcinoma (PTC) and the role of angiopoietins as biomarkers predicting the aggressiveness of PTC. METHODS: Expression of angiopoietins was evaluated by immunohistochemistry of tumor specimens from patients with PTC. We demonstrated potential correlations between expression of angiopoietins and clinicopathologic features. RESULTS: High expression of Ang-1 was positively correlated with a tumor size >1 cm, capsular invasion, extrathyroid extension, lymphovascular invasion, lymph node metastasis, and recurrence (P < 0...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28715807/amniotic-fluid-angiogenic-and-inflammatory-factor-profiling-in-foetal-down-syndrome
#5
Monika Zbucka-Kretowska, Karol Charkiewicz, Jan Czerniecki, Joanna Goscik, Slawomir Wolczynski, Piotr Laudanski
OBJECTIVES: Angiogenic factors are proteins that can potentially be related to certain foetal chromosomal abnormalities. The goal of this study was to determine the concentrations of 60 angiogenic factors in the amniotic fluid of women carrying foetuses with Down syndrome (DS). METHODS: After analysis of the karyotyping results, for the purpose of this study, we chose 12 women with foetal DS. For the control group, we selected 12 healthy patients with uncomplicated pregnancies (15-18 weeks of gestation) who delivered healthy newborns at term...
July 15, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28714000/circulating-levels-of-angiogenesis-related-growth-factors-in-breast-cancer-a-study-to-profile-proteins-responsible-for-tubule-formation
#6
Gemma A Barron, Marie Goua, Klaus W J Wahle, Giovanna Bermano
The present study exploited a versatile in vitro endothelial cell/fibroblast co-culture cell system to investigate the association between angiogenesis and breast cancer by comparing the capacity of plasma from women with breast cancer and age-matched controls, to influence tubule formation and modulate angiogenesis in vitro, and to identify plasma circulating factors which might be responsible. Plasma from women with breast cancer (n=8) (added on day 7 after co-culture establishment) significantly increased tubule formation by 57% (P<0...
July 11, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28708595/angptl4-promotes-the-progression-of-cutaneous-melanoma-to-brain-metastasis
#7
Sivan Izraely, Shlomit Ben-Menachem, Orit Sagi-Assif, Tsipi Meshel, Diego M Marzese, Shuichi Ohe, Inna Zubrilov, Metsada Pasmanik-Chor, Dave S B Hoon, Isaac P Witz
In an ongoing effort to identify molecular determinants regulating melanoma brain metastasis, we previously identified Angiopoietin-like 4 (ANGPTL4) as a component of the molecular signature of such metastases.The aim of this study was to determine the functional significance of ANGPTL4 in the shaping of melanoma malignancy phenotype, especially in the establishment of brain metastasis.We confirmed that ANGPTL4 expression is significantly higher in cells metastasizing to the brain than in cells from the cutaneous (local) tumor from the same melanoma in a nude mouse xenograft model, and also in paired clinical specimens of melanoma metastases than in primary melanomas from the same patients...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28707601/potential-role-of-natural-compounds-as-anti-angiogenic-agents-in-cancer
#8
Muthu K Shanmugam, Sudha Warrier, Alan Prem Kumar, Gautam Sethi, Frank Arfuso
BACKGROUND: Neovascularization, also known as angiogenesis, is the process of capillary sprouting from pre-existing blood vessels. This physiological process is a hallmark event in normal embryonic development as blood vessels generally supply both oxygen and nutrients to the cells of the body. Any disruption in this process can lead to the development of various chronic diseases, including cancer. In cancer, aberrant angiogenesis plays a prominent role in maintaining sustained tumor growth to malignant phenotypes and promoting metastasis...
July 12, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28706977/acute-rejection-after-kidney-transplantation-associates-with-circulating-micrornas-and-vascular-injury
#9
Roel Bijkerk, Barend W Florijn, Meriem Khairoun, Jacques M G J Duijs, Gurbey Ocak, Aiko P J de Vries, Alexander F Schaapherder, Marko J K Mallat, Johan W de Fijter, Ton J Rabelink, Anton Jan van Zonneveld, Marlies E J Reinders
BACKGROUND: Acute rejection (AR) of kidney transplants is associated with the loss of endothelial integrity, microvascular rarefaction and, ultimately, graft dysfunction. Circulating angiogenic microRNAs (miRNAs) may serve as markers for microvascular injury. Here, we investigated the short- and long-term effects of AR after kidney transplantation on systemic vascular injury and the associated circulating miRNA profile. METHODS: Systemic vascular injury was determined by measuring capillary tortuosity and density within the oral mucosa as well as by assessing circulating levels of angiopoietin-2/angiopoietin-1 ratio, vascular endothelial growth factor and soluble thrombomodulin...
July 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28698624/naringenin-impairs-two-pore-channel-2-activity-and-inhibits-vegf-induced-angiogenesis
#10
Irene Pafumi, Margherita Festa, Francesca Papacci, Laura Lagostena, Cristina Giunta, Vijay Gutla, Laura Cornara, Annarita Favia, Fioretta Palombi, Franco Gambale, Antonio Filippini, Armando Carpaneto
Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by electrophysiological evidence in a heterologous system, i.e. Arabidopsis vacuoles lacking endogenous TPCs. In view of the control exerted by TPC2 on intracellular calcium signaling, we demonstrated that naringenin dampens intracellular calcium responses of human endothelial cells stimulated with VEGF, histamine or NAADP-AM, but not with ATP or Angiopoietin-1 (negative controls)...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28695891/the-endothelial-transcription-factor-erg-mediates-angiopoietin-1-dependent-control-of-notch-signalling-and-vascular-stability
#11
A V Shah, G M Birdsey, C Peghaire, M E Pitulescu, N P Dufton, Y Yang, I Weinberg, L Osuna Almagro, L Payne, J C Mason, H Gerhardt, R H Adams, A M Randi
Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation and stability. Here we identify the transcription factor ERG as a key regulator of endothelial Notch signalling. We show that ERG controls the balance between Notch ligands by driving Delta-like ligand 4 (Dll4) while repressing Jagged1 (Jag1) expression. In vivo, this regulation occurs selectively in the maturing plexus of the mouse developing retina, where Ang1/Tie2 signalling is active. We find that ERG mediates Ang1-dependent regulation of Notch ligands and is required for the stabilizing effects of Ang1 in vivo...
July 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28693205/oncogenic-function-of-angiopoietin-2-in-vitro-and-its-modulation-of-tumor-progression-in-colorectal-carcinoma
#12
Hyungjoo Kim, Tae Sung Ahn, Chang-Jin Kim, Sang Byung Bae, Han Jo Kim, Chang-Seuk Lee, Tae Hyun Kim, Jungkyun Im, Sang Hun Lee, Myoung Won Son, Moon Soo Lee, Moo Jun Baek, Dongjun Jeong
Angiopoietin-2 (Ang-2) has been investigated in cancer primarily in terms of its angiogenic function, and its role as an oncogene has yet to be elucidated. The current study hypothesized that Ang-2 may be an oncogene and have a function in tumor progression. An investigation of the function of Ang-2 in the LoVo colorectal cancer (CRC) cell line in vitro, which expresses a high level of Ang-2, was performed by knocking down endogenous expression with a targeted short hairpin RNA. The aggressive phenotypic effects of Ang-2 on experimental and control group cells were assessed using cell proliferation, migration and invasion assays...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28684091/visualizing-the-regulatory-role-of-angiopoietin-like-protein-8-angptl8-in-glucose-and-lipid-metabolic-pathways
#13
Amnah Siddiqa, Elisa Cirillo, Samar H K Tareen, Amjad Ali, Martina Kutmon, Lars Eijssen, Jamil Ahmad, Chris T Evelo, Susan L Coort
ANGPTL8 (Angiopoietin-like protein 8) is a newly identified hormone emerging as a novel drug target for treatment of diabetes mellitus and dyslipidemia due to its unique metabolic nature. With increasing number of studies targeting the regulation of ANGPTL8, integration of their findings becomes indispensable. This study has been conducted with the aim to collect, analyze, integrate and visualize the available knowledge in the literature about ANGPTL8 and its regulation. We utilized this knowledge to construct a regulatory pathway of ANGPTL8 which is available at WikiPathways, an open source pathways database...
July 3, 2017: Genomics
https://www.readbyqxmd.com/read/28680385/angiopoietin-like-protein-4-potentiates-dats-induced-inhibition-of-proliferation-migration-and-invasion-of-bladder-cancer-ej-cells-involvement-of-g2-m-phase-cell-cycle-arrest-signaling-pathways-and-transcription-factors-mediated-mmp-9-expression
#14
Seung-Shick Shin, Jun-Hui Song, Byungdoo Hwang, Sung Lyea Park, Won Tae Kim, Sung-Soo Park, Wun-Jae Kim, Sung-Kwon Moon
Background: Diallyl trisulfide (DATS), a bioactive sulfur compound in garlic, has been highlighted due to its strong anti-carcinogenic activity. Objective: The current study investigated the molecular mechanism of garlic-derived DATS in cancer cells. Additionally, we explored possible molecular markers to monitoring clinical responses to DATS-based chemotherapy. Design: EJ bladder carcinoma cells were treated with different concentration of DATS. Molecular changes including differentially expressed genes in EJ cells were examined using immunoblot, FACS cell cycle analysis, migration and invasion assays, electrophoresis mobility shift assay (EMSA), microarray, and bioinformatics analysis...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28679128/comparison-of-intracoronary-and-intravenous-ultrasound-targeted-microbubble-destruction-mediated-ang1-gene-transfection-on-left-ventricular-remodeling-in-canines-with-acute-myocardial-infarction
#15
Sheng Cao, Qing Zhou, Jin-Ling Chen, Jing-Jing Cui, Ying-Guang Shan, Bo Hu, Rui-Qiang Guo
Intravenous ultrasound-targeted microbubble destruction (IV-UTMD) has made distinct but limited progress in gene therapy. Intracoronary (IC) injection may lead to more gene transfection than IV injection. This study compared the therapeutic effects of IC-UTMD-mediated and conventional IV-UTMD-mediated gene transfection in acute myocardial infarction (MI). A canine MI model was successfully established through transcatheter coronary artery embolism, and the animals were divided into several treatment groups: IC injection with UTMD and the negative control plasmid (IC-UTMD); IC injection of the angiopoietin 1 (Ang1) plasmid (IC-Ang1); IC injection with UTMD and the Ang1 plasmid (IC-UTMD-Ang1); and IV injection with UTMD and the Ang1 plasmid (IV-UTMD-Ang1)...
July 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28677792/peroxisome-proliferator%C3%A2-activated-receptor-%C3%AE-mediates-porcine-placental-angiogenesis-through-hypoxia-inducible-factor%C3%A2-vascular-endothelial-growth-factor%C3%A2-and-angiopoietin%C3%A2-mediated-signaling
#16
Juzuo Zhang, Xuan Peng, Anwen Yuan, Yang Xie, Qing Yang, Liqun Xue
Peroxisome proliferator-activated receptor (PPAR) γ has been reported to be implicated in placentation in mice. Previous studies have demonstrated that PPARγ is also expressed in porcine placenta, primarily localized in vascular endothelial cells (VECs). The present study aimed to investigate the roles of PPARγ during porcine placental angiogenesis and examine the molecular mechanisms involved in its actions. VECs were incubated with the PPARγ agonist rosiglitazone and the antagonist T0070907, and their angiogenic potential was evaluated using cellular impedance, wound healing and tube formation assays...
June 30, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28677727/serum-biomarker-analysis-in-patients-with-recurrent-spontaneous-abortion
#17
Ying Wu, Junqin He, Chunyu Guo, Ying Zhang, Wei Yang, Mingwei Xin, Xinyun Liang, Xiaodan Yin, Jingshang Wang, Yanfeng Liu
Recurrent spontaneous abortion (RSA) occurs in 1‑5% of parturients. The sustained therapy and research for RSA is expensive, which is a serious issue faced by both patients and doctors. The aim of the present study was to detect protein expression profiles in the serum of RSA patients and healthy controls, and to identify potential biomarkers for this disease. A 1,000‑protein microarray consisting of a combination of Human L‑507 and L‑493 was used. The microarray data revealed that eight serum protein expression levels were significantly upregulated and 143 proteins were downregulated in RSA patients compared with the healthy controls...
June 30, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28672998/role-of-angiopoietin-2-in-the-cardioprotective-effect-of-fibroblast-growth-factor-21-on-ischemia-reperfusion-induced-injury-in-h9c2-cardiomyocytes
#18
Shuoqiang Hu, Shujun Cao, Jinghua Liu
Fibroblast growth factor 21 (FGF21) exerts a protective effect in ischemia/reperfusion (I/R)-induced cardiac injury. However, the exact molecular mechanism underlying the FGF21 action remains unclear. The present study aimed to evaluate the role of angiopoietin-2 (Angpt2) in the cardioprotective effect of FGF21. For this purpose, the H9C2 cell line was subjected to simulated I/R or aerobic conditions with or without FGF21 administration. Certain groups were also transfected with Angpt2 small interfering RNA (siRNA)...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28666032/pulmonary-vascular-changes-in-extremely-preterm-sheep-after-intra-amniotic-exposure-to-ureaplasma-parvum-and-lipopolysaccharide
#19
Monique G M Willems, Matthew W Kemp, Laura A Fast, Nick M M Wagemaker, Leon E W Janssen, John P Newnham, Matt S Payne, Owen B Spiller, Suhas G Kallapur, Alan H Jobe, Tammo Delhaas, Boris W Kramer, Tim G A M Wolfs
BACKGROUND: Chorioamnionitis can induce pulmonary inflammation and promote bronchopulmonary dysplasia development, distinguished by alveolar simplification and impaired vascular growth. Chorioamnionitis is more common during the extremely preterm canalicular lung stage (crucial for vascular development); and increases the risk for subsequent sepsis. We hypothesized that single/combined exposure to chronic and/or acute inflammation induces pulmonary inflammatory responses and vascular changes...
2017: PloS One
https://www.readbyqxmd.com/read/28660376/bone-metabolism-markers-and-angiogenic-cytokines-as-regulators-of-human-hematopoietic-stem-cell-mobilization
#20
Pantelis Tsirkinidis, Evangelos Terpos, Georgios Boutsikas, Athanasios Papatheodorou, Konstantinos Anargyrou, Eleni Lalou, Aglaia Dimitrakopoulou, Christina Kalpadakis, Konstantinos Konstantopoulos, Marina Siakantaris, Panayiotis Panayiotidis, Gerassimos Pangalis, Marie-Christine Kyrtsonis, Theodoros Vassilakopoulos, Maria K Angelopoulou
Hematopoietic stem cell (HSC) mobilization involves cleavage of ligands between HSC and niche components. However, there are scarce data regarding the role of bone cells in human HSC mobilization. We studied biochemical markers of bone metabolism and angiogenic cytokines during HSC mobilization in 46 patients' sera with lymphoma and multiple myeloma, by ELISA. Significant changes between pre-mobilization and collection samples were found: (1) Bone alkaline phosphatase (BALP) increased, indicating augmentation of bone formation; (2) Receptor activator of Nf-κB ligand/osteoprotegerin ratio (RANKL/OPG) increased, showing osteoclastic differentiation and survival; however, there was no evidence of increased osteoclastic activity; and (3) Angiopoietin-1/Angiopoietin-2 ratio (ANGP-1/ANGP-2) decreased, consistent with vessel destabilization...
June 28, 2017: Journal of Bone and Mineral Metabolism
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