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Bimodality

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https://www.readbyqxmd.com/read/29668016/genetic-and-ecological-niche-modeling-of-calydorea-crocoides-iridaceae-an-endemic-species-of-subtropical-highland-grasslands
#1
Juliana Lustosa Matos de Alencar, Eliane Kaltchuk-Santos, Juliana Fachinetto, Luana Olinda Tacuatiá, Eliana Regina Forni-Martins, Eudes Maria Stiehl-Alves, Tatiana Teixeira de Souza-Chies
Evolutionary analyses have been widely used for evaluation of genetic diversity of natural populations and correlate these data to the fitness of the species, especially in the case of threatened species. Calydorea crocoides occurs in a restricted area at altitudes from 800 to 1500 m in southern Brazil and is considered endangered. A study assessing genetic diversity, cytogenetic features and ecological niche was performed aiming to characterize C. crocoides by multidisciplinary approaches. Molecular data highlighted that most of the total variation (76%; p < 0...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29667527/comparison-of-the-physical-and-chemical-characteristics-of-fine-road-dust-at-different-urban-sites
#2
Kwang Yul Lee, Tsatsral Batmunkh, Hung Soo Joo, Kihong Park
The size distribution and chemical components of a fine fraction (<2.5 μm) of road dust collected at urban sites in Korea (Gwangju) and Mongolia (Ulaanbaatar) where distinct urban characteristics exist were measured. A clear bimodal size distribution was observed for the resuspended fine road dust at the urban sites in Korea. The first mode peaked at 100-110 nm, and the second peak was observed at 435-570 nm. Ultrafine mode (~30 nm) was found for the fine road dust at the Mongolia site, which was significantly affected by residential coal/biomass burning...
April 18, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29664903/on-the-role-of-extrinsic-noise-in-microrna-mediated-bimodal-gene-expression
#3
Marco Del Giudice, Stefano Bo, Silvia Grigolon, Carla Bosia
Several studies highlighted the relevance of extrinsic noise in shaping cell decision making and differentiation in molecular networks. Bimodal distributions of gene expression levels provide experimental evidence of phenotypic differentiation, where the modes of the distribution often correspond to different physiological states of the system. We theoretically address the presence of bimodal phenotypes in the context of microRNA (miRNA)-mediated regulation. MiRNAs are small noncoding RNA molecules that downregulate the expression of their target mRNAs...
April 17, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29664498/-hypophosphatemia-in-preterm-infants-a-bimodal-disorder
#4
María Paz Cubillos Celis, Patricia Mena Nannig
New nutritional approaches to treat extreme premature babies have demonstrated relevant eviden ce of metabolic disturbances with early hypophosphatemia, especially in patients with intrauterine growth restriction (IUGR). They have shown late hypophosphatemia, as well, which is characteristic in the metabolic bone disease. A sytematic search of literature describing metabolic disturbances of phosphorus in preterm newborns is presented, related to the use of early parenteral nutrition and also in the context of metabolic bone disease...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29660364/silibinin-is-a-direct-inhibitor-of-stat3
#5
Sara Verdura, Elisabet Cuyàs, Laura Llorach-Parés, Almudena Pérez-Sánchez, Vicente Micol, Alfons Nonell-Canals, Jorge Joven, Manuel Valiente, Melchor Sánchez-Martínez, Joaquim Bosch-Barrera, Javier A Menendez
We herein combined experimental and computational efforts to delineate the mechanism of action through which the flavonolignan silibinin targets STAT3. Silibinin reduced IL-6 inducible, constitutive, and acquired feedback activation of STAT3 at tyrosine 705 (Y705). Silibinin attenuated the inducible phospho-activation of Y705 in GFP-STAT3 genetic fusions without drastically altering the kinase activity of the STAT3 upstream kinases JAK1 and JAK2. A comparative computational study based on docking and molecular dynamics simulation over 14 different STAT3 inhibitors (STAT3i) predicted that silibinin could directly bind with high affinity to both the Src homology-2 (SH2) domain and the DNA-binding domain (DBD) of STAT3...
April 14, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29658090/bimodal-electrical-properties-of-rat-major-artery-segment-in-situ
#6
S V Revenko, L N Tikhomirova, A V Nesterov, I A Tarakanov
In experiments on narcotized rats, BP in the left femoral artery as well as local electrical potential and electrical impedance of the symmetric segment of the right femoral artery were simultaneously recorded in situ with two extracellular nonpolarizable Ag/AgCl electrodes located along the artery at a distance of 3 mm from each other. The pulsatile arterial electrical potentials with amplitude of 100-200 μV and duration of about 50 msec were recorded, which coincided with the front of BP wave corrected for a 10-msec delay of the pressure transducer...
April 16, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29656535/uterine-and-eggshell-modifications-associated-with-the-evolution-of-viviparity-in-south-american-water-snakes-helicops-spp
#7
Henrique B Braz, Selma M Almeida-Santos, Christopher R Murphy, Michael B Thompson
The evolution of viviparity requires eggshell thinning to bring together the maternal uterus and extraembryonic membranes to form placentae for physiological exchanges. Eggshell thinning likely involves reduced activity of the uterine glands that secrete it. We tested these hypotheses by comparing the uterine and eggshell structure and histochemistry among oviparous and viviparous water snakes (Helicops) using phylogenetic methods. Eggshell thinning occurred convergently in all three origins of viviparity in Helicops and was accomplished by the loss of the mineral layer and thinning of the shell membrane...
April 14, 2018: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/29656016/riding-the-cell-jamming-boundary-geometry-topology-and-phase-of-human-corneal-endothelium
#8
Nigel H Brookes
It is important to assess the viability of eye-banked corneas prior to transplantation due to inherent senescence and known loss of endothelial cells during surgical manipulation. Corneal endothelial cells have a complex basal and paracellular shape making them challenging to accurately measure, particularly in oedematous ex vivo tissue. This study used calibrated centroidal Voronoi Diagrams to segment cells in images of these human corneas, in order to characterize endothelial geometry, topology, and phase...
April 12, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29655328/communication-a-coil-stretch-transition-in-planar-elongational-flow-of-an-entangled-polymeric-melt
#9
Mohammad H Nafar Sefiddashti, Brian J Edwards, Bamin Khomami
Virtual experimentation of atomistic entangled polyethylene melts undergoing planar elongational flow revealed an amazingly detailed depiction of individual macromolecular dynamics and the resulting effect on bistable configurational states. A clear coil-stretch transition was evident, in much the same form as first envisioned by de Gennes for dilute solutions of high polymers, resulting in an associated hysteresis in the configurational flow profile over the range of strain rates predicted by theory. Simulations conducted at steady state revealed bimodal distribution functions, in which equilibrium configurational states were simultaneously populated by relatively coiled and stretched molecules which could transition from one conformational mode to the other over a relatively long time scale at critical values of strain rates...
April 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29655319/molecular-dynamics-simulations-of-site-point-mutations-in-the-tpr-domain-of-cyclophilin-40-identify-conformational-states-with-distinct-dynamic-and-enzymatic-properties
#10
Mert Gur, Elizabeth A Blackburn, Jia Ning, Vikram Narayan, Kathryn L Ball, Malcolm D Walkinshaw, Burak Erman
Cyclophilin 40 (Cyp40) is a member of the immunophilin family that acts as a peptidyl-prolyl-isomerase enzyme and binds to the heat shock protein 90 (Hsp90). Its structure comprises an N-terminal cyclophilin domain and a C-terminal tetratricopeptide (TPR) domain. Cyp40 is overexpressed in prostate cancer and certain T-cell lymphomas. The groove for Hsp90 binding on the TPR domain includes residues Lys227 and Lys308, referred to as the carboxylate clamp, and is essential for Cyp40-Hsp90 binding. In this study, the effect of two mutations, K227A and K308A, and their combinative mutant was investigated by performing a total of 5...
April 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29651929/chronic-iliofemoral-vein-obstruction-an-under-recognized-cause-of-exercise-limitation
#11
Michael J Segel, Ronen Reuveny, Jacob Luboshitz, Dekel Shlomi, Issahar Ben-Dov
Local symptoms of chronic venous insufficiency after deep vein thrombosis (DVT) are well described, but little is known about the effect of residual venous obstruction on exercise capacity. We tested our hypothesis that chronic residual iliofemoral vein occlusion (IFVO) after DVT may impair exercise capacity. Nine post-DVT patients with residual IFVO and effort intolerance were studied; a comparison cohort consisted of 11 healthy volunteers. Exercise tolerance was assessed by bimodality incremental symptom-limited cardiopulmonary testing, using leg and arm ergometers...
April 13, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29643518/-application-of-anoptomagnetic-probe-gd-do3a-ea-fitc-in-imaging-and-analyzing-the-brain-interstitial-space
#12
Y Q Li, Y Sheng, L Liang, Y Zhao, H Y Li, N Bai, T Wang, L Yuan, H B Han
OBJECTIVE: To investigate the application of the optical magnetic bimodal molecular probe Gd-DO3A-ethylthiouret-fluorescein isothiocyanate (Gd -DO3A-EA-FITC) in brain tissue imaging and brain interstitial space (ISS). METHODS: In the study, 24 male SD rats were randomly divided into 3 groups, including magnetic probe group (n=6), optical probe group (n=6) and optical magnetic bimodal probe group (n=12), then the optical magnetic bimodal probe group was divided equally into magnetic probe subgroup (n=6) and optical probe subgroup (n=6)...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29643425/a-novel-two-score-system-for-interferon-status-segregates-autoimmune-diseases-and-correlates-with-clinical-features
#13
Y M El-Sherbiny, A Psarras, M Y Md Yusof, E M A Hensor, R Tooze, G Doody, A A A Mohamed, D McGonagle, M Wittmann, P Emery, E M Vital
Measurement of type I interferon (IFN-I) has potential to diagnose and stratify autoimmune diseases, but existing results have been inconsistent. Interferon-stimulated-gene (ISG) based methods may be affected by the modularity of the ISG transcriptome, cell-specific expression, response to IFN-subtypes and bimodality of expression. We developed and clinically validated a 2-score system (IFN-Score-A and -B) using Factor Analysis of 31 ISGs measured by TaqMan selected from 3-IFN-annotated modules. We evaluated these scores using in-vitro IFN stimulation as well as in sorted cells then clinically validated in a cohort of 328 autoimmune disease patients and healthy controls...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29642934/correlation-of-gene-expression-and-associated-mutation-profiles-of-apobec3a-apobec3b-rev1-ung-and-fhit-with-chemosensitivity-of-cancer-cell-lines-to-drug-treatment
#14
Suleyman Vural, Richard Simon, Julia Krushkal
BACKGROUND: The APOBEC gene family of cytidine deaminases plays important roles in DNA repair and mRNA editing. In many cancers, APOBEC3B increases the mutation load, generating clusters of closely spaced, single-strand-specific DNA substitutions with a characteristic hypermutation signature. Some studies also suggested a possible involvement of APOBEC3A, REV1, UNG, and FHIT in molecular processes affecting APOBEC mutagenesis. It is important to understand how mutagenic processes linked to the activity of these genes may affect sensitivity of cancer cells to treatment...
April 11, 2018: Human Genomics
https://www.readbyqxmd.com/read/29629081/reversible-deactivation-anionic-alternating-ring-opening-copolymerization-of-epoxides-and-cyclic-anhydrides-access-to-orthogonally-functionalizable-multiblock-aliphatic-polyesters
#15
Maria J Sanford, Nathan J Van Zee, Geoffrey W Coates
The alternating copolymerization of epoxides and cyclic anhydrides is an increasingly popular route to aliphatic polyesters that are of interest as biodegradable replacements for petroleum-based polymers and for use in the biomedical field. However, broad and bimodal molecular weight distributions in these polymerizations continues to be an issue, limiting synthesis of multiblock copolymers. By use of a bifunctional catalytic system, the reversible-deactivation anionic alternating ring-opening copolymerization of epoxides and cyclic anhydrides gives unimodal polymers with Đ values generally less than 1...
January 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29625186/bimodal-fuzzy-analytic-hierarchy-process-bfahp-for-coronary-heart-disease-risk-assessment
#16
Farnaz Sabahi
Rooted deeply in medical multiple criteria decision-making (MCDM), risk assessment is very important especially when applied to the risk of being affected by deadly diseases such as coronary heart disease (CHD). CHD risk assessment is a stochastic, uncertain, and highly dynamic process influenced by various known and unknown variables. In recent years, there has been a great interest in fuzzy analytic hierarchy process (FAHP), a popular methodology for dealing with uncertainty in MCDM. This paper proposes a new FAHP, bimodal fuzzy analytic hierarchy process (BFAHP) that augments two aspects of knowledge, probability and validity, to fuzzy numbers to better deal with uncertainty...
April 3, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29623261/increased-relative-risk-of-tick-borne-encephalitis-in-warmer-weather
#17
Milan Daniel, Vlasta Danielová, Alena Fialová, Marek Malý, Bohumír Kříž, Patricia A Nuttall
Tick-borne encephalitis (TBE) is a serious acute neuroinfection of humans caused by a tick-borne flavivirus. The disease is typically seasonal, linked to the host-seeking activity of Ixodes ricinus (predominantly nymphs), the principal European tick vector species. To address the need for accurate risk predictions of contracting TBE, data on 4,044 TBE cases reported in the Czech Republic during 2001-2006 were compared with questing activity of I. ricinus nymphs monitored weekly at a defined location for the same 6-year period...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29621397/voc-gas-sensing-properties-of-bimodal-porous-%C3%AE-fe2o3-with-ultrahigh-sensitivity-and-fast-response
#18
Wangchang Geng, Shaobing Ge, Xiaowei He, Shan Zhang, Junwei Gu, Xiaoyong Lai, Hong Wang, Qiuyu Zhang
Porous solid with multimodal pore size distribution provides plenty of advantages including large specific surface area and superior mass transportation to achieve the high gas-sensing performances. In this study, α-Fe2O3 nanoparticles with bimodal porous structures were prepared successfully through a nanocasting pathway, adopting the bicontinuous 3D cubic symmetry mesoporous silica KIT-6 as the hard template. Its structure and morphology were characterized by X-ray Diffraction, Nitrogen adsorption-desorption, Transmission electron microscope and so on...
April 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29618938/bimodality-treatment-of-patients-with-pelvic-adenoid-cystic-carcinoma-with-photon-intensity-modulated-radiotherapy-plus-carbon-ion-boost-a-case-series
#19
Denise Bernhardt, Florian Sterzing, Sebastian Adeberg, Klaus Herfarth, Sonja Katayama, Robert Foerster, Juliane Hoerner-Rieber, Laila König, Juergen Debus, Stefan Rieken
Background: Treatment of patients with pelvic adenoid cystic carcinoma (ACC) remains a challenge owing to the rarity of the disease, the lack of data, and the relative radioresistance of these tumors. Case reports: This case series presents the results of three patients with recurrent or inoperable pelvic ACC treated with intensity-modulated radiotherapy (IMRT) plus carbon ion (C12) boost. Patients received C12 therapy at a dose of 3 Gray equivalents (GyE) (relative biological effectiveness [RBE]) per fraction up to 24 GyE RBE, followed by 50 GyE of photon IMRT in 25 fractions...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29617421/real-time-loudness-normalisation-with-combined-cochlear-implant-and-hearing-aid-stimulation
#20
Dimitar Spirrov, Maaike Van Eeckhoutte, Lieselot Van Deun, Tom Francart
BACKGROUND: People who use a cochlear implant together with a contralateral hearing aid-so-called bimodal listeners-have poor localisation abilities and sounds are often not balanced in loudness across ears. In order to address the latter, a loudness balancing algorithm was created, which equalises the loudness growth functions for the two ears. The algorithm uses loudness models in order to continuously adjust the two signals to loudness targets. Previous tests demonstrated improved binaural balance, improved localisation, and better speech intelligibility in quiet for soft phonemes...
2018: PloS One
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