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https://www.readbyqxmd.com/read/29050243/cancer-specific-evaluation-system-canes-a-high-accuracy-platform-for-preclinical-single-multi-biomarker-discovery
#1
Min-Seok Kwon, Seungyoon Nam, Sungyoung Lee, Young Zoo Ahn, Hae Ryung Chang, Yon Hui Kim, Taesung Park
The recent creation of enormous, cancer-related "Big Data" public depositories represents a powerful means for understanding tumorigenesis. However, a consistently accurate system for clinically evaluating single/multi-biomarkers remains lacking, and it has been asserted that oft-failed clinical advancement of biomarkers occurs within the very early stages of biomarker assessment. To address these challenges, we developed a clinically testable, web-based tool, CANcer-specific single/multi-biomarker Evaluation System (CANES), to evaluate biomarker effectiveness, across 2,134 whole transcriptome datasets, from 94,147 biological samples (from 18 tumor types)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048991/impacts-of-early-guideline-directed-21-gene-recurrence-score-testing-on-adjuvant-therapy-decision-making
#2
Hannah Dzimitrowicz, Sarah Mougalian, Sherri Storms, Sandra Hurd, Anees B Chagpar, Brigid K Killelea, Nina R Horowitz, Donald R Lannin, Malini Harigopal, Erin Hofstatter, Michael P DiGiovanna, Kerin B Adelson, Andrea Silber, Maysa Abu-Khalaf, Gina Chung, Wajih Zaheer, Osama Abdelghany, Christos Hatzis, Lajos Pusztai, Tara B Sanft
PURPOSE: The 21-gene recurrence score (RS) assay is used to help formulate adjuvant chemotherapy recommendations for patients with estrogen receptor-positive, early-stage breast cancer. Most frequently, medical oncologists order RS after surgery. Results take an additional 2 weeks to return, which can delay decision making. We conducted a prospective quality-improvement project to assess the impact of early guideline-directed RS ordering by surgeons before the first visit with a medical oncologist on adjuvant therapy decision making...
October 19, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29047072/involving-members-of-the-public-in-health-economics-research-insights-from-selecting-health-states-for-valuation-to-estimate-quality-adjusted-life-year-qaly-weights
#3
Elizabeth Goodwin, Kate Boddy, Lynn Tatnell, Annie Hawton
Over recent years, public involvement in health research has expanded considerably. However, public involvement in designing and conducting health economics research is seldom reported. Here we describe the development, delivery and assessment of an approach for involving people in a clearly defined piece of health economics research: selecting health states for valuation in estimating quality-adjusted life-years (QALYs). This involvement formed part of a study to develop a condition-specific preference-based measure of health-related quality of life, the Multiple Sclerosis Impact Scale (MSIS-8D), and the work reported here relates to the identification of plausible, or realistic, health states for valuation...
October 19, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29045282/prediction-model-for-wait-times-in-cardiac-transplantation
#4
David L Joyce, Brian D Lahr, Lyle D Joyce, Sudhir S Kushwaha, Richard C Daly
Wait times have increased for patients approved for heart transplants. We reviewed United Network for Organ Sharing (UNOS) data for 14,242 patients listed for isolated heart transplant (2009-2013) to develop a risk score model for timing left ventricular assist device (LVAD) implantation in bridge-to-transplant patients. We used a multivariable Cox proportional hazards regression model with subsequent bootstrap resampling for internal validation to develop a scoring system that combined risk factors, weighted by the corresponding regression coefficients, to define an individual's risk score...
October 18, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29042844/designing-a-care-pathway-model-a-case-study-of-the-outpatient-total-hip-arthroplasty-care-pathway
#5
Robin I Oosterholt, Lianne Wl Simonse, Stella U Boess, Stephan Bw Vehmeijer
INTRODUCTION: Although the clinical attributes of total hip arthroplasty (THA) care pathways have been thoroughly researched, a detailed understanding of the equally important organisational attributes is still lacking. The aim of this article is to contribute with a model of the outpatient THA care pathway that depicts how the care team should be organised to enable patient discharge on the day of surgery. THEORY: The outpatient THA care pathway enables patients to be discharged on the day of surgery, shortening the length of stay and intensifying the provision and organisation of care...
March 9, 2017: International Journal of Integrated Care
https://www.readbyqxmd.com/read/29041906/from-provocation-to-aggression-the-neural-network
#6
Jonathan Repple, Christina M Pawliczek, Bianca Voss, Steven Siegel, Frank Schneider, Nils Kohn, Ute Habel
BACKGROUND: In-vivo observations of neural processes during human aggressive behavior are difficult to obtain, limiting the number of studies in this area. To address this gap, the present study implemented a social reactive aggression paradigm in 29 healthy men, employing non-violent provocation in a two-player game to elicit aggressive behavior in fMRI settings. RESULTS: Participants responded more aggressively after high provocation reflected in taking more money from their opponents...
October 17, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/29038343/beliefs-regarding-development-and-early-intervention-among-low-income-african-american-and-hispanic-mothers
#7
Dawn M Magnusson, Cynthia S Minkovitz, Karen A Kuhlthau, Tania M Caballero, Kamila B Mistry
OBJECTIVES: Understand the role of health beliefs in shaping maternal decisions regarding help-seeking for children with developmental delay (DD) and explore differences between African American and Hispanic mothers. METHODS: Open-ended, semistructured interviews were conducted with African American and Hispanic mothers of children aged 0 to 36 months with DD. Interviews were recorded, transcribed, and analyzed by using inductive content analysis. RESULTS: Mothers (n = 22) were African American (36%) or Hispanic (64%), 25 to 34 years old (64%), had less than a high school education (59%), and had children receiving public insurance (95%)...
October 16, 2017: Pediatrics
https://www.readbyqxmd.com/read/29034826/voice-of-the-clinician-the-case-of-an-australian-health-system
#8
Mark J Lock, Amber L Stephenson, Jill Branford, Jonathan Roche, Marissa S Edwards, Kathleen Ryan
Purpose The Voice of the Clinician project commenced during an era when practitioner burnout, dissatisfaction, and turnover became an increasingly global health workforce concern. One key problem is clinical staff not being empowered to voice their concerns to decision-makers, as was found in this case study of an Australian public health organization. The following research question informed the present study: What is a better committee system for clinician engagement in decision-making processes? The paper aims to discuss this issue...
September 18, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29034315/emergence-of-%C3%AE-band-oscillations-in-the-aged-rat-amygdala-during-discrimination-learning-and-decision-making-tasks
#9
Rachel D Samson, Adam W Lester, Leroy Duarte, Anu Venkatesh, Carol A Barnes
Older adults tend to use strategies that differ from those used by young adults to solve decision-making tasks. MRI experiments suggest that altered strategy use during aging can be accompanied by a change in extent of activation of a given brain region, inter-hemispheric bilateralization or added brain structures. It has been suggested that these changes reflect compensation for less effective networks to enable optimal performance. One way that communication can be influenced within and between brain networks is through oscillatory events that help structure and synchronize incoming and outgoing information...
September 2017: ENeuro
https://www.readbyqxmd.com/read/29034229/spatiotemporal-modeling-for-fine-scale-maps-of-regional-malaria-endemicity-and-its-implications-for-transitional-complexities-in-a-routine-surveillance-network-in-western-cambodia
#10
Suguru Okami, Naohiko Kohtake
Due to the associated and substantial efforts of many stakeholders involved in malaria containment, the disease burden of malaria has dramatically decreased in many malaria-endemic countries in recent years. Some decades after the past efforts of the global malaria eradication program, malaria elimination has again featured on the global health agenda. While risk distribution modeling and a mapping approach are effective tools to assist with the efficient allocation of limited health-care resources, these methods need some adjustment and reexamination in accordance with changes occurring in relation to malaria elimination...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29032790/formative-qualitative-research-to-develop-community-based-interventions-addressing-low-birth-weight-in-the-plains-of-nepal
#11
Joanna Morrison, Sophiya Dulal, Helen Harris-Fry, Machhindra Basnet, Neha Sharma, Bhim Shrestha, Dharma Manandhar, Anthony Costello, David Osrin, Naomi Saville
OBJECTIVE: To explore the factors affecting intra-household food allocation practices to inform the development of interventions to prevent low birth weight in rural plains of Nepal. DESIGN: Qualitative methodology using purposive sampling to explore the barriers and facilitating factors to improved maternal nutrition. SETTING: Rural Dhanusha District, Nepal. SUBJECTS: We purposively sampled twenty-five young daughters-in-law from marginalised groups living in extended families and conducted semi-structured interviews with them...
October 16, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29030432/protein-kinase-a-deregulation-in-the-medial-prefrontal-cortex-impairs-working-memory-in-murine-oligophrenin1-deficiency
#12
Chun-Lei Zhang, Mattia Aime, Emilie Laheranne, Xander Houbaert, Hajer El Oussini, Christelle Martin, Marilyn Lepleux, Elisabeth Normand, Jamel Chelly, Etienne Herzog, Pierre Billuart, Yann Humeau
Classical and systems genetics have identified wide networks of genes associated with cognitive and neurodevelopmental diseases. In parallel to deciphering the role of each of these genes in neuronal or synaptic function, evaluating the response of neuronal and molecular networks to gene loss-of-function could reveal some pathophysiological mechanisms potentially accessible to non-genetic therapies. Loss of function of the Rho-GAP Oligophrenin-1 is associated with cognitive impairments in both human and mouse...
October 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29030329/effect-of-a-website-that-presents-patients-experiences-on-self-efficacy-and-patient-competence-of-colorectal-cancer-patients-web-based-randomized-controlled-trial
#13
Jürgen M Giesler, Bettina Keller, Tim Repke, Rainer Leonhart, Joachim Weis, Rebecca Muckelbauer, Nina Rieckmann, Jacqueline Müller-Nordhorn, Gabriele Lucius-Hoene, Christine Holmberg
BACKGROUND: Patients often seek other patients' experiences with the disease. The Internet provides a wide range of opportunities to share and learn about other people's health and illness experiences via blogs or patient-initiated online discussion groups. There also exists a range of medical information devices that include experiential patient information. However, there are serious concerns about the use of such experiential information because narratives of others may be powerful and pervasive tools that may hinder informed decision making...
October 13, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29029759/patient-centered-research-priorities-in-ovarian-cancer-a-systematic-review-of-potential-determinants-of-guideline-care
#14
REVIEW
Rachel A Pozzar, Donna L Berry
OBJECTIVE: To (a) determine what is known about the individual and contextual factors that may influence whether a woman with ovarian cancer receives guideline care, and (b) identify patient-centered research priorities in ovarian cancer. METHODS: A systematic review of the PubMed, MEDLINE, CINAHL Complete, and PsycInfo online databases. Eligible articles were published in English, described original research, and either (a) identified factors associated with the receipt of guideline care for ovarian cancer, or (b) described treatment decision making by women with ovarian cancer...
October 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29026986/inter-individual-differences-in-decision-making-flexible-and-goal-directed-behaviors-novel-insights-within-the-prefronto-striatal-networks
#15
Aurélie Fitoussi, Prisca Renault, Catherine Le Moine, Etienne Coutureau, Martine Cador, Françoise Dellu-Hagedorn
Inflexible behavior is a hallmark of several decision-making-related disorders such as ADHD and addiction. As in humans, a subset of healthy rats makes poor decisions and prefers immediate larger rewards despite suffering large losses in a rat gambling task (RGT). They also display a combination of traits reminiscent of addiction, notably inflexible behavior and perseverative responses. The goal of the present work was twofold: (1) to elucidate if behavioral inflexibility of poor decision-makers could be related to a lower quality of goal-directed behavior (action-outcome associations); (2) to uncover the neural basis of inter-individual differences in goal-directed behavior...
October 12, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29025844/investigating-canadian-parents-hpv-vaccine-knowledge-attitudes-and-behaviour-a-study-protocol-for-a-longitudinal-national-online-survey
#16
Gilla K Shapiro, Samara Perez, Anila Naz, Ovidiu Tatar, Juliet R Guichon, Rhonda Amsel, Gregory D Zimet, Zeev Rosberger
INTRODUCTION: Human papillomavirus (HPV), a sexually transmitted infection, can cause anogenital warts and a number of cancers. To prevent morbidity and mortality, three vaccines have been licensed and are recommended by Canada's National Advisory Committee on Immunisation (for girls since 2007 and boys since 2012). Nevertheless, HPV vaccine coverage in Canada remains suboptimal in many regions. This study will be the first to concurrently examine the correlates of HPV vaccine decision-making in parents of school-aged girls and boys and evaluate changes in parental knowledge, attitudes and behaviours over time...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025270/design-of-a-randomized-clinical-trial-of-a-colorectal-cancer-screening-decision-aid-to-promote-appropriate-screening-in-community-dwelling-older-adults
#17
Christine E Kistler, Carol Golin, Carolyn Morris, Alexandra F Dalton, Russell P Harris, Rowena Dolor, Renée M Ferrari, Noel T Brewer, Carmen L Lewis
BACKGROUND: Appropriate colorectal cancer screening in older adults should be aligned with the likelihood of net benefit. In general, patient decision aids improve knowledge and values clarity, but in older adults, they may also help patients identify their individual likelihood of benefit and foster individualized decision-making. We report on the design of a randomized clinical trial to understand the effects of a patient decision aid on appropriate colorectal cancer screening. This report includes a description of the baseline characteristics of participants...
August 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29017192/-horizon-scanning-in-health-care-a-german-perspective
#18
Laura Krabbe, Barbara Buchberger
Background Decision makers in health care act in an area in which expectations increase to make beneficial new technologies available as soon as possible, to protect patients from unsafe or ineffective technologies, and to expedite or decelerate technology diffusion. Horizon Scanning (HS) is a process to identify early new and emerging technologies and to inform about their potential consequences concerning the health care system. Objectives Methods of HS, worldwide existing activities and the status quo in Germany are described...
October 10, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28992072/attention-and-motivated-response-to-simulated-male-advertisement-call-activates-forebrain-dopaminergic-and-social-decision-making-network-nuclei-in-female-midshipman-fish
#19
Paul M Forlano, Roshney R Licorish, Zachary N Ghahramani, Miky Timothy, Melissa Ferrari, William C Palmer, Joseph A Sisneros
Little is known regarding the coordination of audition with decision-making and subsequent motor responses that initiate social behavior including mate localization during courtship. Using the midshipman fish model, we tested the hypothesis that the time spent by females attending and responding to the advertisement call is correlated with the activation of a specific subset of catecholaminergic (CA) and social decision-making network (SDM) nuclei underlying auditory- driven sexual motivation. In addition, we quantified the relationship of neural activation between CA and SDM nuclei in all responders with the goal of providing a map of functional connectivity of the circuitry underlying a motivated state responsive to acoustic cues during mate localization...
July 20, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28986299/reversible-inactivation-of-the-lateral-hypothalamus-reversed-high-reward-choices-in-cost-benefit-decision-making-in-rats
#20
Sara Karimi, Azam Mesdaghinia, Zahra Farzinpour, Gholamali Hamidi, Abbas Haghparast
The Lateral hypothalamus (LH) is an important component of the networks underlying the control of feeding and other motivated behaviors. Cost-benefit decision-making is mediated largely by the prefrontal cortex (PFC) which strongly innervates the LH. Therefore, in the current study, we conducted a series of experiments to elucidate the role of the perifornical area of the lateral hypothalamus (PeF-LH) in effort and/or delay-based decision-making. We trained different groups of rats in a delay-based and/or an effort-based form of cost-benefit T-maze decision- making task in which they could either choose to pay the cost to obtain a high reward in one arm or could obtain a low reward in the other arm with no cost...
October 3, 2017: Neurobiology of Learning and Memory
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