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Yin HH

Xiaoping Yin, Xu Huang, Qiao Li, Li Li, Pei Niu, Minglu Cao, Fei Guo, Xuechao Li, Wenchang Tan, Yunlong Huo
Background: The formation of hepatic hemangiomas (HH) is associated with VEGF and IL-7 that alter conduit arteries and small arterioles. To our knowledge, there are no studies to investigate the effects of HH on the hemodynamics in conduit arteries. The aim of the study is to perform morphometric and hemodynamic analysis in abdominal conduit arteries and bifurcations of HH patients and controls. Methods: Based on morphometry reconstructed from CT images, geometrical models were meshed with prismatic elements for the near wall region and tetrahedral and hexahedral elements for the core region...
2018: Frontiers in Physiology
Roel Geilleit, Hen Zhi Qian, Chong Chia Yin, Loh Ai Poh, Pang Nguk Lan, Gregory M Peterson, Ng Kee Chong, Anita Huis, Dirk F de Korne
BACKGROUND: Various technologies have been developed to improve hand hygiene (HH) compliance in inpatient settings; however, little is known about the feasibility of machine learning technology for this purpose in outpatient clinics. AIM: To assess the effectiveness, user experiences and costs of implementing a real-time HH notification machine learning system in outpatient clinics. METHODS: In our mixed methods study, a multidisciplinary team co-created an infrared guided sensor system to automatically notify clinicians to perform HH just before first patient contact...
April 9, 2018: Journal of Hospital Infection
Gu Gong, Liang Yin, Libang Yuan, Daming Sui, Yangyang Sun, Haiyu Fu, Liang Chen, Xiaowu Wang
High altitude cerebral edema (HACE) is a severe type of acute mountain sickness (AMS) that occurs in response to a high altitude hypobaric hypoxic (HH) environment. GM1 monosialoganglioside can alleviate brain injury under adverse conditions including amyloid-β-peptide, ischemia and trauma. However, its role in HACE-induced brain damage remains poorly elucidated. In this study, GM1 supplementation dose-dependently attenuated increase in rat brain water content (BWC) induced by hypobaric chamber (7600 m) exposurefor 24 h...
February 8, 2018: Molecular Immunology
Wenjing Wu, Jin Zhang, Chen Zhao, Yunmei Sun, Yajun Yin, Yongjia Peng, Weijun Pang, Gongshe Yang
The C1q/TNF-related protein 6 (CTRP6) is an adipokine involved in diverse biological processes. Formerly, we identified that CTRP6 regulates adipocyte differentiation, fatty acid oxidation and triglyceride accumulation in vitro. However, the effects of CTRP6 on adiposity in vivo have not yet been defined. This study aimed to confirm the involvement of CTRP6 in adipose accumulation and brown adipogenesis by intraperitoneal injection of the CTRP6-shRNA lentivirus into mice (CL mice). CL mice were significantly thinner than the control mice after feeding with a high fat diet (HFD), independent of food intake quantity...
June 1, 2018: Experimental Cell Research
Yi Wang, Xu Zhang, Huihui Huang, Yin Xia, YiFei Yao, Arthur Fuk-Tat Mak, Patrick Shu-Hang Yung, Kai-Ming Chan, Li Wang, Chenglin Zhang, Yu Huang, Kingston King-Lun Mak
Both extrinsic and intrinsic tissues contribute to tendon repair, but the origin and molecular functions of extrinsic tissues in tendon repair are not fully understood. Here we show that tendon sheath cells harbor stem/progenitor cell properties and contribute to tendon repair by activating Hedgehog signaling. We found that Osteocalcin ( Bglap ) can be used as an adult tendon-sheath-specific marker in mice. Lineage tracing experiments show that Bglap -expressing cells in adult sheath tissues possess clonogenic and multipotent properties comparable to those of stem/progenitor cells isolated from tendon fibers...
December 15, 2017: ELife
Qingjun Guan, Wei Sun, Yuehua Hu, Zhigang Yin, Changping Guan
A facile method to transform flue gas desulfurization gypsum (FGD gypsum) to α- calcium sulfate hemihydrate (α-HH) whiskers with high aspect ratios mediated by cetyltrimethylammonium bromide (CTAB) and KCl in glycerol-water solutions was studied. Addition of KCl facilitated the dissolution of calcium sulfate dihydrate (DH) and created a much higher supersaturation, which could come into being a larger driving force for the phase transformation from DH to α-HH. CTAB as the crystal modifier can significantly promoted 1-D growth of α-HH whiskers along the c axis and the presence of 0...
August 1, 2017: Scientific Reports
Xu Xiao, Jing-Jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-Ping Qiu, Yue Xiong, Lian-Fang Yang, Hai-Wei Cui, Xiao-Long He, Lei Yin, Wei Qi, Catherine C L Wong, Yun Zhao, Bo-Liang Li, Wen-Wei Qiu, Bao-Liang Song
Hedgehog (Hh) has been known as the only cholesterol-modified morphogen playing pivotal roles in development and tumorigenesis. A major unsolved question is how Hh signaling regulates the activity of Smoothened (SMO). Here, we performed an unbiased biochemical screen and identified that SMO was covalently modified by cholesterol on the Asp95 (D95) residue through an ester bond. This modification was inhibited by Patched-1 (Ptch1) but enhanced by Hh. The SMO(D95N) mutation, which could not be cholesterol modified, was refractory to Hh-stimulated ciliary localization and failed to activate downstream signaling...
April 6, 2017: Molecular Cell
Kah-Yin Loke, Andrew Sng Anjian, Yvonne Lim Yijuan, Cindy Ho Wei Li, Maria Güemes, Khalid Hussain
Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and it's management is challenging. Diazoxide is the first-line treatment, albeit not all patients will fully respond to it, as episodes of hypoglycaemia may persist and it entails unpleasant adverse effects. Sirolimus, an mTOR inhibitor, has reportedly been successful in treating children with severe diffuse HH, thus obviating the need for pancreatectomy. We report a girl with HH, with a novel heterozygous ABCC8 gene missense mutation (c...
2016: Endocrinology, Diabetes & Metabolism Case Reports
Hui Li, Juan Hua, Chun-Xia Guo, Wei-Xian Wang, Bao-Ju Wang, Dong-Liang Yang, Ping Wei, Yin-Ping Lu
Infection of schistosomiasis japonica may eventually lead to liver fibrosis, and no effective antifibrotic therapies are available but liver transplantation. Hedgehog (HH) signaling pathway has been involved in the process and is a promising target for treating liver fibrosis. This study aimed to explore the effects of pentoxifylline (PTX) on liver fibrosis induced by schistosoma japonicum infection by inhibiting the HH signaling pathway. Phorbol12-myristate13-acetate (PMA) was used to induce human acute mononuclear leukemia cells THP-1 to differentiate into macrophages...
June 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
Xiaodong Li, Fang Chen, Qiuhua Zhu, Bingjie Ding, Qingxiu Zhong, Kaikai Huang, Xuejie Jiang, Zhixiang Wang, Changxin Yin, Yufeng Zhu, Zhen Li, Fanyi Meng
Total body irradiation combined with chemotherapy is currently the most effective procedure as a preparative myeloablative regimen. However, resistance to radiotherapy and chemotherapy in refractory acute myeloid leukemia is associated with short-time recurrence after allogeneic hematopoietic stem cell transplantation. To address this issue, we used three cell lines, HL60, HL60/ADR (adriamycin-resistant cells), and HL60/RX (a radiation-resistant cell line established from HL60 cells), as cellular models to investigate the mechanism of the Hedgehog (Hh) signaling pathway resulting in radioresistance, and the efficacy of LDE225 (an inhibitor of the Hh pathway) to enhance radiation sensitivity...
May 31, 2016: Oncotarget
Miao Zhang, Jing Liu, Wenli Guo, Xin Liu, Sijin Liu, Huijun Yin
Systemic iron homeostasis is strictly controlled under normal conditions to ensure a balance between the absorption, utilization, storage and recycling of iron. The hepcidin-ferroportin (FPN) axis is of critical importance in the maintenance of iron homeostasis. Hepcidin deficiency gives rise to enhanced dietary iron absorption, as well as to increased iron release from macrophages, and this in turn results in iron accumulation in the plasma and organs, and is associated with a range of tissue pathologies. Low hepcidin levels have been demonstrated in most forms of hereditary hemochromatosis (HH), as well as in β-thalassemia...
May 2016: International Journal of Molecular Medicine
Jun Yi, Yan Zhu, Yin Jia, Hongdie Jiang, Xin Zheng, Dejing Liu, Shunxiang Gao, Mingjuan Sun, Bo Hu, Binghua Jiao, Lianghua Wang, Kaihui Wang
The neovascularization network of pannus formation plays a crucial role in the development of rheumatoid arthritis (RA). Annexin a2 (Axna2) is an important mediating agent that induces angiogenesis in vascular diseases. The correlation between Axna2 and pannus formation has not been studied. Here, we provided evidence that compared to osteoarthritis (OA) patients and healthy people, the expression of Axna2 and Axna2 receptor (Axna2R) were up-regulated in patients with RA. Joint swelling, inflammation and neovascularization were increased significantly in mice with collagen-induced arthritis (CIA) that were exogenously added Axna2...
2016: PloS One
Rongli Sun, Juan Zhang, Mengzhen Xiong, Haiyan Wei, Kehong Tan, Lihong Yin, Yuepu Pu
Leukemias and hematopoietic disorders induced by benzene may arise from the toxicity of benzene to hematopoietic stem or progenitor cells (HS/PCs). Since there is a latency period between initial benzene exposure and the development of leukemia, subsequent impact of benzene on HS/PCs are crucial for a deeper understanding of the carcinogenicity and hematotoxicity in post-exposure stage. This study aims to explore the effects of benzene on HS/PCs and gene-expression in Wnt, Notch and Hh signaling pathways in post-exposure stage...
August 2015: International Journal of Environmental Research and Public Health
Naqi Lian, Yuanyuan Jiang, Feng Zhang, Huanhuan Jin, Chunfeng Lu, Xiafei Wu, Yin Lu, Shizhong Zheng
Accumulating evidence indicates that Hedgehog (Hh) signaling becomes activated in chronic liver injury and plays a role in the pathogenesis of hepatic fibrosis. Hepatic stellate cells (HSCs) are Hh-responsive cells and activation of the Hh pathway promotes transdifferentiation of HSCs into myofibroblasts. Targeting Hh signaling may be a novel therapeutic strategy for treatment of liver fibrosis. We previously reported that curcumin has potent antifibrotic effects in vivo and in vitro, but the underlying mechanisms are not fully elucidated...
July 2015: Laboratory Investigation; a Journal of Technical Methods and Pathology
Xing-Gang Wu, Yang Wang, Qian Wu, Wai-Hang Cheng, Wenjing Liu, Yueshui Zhao, Claire Mayeur, Paul J Schmidt, Paul B Yu, Fudi Wang, Yin Xia
Mutations in HFE are the most common cause of hereditary hemochromatosis (HH). HFE mutations result in reduced expression of hepcidin, a hepatic hormone, which negatively regulates iron absorption from the duodenum and iron release from macrophages. However, the mechanism by which HFE regulates hepcidin expression in hepatocytes is not well understood. It is known that the bone morphogenetic protein (BMP) pathway plays a central role in controlling hepcidin expression in the liver. Here we show that HFE overexpression increased Smad1/5/8 phosphorylation and hepcidin expression, whereas inhibition of BMP signaling abolished HFE-induced hepcidin expression in Hep3B cells...
August 21, 2014: Blood
Zhuan Hong, Aijing Bi, Dan Chen, Li Gao, Zhimin Yin, Lan Luo
The activation of the hedgehog pathway, which is an important signaling mechanism crucial in embryogenesis, has strong links to carcinogenesis. Aberrant regulation of this pathway can result in the development of tumors. The present study was designed to investigate Hh related protein expression in non-small cell lung cancers. Fifty five non-small cell lung cancers samples were used in the study. By reverse transcription-polymerase chain reaction (RT-PCR), the expression of Shh, Ptch-1, and Gli-1 in tumor and adjacent normal tissues was examined and associated to clinical pathologic features...
October 2014: Pathology Oncology Research: POR
Pei-Chi Chih, Yi-Ching Yang, Jin-Shang Wu, Yin-Fan Chang, Feng-Hwa Lu, Chih-Jen Chang
OBJECTIVE: To investigate the relationship between overweight and erosive esophagitis (EE) in a non-obese Taiwanese population. DESIGN AND METHODS: A total of 7,352 subjects (non-obese, 5,826; obese, 1,526) from a health examination center at National Cheng Kung University Hospital were enrolled. Central obesity was defined by a waist circumference (WC) ≥ 90 cm in male and 80 cm in female. Overweight was defined as body mass index (BMI) of 24-26.9 kg/m(2), and general obesity as BMI ≥ 27 kg/m(2)...
2013: PloS One
Heather Schacht Reisinger, Jun Yin, Lewis Radonovich, V Troy Knighton, Richard A Martinello, Michael J Hodgson, Eli Perencevich
BACKGROUND: Veterans Health Administration (VHA) is a national health care system with variation in hand hygiene (HH) measurement and improvement practices across its facilities. The objective of this national survey was to characterize this variability and identify opportunities for standardization. METHODS: Survey covered 3 major areas of HH: (1) methods of measuring HH compliance, (2) interventions to improve HH compliance, and (3) site-specific targets for HH compliance...
November 2013: American Journal of Infection Control
Zhao Zhang, Xiangdong Lv, Wen-chi Yin, Xiaoyun Zhang, Jing Feng, Wenqing Wu, Chi-chung Hui, Lei Zhang, Yun Zhao
The Cubitus interruptus (Ci)/Gli family of transcription factors can be degraded either completely or partially from a full-length form (Ci155/Gli(FL)) to a truncated repressor (Ci75/Gli(R)) by proteasomes to mediate Hedgehog (Hh) signaling. The mechanism by which proteasomes distinguish ubiquitinated Ci/Gli to carry out complete versus partial degradation is not known. Here, we show that Ter94 ATPase and its mammalian counterpart, p97, are involved in processing Ci and Gli3 into Ci75 and Gli3(R), respectively...
June 24, 2013: Developmental Cell
May Yin Lee, Li Sun, Jacqueline M Veltmaat
The first mouse mutation associated with a heritable defect in embryonic mammary gland development was Extratoes. It represents a functional null-mutation of the gene encoding Gli3, which is best known as a transcription factor mediating canonical Hedgehog (Hh) signaling. Here we review the roles of Hh and Gli proteins in murine embryonic mammary development. We propose that an off-state for Hh signaling, mediated by Gli3-repressor, is determinant for induction of a mammary instead of hair follicle fate in the trunk surface ectoderm...
June 2013: Journal of Mammary Gland Biology and Neoplasia
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