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Yin HH

Kah-Yin Loke, Andrew Sng Anjian, Yvonne Lim Yijuan, Cindy Ho Wei Li, Maria Güemes, Khalid Hussain
: Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and it's management is challenging. Diazoxide is the first-line treatment, albeit not all patients will fully respond to it, as episodes of hypoglycaemia may persist and it entails unpleasant adverse effects. Sirolimus, an mTOR inhibitor, has reportedly been successful in treating children with severe diffuse HH, thus obviating the need for pancreatectomy. We report a girl with HH, with a novel heterozygous ABCC8 gene missense mutation (c...
2016: Endocrinology, Diabetes & Metabolism Case Reports
Hui Li, Juan Hua, Chun-Xia Guo, Wei-Xian Wang, Bao-Ju Wang, Dong-Liang Yang, Ping Wei, Yin-Ping Lu
Infection of schistosomiasis japonica may eventually lead to liver fibrosis, and no effective antifibrotic therapies are available but liver transplantation. Hedgehog (HH) signaling pathway has been involved in the process and is a promising target for treating liver fibrosis. This study aimed to explore the effects of pentoxifylline (PTX) on liver fibrosis induced by schistosoma japonicum infection by inhibiting the HH signaling pathway. Phorbol12-myristate13-acetate (PMA) was used to induce human acute mononuclear leukemia cells THP-1 to differentiate into macrophages...
June 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
Xiaodong Li, Fang Chen, Qiuhua Zhu, Bingjie Ding, Qingxiu Zhong, Kaikai Huang, Xuejie Jiang, Zhixiang Wang, Changxin Yin, Yufeng Zhu, Zhen Li, Fanyi Meng
Total body irradiation combined with chemotherapy is currently the most effective procedure as a preparative myeloablative regimen. However, resistance to radiotherapy and chemotherapy in refractory acute myeloid leukemia is associated with short-time recurrence after allogeneic hematopoietic stem cell transplantation. To address this issue, we used three cell lines, HL60, HL60/ADR (adriamycin-resistant cells), and HL60/RX (a radiation-resistant cell line established from HL60 cells), as cellular models to investigate the mechanism of the Hedgehog (Hh) signaling pathway resulting in radioresistance, and the efficacy of LDE225 (an inhibitor of the Hh pathway) to enhance radiation sensitivity...
May 31, 2016: Oncotarget
Miao Zhang, Jing Liu, Wenli Guo, Xin Liu, Sijin Liu, Huijun Yin
Systemic iron homeostasis is strictly controlled under normal conditions to ensure a balance between the absorption, utilization, storage and recycling of iron. The hepcidin-ferroportin (FPN) axis is of critical importance in the maintenance of iron homeostasis. Hepcidin deficiency gives rise to enhanced dietary iron absorption, as well as to increased iron release from macrophages, and this in turn results in iron accumulation in the plasma and organs, and is associated with a range of tissue pathologies. Low hepcidin levels have been demonstrated in most forms of hereditary hemochromatosis (HH), as well as in β-thalassemia...
May 2016: International Journal of Molecular Medicine
Jun Yi, Yan Zhu, Yin Jia, Hongdie Jiang, Xin Zheng, Dejing Liu, Shunxiang Gao, Mingjuan Sun, Bo Hu, Binghua Jiao, Lianghua Wang, Kaihui Wang
The neovascularization network of pannus formation plays a crucial role in the development of rheumatoid arthritis (RA). Annexin a2 (Axna2) is an important mediating agent that induces angiogenesis in vascular diseases. The correlation between Axna2 and pannus formation has not been studied. Here, we provided evidence that compared to osteoarthritis (OA) patients and healthy people, the expression of Axna2 and Axna2 receptor (Axna2R) were up-regulated in patients with RA. Joint swelling, inflammation and neovascularization were increased significantly in mice with collagen-induced arthritis (CIA) that were exogenously added Axna2...
2016: PloS One
Rongli Sun, Juan Zhang, Mengzhen Xiong, Haiyan Wei, Kehong Tan, Lihong Yin, Yuepu Pu
Leukemias and hematopoietic disorders induced by benzene may arise from the toxicity of benzene to hematopoietic stem or progenitor cells (HS/PCs). Since there is a latency period between initial benzene exposure and the development of leukemia, subsequent impact of benzene on HS/PCs are crucial for a deeper understanding of the carcinogenicity and hematotoxicity in post-exposure stage. This study aims to explore the effects of benzene on HS/PCs and gene-expression in Wnt, Notch and Hh signaling pathways in post-exposure stage...
August 2015: International Journal of Environmental Research and Public Health
Naqi Lian, Yuanyuan Jiang, Feng Zhang, Huanhuan Jin, Chunfeng Lu, Xiafei Wu, Yin Lu, Shizhong Zheng
Accumulating evidence indicates that Hedgehog (Hh) signaling becomes activated in chronic liver injury and plays a role in the pathogenesis of hepatic fibrosis. Hepatic stellate cells (HSCs) are Hh-responsive cells and activation of the Hh pathway promotes transdifferentiation of HSCs into myofibroblasts. Targeting Hh signaling may be a novel therapeutic strategy for treatment of liver fibrosis. We previously reported that curcumin has potent antifibrotic effects in vivo and in vitro, but the underlying mechanisms are not fully elucidated...
July 2015: Laboratory Investigation; a Journal of Technical Methods and Pathology
Xing-Gang Wu, Yang Wang, Qian Wu, Wai-Hang Cheng, Wenjing Liu, Yueshui Zhao, Claire Mayeur, Paul J Schmidt, Paul B Yu, Fudi Wang, Yin Xia
Mutations in HFE are the most common cause of hereditary hemochromatosis (HH). HFE mutations result in reduced expression of hepcidin, a hepatic hormone, which negatively regulates iron absorption from the duodenum and iron release from macrophages. However, the mechanism by which HFE regulates hepcidin expression in hepatocytes is not well understood. It is known that the bone morphogenetic protein (BMP) pathway plays a central role in controlling hepcidin expression in the liver. Here we show that HFE overexpression increased Smad1/5/8 phosphorylation and hepcidin expression, whereas inhibition of BMP signaling abolished HFE-induced hepcidin expression in Hep3B cells...
August 21, 2014: Blood
Zhuan Hong, Aijing Bi, Dan Chen, Li Gao, Zhimin Yin, Lan Luo
The activation of the hedgehog pathway, which is an important signaling mechanism crucial in embryogenesis, has strong links to carcinogenesis. Aberrant regulation of this pathway can result in the development of tumors. The present study was designed to investigate Hh related protein expression in non-small cell lung cancers. Fifty five non-small cell lung cancers samples were used in the study. By reverse transcription-polymerase chain reaction (RT-PCR), the expression of Shh, Ptch-1, and Gli-1 in tumor and adjacent normal tissues was examined and associated to clinical pathologic features...
October 2014: Pathology Oncology Research: POR
Pei-Chi Chih, Yi-Ching Yang, Jin-Shang Wu, Yin-Fan Chang, Feng-Hwa Lu, Chih-Jen Chang
OBJECTIVE: To investigate the relationship between overweight and erosive esophagitis (EE) in a non-obese Taiwanese population. DESIGN AND METHODS: A total of 7,352 subjects (non-obese, 5,826; obese, 1,526) from a health examination center at National Cheng Kung University Hospital were enrolled. Central obesity was defined by a waist circumference (WC) ≥ 90 cm in male and 80 cm in female. Overweight was defined as body mass index (BMI) of 24-26.9 kg/m(2), and general obesity as BMI ≥ 27 kg/m(2)...
2013: PloS One
Heather Schacht Reisinger, Jun Yin, Lewis Radonovich, V Troy Knighton, Richard A Martinello, Michael J Hodgson, Eli Perencevich
BACKGROUND: Veterans Health Administration (VHA) is a national health care system with variation in hand hygiene (HH) measurement and improvement practices across its facilities. The objective of this national survey was to characterize this variability and identify opportunities for standardization. METHODS: Survey covered 3 major areas of HH: (1) methods of measuring HH compliance, (2) interventions to improve HH compliance, and (3) site-specific targets for HH compliance...
November 2013: American Journal of Infection Control
Zhao Zhang, Xiangdong Lv, Wen-chi Yin, Xiaoyun Zhang, Jing Feng, Wenqing Wu, Chi-chung Hui, Lei Zhang, Yun Zhao
The Cubitus interruptus (Ci)/Gli family of transcription factors can be degraded either completely or partially from a full-length form (Ci155/Gli(FL)) to a truncated repressor (Ci75/Gli(R)) by proteasomes to mediate Hedgehog (Hh) signaling. The mechanism by which proteasomes distinguish ubiquitinated Ci/Gli to carry out complete versus partial degradation is not known. Here, we show that Ter94 ATPase and its mammalian counterpart, p97, are involved in processing Ci and Gli3 into Ci75 and Gli3(R), respectively...
June 24, 2013: Developmental Cell
May Yin Lee, Li Sun, Jacqueline M Veltmaat
The first mouse mutation associated with a heritable defect in embryonic mammary gland development was Extratoes. It represents a functional null-mutation of the gene encoding Gli3, which is best known as a transcription factor mediating canonical Hedgehog (Hh) signaling. Here we review the roles of Hh and Gli proteins in murine embryonic mammary development. We propose that an off-state for Hh signaling, mediated by Gli3-repressor, is determinant for induction of a mammary instead of hair follicle fate in the trunk surface ectoderm...
June 2013: Journal of Mammary Gland Biology and Neoplasia
Kun Hao, Xiao-Dong Tian, Chang-Fu Qin, Xue-Hai Xie, Yin-Mo Yang
Pancreatic cancer is one of the most aggressive and devastating malignancies. The Hedgehog (Hh) pathway has been reported to play an important role in pancreatic cancer development and progression. The aim of this study was to examine the activation of the Hh pathway in human pancreatic cancer tissue samples and pancreatic cancer cell lines, and the molecular mechanisms involved in the Hh pathway mediated effects on pancreatic cancer cell proliferation and invasion. The expression levels of Hh molecules in human pancreatic cancer tissue samples and pancreatic cancer cell lines were evaluated using RT-PCR...
March 2013: Oncology Reports
Yimin Ma, Yongxin Ren, Ethan Q Han, Huiwu Li, Di Chen, Joshua J Jacobs, Steven Gitelis, Regis J O'Keefe, Yrjö T Konttinen, Guoyong Yin, Tian-Fang Li
Osteosarcoma (OS) is one of the most common malignant bone tumors in early adolescence. Multi-drug chemotherapy has greatly increased the five year survival rate from 20% to 70%. However, the rate has been staggering for 30 years and the prognosis is particularly poor for patients with recurrence and metastasis. Our study aimed to investigate the role of Wnt-β-catenin, Notch and Hedgehog pathway in OS development because all these pathways are involved in skeletal development, tumorigenesis and chemoresistance...
February 8, 2013: Biochemical and Biophysical Research Communications
Daming Cui, Xianzhen Chen, Jia Yin, Wenhua Wang, Meiqing Lou, Shixin Gu
BACKGROUND: Hedgehog/Gli1 (HH/Gli1) pathway plays an important role in the patterning and development of the central nervous system during embryogenesis. Recent data have shown its potential involvement in a subset of human gliomas and inhibition of the pathway resulted in tumor suppression in both in vitro and in vivo studies. The underlying mechanisms of tumor suppression, however, remain to be fully elucidated. MATERIALS AND METHODS: Gli1 expression was investigated in 60 surgically resected glioma tissues (World Health Organization (WHO) III-IV)...
November 2012: Neurology India
Yin-Lu Ding, Qi-San Wang, Wei-Min Zhao, Lei Xiang
UNLABELLED: BACKGROUDS: The hedgehog (Hh) signaling pathway is composed of patched (PTCH) and smoothened (SMO), two transmembrane proteins, and downstream glioma-associated oncogene homolog (Gli) transcription factors. Hh signaling plays a pathological role in the occurrence and development of various cancers. METHODS: To investigate the expression of SMO protein in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis, immunohistochemistry was performed with paraffin-embedded specimens of 96 cases...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
Chang-fu Qin, Xiao-dong Tian, Kun Hao, Yin-mo Yang
OBJECTIVE: To explore the synergistic effects on proliferation and apoptosis by targeted suppression of epidermal growth factor receptor (EGFR) in combination with blockade of Hedgehog signaling pathways in pancreatic cancer cells and examine the synergistic mechanism of Hedgehog and EGFR signaling pathways. METHODS: The sequences of RNA interference targeting EGFR gene were designed, synthesized and cloned into the pFU-GW-RNAi vector. And a stable transfection cell line was obtained by transfecting the human Panc-1 cells with lentivirus...
July 10, 2012: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Aiping Liu, Xin Yin, Liang Shi, Peng Li, Kent L Thornburg, Ruikang Wang, Sandra Rugonyi
During developmental stages, biomechanical stimuli on cardiac cells modulate genetic programs, and deviations from normal stimuli can lead to cardiac defects. Therefore, it is important to characterize normal cardiac biomechanical stimuli during early developmental stages. Using the chicken embryo model of cardiac development, we focused on characterizing biomechanical stimuli on the Hamburger-Hamilton (HH) 18 chick cardiac outflow tract (OFT), the distal portion of the heart from which a large portion of defects observed in humans originate...
2012: PloS One
Chang-Fu Qin, Kun Hao, Xiao-Dong Tian, Xue-Hai Xie, Yin-Mo Yang
In the present study, we established a new experimental model to investigate the effects of EGFR targeting by RNAi, and the synergistic actions between the hedgehog (Hh) and EGFR signaling pathways on the proliferation and apoptosis in pancreatic cancer cells. Three human pancreatic cancer cell lines expressing EGFR shRNA were established, and gene expression inhibition was assessed in these lines using RT-PCR and western blot analysis. The effects of EGFR RNAi and Hh inhibition on cell proliferation and apoptosis were explored in vitro and in vivo...
August 2012: Oncology Reports
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