M P Fabritius, V Soltani, C C Cyran, J Ricke, P Bartenstein, C J Auernhammer, C Spitzweg, M L Schnitzer, R Ebner, S Mansournia, A Hinterberger, A Lohse, G T Sheikh, M Winkelmann, T Knösel, M Ingenerf, C Schmid-Tannwald, W G Kunz, J Rübenthaler, Freba Grawe
BACKGROUND: Histopathology is the reference standard for diagnosing liver metastases of neuroendocrine tumors (NETs). Somatostatin receptor-positron emission tomography / computed tomography (SSR-PET/CT) has emerged as a promising non-invasive imaging modality for staging NETs. We aimed to assess the diagnostic accuracy of SSR-PET/CT in the identification of liver metastases in patients with proven NETs compared to histopathology. METHODS: Histopathologic reports of 139 resected or biopsied liver lesions of patients with known NET were correlated with matching SSR-PET/CTs and the positive/negative predictive value (PPV/NPV), sensitivity, specificity, and diagnostic accuracy of SSR-PET/CT were evaluated...
September 28, 2023: Cancer Imaging: the Official Publication of the International Cancer Imaging Society