Read by QxMD icon Read

Robert derubeis

John R Keefe, Jay Amsterdam, Qing S Li, Irene Soeller, Robert DeRubeis, Jun J Mao
OBJECTIVE: Patient expectancies are hypothesized to contribute to the efficacy and side effects of psychiatric treatments, but little research has investigated this hypothesis in the context of psychopharmacological therapies for anxiety. We prospectively investigated whether expectancies predicted efficacy and adverse events in oral therapy for Generalized Anxiety Disorder (GAD), controlling for confounding patient characteristics correlating with outcomes. METHODS: Expectancies regarding treatment efficacy and side effects were assessed at baseline of an eight week open-label phase of a trial of chamomile for Generalized Anxiety Disorder (GAD)...
September 30, 2016: Journal of Psychiatric Research
Benjamin D Schalet, Tony Z Tang, Robert J DeRubeis, Steven D Hollon, Jay D Amsterdam, Richard C Shelton
BACKGROUND: Meta-analyses of placebo-controlled trials of SSRIs suggest that only a small portion of the observable change in depression may be attributed to "true" pharmacological effects. But depression is a multidimensional construct, so treatment effects may differ by symptom cluster. We tested the hypothesis that SSRIs uniquely alter psychological rather than somatic symptoms of depression and anxiety. METHOD: Outpatients with moderate to severe MDD were randomly assigned to receive paroxetine (n = 120) or placebo (n = 60)...
2016: PloS One
Nicholas R Forand, Daniel R Strunk, Robert J DeRubeis
"Extreme responding" is the tendency to endorse extreme responses on self-report measures (e.g., 1s and 7s on a 7-point scale). It has been linked to depressive relapse after cognitive therapy (CT), but the mechanisms are unknown. Moreover, findings of positive extreme responding (PER) predicting depressive relapse do not support the original hypothesis of "extreme" negative thinking leading to extreme negative emotional reactions. We assessed the relationships between post-treatment PER on the Dysfunctional Attitudes Scale (DAS) and Attributional Style Questionnaire (ASQ) and these constructs: coping skills, in-session performance of cognitive therapy skills, age, and estimated IQ...
August 2016: Behaviour Research and Therapy
Steven D Hollon, Robert J DeRubeis, Jan Fawcett, Jay D Amsterdam, Richard C Shelton, John Zajecka, Paula R Young, Robert Gallop
No abstract text is available yet for this article.
June 1, 2016: JAMA Psychiatry
Lois A Gelfand, David P MacKinnon, Robert J DeRubeis, Amanda N Baraldi
OBJECTIVE: Survival time is an important type of outcome variable in treatment research. Currently, limited guidance is available regarding performing mediation analyses with survival outcomes, which generally do not have normally distributed errors, and contain unobserved (censored) events. We present considerations for choosing an approach, using a comparison of semi-parametric proportional hazards (PH) and fully parametric accelerated failure time (AFT) approaches for illustration...
2016: Frontiers in Psychology
Jay D Amsterdam, Lorenzo Lorenzo-Luaces, Irene Soeller, Susan Qing Li, Jun J Mao, Robert J DeRubeis
BACKGROUND: Controversy exists over antidepressant use in bipolar II depression. AIMS: To compare the safety and effectiveness of antidepressantv.mood stabiliser monotherapy for bipolar type II major depressive episodes. METHOD: Randomised, double-blind, parallel-group, 12-week comparison of venlafaxine (n= 65)v.lithium (n= 64) monotherapy in adult out-patients (trial registration numberNCT00602537). RESULTS: Primary outcome - venlafaxine produced a greater response rate (67...
April 2016: British Journal of Psychiatry: the Journal of Mental Science
Jeffrey R Vittengl, Robin B Jarrett, Erica Weitz, Steven D Hollon, Jos Twisk, Ioana Cristea, Daniel David, Robert J DeRubeis, Sona Dimidjian, Boadie W Dunlop, Mahbobeh Faramarzi, Ulrich Hegerl, Sidney H Kennedy, Farzan Kheirkhah, Roland Mergl, Jeanne Miranda, David C Mohr, A John Rush, Zindel V Segal, Juned Siddique, Anne D Simons, Pim Cuijpers
OBJECTIVE: Although the average depressed patient benefits moderately from cognitive-behavioral therapy (CBT) or pharmacotherapy, some experience divergent outcomes. The authors tested frequencies, predictors, and moderators of negative and unusually positive outcomes. METHOD: Sixteen randomized clinical trials comparing CBT and pharmacotherapy for unipolar depression in 1,700 patients provided individual pre- and posttreatment scores on the Hamilton Depression Rating Scale (HAM-D) and/or Beck Depression Inventory (BDI)...
May 1, 2016: American Journal of Psychiatry
Marcus J H Huibers, Zachary D Cohen, Lotte H J M Lemmens, Arnoud Arntz, Frenk P M L Peeters, Pim Cuijpers, Robert J DeRubeis
No abstract text is available yet for this article.
2016: PloS One
Lotte H J M Lemmens, Robert J DeRubeis, Arnoud Arntz, Frenk P M L Peeters, Marcus J H Huibers
OBJECTIVE: We examined the rates, baseline predictors and clinical impact of sudden gains in a randomized comparison of individual Cognitive Therapy (CT) and Interpersonal Psychotherapy (IPT) for adult depression. METHOD: 117 depressed outpatients received 16-20 sessions of either CT or IPT. Session-by-session symptom severity was assessed using the BDI-II. Sudden gains were examined using the original criteria as defined by Tang and DeRubeis (1999b). Furthermore, we examined whether the duration of the between-session interval at which sudden gains were recorded affected the results...
February 2016: Behaviour Research and Therapy
John R Keefe, Christian A Webb, Robert J DeRubeis
OBJECTIVE: Patients with major depressive disorder (MDD) and a comorbid personality disorder (PD) have been found to exhibit relatively poor outcomes in cognitive therapy (CT) and other treatments. Adaptations of CT focusing heavily on patients' core beliefs have yielded promising findings in the treatment of PD. However, there have been no investigations that have specifically tested whether increased focus on maladaptive beliefs contributes to CT's efficacy for these patients. METHOD: CT technique use from an early CT session was assessed for 59 patients (33 without PD, 26 with PD-predominantly Cluster C) who participated in a randomized controlled trial for moderate to severe MDD...
April 2016: Journal of Consulting and Clinical Psychology
Lorenzo Lorenzo-Luaces, Robert J DeRubeis, Ian M Bennett
BACKGROUND AND OBJECTIVES: Most outpatient treatment for depression is delivered by primary care physicians (PCPs), yet little is known about which patient variables affect PCPs' selection of high-intensity interventions, namely antidepressant medications or psychotherapy, as opposed to less-intensive treatment regimens (eg, watchful waiting, exercise). Our objective was to ascertain whether the patient's symptom severity, presenting psychosocial stress, and lifestyle habits influenced treatment recommendations...
July 2015: Family Medicine
Marcus J H Huibers, Zachary D Cohen, Lotte H J M Lemmens, Arnoud Arntz, Frenk P M L Peeters, Pim Cuijpers, Robert J DeRubeis
INTRODUCTION: Although psychotherapies for depression produce equivalent outcomes, individual patients respond differently to different therapies. Predictors of outcome have been identified in the context of randomized trials, but this information has not been used to predict which treatment works best for the depressed individual. In this paper, we aim to replicate a recently developed treatment selection method, using data from an RCT comparing the effects of cognitive therapy (CT) and interpersonal psychotherapy (IPT)...
2015: PloS One
Patricia Otero, Filip Smit, Pim Cuijpers, Robert J DeRubeis, Ángela Torres, Fernando L Vázquez
Depression is one of the most common mental disorders in caregivers. Therefore, preventive interventions for this population are needed, especially for caregivers with subclinical symptoms of depression. However, no study to date has identified the characteristics of caregivers that help to predict who will or will not benefit from such a preventive intervention. This study aimed to identify moderators of response to intervention comparing problem solving and usual care in indicated prevention of depression among informal caregivers...
December 15, 2015: Psychiatry Research
Katherine E Sasso, Daniel R Strunk, Justin D Braun, Robert J DeRubeis, Melissa A Brotman
OBJECTIVE: Little is known about the influence of patients' pretreatment characteristics on the adherence-outcome relation in cognitive therapy (CT) for depression. In a sample of 57 depressed adults participating in CT, the authors examined interactions between pretreatment patient characteristics and therapist adherence in predicting session-to-session symptom change. METHOD: Using items from the Collaborative Study Psychotherapy Rating Scale, the authors assessed 3 facets of therapist adherence: cognitive methods, negotiating/structuring, and behavioral methods/homework...
October 2015: Journal of Consulting and Clinical Psychology
Andrew A Cooper, Daniel R Strunk, Elizabeth T Ryan, Robert J DeRubeis, Steven D Hollon, Robert Gallop
BACKGROUND: Previous psychotherapy research has examined the therapeutic alliance and therapist adherence as correlates or predictors of symptom change. While some initial evidence suggests the alliance is associated with risk of dropout in cognitive behavioral treatment for depression, evidence of such relations has been limited to date. We examined the relation of these psychotherapy process variables and dropout in the context of cognitive therapy for depression when provided in combination with pharmacotherapy...
March 2016: Journal of Behavior Therapy and Experimental Psychiatry
Jay D Amsterdam, Lorenzo Lorenzo-Luaces, Irene Soeller, Susan Qing Li, Jun J Mao, Robert J DeRubeis
OBJECTIVE: Compare the safety and effectiveness of continuation antidepressant versus mood stabilizer monotherapy for preventing depressive relapse in bipolar II disorder. METHODS: Subjects ≥18 years old with bipolar II depression (n=129) were randomized to double-blind venlafaxine or lithium monotherapy for 12 weeks. Responders with a ≥50% reduction in depression score were continued for an additional 6 months of relapse-prevention monotherapy. Primary outcome was depressive relapse during continuation monotherapy...
October 1, 2015: Journal of Affective Disorders
Katherine E Sasso, Daniel R Strunk, Justin D Braun, Robert J DeRubeis, Melissa A Brotman
OBJECTIVE: We previously examined alliance and therapist adherence as predictors of symptom change. Applying a new analytic strategy, we can ensure that any relations identified were not attributable to stable patient characteristics. METHOD: Participants were 57 depressed cognitive therapy patients. We disaggregated within- and between-patient variation in process measures. RESULTS: Between-patients, variability in adherence to Cognitive Methods and Negotiating/Structuring predicted patients' symptom change...
July 2016: Psychotherapy Research: Journal of the Society for Psychotherapy Research
Shelley McMain, Michelle G Newman, Zindel V Segal, Robert J DeRubeis
Cognitive behavioral therapy (CBT), an umbrella term that includes a diverse group of treatments, is defined by a strong commitment to empiricism. While CBT has a robust empirical base, areas for improvement remain. This article reviews the status of the current empirical base and its limitations, and presents future directions for advancement of the field. Ultimately, studies are needed that will identify the predictors, mediators, and moderators of treatment response in order to increase knowledge on how to personalize interventions for each client and to strengthen the impact of CBT...
2015: Psychotherapy Research: Journal of the Society for Psychotherapy Research
Lorenzo Lorenzo-Luaces, Ramaris E German, Robert J DeRubeis
Many attempts have been made to discover and characterize the mechanisms of change in psychotherapies for depression, yet no clear, evidence-based account of the relationship between therapeutic procedures, psychological mechanisms, and symptom improvement has emerged. Negatively-biased thinking plays an important role in the phenomenology of depression, and most theorists acknowledge that cognitive changes occur during successful treatments. However, the causal role of cognitive change procedures in promoting cognitive change and alleviating depressive symptoms has been questioned...
November 2015: Clinical Psychology Review
Pim Cuijpers, Erica Weitz, Jos Twisk, Christine Kuehner, Ioana Cristea, Daniel David, Robert J DeRubeis, Sona Dimidjian, Boadie W Dunlop, Mahbobeh Faramarzi, Ulrich Hegerl, Robin B Jarrett, Sidney H Kennedy, Farzan Kheirkhah, Roland Mergl, Jeanne Miranda, David C Mohr, Zindel V Segal, Juned Siddique, Anne D Simons, Jeffrey R Vittengl, Steven D Hollon
BACKGROUND: It has yet to be established whether gender moderates or predicts outcome of psychological and pharmacological treatments for adult depression because: (1) individual randomized trials typically lack sufficient statistical power to detect moderators and predictors and (2) meta-analyses cannot examine such associations directly. METHODS: We conducted an "individual patient data" meta-analysis with the primary data of 1,766 patients from 14 eligible randomized trials comparing cognitive behavior therapy (CBT) with pharmacotherapy...
November 2014: Depression and Anxiety
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"