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Robert derubeis

Eliora Porter, Dianne L Chambless, Kevin S McCarthy, Robert J DeRubeis, Brian A Sharpless, Marna S Barrett, Barbara Milrod, Steven D Hollon, Jacques P Barber
Although widely used, the Hamilton Rating Scale for Depression (HRSD) and Hamilton Anxiety Rating Scale (HARS) discriminate poorly between depression and anxiety. To address this problem, Riskind, Beck, Brown, and Steer (J Nerv Ment Dis. 175:474-479, 1987) created the Reconstructed Hamilton Scales by reconfiguring HRSD and HARS items into modified scales. To further analyze the reconstructed scales, we examined their factor structure and criterion-related validity in a sample of patients with major depressive disorder and no comorbid anxiety disorders (n = 215) or with panic disorder and no comorbid mood disorders (n = 149)...
February 20, 2017: Journal of Nervous and Mental Disease
Lorenzo Lorenzo-Luaces, Robert J DeRubeis, Annemieke van Straten, Bea Tiemens
BACKGROUND: Prognostic indices (PIs) combining variables to predict future depression risk may help guide the selection of treatments that differ in intensity. We develop a PI and show its promise in guiding treatment decisions between treatment as usual (TAU), treatment starting with a low-intensity treatment (brief therapy (BT)), or treatment starting with a high-intensity treatment intervention (cognitive-behavioral therapy (CBT)). METHODS: We utilized data from depressed patients (N=622) who participated in a randomized comparison of TAU, BT, and CBT in which no statistically significant differences in the primary outcomes emerged between the three treatments...
February 7, 2017: Journal of Affective Disorders
Jay D Amsterdam, Lorenzo Lorenzo-Luaces, Robert J DeRubeis
OBJECTIVES: We examined differences in treatment outcome between Diagnostic and Statistical Manual Fourth Edition (DSM-IV)-defined rapid cycling and average lifetime-defined rapid cycling in subjects with bipolar II disorder. We hypothesized that, compared with the DSM-IV definition, the average lifetime definition of rapid cycling may better identify subjects with a history of more mood lability and a greater likelihood of hypomanic symptom induction during long-term treatment. METHODS: Subjects ≥18 years old with a bipolar II major depressive episode (n=129) were categorized into DSM-IV- and average lifetime-defined rapid cycling and prospectively treated with either venlafaxine or lithium monotherapy for 12 weeks...
February 2017: Bipolar Disorders
Nicholas R Forand, Marcus J H Huibers, Robert J DeRubeis
OBJECTIVE: Understanding how treatments work is a goal of psychotherapy research, however the strength of relationships between therapy processes and outcomes is inconsistent. DeRubeis, Cohen, et al. (2014) proposed that process-outcome relationships are moderated by patient characteristics. These "patient response patterns" (PRPs) indicate individuals' responsiveness to the active ingredients of treatment. Given the same quality of therapy, one individual may receive more benefit than another depending on their PRP...
May 2017: Journal of Consulting and Clinical Psychology
Toshi A Furukawa, Erica S Weitz, Shiro Tanaka, Steven D Hollon, Stefan G Hofmann, Gerhard Andersson, Jos Twisk, Robert J DeRubeis, Sona Dimidjian, Ulrich Hegerl, Roland Mergl, Robin B Jarrett, Jeffrey R Vittengl, Norio Watanabe, Pim Cuijpers
BackgroundThe influence of baseline severity has been examined for antidepressant medications but has not been studied properly for cognitive-behavioural therapy (CBT) in comparison with pill placebo.AimsTo synthesise evidence regarding the influence of initial severity on efficacy of CBT from all randomised controlled trials (RCTs) in which CBT, in face-to-face individual or group format, was compared with pill-placebo control in adults with major depression.MethodA systematic review and an individual-participant data meta-analysis using mixed models that included trial effects as random effects...
March 2017: British Journal of Psychiatry: the Journal of Mental Science
Lorenzo Lorenzo-Luaces, John R Keefe, Robert J DeRubeis
Since the introduction of Beck's cognitive theory of emotional disorders, and their treatment with psychotherapy, cognitive-behavioral approaches have become the most extensively researched psychological treatment for a wide variety of disorders. Despite this, the relative contribution of cognitive to behavioral approaches to treatment are poorly understood and the mechanistic role of cognitive change in therapy is widely debated. We critically review this literature, focusing on the mechanistic role of cognitive change across cognitive and behavioral therapies for depressive and anxiety disorders...
November 2016: Behavior Therapy
Pim Cuijpers, Erica Weitz, Femke Lamers, Brenda W Penninx, Jos Twisk, Robert J DeRubeis, Sona Dimidjian, Boadie W Dunlop, Robin B Jarrett, Zindel V Segal, Steven D Hollon
BACKGROUND: Melancholic and atypical depression are widely thought to moderate or predict outcome of pharmacological and psychological treatments of adult depression, but that has not yet been established. This study uses the data from four earlier trials comparing cognitive behavior therapy (CBT) versus antidepressant medications (ADMs; and pill placebo when available) to examine the extent to which melancholic and atypical depression moderate or predict outcome in an "individual patient data" meta-analysis...
December 6, 2016: Depression and Anxiety
Robert J DeRubeis, Lorenzo Lorenzo-Luaces
No abstract text is available yet for this article.
January 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
Jay D Amsterdam, Lorenzo Lorenzo-Luaces, Robert J DeRubeis
OBJECTIVE: This study examined the relationship between the number of prior antidepressant treatment trials and step-wise increase in pharmacodynamic tolerance (or progressive loss of effectiveness) in subjects with bipolar II depression. METHODS: Subjects ≥18 years old with bipolar II depression (n=129) were randomized to double-blind venlafaxine or lithium carbonate monotherapy for 12 weeks. Responders (n=59) received continuation monotherapy for six additional months...
November 2016: Bipolar Disorders
John R Keefe, Jay Amsterdam, Qing S Li, Irene Soeller, Robert DeRubeis, Jun J Mao
OBJECTIVE: Patient expectancies are hypothesized to contribute to the efficacy and side effects of psychiatric treatments, but little research has investigated this hypothesis in the context of psychopharmacological therapies for anxiety. We prospectively investigated whether expectancies predicted efficacy and adverse events in oral therapy for Generalized Anxiety Disorder (GAD), controlling for confounding patient characteristics correlating with outcomes. METHODS: Expectancies regarding treatment efficacy and side effects were assessed at baseline of an eight week open-label phase of a trial of chamomile for Generalized Anxiety Disorder (GAD)...
January 2017: Journal of Psychiatric Research
Benjamin D Schalet, Tony Z Tang, Robert J DeRubeis, Steven D Hollon, Jay D Amsterdam, Richard C Shelton
BACKGROUND: Meta-analyses of placebo-controlled trials of SSRIs suggest that only a small portion of the observable change in depression may be attributed to "true" pharmacological effects. But depression is a multidimensional construct, so treatment effects may differ by symptom cluster. We tested the hypothesis that SSRIs uniquely alter psychological rather than somatic symptoms of depression and anxiety. METHOD: Outpatients with moderate to severe MDD were randomly assigned to receive paroxetine (n = 120) or placebo (n = 60)...
2016: PloS One
Nicholas R Forand, Daniel R Strunk, Robert J DeRubeis
"Extreme responding" is the tendency to endorse extreme responses on self-report measures (e.g., 1s and 7s on a 7-point scale). It has been linked to depressive relapse after cognitive therapy (CT), but the mechanisms are unknown. Moreover, findings of positive extreme responding (PER) predicting depressive relapse do not support the original hypothesis of "extreme" negative thinking leading to extreme negative emotional reactions. We assessed the relationships between post-treatment PER on the Dysfunctional Attitudes Scale (DAS) and Attributional Style Questionnaire (ASQ) and these constructs: coping skills, in-session performance of cognitive therapy skills, age, and estimated IQ...
August 2016: Behaviour Research and Therapy
Steven D Hollon, Robert J DeRubeis, Jan Fawcett, Jay D Amsterdam, Richard C Shelton, John Zajecka, Paula R Young, Robert Gallop
No abstract text is available yet for this article.
June 1, 2016: JAMA Psychiatry
Lois A Gelfand, David P MacKinnon, Robert J DeRubeis, Amanda N Baraldi
OBJECTIVE: Survival time is an important type of outcome variable in treatment research. Currently, limited guidance is available regarding performing mediation analyses with survival outcomes, which generally do not have normally distributed errors, and contain unobserved (censored) events. We present considerations for choosing an approach, using a comparison of semi-parametric proportional hazards (PH) and fully parametric accelerated failure time (AFT) approaches for illustration...
2016: Frontiers in Psychology
Jay D Amsterdam, Lorenzo Lorenzo-Luaces, Irene Soeller, Susan Qing Li, Jun J Mao, Robert J DeRubeis
BACKGROUND: Controversy exists over antidepressant use in bipolar II depression. AIMS: To compare the safety and effectiveness of antidepressantv.mood stabiliser monotherapy for bipolar type II major depressive episodes. METHOD: Randomised, double-blind, parallel-group, 12-week comparison of venlafaxine (n= 65)v.lithium (n= 64) monotherapy in adult out-patients (trial registration numberNCT00602537). RESULTS: Primary outcome - venlafaxine produced a greater response rate (67...
April 2016: British Journal of Psychiatry: the Journal of Mental Science
Jeffrey R Vittengl, Robin B Jarrett, Erica Weitz, Steven D Hollon, Jos Twisk, Ioana Cristea, Daniel David, Robert J DeRubeis, Sona Dimidjian, Boadie W Dunlop, Mahbobeh Faramarzi, Ulrich Hegerl, Sidney H Kennedy, Farzan Kheirkhah, Roland Mergl, Jeanne Miranda, David C Mohr, A John Rush, Zindel V Segal, Juned Siddique, Anne D Simons, Pim Cuijpers
OBJECTIVE: Although the average depressed patient benefits moderately from cognitive-behavioral therapy (CBT) or pharmacotherapy, some experience divergent outcomes. The authors tested frequencies, predictors, and moderators of negative and unusually positive outcomes. METHOD: Sixteen randomized clinical trials comparing CBT and pharmacotherapy for unipolar depression in 1,700 patients provided individual pre- and posttreatment scores on the Hamilton Depression Rating Scale (HAM-D) and/or Beck Depression Inventory (BDI)...
May 1, 2016: American Journal of Psychiatry
Marcus J H Huibers, Zachary D Cohen, Lotte H J M Lemmens, Arnoud Arntz, Frenk P M L Peeters, Pim Cuijpers, Robert J DeRubeis
No abstract text is available yet for this article.
2016: PloS One
Lotte H J M Lemmens, Robert J DeRubeis, Arnoud Arntz, Frenk P M L Peeters, Marcus J H Huibers
OBJECTIVE: We examined the rates, baseline predictors and clinical impact of sudden gains in a randomized comparison of individual Cognitive Therapy (CT) and Interpersonal Psychotherapy (IPT) for adult depression. METHOD: 117 depressed outpatients received 16-20 sessions of either CT or IPT. Session-by-session symptom severity was assessed using the BDI-II. Sudden gains were examined using the original criteria as defined by Tang and DeRubeis (1999b). Furthermore, we examined whether the duration of the between-session interval at which sudden gains were recorded affected the results...
February 2016: Behaviour Research and Therapy
John R Keefe, Christian A Webb, Robert J DeRubeis
OBJECTIVE: Patients with major depressive disorder (MDD) and a comorbid personality disorder (PD) have been found to exhibit relatively poor outcomes in cognitive therapy (CT) and other treatments. Adaptations of CT focusing heavily on patients' core beliefs have yielded promising findings in the treatment of PD. However, there have been no investigations that have specifically tested whether increased focus on maladaptive beliefs contributes to CT's efficacy for these patients. METHOD: CT technique use from an early CT session was assessed for 59 patients (33 without PD, 26 with PD-predominantly Cluster C) who participated in a randomized controlled trial for moderate to severe MDD...
April 2016: Journal of Consulting and Clinical Psychology
Lorenzo Lorenzo-Luaces, Robert J DeRubeis, Ian M Bennett
BACKGROUND AND OBJECTIVES: Most outpatient treatment for depression is delivered by primary care physicians (PCPs), yet little is known about which patient variables affect PCPs' selection of high-intensity interventions, namely antidepressant medications or psychotherapy, as opposed to less-intensive treatment regimens (eg, watchful waiting, exercise). Our objective was to ascertain whether the patient's symptom severity, presenting psychosocial stress, and lifestyle habits influenced treatment recommendations...
July 2015: Family Medicine
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