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Multiple myloma

Ya-Lin Liu, Wen-Juan Wang, Hai-Bo Liu
OBJECTIVE: To explore the value of bone marrow smear and biopsy simultaneously applied to diagnosis of multiple myloma (MM). METHODS: Clinical data of 30 cases of multiple myloma were collected from our hospital in the year 2014 and analyzed retrospectively, and the results of the bone marrow smear and the simultaneous bone marrow biopsy were compared. RESULTS: Hyperplasia levels in bone marrow biopsy was significantly higher than that in bone marrow smears, and the active and highly active hyperplasia of nucleated cells were observed in all the bone marrow biopsies; the myeloma cells showed a focal or diffuse distribution, the binuclear or polynuclear myeloma cells were observed in 22 patients (73%), but the detection rate of abnormal myeloma cells was 40% in bone marrow smear (P < 0...
August 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
E Q Micheo, E J Calcagno, S R de Sijvarger, S I Calabria, E Maccione, S C Besuschio, J H Magnasco, C Barros, F S Muriel, Z C de Soto
The mortality caused by blood neoplasms in Argentina shows great irregularity. This was found to be caused in certain ways by (a) differences in the sexes and ages of the populations studied; (b) differences in available health services; and (c) environmental factors. Thus high rates and clusters of lymphomas and multiple mylomas were observed in zones with arsenical water, for example.In rural districts, the rates are lower, especially among old-aged people.Lower rates of leukemias were also observed among Spaniards compared to Italians (p=0...
August 1979: Biological Trace Element Research
Xiao Han, Dao-Bin Zhou, Ming-Hui Duan, Xuan Wang, Jie-Ping Zhang, Yong-Qiang Zhao, Ti Shen, Yong-Ji Wu
Disorders of iron utilization caused by abnormal elevation of hepcidin levels are the main mechanism of anemia of chronic disease. Hepcidin is mainly produced by the liver. Recently it has been found that monocytes are another source of hepcidin. The increased hepcidin in serum and urine of multiple myeloma patients may be one cause of anemia of chronic disease (ACD). However it is unclear whether the peripheral blood monocyte hepcidin is involved in the pathogenesis of anemia of chronic disease. This study was purposed to investigate the role of monocyte hepcidin in multiple myeloma patients with anemia of chronic disease...
April 2013: Zhongguo Shi Yan Xue Ye Xue za Zhi
Yuhui Weng, Liang Shao, Hongmei Ouyang, Yuebo Liu, Jin Yao, Hong Yang, Yunjiao Luo, Hao Wang, Zhenyu Zhao, Hong Mou, Zeping Zhou, You Zhang
Multiple myeloma (MM) is a clonal B-cell malignancy charactered by the aberrant proliferation of malignant plasma cells in the bone marrow. MM is still an incurable malignancy. In this regard, novel treatments are urgently required. MUC1 (mucin 1), a type І transmembrane protein, is overexpressed and aberrantly glycosylated in many carcinomas particularly in MM resulting in an antigenically distinct molecule and may be a potential target for specific immunotherapy. In this study, we first designed a unique DNA vaccine, termed MUC1-2-VNTR (various number tandem repeats) to investigate whether the vaccine could specifically suppress tumor growth in a murine multiple myloma model...
June 2012: Oncology Reports
Yan-Song Ding, Wen-Ming Chen
This study was aimed to investigate the effect of T cells activated by DCs loaded with whole antigens of U266 cells on the U266 cells survival in vitro. Peripheral blood mononuclear cells were isolated from healthy donor, and adherented on culture plate. Adherent cells were cultured in AIM-V serum-free medium or in RPMI 1640 medium contained 20% fetal bovine serum (FBS), supplemented with granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-4 (IL-4). Methyl thiazolyl tetrazolium (MTT) assay was used to evaluate killing rate of U266 cells by T cells activated by DCs loaded with whole antigen of U266 cells...
June 2007: Zhongguo Shi Yan Xue Ye Xue za Zhi
Ernesto Pérez-Persona, María-Belén Vidriales, Gema Mateo, Ramón García-Sanz, Maria-Victoria Mateos, Alfonso García de Coca, Josefina Galende, Guillermo Martín-Nuñez, José M Alonso, Natalia de Las Heras, José M Hernández, Alejandro Martín, Consuelo López-Berges, Alberto Orfao, Jesús F San Miguel
Monoclonal gammopathy of uncertain significance (MGUS) and smoldering multiple myeloma (SMM) are plasma cell disorders with a risk of progression of approximately 1% and 10% per year, respectively. We have previously shown that the proportion of bone marrow (BM) aberrant plasma cells (aPCs) within the BMPC compartment (aPC/BMPC) as assessed by flow cytometry (FC) contributes to differential diagnosis between MGUS and multiple myloma (MM). The goal of the present study was to investigate this parameter as a marker for risk of progression in MGUS (n = 407) and SMM (n = 93)...
October 1, 2007: Blood
S Kaise, T Nishimaki, T Morito, H Yoshida, R Kasukawa, S Asano, H Wakasa
No abstract text is available yet for this article.
May 1982: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
H Hamza, H Ben Maiz, K Ayed, L Morel-Maroger, F Kouki, M Moalla, H Ben Ayed
A 52 year old man was admitted to hospital for persistent back pain, fixed proteinuria of 6g/24 h that lead to the nephrotic syndrome (proteids 40 g/l, albumin 21,2 g/l). Two possible etiologies were envisaged: 1) Myeloma with K light chains as evidenced by biological findings (absence of normal Ig, presence of K light chains both in blood and urine, malignant medullary plasmocytosis) as well as x-rays (small punched out lesions). 2. Diabetes mellitus (blood glucose 2,4 g/l) with retinal and neurological involvement...
1981: Néphrologie
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