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estimated GFR children

Afshin Safaei-Asl, Mercede Enshaei, Abtin Heydarzadeh, Shohreh Maleknejad
INTRODUCTION: Assessment of glomerular filtration rate (GFR) is an important tool for monitoring renal function. OBJECTIVES: Regarding to limitations in available methods, we intended to calculate GFR by cystatin C (Cys C) based formulas and determine correlation rate of them with current methods. PATIENTS AND METHODS: We studied 72 children (38 boys and 34 girls) with renal disorders. The 24 hour urinary creatinine (Cr) clearance was the gold standard method...
2016: Journal of Renal Injury Prevention
Wun Fung Hui, Aisha Betoko, Jonathan D Savant, Alison G Abraham, Larry A Greenbaum, Bradley Warady, Marva M Moxey-Mims, Susan L Furth
OBJECTIVE: Our aim was to characterize the nutrient intake of children with chronic kidney disease (CKD) relative to recommended intake levels. METHODS: We conducted a cross-sectional study of dietary intake assessed by Food Frequency Questionnaire (FFQ) in The North American Chronic Kidney Disease in Children (CKiD) prospective cohort study. Nutrient intake was analyzed to estimate the daily consumption levels of various nutrients and compared with national guidelines for intake...
September 29, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
A M Abdel-Karim, A Fahmy, A Moussa, H Rashad, M Elbadry, H Badawy, A Hammady
INTRODUCTION AND OBJECTIVES: Recurrent ureteropelvic junction obstruction (UPJO) in children is an operative challenge. Minimally invasive endourological treatment options for secondary UPJO have suboptimal success rates; hence, there is a re-emergence of interest about redo pyeloplasty. The present study presented experience with laparoscopic management of previously failed pyeloplasty compared with open redo pyeloplasty in children. STUDY DESIGN: Twenty-four children with recurrent UPJO who underwent transperitoneal dismembered laparoscopic pyeloplasty were studied...
July 21, 2016: Journal of Pediatric Urology
Anthony A Portale, Myles S Wolf, Shari Messinger, Farzana Perwad, Harald Jüppner, Bradley A Warady, Susan L Furth, Isidro B Salusky
BACKGROUND AND OBJECTIVES: Plasma fibroblast growth factor 23 (FGF23) concentrations increase early in the course of CKD in children. High FGF23 levels associate with progression of CKD in adults. Whether FGF23 predicts CKD progression in children is unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We tested the hypothesis that high plasma FGF23 is an independent risk factor for CKD progression in 419 children, aged 1-16 years, enrolled in the Chronic Kidney Disease in Children (CKiD) cohort study...
August 25, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Pankaj P Dangle, Omar Ayyash, Audry Kang, Carlton Bates, Janelle Fox, Heidi Stephany, Glenn Cannon
OBJECTIVE: To asses if cystatin c calculated GFR can reveal CKD not detected by creatinine-based calculations in a larger prospective cohort of children with MMC. Wheel chair bound meningomyelocele (MMC) patients frequently have low muscle mass, and assessing renal deterioration based on creatinine based glomerular filtration rate is imprecise. MMC patients are also at risk for end stage renal disease. METHODS: Prospectively enrolled patients with MMC underwent annual serum creatinine and cystatin c testing...
August 16, 2016: Urology
Patience Ngozi Obiagwu, Priya Gajjar, Mignon McCulloch, Christian Scott, Alp Numanoglu, Peter Nourse
BACKGROUND: Renal artery revascularisation procedures are usually carried out on children with renal artery stenosis from varied causes, including Takayasu's arteritis. Reports on the outcome of such procedures in children usually refer to the improvement in blood pressure, with only minimal mention of effects on renal function. OBJECTIVE: Salvageability of renal function in children who underwent renal revascularisation for Takayasu's arteritis-induced renal artery stenosis (TARAS) was the focus of this study...
August 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Lucia Pacifico, Enea Bonci, Gian Marco Andreoli, Michele Di Martino, Alessia Gallozzi, Ester De Luca, Claudio Chiesa
The association between nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease has attracted interest and attention over recent years. However, no data are available in children. We determined whether children with NAFLD show signs of renal functional alterations, as determined by estimated glomerular filtration rate (eGFR) and urinary albumin excretion. We studied 596 children with overweight/obesity, 268 with NAFLD (hepatic fat fraction ≥5% on magnetic resonance imaging) and 328 without NAFLD, and 130 healthy normal-weight controls...
2016: International Journal of Molecular Sciences
Jeremy A Saban, Michael Zappitelli, Susan M Samuel, Manish M Sood, R Todd Alexander, Steven Arora, Robin L Erickson, Kristine Kroeker, Braden J Manns, Allison B Dart
BACKGROUND: Significant practice variation exists in Canada with respect to timing of dialysis initiation in children. In the absence of evidence to guide practice, physicians' perceptions may significantly influence decision-making. OBJECTIVE: The objectives of this study are to (1) evaluate Canadian pediatric nephrologists' perceptions regarding dialysis initiation in children with chronic kidney disease (CKD) and (2) determine the factors guiding practice that may contribute to practice variation across Canada...
2016: Canadian Journal of Kidney Health and Disease
Camilla Tøndel, Bjørn Bolann, Cathrin Lytomt Salvador, Damien Brackman, Anna Bjerre, Einar Svarstad, Atle Brun
BACKGROUND: In children, estimated glomerular filtration rate (eGFR) methods are hampered by inaccuracy, hence there is an obvious need for safe, simplified, and accurate measured GFR (mGFR) methods. The aim of this study was to evaluate different formulas and determine the optimal sampling points for calculating mGFR based on iohexol clearance measurements on blood samples drawn at two time points (GFR2p). METHODS: The GFR of 96 children with different stages of chronic kidney disease (CKD) (median age 9...
July 1, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Alexandra Bruel, Jean-Christophe Rozé, Marie-Pierre Quere, Cyril Flamant, Marion Boivin, Gwenaëlle Roussey-Kesler, Emma Allain-Launay
OBJECTIVES: Acute kidney injury (AKI) is a severe complication of prematurity, with currently unknown consequences for renal function in childhood. The objective of this study was to search for signs of reduced nephron number in children aged 3-10 years who had been born preterm with neonatal AKI and compare this group to control children. METHODS: IRENEO was a prospective, controlled study conducted in 2013 in Nantes University Hospital. Children who were born at less than 33 weeks gestational age (GA) and included in the LIFT cohort were eligible for entry...
June 22, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Katarzyna Musiol, Grażyna Sobol-Milejska, Łukasz Nowotka, Karolina Torba, Maria Kniażewska, Halina Wos
AIM: The aim of the study was to evaluate renal function and to assess the usefulness of the following nephrotoxicity markers: cystatin C (CYS C), beta-2 microglobulin (B2MG) and neutrophil gelatinase-associated lipocalin (NGAL) in 38 (18 girls, 20 boys) children previously treated for central nervous system malignancy. MATERIAL: Median age at evaluation was 13.7 years (range 2.1-22 years). The mean follow-up time after the completion of chemotherapy was 3.2 years (range 0...
August 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Kevin V Lemley, Serena M Bagnasco, Cynthia C Nast, Laura Barisoni, Catherine M Conway, Stephen M Hewitt, Peter X K Song
OBJECTIVE: Most predictive models of kidney disease progression have not incorporated structural data. If structural variables have been used in models, they have generally been only semi-quantitative. METHODS: We examined the predictive utility of quantitative structural parameters measured on the digital images of baseline kidney biopsies from the NEPTUNE study of primary proteinuric glomerulopathies. These variables were included in longitudinal statistical models predicting the change in estimated glomerular filtration rate (eGFR) over up to 55 months of follow-up...
2016: PloS One
Andrew J Dodgshun, Catherine Quinlan, Michael J Sullivan
BACKGROUND: Assessing the glomerular filtration rate (GFR) of paediatric patients receiving nephrotoxic chemotherapy is a vital element of clinical practice. Isotopically measured GFR is the gold standard in terms of accuracy but requires injection of tracer followed by several hours of blood tests. Estimation of GFR using creatinine is widely used but inaccurate, and there is increasing concern regarding its usage for paediatric oncology patients. Cystatin C (CysC) based equations are increasingly used in other paediatric specialities to estimate GFR, and their usefulness in paediatric oncology practice is becoming evident...
September 2016: Pediatric Blood & Cancer
Jeffrey M Saland, Lisa M Satlin, Jeanna Zalsos-Johnson, Serge Cremers, Henry N Ginsberg
Dyslipidemia in chronic kidney disease (CKD) is usually characterized by hypertriglyceridemia. Here we studied postprandial lipemia in children and young adults to determine whether an increasing degree of CKD results in a proportional increase in triglyceride and chylomicron concentration. Secondary goals were to determine whether subnephrotic proteinuria, apolipoprotein (apo)C-III and insulin resistance modify the CKD effect. Eighteen fasting participants (mean age of 15 years, mean glomerular filtration rate (GFR) of 50 ml/min/1...
July 2016: Kidney International
Teresa V Lewis, Donald L Harrison, Brooke L Gildon, Sandra M Carter, Martin A Turman
STUDY OBJECTIVE: To determine if significant correlations exist between glomerular filtration rate (GFR) prediction equation values, derived by using the original Schwartz equation and the Chronic Kidney Disease in Children (CKiD) bedside equation with a 24-hour urine creatinine clearance (Clcr ) value normalized to a body surface area of 1.73 m(2) in overweight and obese children. DESIGN: Prospective analysis (20 patients) and retrospective analysis (43 patients)...
June 2016: Pharmacotherapy
Hans Pottel
Glomerular filtration rate (GFR) is the best index for kidney function in health and disease. Knowledge of the GFR is essential for the detection (diagnosis) and monitoring of renal function during disease progression and for ensuring correct medication doses. Inulin clearance (plasma or urine) is currently considered to be the gold standard for measuring GFR, but in clinical practice the measurement of other exogenous filtration markers from the plasma often replaces that of inulin clearance. Different protocols can be used to determine the area under the plasma disappearance curve, and an understanding of these methods is important...
April 26, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Randula Ranawaka, Carla Lloyd, Pat J McKiernan, Sally A Hulton, Khalid Sharif, David V Milford
BACKGROUND: Combined liver-kidney transplantation (CLKT) is the accepted treatment for patients with both liver failure and progressive renal insufficiency. Long-term outcome data for CLKT in children is sparse and controversy exists as to whether simultaneous CLKT with organs from the same donor confers immunologic and survival benefit to the kidney allograft. We report the long-term renal graft outcomes of 40 patients who had simultaneous CLKT. METHODS: A retrospective analysis of kidney graft survival (time from transplantation to death, return to dialysis or last follow-up event) in all pediatric patients (age < 18 years old) who underwent CLKT from March 1994 to January 2015...
September 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Hossein-Emad Momtaz, Arash Dehghan, Mohammad Karimian
INTRODUCTION: The use of a simple and accurate glomerular filtration rate (GFR) estimating method aiming minute assessment of renal function can be of great clinical importance. OBJECTIVES: This study aimed to determine the association of a GFR estimating by equation that includes only cystatin C (Gentian equation) to equation that include only creatinine (Schwartz equation) among children. PATIENTS AND METHODS: A total of 31 children aged from 1 day to 5 years with the final diagnosis of unilateral or bilateral hydronephrosis referred to Besat hospital in Hamadan, between March 2010 and February 2011 were consecutively enrolled...
2016: Journal of Renal Injury Prevention
Katarzyna Zachwieja, Przemysław Korohoda, Joanna Kwinta-Rybicka, Monika Miklaszewska, Anna Moczulska, Jolanta Bugajska, Joanna Berska, Dorota Drożdż, Jacek A Pietrzyk
AIM: Estimation of eGFR in children with normal kidney function using the Schwartz equations results in underestimating real GFR. MATERIALS AND METHODS: We propose modification of three Schwartz equations - two based on creatinine concentration (eGFRScrBS bedside) and (eGFRScr) and one 3-marker based on creatinine, urea and cystatin C concentrations (eGFRS3M). The iohexol test (reference method) was performed 417 times in 353 children >2 years with mean GFR: 98 ± 31...
June 2016: Renal Failure
Luciano Selistre, Muriel Rabilloud, Pierre Cochat, Vandréa de Souza, Jean Iwaz, Sandrine Lemoine, Françoise Beyerle, Carlos E Poli-de-Figueiredo, Laurence Dubourg
BACKGROUND: Estimating kidney glomerular filtration rate (GFR) is of utmost importance in many clinical conditions. However, very few studies have evaluated the performance of GFR estimating equations over all ages and degrees of kidney impairment. We evaluated the reliability of two major equations for GFR estimation, the CKD-EPI and Schwartz equations, with urinary clearance of inulin as gold standard. METHODS AND FINDINGS: The study included 10,610 participants referred to the Renal and Metabolic Function Exploration Unit of Edouard Herriot Hospital (Lyon, France)...
March 2016: PLoS Medicine
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