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pediatric GFR

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https://www.readbyqxmd.com/read/28419086/low-birth-weight-is-associated-with-impaired-murine-kidney-development-and-function
#1
Christina Barnett, Oluwadara Nnoli, Wasan Abdulmahdi, Lauren Nesi, Michael Shen, Joseph A Zullo, David L Payne, Tala Azar, Parth Dwivedi, Kunzah Syed, Jonathan Gromis, Mark Lipphardt, Edson Jules, Eric L Maranda, Amy Patel, May M Rabadi, Brian B Ratliff
BACKGROUND: Low birth weight (LBW) neonates have impaired kidney development that leaves them susceptible to kidney disease and hypertension during adulthood. The study here identifies events that blunt nephrogenesis and kidney development in the murine LBW neonate. METHODS: We examined survival, kidney development, GFR, gene expression, and cyto-/chemokines in the LBW offspring of malnourished (caloric and protein restricted) pregnant mice. RESULTS: Malnourished pregnant mothers gave birth to LBW neonates that had 40% reduced body weight and 54% decreased survival...
April 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28407629/combining-cystatin-c-and-creatinine-yields-a-reliable-glomerular-filtration-rate-estimation-in-older-adults-in-contrast-to-%C3%AE-trace-protein-and-%C3%AE-2-microglobulin
#2
Karin Werner, Mats Pihlsgård, Sölve Elmståhl, Helen Legrand, Ulf Nyman, Anders Christensson
BACKGROUND: The glomerular filtration rate (GFR) is the most important measure of kidney function and chronic kidney disease (CKD). This study aims to validate commonly used equations for estimated GFR (eGFR) based on creatinine (cr), cystatin C (cys), β-trace protein (BTP), and β2-microglobulin (B2M) in older adults. METHOD: We conducted a validation study with 126 participants aged between 72 and 98 with a mean measured GFR (mGFR) by iohexol clearance of 54 mL/min/1...
April 14, 2017: Nephron
https://www.readbyqxmd.com/read/28385450/predictors-of-upper-tract-damage-in-pediatric-neurogenic-bladder
#3
Raghu Prakash, Archana Puri, Rama Anand, Ajay K Jain, Brahmanand Lal, Vaibhav Garg
INTRODUCTION: Upper tract damage (UTD) is a life-threatening complication of neurogenic bladder (NB). Early identification of risk factors for UTD and institution of remedial measures may probably prevent UTD. The aim was to study the predictors of UTD in children 2 years or older with NB. METHOD: This cross-sectional, observational study over 2 years included 30 children. UTD was defined as serum creatinine of >1 mg/dL or society of fetal urology grade III-IV hydronephrosis or hydroureteronephrosis on ultrasonography or renal scars on (99)(m)technetium dimercaptosuccinic scan or subnormal glomerular filtration rate (GFR) for age...
March 22, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28383392/valganciclovir-dosing-for-cytomegalovirus-prophylaxis-in-pediatric-solid-organ-transplant-recipients-a-prospective-pharmacokinetic-study
#4
Orit Peled, Matitiahu Berkovitch, Eran Rom, Efraim Bilavsky, Yael Bernfeld, Lev Dorfman, Adi Pappo, Tomer Ziv-Baran, Nurit Brandriss, Adina Bar-Haim, Jacob Amir, Liat Ashkenazi-Hoffnung
BACKGROUND: Valganciclovir is extensively used for prophylaxis and treatment of CMV infection in solid-organ transplant recipients. However, pharmacokinetic data in children are scarce, and the pediatric dosing regimen is uncertain. This study sought to prospectively evaluate the pharmacokinetic profile, the clinical efficacy and safety of oral valganciclovir in pediatric transplant recipients and compare different dosing regimens. METHODS: The cohort included solid-organ transplant recipients treated with valganciclovir for CMV prophylaxis in 2014-2015 at a tertiary pediatric medical center...
April 5, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28306525/efficient-reporting-of-the-estimated-glomerular-filtration-rate-without-height-in-pediatric-patients-with-cancer
#5
Tae-Dong Jeong, Eun-Jung Cho, Woochang Lee, Sail Chun, Ki-Sook Hong, Won-Ki Min
BACKGROUND: The updated bedside Schwartz equation requires constant, serum creatinine concentration and height measurements to calculate the estimated glomerular filtration rate (eGFR) in pediatric patients. Unlike the serum creatinine levels, obtaining height information from the laboratory information system (LIS) is not always possible in a clinical laboratory. Recently, the height-independent eGFR equation, the full age spectrum (FAS) equation, has been introduced. We evaluated the performance of height-independent eGFR equation in Korean children with cancer...
March 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28289595/case-report-of-a-novel-mutation-of-the-eya1-gene-in-a-patient-with-branchio-oto-renal-syndrome
#6
L Spahiu, B Merovci, V Ismaili Jaha, A Batalli Këpuska, H Jashari
Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder characterized by the coexistence of branchial cysts or fistulae, external ear malformation with pre-auricular pits or tags, hearing impairment and renal malformations. However, the presence of the main features varies in affected families. Here, we present a 16-year-old boy admitted to the Department of Nephrology at the Pediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo because of severe renal insufficiency diagnosed 6 years ago, which progressed to end-stage renal failure...
December 1, 2016: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/27997529/renal-dysfunction-in-early-adulthood-following-birth-asphyxia-in-male-spiny-mice-and-its-amelioration-by-maternal-creatine-supplementation-during-pregnancy
#7
Stacey J Ellery, Domenic A LaRosa, Luise A Cullen-McEwen, Russell D Brown, Rod J Snow, David W Walker, Michelle M Kett, Hayley Dickinson
BACKGROUND: Acute kidney injury affects ~70% of asphyxiated newborns, and increases their risk of developing chronic kidney disease later in life. Acute kidney injury is driven by renal oxygen deprivation during asphyxia, thus we hypothesized that creatine administered antenatally would protect the kidney from the long-term effects of birth asphyxia. METHODS: Pregnant spiny mice were fed standard chow or chow supplemented with 5% creatine from 20-d gestation (midgestation)...
April 2017: Pediatric Research
https://www.readbyqxmd.com/read/27878110/discontinuation-of-antimicrobial-prophylaxis-ap-in-children-with-spina-bifida-a-case-series-analysis
#8
Kevin G Couloures, Michael Anderson, Michael Machiorlatti, Olivera Marsenic, Lawrence Opas
BACKGROUND: Spina bifida increases the risk for urinary tract infections (UTI). Antimicrobial prophylaxis (AP) reduces symptomatic UTI's but selects resistant organisms. Measures to ensure regular and complete emptying of the bladder combined with treatment of constipation reduce the risk for UTI. OBJECTIVES: Demonstrate that close adherence to a catheterization regimen in children with spina bifida (Selective Treatment - ST) reduces the need for antimicrobial prophylaxis...
September 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27827310/cardiovascular-phenotypes-in-children-with-ckd-the-4c-study
#9
Franz Schaefer, Anke Doyon, Karolis Azukaitis, Aysun Bayazit, Nur Canpolat, Ali Duzova, Ana Niemirska, Betul Sözeri, Daniela Thurn, Ali Anarat, Bruno Ranchin, Mieczyslav Litwin, Salim Caliskan, Cengiz Candan, Esra Baskin, Ebru Yilmaz, Sevgi Mir, Marietta Kirchner, Anja Sander, Dieter Haffner, Anette Melk, Elke Wühl, Rukshana Shroff, Uwe Querfeld
BACKGROUND AND OBJECTIVES: Cardiovascular disease is the most important comorbidity affecting long-term survival in children with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Cardiovascular Comorbidity in Children with CKD Study is a multicenter, prospective, observational study in children ages 6-17 years old with initial GFR of 10-60 ml/min per 1.73 m(2). The cardiovascular status is monitored annually, and subclinical cardiovascular disease is assessed by noninvasive measurements of surrogate markers, including the left ventricular mass index, carotid intima-media thickness, and central pulse wave velocity...
January 6, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27826732/renin-angiotensin-ii-aldosterone-system-blockers-and-time-to-renal-replacement-therapy-in-children-with-ckd
#10
Alison G Abraham, Aisha Betoko, Jeffrey J Fadrowski, Christopher Pierce, Susan L Furth, Bradley A Warady, Alvaro Muñoz
BACKGROUND: Clinical care decisions to treat chronic kidney disease (CKD) in a growing child must often be made without the benefit of evidence from clinical trials. We used observational data from the Chronic Kidney Disease in Children cohort to estimate the effectiveness of renin-angiotensin II-aldosterone system blockade (RAAS) to delay renal replacement therapy (RRT) in children with CKD. METHODS: A total of 851 participants (median age: 11 years, median glomerular filtration rate [GFR]: 52 ml/min/1...
April 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27821253/bone-mineral-density-in-children-with-idiopathic-nephrotic-syndrome
#11
Ghada Mohamed El-Mashad, Mahmoud Ahmed El-Hawy, Sally Mohamed El-Hefnawy, Sanaa Mansour Mohamed
OBJECTIVES: To assess bone mineral density (BMD) in children with idiopathic nephrotic syndrome (NS) and normal glomerular filtration rate (GFR). METHODS: Cross-sectional case-control study carried out on 50 children: 25 cases of NS (16 steroid-sensitive [SSNS] and nine steroid-resistant [SRNS] under follow up in the pediatric nephrology unit of Menoufia University Hospital, which is tertiary care center, were compared to 25 healthy controls with matched age and sex...
November 5, 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27812743/glomerular-hyperfiltration-in-children-with-cancer-prevalence-and-a-hypothesis
#12
Neha S Kwatra, Holly J Meany, Sunil J Ghelani, David Zahavi, Nayan Pandya, Massoud Majd
BACKGROUND: Glomerular hyperfiltration has recently been reported in children with malignancies and has been attributed to increased solute from breakdown of tumor tissues. OBJECTIVE: To evaluate the prevalence of hyperfiltration in the pediatric oncology population and explore its pathophysiological mechanism. MATERIALS AND METHODS: Tc-99 m diethylenetriaminepentaacetic acid (DTPA) glomerular filtration rate (GFR) examinations (437 studies) and medical records of 177 patients <21 years of age diagnosed with a malignancy between January 2005 and October 2013 were retrospectively reviewed...
February 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/27704256/achieving-remission-of-proteinuria-in-childhood-ckd
#13
Piero Ruggenenti, Paolo Cravedi, Antonietta Chianca, MariaRosa Caruso, Giuseppe Remuzzi
BACKGROUND: A multidrug treatment strategy that targets urinary proteins with an angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) up-titrated to the respective maximum tolerated dose combined with intensified blood pressure (BP) control has been found to prevent renal function loss in adults with proteinuric nephropathies. Herein, we investigated the effects of this treatment protocol in the pediatric patient population. METHODS: From May 2002 to September 2014 we included in this observational, longitudinal, cohort study 20 consecutive children with chronic nephropathies and 24-h proteinuria of >200 mg who had received ramipril and losartan up-titrated to the respective maximum approved and tolerated doses [mean (standard deviation) dose:2...
February 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27662811/application-of-an-epitope-based-allocation-system-in-pediatric-kidney-transplantation
#14
Joshua Y Kausman, Amanda M Walker, Linda S Cantwell, Catherine Quinlan, Matthew P Sypek, Francesco L Ierino
Donor-recipient HLA mismatch remains a leading cause for sensitization and graft loss in kidney transplantation. HLA compatibility at an epitope level is emerging as an improved method of matching compared with current HLA antigen allocation. A novel epitope-based allocation approach to prospectively exclude donors with high-level mismatches was implemented for pediatric KTRs on the DD waiting list. Nineteen consecutive transplants were followed for 12 months, including eight DD KTRs listed with eplet exclusions, as well as three DD KTRs and eight LD KTRs without exclusions...
November 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27642522/acute-kidney-injury-and-atypical-features-during-pediatric-poststreptococcal-glomerulonephritis
#15
Rose M Ayoob, Andrew L Schwaderer
The most common acute glomerulonephritis in children is poststreptococcal glomerulonephritis (PSGN) usually occurring between 3 and 12 years old. Hypertension and gross hematuria are common presenting symptoms. Most PSGN patients do not experience complications, but rapidly progressive glomerulonephritis and hypertensive encephalopathy have been reported. This paper reports 17 patients seen in 1 year for PSGN including 4 with atypical PSGN, at a pediatric tertiary care center. Seventeen children (11 males), mean age of 8 years, were analyzed...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27620552/anemia-and-markers-of-erythropoiesis-in-pediatric-kidney-transplant-recipients-compared-to-children-with-chronic-renal-failure
#16
Irit Krause, Miriam Davidovits, Hannah Tamary, Maria Yutcis, Amit Dagan
PTA and anemia of CKD share a similar pathogenesis. However, PTA may be disproportionate to the reduction in the GFR. Data relating to the mechanism of PTA are scarce. We evaluated the erythropoiesis parameters in pediatric kidney recipients compared to children with CKD. A total of 100 patients (54 post-kidney TX, 46 with CKD) were enrolled in the single-center cohort study. GFR was found to be significantly lower in the CKD group (49.7±22.4 vs 72.9±28.5 mL/min/1.73 m², P<.001); anemia was significantly more common in the TX patients (52% vs 41...
November 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27576676/anemia-and-low-grade-inflammation-in-pediatric-kidney-transplant-recipients
#17
Jenni Miettinen, Juuso Tainio, Timo Jahnukainen, Mikko Pakarinen, Jouni Lauronen, Hannu Jalanko
BACKGROUND: Anemia and low-grade inflammation are reported to be associated with impaired long-term graft outcome in renal transplant (RTx) recipients. In this study, hemoglobin (Hb) and inflammation marker levels were correlated with measured glomerular filtration rate (GFR) in 128 pediatric RTx recipients over a median follow-up period of 10 years. METHODS: Serum levels of erythropoietin (EPO), hepcidin-25, high-sensitivity C-reactive protein (CRP) (hsCRP) and interleukin-6 (IL-6) were analyzed by enzyme-linked immunosorbent assays, and GFR was analyzed by (51)Cr-EDTA clearance...
February 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27573641/iga-nephropathy-in-children-a-multicenter-study-in-poland
#18
M Mizerska-Wasiak, A Turczyn, A Such, K Cichoń-Kawa, J Małdyk, M Miklaszewska, J Pietrzyk, A Rybi-Szumińska, A Wasilewska, A Firszt-Adamczyk, R Stankiewicz, M Szczepańska, B Bieniaś, M Zajączkowska, A Pukajło-Marczyk, D Zwolińska, K Siniewicz-Luzeńczyk, M Tkaczyk, K Gadomska-Prokop, R Grenda, U Demkow, M Pańczyk-Tomaszewska
IgA nephropathy (IgAN) is the most common form of glomerulonephritis in pediatric population. The clinical presentation of the disease in children ranges from microscopic hematuria to end-stage kidney disease. The aim of the study was to retrospectively assess clinical and kidney biopsy features in children with IgAN. We assessed a cohort of 140 children, 88 boys, 52 girls with the diagnosis of IgAN in the period of 2000-2015, entered into the national Polish pediatric IgAN registry. The assessment included the following: proteinuria, hematuria, glomerular filtration rate (GFR), arterial blood pressure, and the renal pathological changes according to the Oxford classification and crescents formation, as modifiable and unmodifiable risk factors...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27555681/follow-up-imaging-after-pediatric-pyeloplasty
#19
Manoj Kumar, Sanjeet Kumar Singh, Sohrab Arora, Varun Mittal, Nitesh Patidar, Sanjoy Kumar Sureka, M S Ansari
INTRODUCTION: The duration, methods and frequency of radiographic follow-up after pediatric pyeloplasty is not well-defined. We prospectively evaluated a cohort of children undergoing pyeloplasty to determine the method for follow-up. METHODS: Between 2000 and 2008, children undergoing pyeloplasty for unilateral ureteropelvic junction obstruction were evaluated for this study. All patients were evaluated preoperatively with protocol ultrasound (USG) and diuretic renal scan (RS)...
July 2016: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/27392619/hypophosphatemia-in-critically-ill-children-risk-factors-outcome-and-mechanism
#20
Satish Kumar Shah, Mohammad Irshad, Nandita Gupta, Sushil Kumar Kabra, Rakesh Lodha
OBJECTIVES: To determine the prevalence of hypophosphatemia in critically ill children and its association with clinical outcomes; to determine risk factors and mechanism of hypophosphatemia. METHODS: Levels of serum phosphate, phosphate intake, renal phosphate handling indices and blood gases were measured on days 1, 3, 7 and 10 of pediatric intensive care unit (PICU) stay. Hypophosphatemia was defined as any serum phosphorus <3.8 mg/dl for children younger than 2 y and <3...
November 2016: Indian Journal of Pediatrics
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