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https://www.readbyqxmd.com/read/27882909/european-initiative-for-the-application-of-the-international-classification-of-functioning-disability-and-health-development-of-clinical-assessment-schedules-for-specified-rehabilitation-services
#1
Birgit Prodinger, Anke Scheel-Sailer, Reuben Escorpizo, Gerold Stucki
BACKGROUND: Clinical assessment schedule (CLAS) is a core part of the ICF-based implementation of functioning reporting across health conditions and along the continuum of care. AIM: The Physical and Rehabilitation Medicine Section and Board of the European Union of Medical Specialists (UEMS PRM) workshop held in January 2016 aimed to develop and specify a CLAS within the context of rehabilitation services. SETTING: UEMS PRM Workshop in Nottwil, Switzerland, January 2016...
November 24, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27861951/plasma-is-a-strategic-resource
#2
Paul F W Strengers, Harvey G Klein
Plasma-derived medicinal products (PDMPs) such as immunoglobulins and clotting factors are listed by the World Health Organization as essential medicines. These and other PDMPs are crucial for the prophylaxis and treatment of patients with bleeding disorders, immune deficiencies, autoimmune and inflammatory diseases, and a variety of congenital deficiency disorders. While changes in clinical practice in developed countries have reduced the need for red blood cell transfusions thereby significantly reducing the collection volumes of whole blood and recovered plasma suitable for fractionation, the need for PDMPs worldwide continues to increase...
November 12, 2016: Transfusion
https://www.readbyqxmd.com/read/27849442/to-genotype-or-phenotype-for-personalized-medicine-cyp450-drug-metabolizing-enzyme-genotype-phenotype-concordance-and-discordance-in-the-ecuadorian-population
#3
Fernando De Andrés, Santiago Terán, Francisco Hernández, Enrique Terán, Adrián LLerena
Genetic variations within the cytochrome P450 (CYP450) superfamily of drug metabolizing enzymes confer substantial person-to-person and between-population differences in pharmacokinetics, and by extension, highly variable clinical effects of medicines. In this context, "personalized medicine," "precision medicine," and "stratified medicine" are related concepts attributed to what is essentially targeted therapeutics and companion diagnostics, aimed at improving safety and effectiveness of health interventions...
November 16, 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27846216/the-quality-of-selected-essential-medicines-sold-in-accredited-drug-dispensing-outlets-and-pharmacies-in-tanzania
#4
Eliangiringa Kaale, Vicky Manyanga, Mhina Chambuso, Jafary Liana, Edmund Rutta, Martha Embrey, Thomas Layloff, Keith Johnson
INTRODUCTION: The purpose of this study was to investigate the quality of a select group of medicines sold in accredited drug dispensing outlets (ADDOs) and pharmacies in different regions of Tanzania as part of an in-depth cross-sectional assessment of community access to medicines and community use of medicines. METHODS: We collected 242 samples of amoxicillin trihydrate, artemether-lumefantrine (ALu), co-trimoxazole, ergometrine maleate, paracetamol, and quinine from selected ADDOs and pharmacies in Mbeya, Morogoro, Singida, and Tanga regions...
2016: PloS One
https://www.readbyqxmd.com/read/27828770/responding-to-a-zoonotic-emergency-with-multi-omics-research-pentatrichomonas-hominis-hydrogenosomal-protein-characterization-with-use-of-rna-sequencing-and-proteomics
#5
Yi-Kai Fang, Kun-Yi Chien, Kuo-Yang Huang, Wei-Hung Cheng, Fu-Mann Ku, Rose Lin, Ting-Wen Chen, Po-Jung Huang, Cheng-Hsun Chiu, Petrus Tang
Pentatrichomonas hominis is an anaerobic flagellated protist that colonizes the large intestine of a number of mammals, including cats, dogs, nonhuman primates, and humans. The wide host range of this organism is alarming and suggests a rising zoonotic emergency. However, knowledge on in-depth biology of this protist is still limited. Similar to the human pathogen, Trichomonas vaginalis, P. hominis possesses hydrogenosomes instead of mitochondria. Studies in T. vaginalis indicated that hydrogenosome is essential for cell survival and associated with numerous pivotal biological functions, including drug resistance...
November 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27814729/assessment-of-the-scope-and-practice-of-evaluation-among-medical-donation-programs
#6
Alisa M Jenny, Meng Li, Elizabeth Ashbourne, Myron Aldrink, Christine Funk, Andy Stergachis
BACKGROUND: Medical donation programs for drugs, other medical products, training and other supportive services can improve access to essential medicines in low- and middle-income countries (LMICs) and provide emergency and disaster relief. The scope and extent to which medical donation programs evaluate their impact on recipients and health systems is not well documented. METHODS: We conducted a survey of the member organizations of the Partnership for Quality Medical Donations (PQMD), a global alliance of non-profit and corporate organizations, to identify evaluations conducted in conjunction with donation programs...
November 4, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27780218/current-situation-determinants-and-solutions-to-drug-shortages-in-shaanxi-province-china-a-qualitative-study
#7
Caijun Yang, Lina Wu, Wenfang Cai, Wenwen Zhu, Qian Shen, Zongjie Li, Yu Fang
OBJECTIVE: Drug shortages were a complex global problem. The aim of this study was to analyze, characterize, and assess the drug shortages, and identify possible solutions in Shaanxi Province, western China. METHODS: A qualitative methodological approach was conducted during May-June 2015 and December 2015-January 2016. Semi-structured interviews were performed to gather information from representatives of hospital pharmacists, wholesalers, pharmaceutical producers, and local health authorities...
2016: PloS One
https://www.readbyqxmd.com/read/27753828/sy-03-1-genetic-basis-of-blood-pressure-and-hypertension
#8
Anna Dominiczak
Human primary or essential hypertension is a complex, polygenic trait with some 50% contribution from genes and environment. Richard Lifton and colleagues provided elegant dissection of several rare Mendelian forms of hypertension, exemplified by the glucocorticoid remediable aldosteronism and Liddle's syndrome. These discoveries illustrate that a single gene mutation can explain the entire pathogenesis of severe, early onset hypertension as well as dictating the best treatment.The dissection of the much more common polygenic hypertension has proven much more difficult...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27720436/supply-chain-management-of-health-commodities-for-reducing-global-disease-burden-are-pharmacists-in-nigeria-aware-and-ready-to-play-a-key-role
#9
Otuto Amarauche Chukwu, Valentine Nnaemeka Ezeanochikwa, Benedict Ejikeme Eya
PURPOSE: Reducing global disease burden requires improving access to medicines, thus the need for efficient and effective supply chain management for medicines. The Nigerian government came up with new policies on Mega Drug Distribution Centres and National Drug Distribution Guidelines to improve access to quality medicines with pharmacists having a key role to play. However, pharmacists in Nigeria seem not to be aware and adequately equipped to handle the medicines supply chain. This article aimed at assessing the awareness and readiness of Nigerian pharmacists on supply chain management practices for improving access to medicines...
September 12, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27716386/the-production-and-sales-of-anti-tuberculosis-drugs-in-china
#10
Yang-Mu Huang, Qi-Peng Zhao, Qiao-Meng Ren, Dan-Lu Peng, Yan Guo
BACKGROUND: Tuberculosis (TB) is a major infectious disease globally. Adequate and proper use of anti-TB drugs is essential for TB control. This study aims to study China's production capacity and sales situation of anti-TB drugs, and to further discuss the potential for China to contribute to global TB control. METHODS: The production data of anti-TB drugs in China from 2011 to 2013 and the sales data from 2010 to 2014 were extracted from Ministry of Industry and Information Technology database of China and IMS Health database, respectively...
October 4, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27651828/the-peacebuilding-potential-of-healthcare-training-programs
#11
Kyle G Ratner, Lindsay B Katona
Global health professionals regularly conduct healthcare trainings, such as first aid courses, in disadvantaged communities across the world. Many of these communities lack healthcare infrastructure because of war and political conflict. The authors draw on their experience conducting a first aid course in South Sudan to provide a perspective on how healthcare trainings for people with no medical background can be used to bridge ethnic, political, and religious differences. They argue that a necessary step for turning a healthcare training into a vehicle for peacebuilding is to bring people from different communities to the same physical space to learn the course material together...
2016: Conflict and Health
https://www.readbyqxmd.com/read/27642881/sy-03-1-genetic-basis-of-blood-pressure-and-hypertension
#12
Anna Dominiczak
Human primary or essential hypertension is a complex, polygenic trait with some 50% contribution from genes and environment. Richard Lifton and colleagues provided elegant dissection of several rare Mendelian forms of hypertension, exemplified by the glucocorticoid remediable aldosteronism and Liddle's syndrome. These discoveries illustrate that a single gene mutation can explain the entire pathogenesis of severe, early onset hypertension as well as dictating the best treatment.The dissection of the much more common polygenic hypertension has proven much more difficult...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27633405/development-of-ayurveda-tradition-to-trend
#13
Pulok K Mukherjee, Ranjit K Harwansh, Shiv Bahadur, Subhadip Banerjee, Amit Kar, Joydeb Chanda, Sayan Biswas, Sk Milan Ahmmed, C K Katiyar
ETHNOPHARMACOLOGICAL RELEVANCE: Ayurveda entails a scientific tradition of harmonious living and its origin can be traced from ancient knowledge contained in Rigveda and Atharvaveda. Ayurveda is a traditional healthcare system of Indian medicine since time immortal. Several Ayurvedic medicines have been exploiting for treatment and management of various diseases in human beings. The several drugs have been developed and practiced from Ayurveda since ancient time to modern practice as 'tradition to trend'...
September 12, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27633188/use-of-wonca-global-standards-to-evaluate-family-medicine-postgraduate-education-for-curriculum-development-and-review-in-nepal-and-myanmar
#14
Christine Gibson, Farah Ladak, Ashis Shrestha, Bharat Yadav, Kyaw Thu, Tin Aye
Family medicine is an integral part of primary care within health systems. Globally, training programmes exhibit a great degree of variability in content and skill acquisition. While this may in part reflect the needs of a given setting, there exists standard criteria that all family medicine programmes should consider core activities. WONCA has provided an open-access list of standards that their expert community considers essential for family medicine (GP) post-graduate training. Evaluation of developing or existing training programmes using these standards can provide insight into the degree of variability, gaps within programmes and equally as important, gaps within recommendations...
September 2016: Education for Primary Care
https://www.readbyqxmd.com/read/27605953/non-communicable-diseases-among-children-in-ghana-health-and-social-concerns-of-parent-caregivers
#15
Alfred E Yawson, Aaron A Abuosi, Delali M Badasu, Deborah Atobra, Francis A Adzei, John K Anarfi
BACKGROUND: Globally, there is a progressive rise in the burden of non-communicable diseases (NCDs). This paper examined the health and social concerns of parents/caregivers on in-patient care for children with NCDs in Ghana. METHODS: This was a cross-sectional study in three large health facilities in Ghana (the largest in the South, the largest in the North and the largest in the Eastern part of Ghana. Data was collected with a structured questionnaire among 225 caregivers (≥18 years) of 149 children with NCDs in health facilities in the three regions...
June 2016: African Health Sciences
https://www.readbyqxmd.com/read/27559728/target-product-profile-for-a-diagnostic-assay-to-differentiate-between-bacterial-and-non-bacterial-infections-and-reduce-antimicrobial-overuse-in-resource-limited-settings-an-expert-consensus
#16
Sabine Dittrich, Birkneh Tilahun Tadesse, Francis Moussy, Arlene Chua, Anna Zorzet, Thomas Tängdén, David L Dolinger, Anne-Laure Page, John A Crump, Valerie D'Acremont, Quique Bassat, Yoel Lubell, Paul N Newton, Norbert Heinrich, Timothy J Rodwell, Iveth J González
Acute fever is one of the most common presenting symptoms globally. In order to reduce the empiric use of antimicrobial drugs and improve outcomes, it is essential to improve diagnostic capabilities. In the absence of microbiology facilities in low-income settings, an assay to distinguish bacterial from non-bacterial causes would be a critical first step. To ensure that patient and market needs are met, the requirements of such a test should be specified in a target product profile (TPP). To identify minimal/optimal characteristics for a bacterial vs...
2016: PloS One
https://www.readbyqxmd.com/read/27470330/shining-evolutionary-light-on-human-sleep-and-sleep-disorders
#17
REVIEW
Charles L Nunn, David R Samson, Andrew D Krystal
Sleep is essential to cognitive function and health in humans, yet the ultimate reasons for sleep-i.e. 'why' sleep evolved-remain mysterious. We integrate findings from human sleep studies, the ethnographic record, and the ecology and evolution of mammalian sleep to better understand sleep along the human lineage and in the modern world. Compared to other primates, sleep in great apes has undergone substantial evolutionary change, with all great apes building a sleeping platform or 'nest'. Further evolutionary change characterizes human sleep, with humans having the shortest sleep duration, yet the highest proportion of rapid eye movement sleep among primates...
2016: Evolution, Medicine, and Public Health
https://www.readbyqxmd.com/read/27454379/how-can-we-estimate-sepsis-incidence-and-mortality
#18
André Luiz Nunes Gobatto, Bruno Adler Maccagnan Pinheiro Besen, Luciano Cesar Pontes Azevedo
Sepsis is one of the oldest and complex syndromes in medicine that has been in debate for over two millennia. Valid and comparable data on the population burden of sepsis constitute an essential resource for guiding health policy and resource allocation. Despite current epidemiological data suggest that the global burden of sepsis is huge, the knowledge of its incidence, prevalence, mortality and case-fatality rates is subject to several flaws. The objective of this narrative review is to assess how sepsis incidence and mortality can be estimated, providing examples on how it has been done so far in medical literature and discussing its possible biases...
July 21, 2016: Shock
https://www.readbyqxmd.com/read/27405974/has-the-biobank-bubble-burst-withstanding-the-challenges-for-sustainable-biobanking-in-the-digital-era
#19
REVIEW
Don Chalmers, Dianne Nicol, Jane Kaye, Jessica Bell, Alastair V Campbell, Calvin W L Ho, Kazuto Kato, Jusaku Minari, Chih-Hsing Ho, Colin Mitchell, Fruzsina Molnár-Gábor, Margaret Otlowski, Daniel Thiel, Stephanie M Fullerton, Tess Whitton
Biobanks have been heralded as essential tools for translating biomedical research into practice, driving precision medicine to improve pathways for global healthcare treatment and services. Many nations have established specific governance systems to facilitate research and to address the complex ethical, legal and social challenges that they present, but this has not lead to uniformity across the world. Despite significant progress in responding to the ethical, legal and social implications of biobanking, operational, sustainability and funding challenges continue to emerge...
2016: BMC Medical Ethics
https://www.readbyqxmd.com/read/27397745/collaborating-internationally-on-physician-leadership-education-first-steps
#20
Anne Matlow, Ming-Ka Chan, Jordan David Bohnen, Daniel Mark Blumenthal, Melchor Sánchez-Mendiola, Diane de Camps Meschino, Lindy Michelle Samson, Jamiu Busari
Purpose Physicians are often ill-equipped for the leadership activities their work demands. In part, this is due to a gap in traditional medical education. An emergent international network is developing a globally relevant leadership curriculum for postgraduate medical education. The purpose of this article is to share key learnings from this process to date. Design/methodology/approach The Toronto International Summit on Leadership Education for Physicians (TISLEP) was hosted by the Royal College of Physicians and Surgeons of Canada, and the University of Toronto's Faculty of Medicine and Institute of Health Policy, Management and Evaluation...
July 4, 2016: Leadership in Health Services
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