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Maja Bech Juul, Pernille Hammershoej Jensen, Henriette Engberg, Sonja Wehberg, Andriette Dessau-Arp, Donika Haziri, Helene Bjoerg Kristensen, Joachim Baech, Lene Schurmann, Michael Roost Clausen, Rebecca Valentin, Lene Meldgaard Knudsen, Lars Munksgaard, Tarec Christoffer El-Galaly, Henrik Frederiksen, Thomas Stauffer Larsen
BACKGROUND: Optimal treatment strategy for the oldest patients with diffuse large B-cell lymphoma (DLBCL) remains controversial, as this group often is precluded from clinical trials, and population-based studies are limited. METHODS: All Danish DLBCL-patients ≥75 years diagnosed from 2003 to 2012 were identified, using the Danish National Lymphoma Registry (LYFO). Information regarding baseline characteristics, treatment, comorbidities and outcomes was retrieved from LYFO, the Danish National health registries and medical records...
June 20, 2018: European Journal of Cancer
Mohsen Khalili, Mitra Alavi, Elham Esmaeil-Jamaat, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Brain inflammation is associated with cognitive dysfunction, especially in elderly. Trigonelline is a plant alkaloid and a major component of coffee and fenugreek with anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. In this study, the beneficial effect of trigonelline against lipopolysaccharide (LPS)-induced cognitive decline was assessed in the rat. LPS was injected i.p. at a dose of 500 μg/kg to induce neuroinflammation and trigonelline was administered p.o. at doses of 20, 40, or 80 mg/kg/day 1 h after LPS that continued for one week...
June 20, 2018: International Immunopharmacology
Julia Isidro, Javier Llanos, Cristina Sáez, Dirk Brackemeyer, Pablo Cañizares, Thorsten Matthee, Manuel A Rodrigo
In this work, the disinfection of highly faecal-polluted surface water was studied using a new electrochemical cell (CabECO® cell, manufactured by CONDIAS) specifically designed to produce ozone in water with very low conductivity. The disinfection tests were carried out in a discontinuous mode to evaluate the influence of the electrode current charge passed. The effect of the current density was also studied in order to optimize the disinfection conditions and to simultaneously prevent the formation of undesirable by-products (chlorates and perchlorates) during the electrolysis...
June 18, 2018: Chemosphere
Kayoko Kato, Akil A Kalathil, Ayesha M Patel, Xiaoyun Ye, Antonia M Calafat
Per- and polyfluoroalkyl substances (PFAS), man-made chemicals with variable length carbon chains containing the perfluoroalkyl moiety (Cn F2n+1 -), are used in many commercial applications. Since 1999-2000, several long-chain PFAS, including perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), have been detected at trace levels in the blood of most participants of the National Health and Nutrition Examination Survey (NHANES)-representative samples of the U.S. general population-while short-chain PFAS have not...
June 14, 2018: Chemosphere
Dandan Song, Qian Li, Xiong Lu, Yanshan Li, Yan Li, Yuanzhe Wang, Faming Gao
A novel electrochemical biosensor was designed for sensitive detection of organophosphate pesticides based on three-dimensional porous bimetallic alloy architecture with ultrathin nanowires (PdCo NWs, PdCu NWs, PdNi NWs) and monolayer MoS2 nanosheet (m-MoS2 ). The bimetallic alloy NWs/m-MoS2 nanomaterials were used as a sensing platform for electrochemical analysis of omethoate, a representative organophosphate pesticide, via acetylcholinesterase inhibition pathway. We demonstrated that all three bimetallic alloy NWs enhanced electrochemical responses of enzymatic biosensor, benefited from bimetallic synergistic action and porous structure...
June 18, 2018: Journal of Hazardous Materials
Klariz Tucker, Tyra Dark, Jeffrey S Harman
PURPOSE: Given that out-of-pocket (OOP) costs impact adherence to treatment and recent and proposed changes to the health insurance system that impact OOP costs, it is imperative to understand the OOP cost burden faced by individuals with anxiety disorders depending upon type of insurance coverage. The objective of this study was to determine the annual OOP cost burden faced by individuals with anxiety disorders and the variation of these costs by type of insurance coverage. METHODS: Using weighted nationally representative data from the 2011-2014 Medical Expenditure Panel Surveys, total OOP health care costs were assessed for all respondents who indicated that they had an anxiety disorder (N = 9985)...
June 15, 2018: Journal of Anxiety Disorders
Yang Yang, Ting Fong May Chui
Attention is increasingly being paid to low impact development (LID) practices in urban stormwater management. Because LID practices offer a wide variety of hydro-environmental benefits, it is often necessary to account for these benefits collectively in cost-benefit analysis and LID alternative selection. The conventional methods of quantifying these benefits, however, can hardly incorporate the preferences of decision makers, and commonly involve tedious parameter estimations. To address these shortcomings, this study adopts a relative performance evaluation method to assess the various hydro-environmental impacts of LID alternatives in small urban catchments...
June 20, 2018: Journal of Environmental Management
Nikita Nirwan, Fouzia Siraj, Divya Vohora
OBJECTIVE: Currently, lacosamide (LCM) is not approved for use in status epilepticus (SE) but several shreds of evidence are available to support its use. The present study was, therefore, undertaken to evaluate the effect of LCM on pilocarpine (PILO) induced SE and neurodegeneration in C57BL/6 mice and to ascertain the involvement of CRMP-2 in mediating above effect. METHODS: Pilocarpine-induced SE model was developed to explore the effect of LCM 20, 40 and 80 mg/kg in mice...
June 18, 2018: Epilepsy Research
H A P Archbold, A T Rankin, M Webb, R Nicholas, N W A Eames, R K Wilson, L A Henderson, G J Heyes, R Davies, C M Bleakley
OBJECTIVES: To establish patterns of subsequent injury in U18 rugby, to quantify the burden of within season injury recurrence. DESIGN: Secondary analysis of prospective data. SETTING: 28 Schools in Ireland. PARTICIPANTS: 825 male rugby players (aged 15-18 years). MAIN OUTCOME MEASURES: Subsequent injuries were classified as: new, local or recurrent (same site and type as index injury). All recurrent injuries were sub-grouped by body part and diagnosis...
June 18, 2018: Physical Therapy in Sport
Violeta Milutinović, Marjan Niketić, Aleksej Krunić, Dejan Nikolić, Miloš Petković, Ljuboš Ušjak, Silvana Petrović
Four sesquiterpene lactones (SLs), including three undescribed proline-SL conjugates, the guaianolides calophyllamine A and 8-epiixerisamine A, and the eudesmanolide calophyllamine B, were isolated from the methanol extract of Hieracium calophyllum R. Uechtr. (Compositae) flowering heads. Another known guaianolide, crepiside E, was detected in Hieracium L. species for the first time. Their structures were elucidated using extensive 1D and 2D NMR spectroscopy in combination with HRMS. The isolated SLs were used as external standards for qualitative and quantitative LC-MS analysis of the dry methanol extracts of the flowering aerial parts of 28 Hieracium species from the Balkan Peninsula...
June 20, 2018: Phytochemistry
Boman Chen, Min Cheng, Siqi Hong, Shuang Liao, Jiannan Ma, Tingsong Li, Li Jiang
PURPOSE: To assess the clinical outcome and evolution of recurrent afebrile seizures in children initially diagnosed with benign convulsions associated with mild gastroenteritis (CwG). METHODS: We reviewed and analyzed the medical records of 37 patients who were diagnosed as CwG at onset, followed by recurrent afebrile seizures and followed up for at least 24 months. RESULTS: The follow-up period ranged from 2 to 7 years (median, 40.1 months)...
May 30, 2018: Seizure: the Journal of the British Epilepsy Association
Florence Mei Fung Wong
BACKGROUND: Small group work is an effective teaching-learning approach in nursing education to enhance students' learning in theoretical knowledge and skill development. Despite its potential advantageous effects on learning, little is known about its actual effects on students' learning from students' and educators' perspectives. OBJECTIVES: To understand students' learning through small group work from the perspectives of students and educators. DESIGN: A qualitative study with focus group interviews was carried out...
June 18, 2018: Nurse Education Today
Namrata Chaudhari, Palaniyandi Ravanan
BACKGROUND: Bardoxolone methyl (RTA 402, CDDOMe) has been long known for its anti-inflammatory and exceptional cytotoxic activity. The biological responses to CDDOMe are truly dose dependent. And owing to the structural modifications introduced in its parent molecule oleanolic acid, CDDOMe is able to form reversible adducts with cellular proteins containing redox sensitive cysteine residues. This nature of CDDOMe makes it a multifunctional molecule targeting multiple signaling pathways...
February 10, 2018: Pharmacological Reports: PR
Saeed Mehrzadi, Iman Fatemi, Ali Reza Malayeri, Ali Khodadadi, Fatemeh Mohammadi, Esrafil Mansouri, Mohammad Rashno, Mehdi Goudarzi
BACKGROUND: The aim of this study was to investigate the effect of ellagic acid (EA) on arsenic-induced renal and hepatic toxicity in rats. METHODS: A total number of 35 male Wistar rats were randomly divided into five experimental groups. Group 1 received normal saline (po). Group 2 received sodium arsenite (SA, 10 mg/kg, po) for 21 days. Group 3 received EA (30 mg/kg, po) for 14 days. Groups 4 and 5 received SA 7 days prior to EA (10 and 30 mg/kg respectively) treatment and continued up to 21 days simultaneous with SA administration...
February 5, 2018: Pharmacological Reports: PR
Wen-Xin Wei, Zhi-Shi Yang, Li-Hua Lu, Jun Li, Zheng-Qing Lei, Kui Wang, Yong Xia, Zhen-Lin Yan, Feng Shen
BACKGROUND: The current study aimed to examine the long-term survival after partial hepatectomy for patients with BCLC intermediate stage hepatocellular carcinoma (HCC) stratified by the Bolondi's sub-staging model. MATERIALS AND METHODS: This cohort consisted of 360 patients with BCLC intermediate stage HCC who underwent partial hepatectomy between January 2008 and February 2010. Patients were stratified into 3 subgroups (B1-B3) based on the Bolondi's sub-staging model...
June 20, 2018: International Journal of Surgery
Arisa Nakazato, Kinumi Kajita, Masato Ooka, Remi Akagawa, Takuya Abe, Shunichi Takeda, Dana Branzei, Kouji Hirota
Prolonged replication arrest on damaged templates is a cause of fork collapse, potentially resulting in genome instability. Arrested replication is rescued by translesion DNA synthesis (TLS) and homologous recombination (HR)-mediated template switching. SPARTAN, a ubiquitin-PCNA-interacting regulator, regulates TLS via mechanisms incompletely understood. Here we show that SPARTAN promotes diversification of the chicken DT40 immunoglobulin-variable λ gene by facilitating TLS-mediated hypermutation and template switch-mediated gene-conversion, both induced by replication blocks at abasic sites...
June 18, 2018: DNA Repair
Frédérique Eyrolle, Hugo Lepage, Yoann Copard, Loic Ducros, David Claval, Lionel Saey, Catherine Cossonnet, Franck Giner, David Mourier
Tritium (3 H) and Carbon-14 (14 C) are radionuclides of natural (cosmogenic) origin that have also been introduced into the environment by humans since the middle of the last century. They are therefore not compounds that have only recently been released into the environment and they do not pose a recognized health threat due to their low radiotoxicity. However, they hold an important place among current concerns because they are being discharged into the environment by the nuclear industry in large quantities compared to other radionuclides...
June 20, 2018: Science of the Total Environment
Zhaoan Xu, Tao Li, Jun Bi, Ce Wang
Natural lakes play a vital role as receiving system of a cocktail of antibiotics (ABs) which have triggered a major health concern. The comparisons of ABs concentrations have been substantially implemented throughout the worldwide range. However, from lake management, the questions are not yet adequately solved: "when and where does the overall pollution level of ABs present more serious, and what AB species dominate". In this study, we detected 22 ABs in water column and sediment bottom in Taihu Lake Basin in January, April, July and October in 2017...
June 20, 2018: Science of the Total Environment
Yang Yanfang, Zhang Kaikai, Yang Liying, Lv Xing, Wu Ying, Liu Hongwei, Lu Qiang, Chen Duanfen, Qiu Deyou
Myelocytomatosis (MYC) transcription factors (TFs) are key regulators of the jasmonic acid (JA) signaling pathway. In cell cultures, methyl jasmonate (MeJA) can improve the production of taxol, which is a complex terpenoid compound with an intense antitumor activity. However, the functions of MYC genes in Taxus sp. (yew trees) remain poorly known. Based on Taxus sp. transcriptome changes induced by MeJA, a TcMYC gene was isolated in a previous study. Here, we further characterized the TcMYC TF encoded by that gene and four other yew MYC TFs previously obtained...
June 20, 2018: Gene
Li Wu, Wei Qin, Yuanzhi He, Weifeng Zhu, Xiaohong Ren, Peter York, Tiqiao Xiao, Xianzhen Yin, Jiwen Zhang
Smart microstructure design of dosage forms such as microcapsules that protect the microorganism, can improve probiotics survival from gastric pH challenges and prolong their shelf life. In this study, synchrotron radiation X-ray microcomputed tomography (SR-μCT) was applied to quantitatively reveal the material distributions and functional structures of bifidobacterium and lactobacillus microcapsules. The shell layer, middle protective layer, and the microorganisms as particles in the center layer were extracted and visualized...
June 20, 2018: European Journal of Pharmaceutical Sciences
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