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Atopic dermatitis and asthma

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https://www.readbyqxmd.com/read/28818439/variations-in-risk-of-asthma-and-seasonal-allergies-between-early-and-late-onset-pediatric-atopic-dermatitis-a-cohort-study
#1
Joy Wan, Nandita Mitra, Ole J Hoffstad, Joel M Gelfand, Albert C Yan, David J Margolis
BACKGROUND: Atopic dermatitis is associated with other allergic conditions, but variations in this "atopic march" are poorly understood. OBJECTIVE: To determine the impact of the age of atopic dermatitis onset on the risk for asthma and seasonal allergies. METHODS: A cohort study was performed using the Pediatric Eczema Elective Registry, which is an observational cohort of subjects with pediatric onset atopic dermatitis. RESULTS: In total, 3966 children were included, and 73% reported atopic dermatitis onset before age 2 years...
August 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28814359/the-risk-of-autoimmune-connective-tissue-diseases-in-patients-with-atopy-a-nationwide-population-based-cohort-study
#2
Yi-Chun Hou, Hsiao-Yun Hu, I-Lin Liu, Yun-Ting Chang, Chen-Yi Wu
BACKGROUND: The relationship between autoimmune connective tissue disease (ACTD) and atopy is controversial. OBJECTIVES: To investigate the risks of ACTDs in patients with atopic triad diseases, including atopic dermatitis, allergic rhinitis, and asthma, by using a nationwide data base. METHODS: A cohort of 155,311 patients newly diagnosed with atopic dermatitis, allergic rhinitis, or asthma in 2002-2011 was obtained from the Taiwan National Health Insurance Research Database...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28814067/neuro-immune-interactions-in-allergic-diseases-novel-targets-for-therapeutics
#3
Tiphaine Voisin, Amélie Bouvier, Isaac M Chiu
Recent studies have highlighted an emerging role for neuro-immune interactions in mediating allergic diseases. Allergies are caused by an overactive immune response to a foreign antigen. The peripheral sensory and autonomic nervous system densely innervates mucosal barrier tissues including the skin, respiratory tract and gastrointestinal (GI) tract that are exposed to allergens. It is increasingly clear that neurons actively communicate with and regulate the function of mast cells, dendritic cells, eosinophils, Th2 cells and type 2 innate lymphoid cells in allergic inflammation...
June 1, 2017: International Immunology
https://www.readbyqxmd.com/read/28811862/allergic-profiles-of-mothers-and-fathers-in-the-japan-environment-and-children-s-study-jecs-a-nationwide-birth-cohort-study
#4
Kiwako Yamamoto-Hanada, Limin Yang, Kazue Ishitsuka, Tadayuki Ayabe, Hidetoshi Mezawa, Mizuho Konishi, Testsuo Shoda, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya
BACKGROUND: The Japan Environment and Children's Study (JECS) is a nationwide, multicenter, prospective birth cohort investigation launched by the Ministry of Environment in Japan. The purpose of the JECS is to evaluate the influence of prenatal and postnatal exposures to environmental factors on the postnatal health of the children. In this study, we evaluated the allergic characteristics of parents within the JECS cohort. METHODS: This study covered a wide geographical area and encompassed 15 regional centers...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28808975/isolation-of-group-2-innate-lymphoid-cells-from-mouse-lungs
#5
Claudia U Duerr, Jörg H Fritz
The recently described group 2 innate lymphoid cells (ILC2) exert critical roles in type 2 immune responses, epithelial repair at mucosal tissues and metabolic homeostasis. ILC2 release large amounts of type 2 cytokines such as interleukin 4 (IL-4), IL-5, and IL-13, driving type 2 immunity such as the defense against helminths. However, if not tightly regulated ILC2 can trigger unwanted type 2 immunopathologies including allergic airway inflammation, airway hyper-responsiveness, and atopic dermatitis. Viral respiratory tract infections, archetypal triggers of type 1 immune responses, often give rise to pulmonary type 2 immunopathologies such as asthma and asthma exacerbations...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28804130/innate-lymphoid-cells-major-players-in-inflammatory-diseases
#6
REVIEW
Mikaël Ebbo, Adeline Crinier, Frédéric Vély, Eric Vivier
Recent years have seen a marked increase in our understanding of innate lymphoid cells (ILCs). ILCs can be classified into different groups based on their similarity to T cell subsets in terms of their expression of key transcription factors and cytokine production. Various immunological functions of ILCs have been described, and increasing numbers of studies have implicated these cells in inflammatory disorders. Here, we detail the roles of ILCs in inflammatory diseases; we cover type 2 inflammatory diseases (such as asthma, chronic rhinosinusitis and atopic dermatitis), as well as inflammatory bowel diseases, psoriasis and other systemic or organ-specific inflammatory and autoimmune diseases...
August 14, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28801155/vaccinations-in-the-first-year-of-life-and-risk-of-atopic-disease-results-from-the-kiggs-study
#7
Martin Schlaud, Roma Schmitz, Christina Poethko-Müller, Ronny Kuhnert
BACKGROUND: The study focused on the question of whether and - if so - to what direction and extent immunisations in the 1st year may be associated with the risk of being diagnosed with atopic diseases after the 1st year of life. METHODS: Data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS, 2003-2006) were analysed. For analyses of potential associations between vaccination status and risk of hay fever, atopic dermatitis or asthma, sample sizes of 15254, 14297, and 15262, respectively, were available...
August 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28798526/environmental-pollution-and-allergies
#8
REVIEW
Hirohisa Takano, Ken-Ichiro Inoue
Environmental changes are thought to be the main factor in the rapid increase and worsening of allergic diseases. While there have been significant changes in many environmental factors, including in environments such as residential, health and sanitation, food, and water/soil/atmospheric environments, the root of each of these changes is likely an increase in chemical substances. In fact, various environmental pollutants, such as air pollutants and chemical substances, have been shown to worsen various allergies in experimental studies...
July 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28792151/physical-activity-sedentary-habits-sleep-and-obesity-are-associated-with-asthma-allergic-rhinitis-and-atopic-dermatitis-in-korean-adolescents
#9
Man Sup Lim, Chang Hee Lee, Songyong Sim, Sung Kwang Hong, Hyo Geun Choi
PURPOSE: Since pathophysiologic evidence has been raised to suggest that obesity could facilitate an allergic reaction, obesity has been known as an independent risk factor for allergic disease such as asthma. However, the relationship between sedentary behavior and lifestyle which could lead to obesity, and those allergic diseases remains unclear. MATERIALS AND METHODS: We analyzed the relations between physical activity, including sitting time for study, sitting time for leisure and sleep time, and obesity, asthma, allergic rhinitis, and atopic dermatitis using the Korea Youth Risk Behavior Web-based Survey, which was conducted in 2013...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28775219/assessment-of-dietary-food-and-nutrient-intake-and-bone-density-in-children-with-eczema
#10
T F Leung, S S Wang, F Y Kwok, L W Leung, C M Chow, E K Hon
INTRODUCTION: Dietary restrictions are common among patients with eczema, and such practice may lead to diminished bone mineral density. This study investigated dietary intake and bone mineral density in Hong Kong Chinese children with eczema. METHODS: This cross-sectional and observational study was conducted in a university-affiliated teaching hospital in Hong Kong. Chinese children aged below 18 years with physician-diagnosed eczema were recruited from our paediatric allergy and dermatology clinics over a 6-month period in 2012...
August 4, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28750923/didox-3-4-dihydroxybenzohydroxamic-acid-suppresses-il-33-induced-cytokine-production-in-primary-mouse-mast-cells
#11
Heather L Caslin, Jamie Josephine Avila McLeod, Andrew J Spence, Amina Abdul Qayum, Elizabeth Motunrayo Kolawole, Marcela T Taruselli, Anuya Paranjape, Howard L Elford, John J Ryan
While IgE is considered the primary mediator of mast cell activation, IL-33 contributes substantially in asthma, allergic rhinitis, and atopic dermatitis. To develop effective treatments for allergic disease, it is important to understand the role of therapeutic agents on IL-33 activation. We examined the effect of Didox (3,4-dihydroxybenzohydroxamic acid), an antioxidant and ribonucleotide reductase (RNR) inhibitor, on IL-33-mediated mast cell activation. Didox suppressed IL-6, IL-13, TNF, and MIP-1α (CCL3) production in bone marrow derived mast cells following IL-33 activation...
July 11, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28735503/association-between-allergic-disease-sleep-disordered-breathing-and-childhood-nocturnal-enuresis-a-population-based-case-control-study
#12
Jeng-Dau Tsai, Hsuan-Ju Chen, Min-Sho Ku, Shan-Ming Chen, Chih-Chuan Hsu, Min-Che Tung, Che-Chen Lin, Hsing-Yi Chang, Ji-Nan Sheu
BACKGROUND: Little is known about the associations between allergic disease, sleep-disordered breathing (SDB), and childhood nocturnal enuresis (NE). We examined whether allergic disease and SDB were associated with childhood NE. METHODS: Data were assessed from the 2007-2012 Taiwan National Health Insurance Research Database. We enrolled 4308 children aged 5-18 years having NE diagnosis and age- and sex-matched 4308 children as the control group. The odds ratios of NE were calculated to determine an association with preexisting allergic disease and SDB...
July 22, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28709566/selected-comorbidities-of-atopic-dermatitis-atopy-neuropsychiatric-and-musculoskeletal-disorders
#13
Jonathan I Silverberg
Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease with substantial morbidity and quality of life impairment. There are a number of comorbid health problems that occur in patients with AD, aside from the cutaneous signs and symptoms. Chronic pruritus and inflammation can lead to sleep disturbances and mental health symptoms, which are not mutually exclusive. AD is associated with and may predispose to higher risk of other atopic disorders, including asthma and hay fever. Persons with AD appear to be at higher risk for multiple neuropsychiatric disorders, including depression, attention-deficit/hyperactivity disorder, speech disorders in childhood, headaches, and seizures...
July 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28709563/the-history-of-atopic-dermatitis
#14
Owen N Kramer, Mark A Strom, Barry Ladizinski, Peter A Lio
Fred Wise (1881-1950) and Marion Sulzberger (1895-1983) are often credited with introducing the term atopic dermatitis to dermatology in 1933. This definition was based on atopy, a term first created by Arthur Coca (1875-1959) and Robert Cooke (1880-1960) in 1923, when they recognized an association between allergic rhinitis and asthma. Despite its recent introduction into our medical lexicon, historical precursors of atopic dermatitis date back to at least as early as 69-140 ce. In this contribution, we highlight both the prominent individuals credited with shaping the disorder into our current interpretation and the suspected historical precursors of this disease and reported treatments...
July 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28707285/burden-of-atopic-dermatitis-in-the-united-states-analysis-of-healthcare-claims-data-in-the-commercial-medicare-and-medi-cal-databases
#15
Sulena Shrestha, Raymond Miao, Li Wang, Jingdong Chao, Huseyin Yuce, Wenhui Wei
INTRODUCTION: Comparative data on the burden of atopic dermatitis (AD) in adults relative to the general population are limited. We performed a large-scale evaluation of the burden of disease among US adults with AD relative to matched non-AD controls, encompassing comorbidities, healthcare resource utilization (HCRU), and costs, using healthcare claims data. The impact of AD disease severity on these outcomes was also evaluated. METHODS: Adult AD patients in the Commercial (n = 83,106), Medicare (n = 31,060), and Medi-Cal (n = 5550) databases were matched (1:1) to non-AD controls by demographic characteristics...
July 13, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28698747/association-among-thyroid-dysfunction-asthma-allergic-rhinitis-and-eczema-in-children-with-alopecia-areata
#16
Javad Ghaffari, Ghasem Rahmatpour Rokni, Armaghan Kazeminejad, Hosein Abedi
BACKGROUND: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition. AIM: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals. METHODS: This case-control study was conducted on 50 patients with alopecia areata, diagnosed by a dermatologist, and 150 healthy individuals as the control group...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28698345/suboptimal-vitamin-d-status-in-korean-adolescents-a-nationwide-study-on-its-prevalence-risk-factors-including-cotinine-verified-smoking-status-and-association-with-atopic-dermatitis-and-asthma
#17
Eun Jung Byun, Jinyoung Heo, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
OBJECTIVE: To determine the prevalence and risk factors for suboptimal vitamin D status in Korean adolescents and to assess its relationship with atopic dermatitis (AD) and asthma at a national level. DESIGN: This is a cross-sectional study with data from the Korean National Health and Nutrition Examination Survey. Information regarding socioeconomic characteristics, clinical data and environmental factors was collected. Blood and urine samples were taken for vitamin D and cotinine, respectively...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28695832/the-investigation-of-the-presence-of-mites-in-some-served-dry-foodstuffs
#18
Emel Uzunoğlu Karagöz, Cihangir Akdemir, Şahin Direkel, Nejla Cebeci Güler
OBJECTIVE: Mites are microscopic organisms that lower the quality of life of people who are sensitive to them by causing conditions such as atopic dermatitis, allergic rhinitis, and asthma. These organisms are found in every habitat where humans live. This study was conducted to determine the presence of storage mites in dry food items. METHODS: Various food items were procured 10 times each in 300-gram samples. Mites were extracted with a Berlese funnel apparatus over Erlenmeyer flasks containing 70% alcohol placed at the end of the funnel stems for over 48 h...
June 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28681396/association-of-atopy-and-tentative-diagnosis-of-skin-cancer-results-from-occupational-skin-cancer-screenings
#19
I Schäfer, P Mohr, N Zander, R Fölster-Holst, M Augustin
BACKGROUND: The relationship between atopic conditions and carcinoma of the skin has been described inconsistently. Population-based data providing information on atopic diseases as well as on skin-cancer are sparse. OBJECTIVE: To determine the correlation between atopy and prevalence of precanceroses, nonmelanoma skin-cancer and malignant melanoma (MM), while taking into account known risk factors for skin cancer. METHODS: Data from occupational skin cancer screenings were analysed in a cross-sectional study...
July 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28675776/vitamin-d-supplementation-in-primary-allergy-prevention-systematic-review-of-randomized-and-non-randomized-studies
#20
REVIEW
Juan José Yepes-Nuñez, Jan L Brożek, Alessandro Fiocchi, Ruby Pawankar, Carlos Cuello-García, Yuan Zhang, Gian Paolo Morgano, Arnav Agarwal, Shreyas Gandhi, Luigi Terracciano, Holger J Schünemann
BACKGROUND: To date, a systematic review of the evidence regarding the association between Vitamin D and allergic diseases development has not yet been undertaken. OBJECTIVE: To review the efficacy and safety of Vitamin D supplementation when compared to no supplementation in pregnant women, breastfeeding women, infants and children for the prevention of allergies. METHODS: Three databases were searched through 30 January 2016 including randomized (RCT) and non-randomized studies (NRS)...
July 4, 2017: Allergy
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