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Atopic dermatitis and asthma

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https://www.readbyqxmd.com/read/29046027/-frequency-of-skin-reactivity-to-food-allergens-in-allergic-patients
#1
Heriberto Camero-Martínez, Aída Inés López-García, Daniela Rivero-Yeverino, Chrystopherson Gengyny Caballero-López, Oswaldo Arana-Muñoz, Sergio Papaqui-Tapia, Isabel Cristina Rojas-Méndez, Elizabeth Vázquez-Rojas
BACKGROUND: Food allergy is deemed to have a worldwide prevalence ranging from 2 to 10 %. OBJECTIVE: To determine the frequency of skin reactivity to food allergens by age groups. METHODS: Cross-sectional, descriptive, prolective, observational study. Patients aged from 2 to 64 years with symptoms consistent with allergic disease were included. Skin prick tests were carried out with food allergens. Frequencies and percentages were estimated...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29038613/nasal-cytology-as-a-marker-of-atopy-in-children
#2
Anna Mierzejewska, Anna Jung, Bolesław Kalicki
The aim of this study was to evaluate the cytological picture of nasal mucosa in children with atopic diseases and to determine the diagnostic value of the test for the diagnosis of atopic diseases. The study included 140 children from 4 months to 17 years old. Among children with a history of atopy, there were 30 children with atopic dermatitis, 30 children with asthma, and 46 children with allergic rhinitis. The control group consisted of 34 healthy children. The nasal scraping technique has been used to collect samples from the nasal cavity...
2017: Disease Markers
https://www.readbyqxmd.com/read/29034234/interleukin-13-in-asthma-and-other-eosinophilic-disorders
#3
Emma Doran, Fang Cai, Cécile T J Holweg, Kit Wong, Jochen Brumm, Joseph R Arron
Asthma is characterized by episodic, reversible airflow obstruction associated with variable levels of inflammation. Over the past several decades, there has been an increasing appreciation that the clinical presentation of asthma comprises a diverse set of underlying pathologies. Rather than being viewed as a single disease entity, asthma is now thought of as a clinical syndrome with the involvement of multiple pathological mechanisms. While it is appreciated that eosinophilia is present in only a subset of patients, it remains a key feature of asthma and other eosinophilic disorders such as atopic dermatitis, eosinophilic esophagitis, and chronic rhinosinusitis with nasal polyps...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29022537/respiratory-comorbidity-in-south-african-children-with-atopic-dermatitis
#4
C L Gray, M E Levin, G Du Toit
BACKGROUND: Atopic dermatitis (AD) is an early and important step in the propagation of the allergic march, enhancing food and respiratory allergies via epicutaneous sensitisation to allergens. OBJECTIVES: To determine the prevalence and patterns of aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children with AD. METHODS: This was a prospective, observational study in a paediatric university hospital in Cape Town, SA...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28993393/recurrent-wheeze-and-its-relationship-with-lung-function-and-airway-inflammation-in-preschool-children-a-cross-sectional-study-in-south-korea
#5
Ji Eun Soh, Kyung-Moon Kim, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Hyo-Bin Kim, So-Yeon Lee, Gwang-Cheon Jang, Dae-Jin Song, Woo Kyung Kim, Young-Ho Jung, Soo-Jong Hong, Jung Yeon Shim
BACKGROUND: Relationship between recurrent wheeze and airway function and inflammation in preschool children is not fully known. OBJECTIVE: To investigate the relationship between recurrent wheeze and airway inflammation, lung function, airway hyper-reactivity (AHR) and atopy in preschool children. DESIGN: Observational study, comparing forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and mid-forced expiratory flow (FEF25%-75%), dose-response slope (DRS), exhaled nitric oxide (eNO) and atopic sensitisation between children with recurrent wheeze and those without...
October 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28990423/dupilumab-for-the-treatment-of-asthma
#6
Corrado Pelaia, Alessandro Vatrella, Luca Gallelli, Rosa Terracciano, Paolo Navalesi, Rosario Maselli, Girolamo Pelaia
Dupilumab is a fully human IgG4 monoclonal antibody directed against the α subunit of the interleukin (IL)-4 receptor (IL-4Rα). Since the activation of IL-4Rα is utilized by both IL-4 and IL-13 to mediate their pathophysiological effects, dupilumab behaves as a dual antagonist of these two sister cytokines, which blocks IL-4/IL-13-dependent signal transduction. Areas covered: Herein, the authors review the cellular and molecular pathways activated by IL-4 and IL-13, which are relevant to asthma pathobiology...
October 8, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28983485/anti-ige-treatment-for-disorders-other-than-asthma
#7
REVIEW
Jeffrey Stokes
Immunoglobulin E (IgE) plays a key role in the pathogenesis of many allergic diseases. Thus, IgE-mediated immunologic pathways are an attractive target for intervention in allergic diseases. Omalizumab is a recombinant humanized monoclonal antibody that binds IgE and has been used treat allergic asthma for over a decade. Currently, omalizumab is approved for the treatment of both allergic asthma and chronic spontaneous urticaria. Since IgE plays a critical role in other allergic diseases, anti-IgE therapy has been evaluated in other allergic diseases in small clinical trials and case reports...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28964637/neuroendocrine-cells-derived-chemokine-vasoactive-intestinal-polypeptide-vip-in-allergic-diseases
#8
REVIEW
Alok K Verma, Murli Manohar, Sathisha Upparahalli Venkateshaiah, Anil Mishra
Worldwide increase incidences of allergic diseases have heightened the interest of clinicians and researchers to understand the role of neuroendocrine cells in the recruitment and activation of inflammatory cells. Several pieces of evidence revealed the association of neuropeptides in the pathogenesis of allergic diseases. Importantly, one such peptide that is secreted by neuronal cells and immune cells exerts a wide spectrum of immunological functions as cytokine/chemokine is termed as Vasoactive Intestinal Peptide (VIP)...
September 23, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28964307/the-association-between-the-parenting-stress-of-the-mother-and-the-incidence-of-allergic-rhinitis-in-their-children
#9
Min Bum Kim, Jeong Hong Kim, Keun-Hwa Lee, Seong-Chul Hong, Hye-Sook Lee, Ju Wan Kang
OBJECTIVES: The prevalence of allergic rhinitis and the social burden related to the management of allergic rhinitis have persistently increased. There are many studies investigating the association between the allergic diseases of children and the stress of their parent. However, the relationship between parenting stress and the incidence of allergic rhinitis among children requires further investigation. We aimed to investigate the significance of parenting stress for mothers with children treated for allergic rhinitis...
October 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28950944/emerging-roles-for-mas-related-g-protein-coupled-receptor-x2-in-host-defense-peptide-opioid-and-neuropeptide-mediated-inflammatory-reactions
#10
Hydar Ali
Mast cells (MCs) are tissue-resident immune cells that contribute to host defense but are best known for their roles in allergic and inflammatory diseases. In humans, MCs are divided into two subtypes based on the protease content of their secretory granules. Thus, human lung MCs contain only tryptase and are known as MCT, whereas skin MCs contain both tryptase and chymase and are known as MCTC. Patients with severe asthma display elevated MCs in the lung, which undergo phenotypic change from MCT to MCTC. Although the human genome contains four Mas related G protein coupled receptor X (MRGPRX) genes, an important feature of MCTC is that they selectively express MRGPRX2...
2017: Advances in Immunology
https://www.readbyqxmd.com/read/28947906/oral-food-challenge-outcomes-in-a-pediatric-tertiary-care-center
#11
Elissa M Abrams, Allan B Becker
BACKGROUND: Oral food challenges are the clinical standard for diagnosis of food allergy. Little data exist on predictors of oral challenge failure and reaction severity. METHODS: A retrospective chart review was done on all pediatric patients who had oral food challenges in a tertiary care pediatric allergy clinic from 2008 to 2010. RESULTS: 313 oral challenges were performed, of which the majority were to peanut (105), egg (71), milk (41) and tree nuts (29)...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28939136/exercise-induced-bronchoconstriction-in-children-with-asthma-an-observational-cohort-study
#12
Li-Lun Lin, Shu-Jung Huang, Liang-Shiou Ou, Tsung-Chieh Yao, Kuo-Chieh Tsao, Kuo-Wei Yeh, Jing-Long Huang
BACKGROUND/PURPOSE: The diagnosis of exercise-induced bronchoconstriction (EIB) was established by changes in lung function after exercise challenge. The prevalence of EIB and factors related to EIB were not fully described in children with asthma. The aim of this study was to investigate the prevalence and predictors of EIB in children with asthma. METHODS: A total of 149 children with physician-diagnosed asthma above 5 years of age underwent standardized treadmill exercise challenge for EIB and methacholine challenge for airway hyper-responsiveness from October 2015 to December 2016...
September 6, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28921377/basophils-activated-via-tlr-signaling-may-contribute-to-pathophysiology-of-type-1-autoimmune-pancreatitis
#13
Masato Yanagawa, Kazushige Uchida, Yugo Ando, Takashi Tomiyama, Takashi Yamaguchi, Tsukasa Ikeura, Toshiro Fukui, Akiyoshi Nishio, Yoshiko Uemura, Takayuki Miyara, Hiroyuki Okamoto, Souhei Satoi, Kazuichi Okazaki
BACKGROUND: Pathophysiology of type 1 autoimmune pancreatitis (AIP) is still unclear. We previously reported that M2 macrophages might play an important role in type 1 AIP. Recently, it has been reported that basophils regulate differentiation to M2 macrophages. In this study, we investigated basophils from the pancreatic tissue and peripheral blood of individuals with type 1 AIP. METHODS: By using immunohistochemistry, we investigated basophils in pancreatic tissue from 13 patients with type 1 AIP and examined expression of toll-like receptors (TLRs) by these cells...
September 18, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28915908/advances-in-paediatrics-in-2016-current-practices-and-challenges-in-allergy-autoimmune-diseases-cardiology-endocrinology-gastroenterology-infectious-diseases-neonatology-nephrology-neurology-nutrition-pulmonology
#14
REVIEW
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Sergio Bernasconi
This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28915242/a-retrospective-cost-analysis-of-additional-homeopathic-treatment-in-germany-long-term-economic-outcomes
#15
Julia K Ostermann, Claudia M Witt, Thomas Reinhold
OBJECTIVES: This study aimed to provide a long-term cost comparison of patients using additional homeopathic treatment (homeopathy group) with patients using usual care (control group) over an observation period of 33 months. METHODS: Health claims data from a large statutory health insurance company were analysed from both the societal perspective (primary outcome) and from the statutory health insurance perspective (secondary outcome). To compare costs between patient groups, homeopathy and control patients were matched in a 1:1 ratio using propensity scores...
2017: PloS One
https://www.readbyqxmd.com/read/28912020/intestinal-dysbiosis-featuring-abundance-of-ruminococcus-gnavus-associates-with-allergic-diseases-in-infants
#16
Huey-Huey Chua, Hung-Chieh Chou, Ya-Ling Tung, Bor-Luen Chiang, Chien-Chia Liao, Hong-Hsing Liu, Yen-Hsuan Ni
BACKGROUND & AIMS: Dysbiosis of the intestinal microbiota has been associated with development of allergies in infants. However, it is not clear what microbes might contribute to this process. We investigated what microbe(s) might be involved in analyses of infant twins and mice. METHODS: We studied fecal specimens prospectively in a twin cohort (n=30) and age-matched singletons (n=14) born at National Taiwan University Children's Hospital, Taipei, Taiwan, from April 2011 to March 2013...
September 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28904968/the-prevalence-of-ocular-allergy-and-comorbidities-in-chinese-school-children-in-shanghai
#17
Yanqing Feng, Xiangning Wang, Fang Wang, Rongming Liu, Lu Chen, Shuqin Wu, Xia Yang, Miaoying Chen, Yu-Qing Rao, Jing Li
OBJECTIVE: To investigate the prevalence and features of ocular allergy (OA) and comorbidities among school children in Shanghai, China. METHODS: This was a population-based cross-sectional study. Each participant completed an ISAAC-based questionnaire. The prevalence of OA symptoms, allergic rhinitis (AR) asthma, atopic dermatitis (AD), and sensitization to mites, pollen, and food was analyzed. RESULTS: A total of 724 and 942 completed questionnaires from the 7-9-year-old (young group) and the 12-14-year-old (teen group) groups were analyzed, respectively...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28895954/diagnosis-comorbidity-and-psychosocial-impact-of-atopic-dermatitis
#18
Dawn Marie Davis, Andrea Waldman, Sharon Jacob, Jennifer LeBovidge, Jusleen Ahluwalia, Megha Tollefson, Nathan Jetter, Jonathan Spergel
Atopic dermatitis (AD) is a chronic inflammatory skin disease, with a remitting relapsing course. The central diagnostic features of AD include pruritus, xerosis, eczematous lesions with a characteristic morphology and distribution, and a personal or family history of atopic disease. Several clinical studies have emphasized the link between AD and other atopic disorders including asthma, allergic rhinitis, and food allergies. More recent studies indicate possible links between AD and other nonatopic disorders, including ADHD, sleep disturbance, and mental health disorders, suggesting an even more profound impact of this disease...
September 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28895020/role-of-type-2-innate-lymphoid-cells-in-allergic-diseases
#19
REVIEW
Lorenzo Cosmi, Francesco Liotta, Laura Maggi, Francesco Annunziato
PURPOSE OF REVIEW: The adaptive immune response orchestrated by type 2 T helper (Th2) lymphocytes, strictly cooperates with the innate response of group 2 innate lymphoid cells (ILC2), in the protection from helminths infection, as well as in the pathogenesis of allergic disease. The aim of this review is to explore the pathogenic role of ILC2 in different type 2-mediated disorders. RECENT FINDINGS: Recent studies have shown that epithelial cell-derived cytokines and their responding cells, ILC2, play a pathogenic role in bronchial asthma, chronic rhinosinusitis, and atopic dermatitis...
September 11, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28890990/child-with-allergies-or-allergic-reactions
#20
REVIEW
Reshma A, Arun K Baranwal
Incidence of allergic disorders in children has increased significantly over time due to environmental and life-style changes. These include allergic rhinitis, atopic dermatitis, allergic conjunctivitis, food allergies, bronchial asthma, drug allergies, insect bites and anaphylaxis; most being IgE-mediated type 1 hypersensitivity reactions to common environmental and food antigens. Although most of them are self-limiting, they may adversely affect the quality of life and sometimes become life-threatening as well...
September 11, 2017: Indian Journal of Pediatrics
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