Francesca Bibbò, Fatemeh Asadzadeh, Angelo Boccia, Carmen Sorice, Orazio Bianco, Carmen Daniela Saccà, Barbara Majello, Vittoria Donofrio, Delfina Bifano, Lucia De Martino, Lucia Quaglietta, Adriana Cristofano, Eugenio Maria Covelli, Giuseppe Cinalli, Veronica Ferrucci, Pasqualino De Antonellis, Massimo Zollo
Medulloblastoma (MB) is a highly malignant childhood brain tumor. Group 3 MB (Gr3 MB) is considered to have the most metastatic potential, and tailored therapies for Gr3 MB are currently lacking. Gr3 MB is driven by PRUNE-1 amplification or overexpression. In this paper, we found that PRUNE-1 was transcriptionally regulated by lysine demethylase LSD1/KDM1A. This study aimed to investigate the therapeutic potential of inhibiting both PRUNE-1 and LSD1/KDM1A with the selective inhibitors AA7.1 and SP-2577, respectively...
March 31, 2024: International Journal of Molecular Sciences