keyword
https://read.qxmd.com/read/38432717/creatine-and-pregnancy-outcomes-a-prospective-cohort-study-of-creatine-metabolism-in-low-risk-pregnant-females
#21
JOURNAL ARTICLE
Deborah L de Guingand, Kirsten R Palmer, Damien L Callahan, Rod J Snow, Miranda L Davies-Tuck, Stacey J Ellery
BACKGROUND: Physiological adaptations during pregnancy alter nutrient and energy metabolism. Creatine may be important for maintaining cellular energy homeostasis throughout pregnancy. However, the impact of pregnancy on endogenous and exogenous creatine availability has never been comprehensively explored. OBJECTIVES: To undertake a prospective cohort study and determine the physiological ranges of creatine and associated metabolites throughout human pregnancy...
March 2024: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38426290/figo-preconception-checklist-preconception-care-for-mother-and-baby
#22
JOURNAL ARTICLE
Chiara Benedetto, Fulvio Borella, Hema Divakar, Sarah L O'Riordan, Martina Mazzoli, Mark Hanson, Sharleen O'Reilly, Bo Jacobsson, Jeanne A Conry, Fionnuala M McAuliffe
The preconception period is a unique and opportunistic time in a woman's life when she is motivated to adopt healthy behaviors that will benefit her and her child, making this time period a critical "window of opportunity" to improve short- and long-term health. Improving preconception health can ultimately improve both fetal and maternal outcomes. Promoting health before conception has several beneficial effects, including an increase in seeking antenatal care and a reduction in neonatal mortality. Preconception health is a broad concept that encompasses the management of chronic diseases, including optimal nutrition, adequate consumption of folic acid, control of body weight, adoption of healthy lifestyles, and receipt of appropriate vaccinations...
March 1, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38421237/the-outcome-of-reduced-and-non-reduced-triplet-pregnancies-managed-in-a-tertiary-hospital-during-a-15-year-period%C3%A2-a-retrospective-cohort-study
#23
JOURNAL ARTICLE
Riina Maria Jernman, Annu-Riikka Susanna Rissanen, Vedran Stefanovic
OBJECTIVES: Triplet pregnancies involve several complications, the most important being prematurity as virtually all triplets are born preterm. We conducted this study to compare the outcomes of reduced vs. non-reduced triplet pregnancies managed in the largest tertiary hospital in Finland. METHODS: This was a retrospective cohort study in the Helsinki University Hospital during 2006-2020. Data on the pregnancies, parturients and newborns were collected from patient records...
March 1, 2024: Journal of Perinatal Medicine
https://read.qxmd.com/read/38420785/placental-pathology-contributes-to-impaired-volumetric-brain-development-in-neonates-with-congenital-heart-disease
#24
JOURNAL ARTICLE
Maaike Nijman, Lotte E van der Meeren, Peter G J Nikkels, Raymond Stegeman, Johannes M P J Breur, Nicolaas J G Jansen, Henriette Ter Heide, Trinette J Steenhuis, Roel de Heus, Mireille N Bekker, Nathalie H P Claessens, Manon J N L Benders
BACKGROUND: Neonates with congenital heart disease are at risk for impaired brain development in utero, predisposing children to postnatal brain injury and adverse long-term neurodevelopmental outcomes. Given the vital role of the placenta in fetal growth, we assessed the incidence of placental pathology in fetal congenital heart disease and explored its association with total and regional brain volumes, gyrification, and brain injury after birth. METHODS AND RESULTS: Placentas from 96 term singleton pregnancies with severe fetal congenital heart disease were prospectively analyzed for macroscopic and microscopic pathology...
February 29, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38414887/are-junior-residents-accurate-at-predicting-fetal-weight-an-analysis-of-junior-residents-performance-of-estimated-fetal-weight-using-ultrasound-and-leopold-s-maneuver
#25
JOURNAL ARTICLE
Kimberly Huynh, Alicia Lunardhi, Karren Lewis, Trevor Pickering, Hindi E Stohl
BACKGROUND: Performing accurate estimated fetal weights (EFWs) is a critical skill developed in obstetrics residency training. Resident physicians are often the first to perform EFWs on obstetric patients when they enter care. Evaluating residents' accuracy in performing EFWs is crucial for assessing their achievement in residency training milestones and providing patient care. METHODS: As part of an educational initiative program between 2014 and 2020, postgraduate year 1 (PGY1) and postgraduate year 2 (PGY2) residents performed EFW measurements on 10 term (>37w0d) patients using ultrasound and Leopold's maneuver and 10 preterm (>24w0d and <37w0d) patients using ultrasound...
2024: Women's health reports
https://read.qxmd.com/read/38408725/maternal-plasma-phospholipid-polyunsaturated-fatty-acids-in-early-pregnancy-and-thyroid-function-throughout-pregnancy-a-longitudinal-study
#26
JOURNAL ARTICLE
Ling-Jun Li, Ruijin Lu, Shristi Rawal, Anna Birukov, Natalie L Weir, Michael Y Tsai, Jing Wu, Zhen Chen, Cuilin Zhang
BACKGROUND: Evidence has indicated that polyunsaturated fatty acids (PUFAs)-enriched diet could reduce inflammation due to thyroid autoimmunity in vivo, and therefore, enhance thyroid function. OBJECTIVE: We investigated whether early pregnancy plasma phospholipid PUFAs could benefit maternal thyroid function across pregnancy, which is critical to fetal brain development and growth in pregnancy. METHODS: Within the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singleton Cohort, we collected plasma samples longitudinally from 214 subjects (107 with gestational diabetes mellitus [GDM] matched with 107 controls) with a singleton pregnancy...
February 24, 2024: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38405696/mitigation-of-fetal-irradiation-injury-from-mid-gestation-total-body-radiation-with-mitochondrial-targeted-gs-nitroxide-jp4-039
#27
Yijen L Wu, Anthony G Christodoulou, Jan H Beumer, Lora H Rigatti, Renee Fisher, Mark Ross, Simon Watkins, Devin R E Cortes, Cody Ruck, Shanim Manzoor, Samuel K Wyman, Margaret C Stapleton, Eric Goetzman, Sivakama Bharathi, Peter Wipf, Tuantuan Tan, Julie L Eiseman, Susan M Christner, Jianxia Guo, Cecilia W Y Lo, Michael W Epperly, Joel S Greenberger
UNLABELLED: Victims of a radiation terrorist event will include pregnant women and unborn fetuses. Mitochondrial dysfunction and oxidative stress are key pathogenic factors of fetal irradiation injury. The goal of this preclinical study is to investigate the efficacy of mitigating fetal irradiation injury by maternal administration of the mitochondrial-targeted gramicidin S (GS)- nitroxide radiation mitigator, JP4-039. Pregnant female C57BL/6NTac mice received 3 Gy total body ionizing irradiation (TBI) at mid-gestation embryonic day 13...
February 14, 2024: bioRxiv
https://read.qxmd.com/read/38404010/plasma-derived-from-human-umbilical-cord-blood-restores-ovarian-function-and-improves-serum-reproductive-hormones-levels-in-mice-with-premature-ovarian-insufficiency-poi-through-cytokines-and-growth-factors
#28
JOURNAL ARTICLE
Tie Cheng Sun, Yi Ming Guo, Dong Mei Li, Yu Jie Wen, Zhu Xue Jiao, Ju Li, Hui Ping Wang, Yan Jun Jia, Shan Jie Zhou
Premature ovarian insufficiency (POI) patients experience a decline in ovarian function and a reduction in serum reproductive hormones, leading to a significant impact on the outcomes of assisted reproductive technology. Despite the absence of an effective clinical treatment to restore fertility in POI patients, recent research has indicated that cord blood plasma (CBP) derived from human umbilical cord blood (hUCB) may offer therapeutic benefits for various degenerative diseases. The primary aim of this study is to explore approaches for enhancing ovarian function and serum reproductive hormones through the administration of CBP in a murine model...
February 2024: Molecular Reproduction and Development
https://read.qxmd.com/read/38400089/change-in-prevalence-of-hepatitis-b-virus-infection-in-pregnant-women-in-the-last-two-decades-in-thailand
#29
JOURNAL ARTICLE
Yosagorn Porngasemsart, Sirinart Sirilert, Theera Tongsong
Objectives: In Thailand, there has been a strategy to prevent the mother-to-child transmission of HBV for over 30 years. However, there is still a lack of empirical evidence regarding the effectiveness of this strategy. This study aims to investigate the trends in the prevalence of HBV infection in pregnant women and to identify factors that may be associated with the prevalence of HBV infection in pregnant women. Patients and Methods: A maternal-fetal medicine database was accessed to retrieve the consecutive obstetric records of women giving birth at Chiang Mai University Hospital, Thailand, from January 2003 to December 2022...
February 19, 2024: Viruses
https://read.qxmd.com/read/38398090/modulation-of-estrogen-receptor-alpha-er%C3%AE-and-tumor-suppressor-gene-brca1-in-breast-cancer-cells-by-bazedoxifene-acetate-bza
#30
JOURNAL ARTICLE
Monica Szmyd, Aisha Zanib, Victoria Behlow, Erin Hallman, Samantha Pfiffner, Raquel Yaldo, Nina Prudhomme, Katelyn Farrar, Sumi Dinda
Selective estrogen receptor modulators (SERMs) are steroid analogs with dual functionality, acting as partial estrogen receptor agonists to preserve postmenopausal bone density and as estrogen receptor antagonists in breast tissue. Bazedoxifene acetate (BZA) is an FDA-approved, third-generation SERM used in the treatment of osteoporosis in women. It demonstrates potential as a therapeutic option for breast cancer patients undergoing endocrine therapy. Our study aimed to assess BZA's effects on Estrogen Receptor Alpha (ERα) and tumor suppressor gene BRCA1 in T-47D and MCF-7 breast cancer cells, using Western blots, cellular viability, apoptosis assays, and RT-qPCR...
February 7, 2024: Cancers
https://read.qxmd.com/read/38396719/overexpression-of-human-sflt1-in-the-spongiotrophoblast-is-sufficient-to-induce-placental-dysfunction-and-fetal-growth-restriction-in-transgenic-mice
#31
JOURNAL ARTICLE
Rebekka Vogtmann, Alina Riedel, Ivanka Sassmannshausen, Sarah Langer, Elisabeth Kühnel-Terjung, Rainer Kimmig, Hubert Schorle, Elke Winterhager, Alexandra Gellhaus
Preeclampsia (PE) is characterized by maternal hypertension and placental dysfunction, often leading to fetal growth restriction (FGR). It is associated with an overexpression of the anti-angiogenic sFLT1 protein, which originates from the placenta and serves as a clinical biomarker to predict PE. To analyze the impact of sFLT1 on placental function and fetal growth, we generated transgenic mice with placenta-specific human sFLT1 (hsFLT1) overexpression. Immunohistochemical, morphometrical, and molecular analyses of the placentas on 14...
February 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38394779/an-infant-type-hemispheric-glioma-with-sox5-alk-a-novel-fusion
#32
JOURNAL ARTICLE
Chia Chin Tsai, Man-Hsu Huang, Chia-Lang Fang, Kevin Li-Chun Hsieh, Tsung-Han Hsieh, Wan-Ling Ho, Hsi Chang, Min-Lan Tsai, Yu-Chien Kao, James S Miser, Tai-Tong Wong, Min-Yu Su, Yen-Lin Liu
Infant-type hemispheric glioma (IHG) is a rare pediatric brain tumor with variable response to chemotherapy and radiotherapy. Molecular insights into IHG can be useful in identifying potentially active targeted therapy. A male fetus was found to have congenital hydrocephalus at the gestational age of 37 weeks. Fetal MRI showed a 2.6 × 2.0-cm tumor located at the frontal horn of the left lateral ventricle, involving the left basal nuclei and thalamus. Tumor biopsy at the age of 2 days revealed an IHG consisting of spindle tumor cells with strong expression of GFAP and ALK...
February 2024: Journal of the National Comprehensive Cancer Network: JNCCN
https://read.qxmd.com/read/38394717/umbilical-artery-thrombosis-a-case-report-of-prenatal-diagnosis-and-systematic-review-of-the-literature
#33
REVIEW
Eleonora Romani, Laura Marinelli, Ilaria Ponziani, Giulia Masini, Francesca Castiglione, Eleonora Nardi, Lucia Pasquini
Umbilical Artery Thrombosis (UAT) is an extremely rare complication of pregnancy strongly associated with severe fetal distress and death. The pathogenesis is still unclear but it is often associated with anatomical cord abnormalities that leads to blood stasis and thrombosis formation. Other possible risk factors are maternal thrombophilia, autoimmune disease, gestational diabetes, hypertension disorders of pregnancy and Rh-alloimmunization. The most common clinical symptom is the reduction of fetal movements...
February 10, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38389231/-feasibility-study-of-expectant-management-of-different-degrees-of-vaginal-fluid-in-pregnant-women-with-premature-rupture-of-membranes-in-the-second-trimester
#34
JOURNAL ARTICLE
Y M Gao, S H Wu, H X Shang, Y L Yang, B H Zhou, X Yang
Objective: To investigate the feasibility of expectant management of different degrees of vaginal fluid in pregnant women with premature rupture of membranes in the second trimester. Methods: A retrospective cohort study was conducted to collect 103 pregnant women who were diagnosed with premature rupture of membranes in the second trimester of pregnancy and insisted on continuing the pregnancy in Shanxi Bethune Hospital from July 2012 to July 2022. According to the degree of vaginal fluid, pregnant women were divided into rupture group (with typical vaginal fluid, 48 cases) and leakage group (without typical vaginal fluid, 55 cases)...
February 25, 2024: Zhonghua Fu Chan Ke za Zhi
https://read.qxmd.com/read/38387452/indication-specific-effect-of-a-phytotherapeutic-remedy-on-human-fetal-osteoblastic-cells-an-in-vitro-analysis
#35
JOURNAL ARTICLE
Victoria Franziska Struckmann, Stephanie Allouch-Fey, Ulrich Kneser, Leila Harhaus, Matthias Schulte
Background Impaired fracture healing is a recurring interdisciplinary medical challenge. Alternative treatment concepts, apart from conventional medicine are popular, but scientific evidence on their effects is still lacking. Plant-derived substances are widely assumed to support bone homeostasis. To clarify the effects on bone healing mechanisms, a commercially available, homeopathic-spagyric remedy, containing inter alia two herbal substances with assumed osteogenic potential, equisetum arvense and bellis perennis, was analyzed...
February 22, 2024: Complementary Medicine Research
https://read.qxmd.com/read/38383397/evaluation-of-cesarean-delivery-rates-and-factors-associated-with-cesarean-delivery-among-women-enrolled-in-a-pregnancy-cohort-study-at-two-tertiary-hospitals-in-thailand
#36
JOURNAL ARTICLE
Orada Patamasingh Na Ayudhaya, Wanitchaya Kittikraisak, Podjanee Phadungkiatwatana, Danielle Rentz Hunt, Krissada Tomyabatra, Tawee Chotpitayasunondh, Romeo R Galang, Karen Chang, Tana Brummer, Lunthaporn Puttanavijarn, Parker Malek, Fatimah S Dawood, Joshua A Mott
BACKGROUND: Cesarean delivery rates have increased globally resulting in a public health concern. We estimate rates of cesarean deliveries among Thai women using the World Health Organization (WHO) Robson Classification system and compare rates by Robson group to the Robson guideline for acceptable rates to identify groups that might benefit most from interventions for rate reduction. METHODS: In 2017 and 2018, we established cohorts of pregnant women aged ≥ 18 years seeking prenatal care at two tertiary Thai hospitals and followed them until 6-8 weeks postpartum...
February 21, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38374304/exploring-rabbit-as-a-nonrodent-species-for-general-toxicology-studies
#37
JOURNAL ARTICLE
Katie Sokolowski, Patricia V Turner, Elise Lewis, Ronald L Wange, Marie C Fortin
To avoid adverse events in humans, toxicity studies in nonclinical species have been the foundation of safety evaluation in the pharmaceutical industry. However, it is recognized that working with animals in research is a privilege, and conscientious use should always respect the 3Rs: replacement, reduction, and refinement. In the wake of the shortages in routine nonrodent species and considering that non-animal methods are not yet sufficiently mature, the value of the rabbit as a non-rodent species is worth exploring...
February 19, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38370646/the-glucocorticoid-receptor-elicited-proliferative-response-in-human-erythropoiesis-is-bcl11a-dependent
#38
Maria Mazzarini, Jennifer Cherone, Truong Nguyen, Fabrizio Martelli, Lilian Varricchio, Alister P W Funnell, Thalia Papayannopoulou, Anna Rita Migliaccio
Prior evidence indicates that the erythroid cellular response to glucocorticoids (GC) has developmental specificity, namely, that developmentally more advanced cells that are undergoing or have undergone fetal to adult globin switching are more responsive to GC-induced expansion. To investigate the molecular underpinnings of this, we focused on the major developmental globin regulator BCL11A. We compared: a) levels of expression and nuclear content of BCL11A in adult erythroid cells upon GC stimulation; b) response to GC of CD34+ cells from patients with BCL11A microdeletions and reduced BCL11A expression, and; c) response to GC of two cellular models (HUDEP-2 and adult CD34+ cells) before and after reduction of BCL11A expression by shRNA...
February 8, 2024: bioRxiv
https://read.qxmd.com/read/38368443/protective-efficacy-of-a-zika-purified-inactivated-virus-vaccine-candidate-during-pregnancy-in-marmosets
#39
JOURNAL ARTICLE
In-Jeong Kim, Olga Gonzalez, Michael P Tighe, Paula A Lanthier, Madeline J Clark, Kelsey L Travis, Timothy C Low-Beer, Kathleen G Lanzer, Derek T Bernacki, Frank M Szaba, Rafael A De La Barrera, Vincent Dussupt, Letzibeth Mendez-Rivera, Shelly J Krebs, Corinna N Ross, Stephanie D Mdaki, Kathleen M Brasky, Donna Layne-Colon, Suzette D Tardif, Stephen J Thomas, Kayvon Modjarrad, Marcia A Blackman, Jean L Patterson
Zika virus (ZIKV) infection during pregnancy poses significant threats to maternal and fetal health, leading to intrauterine fetal demise and severe developmental malformations that constitute congenital Zika syndrome (CZS). As such, the development of a safe and effective ZIKV vaccine is a critical public health priority. However, the safety and efficacy of such a vaccine during pregnancy remain uncertain. Historically, the conduct of clinical trials in pregnant women has been challenging. Therefore, clinically relevant animal pregnancy models are in high demand for testing vaccine efficacy...
February 17, 2024: NPJ Vaccines
https://read.qxmd.com/read/38368201/the-improvement-and-retention-of-skills-in-shoulder-dystocia-management-with-the-use-of-high-fidelity-simulation-the-safe-simulation-high-fidelity-study
#40
JOURNAL ARTICLE
Dimitrios Papoutsis, Paraskevi Klazoglou, George Valasoulis, Chara Tzavara
BACKGROUND: Shoulder dystocia is a relatively uncommon but serious childbirth-related emergency. AIM: To explore the improvement and retention of skills in shoulder dystocia management through high-fidelity simulation training. METHODS: The SAFE (SimulAtion high-FidElity) study was a prospective cohort study that utilised a high-fidelity birth simulator. Registered midwives and final year midwifery students were invited to participate in a one-day workshop at 6-monthly intervals...
February 16, 2024: Women and Birth
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