keyword
https://read.qxmd.com/read/38492349/pregnancy-renders-anatomical-changes-in-hypothalamic-substructures-of-the-human-brain-that-relate-to-aspects-of-maternal-behavior
#1
JOURNAL ARTICLE
Klara Spalek, Milou Straathof, Lal Koyuncu, Håkon Grydeland, Anouk van der Geest, Sophie R Van't Hof, Eveline A Crone, Erika Barba-Müller, Susana Carmona, Damiaan Denys, Christian K Tamnes, Sarah Burke, Elseline Hoekzema
Animal studies have shown that pregnancy is associated with neural adaptations that promote maternal care. The hypothalamus represents a central structure of the mammalian maternal brain and hormonal priming of specific hypothalamic nuclei plays a key role in the induction and expression of maternal behavior. In humans, we have previously demonstrated that becoming a mother involves changes in grey matter anatomy, primarily in association areas of the cerebral cortex. In the current study, we investigated whether pregnancy renders anatomical changes in the hypothalamus...
March 12, 2024: Psychoneuroendocrinology
https://read.qxmd.com/read/38490241/evaluation-of-cerebral-autoregulation-of-oxygen-by-nirs-method-during-postnatal-transition-period-in-term-and-late-preterm-newborns-without-resuscitation-requirement
#2
JOURNAL ARTICLE
Omer Ertekin, Mehmet Buyuktiryaki, Sehribanu Isik, Nilufer Okur, Serife Suna Oguz
BACKGROUND: Pulse oximetry is commonly used to monitor arterial oxygen saturation and heart rate during the transition period and reference intervals have been determined. However, the effect of the change in arterial oxygen saturation on tissue oxygenation does not seem to be the same. So, a non-invasive method for monitoring cerebral or regional tissue oxygenation will be potentially useful for vulnerable infants. This study aims to evaluate the effectiveness of cerebral autoregulation in the first 10 min after delivery in term and late preterm newborns without resuscitation requirement...
February 7, 2024: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38489065/anatomical-evaluation-of-p1-segment-of-posterior-cerebral-artery-and-posterior-communicanting-artery-in-340-human-hemispheres-a-proposal-for-morphological-classification
#3
JOURNAL ARTICLE
Emine Nas, Gkionoul Nteli Chatzioglou, Özcan Gayretli
PURPOSE: The aim of our study is to examine the morphometry of the P1 segment of the posterior cerebral artery (P1) and the posterior communicating artery (PcomA) and to present a descriptive classification according to morphometric findings. METHODS: 340 hemispheres from 170 cadavers were included. The outer diameters of P1 and PcomA were measured with ImageJ software. Then, the configurations of the posterior cerebral artery were revealed as fetal, adult and transitional...
March 15, 2024: Surgical and Radiologic Anatomy: SRA
https://read.qxmd.com/read/38488252/temporal-effects-of-caffeine-on-intrapulmonary-shunt-in-preterm-ventilated-infants
#4
JOURNAL ARTICLE
Ourania Kaltsogianni, Ravindra Bhat, Anne Greenough, Theodore Dassios
OBJECTIVES: We hypothesized that caffeine would be associated with a transient reduction in the right-to-left shunt and VA /Q. We aimed to explore the temporal effects of caffeine on right-to-left shunt, ventilation perfusion ratio (VA /Q) and shift of the oxyhaemoglobin dissociation curve (ODC) in premature ventilated infants. METHODS: Retrospective cohort study at a tertiary neonatal unit of infants born at less than 31 weeks of gestation that were mechanically ventilated on day three of life...
March 18, 2024: Journal of Perinatal Medicine
https://read.qxmd.com/read/38479490/the-use-of-intrapartum-ultrasound-in-operative-vaginal-birth-a-retrospective-cohort-study
#5
JOURNAL ARTICLE
Sasha M Skinner, Peter Neil, Ryan J Hodges, Ms Nadine Murray, Ben W Mol, Daniel L Rolnik
BACKGROUND: Poor outcomes from operative vaginal birth (OVB) have been associated with failure to recognize malposition, breakdown in interdisciplinary communication and deviation from accepted guidelines. We recently implemented a safety bundle, including routine intrapartum ultrasound (IPUS), a structured time-out and procedural checklist, aiming to reduce maternal and perinatal morbidity from OVB. OBJECTIVES: To compare births where IPUS was and was not used during the safety bundle implementation period at Monash Health...
March 11, 2024: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/38477071/extrusion-3d-printed-tricalcium-phosphate-polycaprolactone-biocomposites-for-quercetin-kcl-delivery-in-bone-tissue-engineering
#6
JOURNAL ARTICLE
Connor Toulou, Vishal Sharad Chaudhari, Susmita Bose
Critical-sized bone defects pose a significant challenge in advanced healthcare due to limited bone tissue regenerative capacity. The complex interplay of numerous overlapping variables hinders the development of multifunctional biocomposites. Phytochemicals show promise in promoting bone growth, but their dose-dependent nature and physicochemical properties halt clinical use. To develop a comprehensive solution, a 3D-printed (3DP) extrusion-based tricalcium phosphate-polycaprolactone (TCP-PCL) scaffold is augmented with quercetin and potassium chloride (KCl)...
March 13, 2024: Journal of Biomedical Materials Research. Part A
https://read.qxmd.com/read/38474404/alcohol-exposure-induces-nucleolar-stress-and-apoptosis-in-mouse-neural-stem-cells-and-late-term-fetal-brain
#7
JOURNAL ARTICLE
Yanping Huang, George R Flentke, Olivia C Rivera, Nipun Saini, Sandra M Mooney, Susan M Smith
Prenatal alcohol exposure (PAE) is a leading cause of neurodevelopmental disability through its induction of neuronal growth dysfunction through incompletely understood mechanisms. Ribosome biogenesis regulates cell cycle progression through p53 and the nucleolar cell stress response. Whether those processes are targeted by alcohol is unknown. Pregnant C57BL/6J mice received 3 g alcohol/kg daily at E8.5-E17.5. Transcriptome sequencing was performed on the E17.5 fetal cortex. Additionally, primary neural stem cells (NSCs) were isolated from the E14...
March 2, 2024: Cells
https://read.qxmd.com/read/38474355/the-impact-of-slc2a8-rna-interference-on-glucose-uptake-and-the-transcriptome-of-human-trophoblast-cells
#8
JOURNAL ARTICLE
Aleksandra Lipka, Łukasz Paukszto, Victoria C Kennedy, Amelia R Tanner, Marta Majewska, Russell V Anthony
While glucose is the primary fuel for fetal growth, the placenta utilizes the majority of glucose taken up from the maternal circulation. Of the facilitative glucose transporters in the placenta, SLC2A8 (GLUT8) is thought to primarily function as an intracellular glucose transporter; however, its function in trophoblast cells has not been determined. To gain insight into the function of SLC2A8 in the placenta, lentiviral-mediated RNA interference (RNAi) was performed in the human first-trimester trophoblast cell line ACH-3P...
February 24, 2024: Cells
https://read.qxmd.com/read/38473894/maternal-age-at-menarche-genes-determines-fetal-growth-restriction-risk
#9
JOURNAL ARTICLE
Evgeny Reshetnikov, Maria Churnosova, Yuliya Reshetnikova, Vadim Stepanov, Anna Bocharova, Victoria Serebrova, Ekaterina Trifonova, Irina Ponomarenko, Inna Sorokina, Olga Efremova, Valentina Orlova, Irina Batlutskaya, Marina Ponomarenko, Vladimir Churnosov, Inna Aristova, Alexey Polonikov, Mikhail Churnosov
We aimed to explore the potential link of maternal age at menarche (mAAM) gene polymorphisms with risk of the fetal growth restriction (FGR). This case (FGR)-control (FGR free) study included 904 women (273 FGR and 631 control) in the third trimester of gestation examined/treated in the Departments of Obstetrics. For single nucleotide polymorphism (SNP) multiplex genotyping, 50 candidate loci of mAAM were chosen. The relationship of mAAM SNPs and FGR was appreciated by regression procedures (logistic/model-based multifactor dimensionality reduction [MB-MDR]) with subsequent in silico assessment of the assumed functionality pithy of FGR-related loci...
February 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38468127/reflections-on-the-multicenter-randomized-trial-of-treatment-for-mild-gestational-diabetes
#10
JOURNAL ARTICLE
Mark B Landon
After the 2006 hyperglycemia and adverse pregnancy outcomes study, which confirmed the relationship between maternal glycemia and pregnancy outcomes, the debate remained on whether treatment benefited gestational diabetes mellitus (GDM). Nonetheless, practitioners continued to universally screen for and treat women identified as GDM. To assess the benefits and harms of screening and treatment of GDM, the National Institute of Child Health and Human Development Maternal and Fetal Medicine Unit Network designed and conducted a well-designed randomized controlled trial in women with mild GDM...
March 12, 2024: Clinical Obstetrics and Gynecology
https://read.qxmd.com/read/38465746/melatonin-protects-oogenesis-from-hypobaric-hypoxia-induced-fertility-damage-in-mice
#11
JOURNAL ARTICLE
Ruina Zhang, Cong Liu, Daolun Yu, Deyong She, Yan Yu, Yongping Cai, Naifu Chen
Environmental hypoxia adversely affects reproductive health in humans and animals at high altitudes. Therefore, how to alleviate the follicle development disorder caused by hypoxia exposure and to improve the competence of fertility in plateau non-habituated female animals are important problems to be solved urgently. In this study, a hypobaric hypoxic chamber was used for 4 weeks to simulate hypoxic conditions in female mice, and the effects of hypoxia on follicle development, proliferation and apoptosis of granulosa cells, reactive oxygen species (ROS) levels in MII oocyte and 2-cell rate were evaluated...
March 11, 2024: Zygote: the Biology of Gametes and Early Embryos
https://read.qxmd.com/read/38462259/soft-tissue-dystocia-due-to-paradoxical-contraction-of-the-levator-ani-as-a-cause-of-prolonged-second-stage-concept-diagnosis-and-potential-treatment
#12
REVIEW
Aly Youssef, Elena Brunelli, Marta Fiorentini, Gianluigi Pilu, Federico Spelzini
Smaller pelvic floor dimensions seem to have been an evolutionary need to provide adequate support for the pelvic organs and the fetal head. Pelvic floor dimension and shape contributed to the complexity of human birth. Maternal pushing associated with pelvic floor muscle relaxation is key to vaginal birth. Using transperineal ultrasound, pelvic floor dimensions can be objectively measured in both static and dynamic conditions, such as pelvic floor muscle contraction and pushing. Several studies have evaluated the role of the pelvic floor in labor outcomes...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38462207/mettl3-promotes-trophoblast-ferroptosis-in-preeclampsia-by-stabilizing-the-acsl4-m-6-a-modification
#13
JOURNAL ARTICLE
Yang Wang, Gang Zhang, Yan Gao, Xuemei Zhang, Hongbo Qi
This study aims to explore the role of methyltransferase-like 3 (METTL3) modulation of ferroptosis in the pathogenesis of trophoblast-mediated preeclampsia. The expression of METTL3 and acyl-CoA synthetase long chain family member 4 (ACSL4) was measured in clinical placental tissues and trophoblasts using qPCR and Western blot techniques. The effects of METTL3 on the symptoms of preeclampsia were also validated in rat models. METTL3 and ACSL4 were upregulated in placental tissues from patients with preeclampsia and in hypoxia-induced trophoblasts...
March 8, 2024: Experimental Cell Research
https://read.qxmd.com/read/38461094/the-ireland-study-investigating-the-role-of-early-low-dose-aspirin-in-diabetes-mellitus-a-double-blinded-placebo-controlled-randomized-trial
#14
JOURNAL ARTICLE
Catherine Finnegan, Patrick Dicker, Denisa Asandei, Mary Higgins, Neil O'Gorman, Mairead O' Riordan, Fidelma Dunne, Geraldine Gaffney, Christine Newman, Fionnuala McAuliffe, Vineta Ciprike, Elena Fernandez, Fergal D Malone, Fionnuala M Breathnach
BACKGROUND: Although aspirin therapy is being increasingly advocated with the intention of risk modification for a wide range of pregnancy complications, women with prepregnancy diabetes mellitus are commonly excluded from clinical trials. OBJECTIVE: The primary aim of this study was to examine the effect of aspirin therapy on a composite measure of adverse perinatal outcome in pregnancies complicated by pregestational diabetes mellitus. STUDY DESIGN: A double-blinded, placebo-controlled randomized trial was conducted at 6 university-affiliated perinatology centers...
March 8, 2024: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/38453984/biochemical-and-functional-characterization-of-heat-inactivated-coelomic-fluid-from-earthworms-as-a-potential-alternative-for-fetal-bovine-serum-in-animal-cell-culture
#15
JOURNAL ARTICLE
Melinda Grace Rossan Mathews, Ravichandran Subramaniam, Saravanakumar Venkatachalam, Johnson Retnaraj Samuel Selvan Christyraj, Beryl Vedha Yesudhason, Kalishwaralal Kalimuthu, Manikandan Mohan, Jackson Durairaj Selvan Christyraj
Fetal bovine serum (FBS) plays a pivotal role in animal cell culture. Due to ethical and scientific issues, searching for an alternative, comprising the three R's (Refinement, Reduction and Replacement) gained global attention. In this context, we have identified the heat inactivated coelomic fluid (HI-CF) of the earthworm, Perionyx excavatus as a potential alternative for FBS. Briefly, we formulated HI-CF (f-HICF) containing serum free medium which can aid the growth, attachment, and proliferation of adherent cells, similar to FBS...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38449926/fetal-reduction-by-potassium-chloride-infusion-in-unruptured-heterotopic-pregnancy-a-comprehensive-review
#16
REVIEW
Manjusha Agrawal, Lucky Srivani Reddy, Drashti Patel, Garapati Jyotsna, Archan Patel
This comprehensive review explores the practice of fetal reduction through potassium chloride infusion in unruptured heterotopic pregnancies. Heterotopic pregnancies, characterized by the simultaneous occurrence of intrauterine and extrauterine gestations, present unique challenges in reproductive medicine. The review defines fetal reduction and underscores its significance in mitigating risks associated with heterotopic pregnancies, including the threat of rupture, maternal morbidity, and adverse outcomes...
February 2024: Curēus
https://read.qxmd.com/read/38448008/performance-of-cell-free-dna-testing-for-common-fetal-trisomies-in-triplet-pregnancies
#17
JOURNAL ARTICLE
Hoda Zakaria, Pascale Kleinfinger, Laurence Lohmann, Jean-Marc Costa, Vassilis Tsatsaris, Laurent J Salomon, Jean-Marie Jouannic, Jonathan Rosenblatt, Adèle Demain, Alexandra Benachi, Laïla El Khattabi, Alexandre J Vivanti
OBJECTIVE: In singleton pregnancies, the use of cell-free DNA (cfDNA) analysis as a screening test for common fetal trisomies has spread worldwide though we still lack sufficient data for its use in triplet pregnancies. The objective of this study is to assess the performance of cfDNA testing in detecting fetal aneuploidies in triplet pregnancies as a first-tier test. METHOD: We performed a retrospective cohort study including data from pregnant women with a triplet pregnancy who underwent cfDNA testing between May 1, 2017, and January 15, 2020...
March 6, 2024: Prenatal Diagnosis
https://read.qxmd.com/read/38435837/hepatitis-c-virus-detection-and-management-after-implementation-of-universal-screening-in-pregnancy
#18
JOURNAL ARTICLE
Sarah Boudova, Danielle M Tholey, Elizabeth Ferries-Rowe
BACKGROUND: Accurately identifying cases of hepatitis C virus has important medical and public health consequences. In the setting of rising hepatitis C virus prevalence and highly effective treatment with direct-acting antivirals, the Society for Maternal-Fetal Medicine guidelines recently changed to recommend universal screening for hepatitis C virus during pregnancy. However, there is little data on the influence of this policy change on case identification and management. OBJECTIVE: We aimed to examine the influence of universal hepatitis C virus screening on our patient population...
February 2024: AJOG global reports
https://read.qxmd.com/read/38434731/factors-associated-with-perinatal-and-neonatal-deaths-in-sao-tome-principe-a-prospective-cohort-study
#19
JOURNAL ARTICLE
Alexandra Vasconcelos, Swasilanne Sousa, Nelson Bandeira, Marta Alves, Ana Luísa Papoila, Filomena Pereira, Maria Céu Machado
BACKGROUND: Neonatal mortality reduction is a global goal, but its factors are seldom studied in most resource-constrained settings. This is the first study conducted to identify the factors affecting perinatal and neonatal deaths in Sao Tome & Principe (STP), the smallest Central Africa country. METHODS: Institution-based prospective cohort study conducted at Hospital Dr. Ayres Menezes. Maternal-neonate dyads enrolled were followed up after the 28th day of life ( n  = 194) for identification of neonatal death-outcome ( n  = 22) and alive-outcome groups ( n  = 172)...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38434136/cesarean-scar-pregnancy-results-of-treatment-using-a-double-balloon-cervical-ripening-catheter
#20
JOURNAL ARTICLE
Azadeh Tarafdari, Alireza Hadizadeh, Elnaz Irandoost, Sedigheh Borna, Azin Ghamari, Fahimeh Ghotbizadeh Vahdani
BACKGROUND: Being considered a life-threatening condition, cesarean scar pregnancy (CSP) leads to loss of fertility, severe bleeding, and even maternal mortality. We intended to assess the effect of double-balloon cervical ripening catheter insertion on CSP termination before nine weeks of gestation. METHOD: All participants were diagnosed CSP by abdominal and transvaginal ultrasound . The cases were treated with a sterile, double-balloon cervical ripening catheter inserted with real-time transabdominal ultrasound guidance and removed three days later...
February 2024: Journal of Obstetrics and Gynaecology of India
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