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Epimedium

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https://www.readbyqxmd.com/read/29783019/total-flavonoid-extract-of-epimedium-herb-increases-the-peak-bone-mass-of-young-rats-involving-enhanced-activation-of-the-ac10-camp-pka-creb-pathway
#1
Hui-Rong Xi, Hui-Ping Ma, Fang-Fang Yang, Yu-Hai Gao, Jian Zhou, Yuan-Yuan Wang, Wen-Yuan Li, Cory J Xian, Ke-Ming Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Epimedium sagittatum brevicornum Maxim. is an important traditional Chinese herb that has long been used to promote bone fracture healing and treat osteoporosis. AIM OF THE STUDY: Achieving peak bone mass by adolescence has now been accepted to be fundamental for preventing osteoporosis in adulthood life. This study investigated the possibility of increasing peak bone mass in young rats using the total flavonoid extract of Epimedium herb (TFE)...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29729232/effect-of-hyperin-and-icariin-on-steroid-hormone-secretion-in-rat-ovarian-granulosa-cells
#2
Xiaowei Nie, Wenjie Sheng, Daorong Hou, Qiang Liu, Ronggen Wang, Yong Tan
AIM OF THE STUDY: This study was designed to investigate the effect of different concentrations of Hyperin and Icariin (ICA)on proliferation and the secretion of estrogen (E2), and progesterone (P) in granulosa cells, and to explore the effect of Hyperin and Icariin on the expression of CYP17 and CYP19. MATERIALS AND METHODS: Rat ovary granulosa cells were cultured in vitro and treated with different concentrations of Hyperin and Icariin. The proliferation of ovarian granulosa cells was measured with the MTT assay...
May 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29710479/antigen-adjuvant-effects-of-icariin-in-enhancing-tumor-specific-immunity-in-mastocytoma-bearing-dba-2j-mice
#3
Xiaodi Zhang, Zhichen Kang, Qingjie Li, Jin Zhang, Sha Cheng, Hao Chang, Shanshan Wang, Shufang Cao, Tie Li, Jiawei Li, Yishan Wang, Yu Song, Hao Yu
Cancer immunotherapy has attracted much attention in recent years because of the ability of immune system to identify tumor cells and limit their growth. Icariin (ICA) is a natural flavonoid glucoside isolated from Epimedium plants and has shown a variety of pharmacological activities such as anti-inflammatory effects, immunological regulation and anticancer potency. Furthermore, it has immunoadjuvant effects on enhancing Th1-immune response, suggesting that ICA may serve as an adjuvant for cancer immunotherapy...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29705515/effects-of-water-extract-from-epimedium-on-neuropeptide-signaling-in-an-ovariectomized-osteoporosis-rat-model
#4
Hengrui Liu, Yingquan Xiong, Haixia Wang, Li Yang, Chaopeng Wang, Xiaoguang Liu, Zhidi Wu, Xiaoyun Li, Ling Ou, Ronghua Zhang, Xiaofeng Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: For the past millenium, water extract from Epimedium (dried leaves of Epimedium brevicornu Maxim.) has been widely used for bone disease therapy in traditional Chinese medicine and has been reported to exhibit salutary effects on osteoporosis in clinical trials. The therapeutic effect of Epimedium is associated with the function of the brain in traditional Chinese medicine theory. STUDY AIM: To determine the potential relationship between treating osteoporosis with Epimedium and neuropeptide regulation...
April 26, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29679717/stat-3-regulation-of-cxcr4-is-necessary-for-the-prenylflavonoid-icaritin-to-enhance-mesenchymal-stem-cell-proliferation-migration-and-osteogenic-differentiation
#5
R Z L Lim, L Li, E L Yong, N Chew
Mesenchymal stem cell (MSC) dysfunction has been implicated in the pathogenesis of osteoporosis. MSCs derived from osteoporotic subjects demonstrate significant impairment in proliferation, adhesion and chemotaxis, and osteogenic differentiation, leading to reduced functional bone-forming osteoblasts and ultimately nett bone loss and osteoporosis. Epimedium herbs and its active compound Icaritin (ICT) have been used in Chinese ethnopharmacology for the treatment of metabolic bone diseases. Using an in-vitro cell culture model, we investigated the benefits of ICT treatment in enhancing MSC proliferation, migration and osteogenic differentiation, and provide novel data to describe its mechanism of action...
April 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29676109/-research-actuality-and-quality-influencing-factor-of-epimedii-folium
#6
Ai-Ping Deng, Wen-Tao Fang, Qing-Gang Zhou, Hong-Jun Yang, Ling Wang, Tie-Gui Nan, Li-Ping Kang, Lan-Ping Guo, Lu-Qi Huang, Zhi-Lai Zhan
Epimedii Folium has a long history in China as a common traditional Chinese medicine. Key factors of Epimedii Folium quality were summarized based on ancient literatures, Chinese Pharmacopoeias and modern research in different period of history. The main reason for unqualified Epimedii Folium is unstable icariin. Therefore, it's suggested that: the precondition of the quality control of epimedium is to find the proper quality marker. It's suggested that the medicinal parts should be reverted to "dry whole plant overground" to solve Epimedium resource shortage problem...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29625193/icaritin-induces-ovarian-cancer-cell-apoptosis-through-activation-of-p53-and-inhibition-of-akt-mtor-pathway
#7
Lvfen Gao, Ming Chen, Yuan Ouyang, Ruobin Li, Xian Zhang, Xuesong Gao, Xiaoyu Wang, Shaoqiang Lin
AIMS: Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers. Currently, the first-line OC treatment consists of cytoreductive surgery and platinum-based chemotherapy. However, most patients develop chemoresistance after the first-line treatment limits the success of treatment. Therefore, there is an urgent need to identify effective therapeutic agents. MAIN METHODS: Cell viabilities were detected by MTS assay; Annexin V-FITC/PI assay and western blotting assay were performed to analyze the apoptotic cells in vitro; An immunofluorescence assay was performed to analyze the TUNEL+ apoptotic cells in vivo; Patient-derived xenografts were established to test the in vivo antitumor effects; The key proteins of p53, caspase-mediated apoptotic pathway and Akt/mTOR pathway were detected by Western blotting...
April 3, 2018: Life Sciences
https://www.readbyqxmd.com/read/29620952/anti-inflammatory-activity-of-epimedium-brevicornu-maxim-ethanol-extract
#8
Shan Huang, Ning Meng, Bingquan Chang, Xianghua Quan, RuiYing Yuan, Bin Li
Epimedium brevicornu Maxim has been used as a traditional herbal drug in China. In this study, the anti-inflammatory effects of E. brevicornu Maxim ethanol extract (EBME) were investigated in RAW264.7 macrophages and mice challenged with lipopolysaccharide (LPS). Results showed that EBME attenuated inflammation by decreasing the production of several proinflammatory mediators, such as nitric oxide (NO), prostaglandin (PG) E2 , inducible nitric oxide synthase, and cyclooxygenase-2, in LPS-stimulated RAW264.7 macrophages...
April 5, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29600643/-study-on-original-investigation-macroscopic-and-microscopic-identification-of-pharmacopoeia-contained-species-of-epmedii-folium
#9
Shuai Kang, Jing Lu, Ji Zhang, Chao-Jie Lian, Ai-Hua Wei, Shuang-Cheng Ma
Epimedii Folium is a commonly used traditional Chinese drug, and now still depends on the wild resource. In recent years, with the surge in consumption, the resources are declining, the use of market varieties are constantly changing. In this paper, Production and sales situation of the five species contained in pharmacopoeia(Epimedium brevicornu, E. sagittatum, E. pubescens, E. koreanum and E. wushanense) have been studied on the basis of the existing researches, in-depth investigation and collection of accurate plant specimens and samples...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29587224/application-of-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-to-investigate-the-regioselective-glucuronidation-of-icaritin-in-vitro
#10
Yi Rong, Zhiyun Meng, Jian Li, Xiaoxia Zhu, Hui Gan, Ruolan Gu, Zhuona Wu, Wenzhong Sun, Taoyun Liu, Ying Zheng, Mingji Jin, Jian Peng, Xinyu Wang, Guifang Dou
Icaritin is one of the Epimedium products with various biological activities. In the present study, we developed a rapid, reliable and robust UHPLC-MS/MS method to simultaneously determine unconjugated icaritin and its multiple glucuronides (icaritin-3-glucuronide, icaritin-7-glucuronide and icaritin-3,7-diglucuronide) in microsomal incubation systems, and applied it to study icaritin regioselective glucuronidation in vitro. We identified the involvement of human UDP-glucuronosyltransferase (UGT) isoforms in icaritin metabolism and further studied the kinetic profiles of icaritin glucuronidation using pooled human liver microsomes (HLMs), pooled rat liver microsomes (RLMs), pooled human intestine microsomes (HIMs) and UGTs, respectively...
February 13, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29575004/a-simple-and-selective-lc-ms-ms-method-for-quantification-of-ikarisoside-a-in-rat-plasma-and-its-application-to-a-pharmacokinetic-study
#11
Yue Cong, Rui Wang, Chen Zhang, Hai Lin
Ikarisoside A is a natural flavonoid isolated from Epimedium plants. To further evaluate its medicinal potential, a sensitive and robust LC-MS/MS method was developed and validated for the assay of ikarisoside A in rat plasma. Orientin was used as an internal standard (IS). The ESI was operated in its negative ion mode while ikarisoside A and IS were measured by selected reaction monitoring (SRM) using precursor-to-product ion transitions of m/z 499.1→353.0 and m/z 446.9→327.6, respectively. This LC-MS/MS method had good sensitivity (LLOQ = 1...
March 25, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29567251/effect-of-drying-processes-on-prenylflavonoid-content-and-antioxidant-activity-of-epimedium-koreanum-nakai
#12
Yudan Zhao, Shifeng Chen, Yadan Wang, Chongning Lv, Jing Wang, Jincai Lu
Epimedium koreanum Nakai is a famous Chinese herbal medicine for the treatment of impotence, osteoporosis, immune suppression and cardiovascular diseases. Drying is the most common and fundamental procedure in post-harvest processing of E. koreanum, which contributes to the variations of flavonoid content, especially prenylflavonoids, the bioactive components. In present study, effect of drying processes on flavonoid content and antioxidant activity were investigated. High performance liquid chromatography coupled with diode-array detection and electrospray ionization quadrupole time-of-flight tandem mass spectrometry methods were employed...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29532884/protective-effects-of-icariin-on-human-vascular-endothelial-cells-induced-by-oxidized-low-density-lipoprotein-via-modulating-caspase-3-and-bcl-2
#13
Yanwu Hu, Haitao Li, Kai Liu, Yang Zhang, Liqun Ren, Zhimin Fan
Icariin belongs to the family of flavonoids that is extracted from Epimedium brevicornum Maxim, and exhibits antioxidative, antitumorigenic, antiosteoporotic, immunoregulatory and antiatherosclerotic properties. To understand the mechanisms underlying the antiatherosclerotic properties of icariin, the present study investigated the effects of icariin on human vascular endothelial cells (HUVECs) following treatment with oxidized low‑density lipoprotein (ox‑LDL). Thus, following pretreatment with icariin at four various concentrations (0, 10, 20 and 40 µM), HUVECs were stimulated with ox‑LDL (100 µg/ml)...
May 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29532868/secretome-analysis-of-rat-osteoblasts-during-icariin-treatment-induced-osteogenesis
#14
Weiqing Qian, Yan Su, Yajie Zhang, Nianwei Yao, Nin Gu, Xu Zhang, Hong Yin
Osteoporosis is a serious public health problem and icariin (ICA) is the active component of the Epimedium sagittatum, a traditional Chinese medicinal herb. The present study aimed to investigate the effects and underlying mechanisms of ICA as a potential therapy for osteoporosis. Calvaria osteoblasts were isolated from newborn rats and treated with ICA. Cell viability, apoptosis, alkaline phosphatase activity and calcium deposition were analyzed. Bioinformatics analyses were performed to identify differentially expressed proteins (DEPs) in response to ICA treatment...
May 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29531934/cartilage-tissue-engineering-via-icariin-and-adipose-derived-stem-cells-in-fibrin-scaffold
#15
Maryam Bahrami, Ali Valiani, Noushin Amirpour, Mohammad Zamani Ra Rani, Batool Hashemibeni
Background: Nowadays, cartilage tissue engineering is the best candidate for regeneration of cartilage defects. This study evaluates the function of herbal extracts icariin (ICA), the major pharmacological constituent of herba Epimedium , compared with transforming growth factor β3 (TGFβ3) to prove its potential effect for cartilage tissue engineering. Materials and Methods: ICA, TGFβ3, and TGFβ3 + ICA were added fibrin-cell constructions derived from adipose tissue stem cells...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29527166/icariin-ameliorate-thiram-induced-tibial-dyschondroplasia-via-regulation-of-wnt4-and-vegf-expression-in-broiler-chickens
#16
Hui Zhang, Khalid Mehmood, Kun Li, Mujeeb U Rehman, Xiong Jiang, Shucheng Huang, Lei Wang, Lihong Zhang, Xiaole Tong, Fazul Nabi, Wangyuan Yao, Muhammad K Iqbal, Muhammad Shahzad, Jiakui Li
Tibial dyschondroplasia (TD) is main bone problem in fast growing poultry birds that effect proximal growth plate (GP) of tibia bone. TD is broadly defined as non-vascularized and non-mineralized, and enlarged GP with tibia bone deformation and lameness. Icariin ( Epimedium sagittatum ) is a traditional Chinese medicine, which is commonly practiced in the treatment of various bone diseases. Recently, many researcher reports about the beneficial effects of icariin in relation to various types of bone conditions but no report is available about promoting effect of icariin against TD...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29455515/-research-on-promotory-effect-of-traditional-chinese-medicine-on-fracture-healing-in-cell-and-molecular-level
#17
REVIEW
Kun Zhang, Liang-Chen Niu, Fu-Jie Yuan, Shen-Peng Liu
Traditional Chinese medicine is widely used in the treatment of fractures, osteoporosis, other bone related diseases for thousands of years. There are many animal experiments and clinical trials demonstrating that the traditional Chinese medicine such as epimedium, Drynaria and other traditional Chinese medicine can stimulate bone regeneration and inhibit bone resorption, accelerating the fracture healing. In recent years many cell experiments have shown that these herbal ingredients up-regulated the expression of intracellular osteogenic transcription factors and osteogenic related genes, and then induced osteoblastic differentiation and stimulated the proliferation of osteoblasts, bone nodule formation and matrix mineralization...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455507/-effect-and-mechanism-of-total-flavone-of-epimedium-on-primary-callus-formation-in-ovariectomized-rats-with-fractures
#18
Xiao-Lin Shi, Bo-Cheng Liang, Peng Wu, Bo Wang, Zhen-Yu Shi, Ling-Cheng Kong, Jian-Liang Yao, Jun-Jun Huang, Chun-Wen Li
OBJECTIVE: To explore the effects and related mechanisms of total flavone of epimedium treatment(TFE)on primary callus for mation in ovariectomized rats. METHODS: Forty male SD rats weighted from 209 to 246 g and aged 6 to 8 weeks were selected. Six weeks after ovariectomy a femur fracture model with middiaphyseal segment fracture was established, estimated and randomly divided into TFE group (150 mg·kg⁻¹·d⁻¹) and control group(received saline). HE staining was used to evaluate the morphologic difference of primary callus during the bone callus healing between these two groups...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29451707/simultaneous-preparation-and-comparison-of-the-osteogenic-effects-of-epimedins-a-c-and-icariin-from-epimedium-brevicornu
#19
Yani Guo, Xiufeng Wang, Jing Gao
In this study, epimedins A-, B-, and C-, and icariin-rich extracts were simultaneously isolated from Epimedium brevicornu Maxim. through a convenient four-stage process consisting of solvent extraction, macroporous resin column pre-concentration, extraction fractionation, and reversed-phase (RP) silica gel column chromatography. Single factor experiments and response surface methodology (RSM) were used to optimize the preparation conditions. In the final products, the purities of epimedins A - C and icariin were 23...
April 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29433393/epimedium-koreanum-ameliorates-oxidative-stress-mediated-liver-injury-by-activating-nuclear-factor-erythroid-2-related-factor-2
#20
Ji Yun Jung, Sang Mi Park, Hae Li Ko, Jong Rok Lee, Chung A Park, Sung Hui Byun, Sae Kwang Ku, Il Je Cho, Sang Chan Kim
Oxidative stress induced by reactive oxygen species is the main cause of various liver diseases. This study investigated the hepatoprotective effect of Epimedium koreanum Nakai water extract (EKE) against arachidonic acid (AA)[Formula: see text][Formula: see text][Formula: see text]iron-mediated cytotoxicity in HepG2 cells and carbon tetrachloride (CCl4 -)-mediated acute liver injury in mice. Pretreatment with EKE (30 and 100[Formula: see text][Formula: see text]g/mL) significantly inhibited AA[Formula: see text][Formula: see text][Formula: see text]iron-mediated cytotoxicity in HepG2 cells by preventing changes in the expression of cleaved caspase-3 and poly(ADP-ribose) polymerase...
2018: American Journal of Chinese Medicine
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