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Epimedium

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https://www.readbyqxmd.com/read/28107963/chromatographic-fingerprinting-as-a-strategy-to-identify-regulated-plants-in-illegal-herbal-supplements
#1
D Custers, N Van Praag, P Courselle, S Apers, E Deconinck
Erectile dysfunction (ED) is a sexual disorder characterized by the inability to achieve or maintain a sufficiently rigid erection. Despite the availability of non-invasive oral treatment options, many patients turn to herbal alternatives. Furthermore, herbal supplements are increasingly gaining popularity in industrialized countries and, as a consequence, quality control is a highly important issue. Unfortunately, this is not a simple task since plants are often crushed and mixed with other plants, which complicates their identification by usage of classical approaches such as microscopy...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28097088/icariin-ameliorates-iga-nephropathy-by-inhibition-of-nuclear-factor-kappa-b-nlrp3-pathway
#2
Lei Zhang, Xing-Zhi Wang, Yu-Shu Li, Lei Zhang, Li-Rong Hao
Immunoglobulin A nephropathy (IgAN) is the most frequent form of glomerulonephritis, which is characterized by glomerular proliferation and renal inflammation. Icariin is a flavonoid from the Chinese herb Epimedium, and its anti-inflammatory effect has been reported. This study aimed to investigate the effects of icariin on the renal damage in IgAN rats and the mechanisms behind these effects. IgAN model was established in Sprague-Dawley rats by oral and intravenous immunization with bovine gamma-globulin for 12 weeks, and rats were treated with icariin from 12 to 18 weeks...
January 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/27975816/inhibitory-effects-of-epimedium-herb-water-extract-on-the-inflammatory-response-in-vitro-and-in-vivo
#3
Y C Oh, Y H Jeong, W K Cho, S J Lee, J Y Ma
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975793/antiviral-effect-of-epimedium-koreanum-extract
#4
W K Cho, J S Lee, J Y Ma
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27959402/effects-of-herbal-epimedium-on-the-improvement-of-bone-metabolic-disorder-through-the-induction-of-osteogenic-differentiation-from-bone-marrow-derived-mesenchymal-stem-cells
#5
Do Rim Kim, Ji Eun Lee, Kyung Jun Shim, Jin Hyoung Cho, Ho Chul Lee, Seong Kyu Park, Mun Seog Chang
Herbal Epimedium (HE) has been commonly used as a tonic, antirheumatic agent and in the treatment of bone‑associated diseases including osteoporosis. Treatment for osteoporosis is important to increase bone mass density and maintain to balance of bone remodeling. The present study was performed to investigate the effects of HE on mouse bone marrow mesenchymal stem cell (mBMMSC) proliferation and osteogenic differentiation, using MTT assays, proliferating cell nuclear antigen (PCNA) detection and apoptosis and differentiation assays...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27916587/genetic-toxicity-of-epimedium-koreanum-nakai
#6
Youn-Hwan Hwang, Hey Jin Yang, Nam-Hui Yim, Jin Yeul Ma
ETHNOPHARMACOLOGICAL RELEVANCE: In Eastern Asia, E. koreanum Nakai (EKN) has traditionally been used as an aphrodisiac herbal medicine. However, there was no available information for its genotoxicity. This study was conducted to evaluate the genotoxic potentials of EKN. MATERIALS AND METHODS: The phytochemicals of EKN were identified using liquid chromatography/tandem mass spectrometry (LC/MS/MS). Three standard battery of genotoxicity assay for bacterial reverse mutation, mammalian chromosomal aberration and in vivo micronuclei formation was employed...
December 1, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27895755/inhibitory-effects-of-chinese-nutritional-herbs-in-isogenic-breast-carcinoma-cells-with-modulated-estrogen-receptor-function
#7
Nitin Telang, Guo Li, Meena Katdare, Daniel Sepkovic, Leon Bradlow, George Wong
In estrogen receptor (ER)+ MCF-7 cells, ER represents a ligand-activated transcription factor, and 17β-estradiol (E2) represents its physiological ligand. Maintenance of the human breast carcinoma-derived MCF-7 cells with 0.7% serum selected a proliferative sub-population of E2-responsive cells with transiently non-functional ER due to limited availability of E2. Culture of MCF-7 cells in the presence of either 0.7% serum, <1 nM E2 or 0.7% serum + 20 nM E2 selected isogenic cells with either non-functional ER (ER-NF) or functional ER (ER-F) phenotype...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27879670/the-protective-effects-of-icariin-against-the-homocysteine-induced-neurotoxicity-in-the-primary-embryonic-cultures-of-rat-cortical-neurons
#8
Xiao-Ang Li, Yuen-Shan Ho, Lei Chen, W L Wendy Hsiao
Icariin, an ingredient in the medicinal herb Epimedium brevicornum Maxim (EbM), has been considered as a potential therapeutic agent for neurodegenerative diseases such as Alzheimer's disease (AD). Hyperhomocysteinaemia is a risk factor for AD and other associated neurological diseases. In this study we aim to investigate whether icariin can reverse homocysteine (Hcy)-induced neurotoxicity in primary embryonic cultures of rat cortical neurons. Our findings demonstrated that icariin might be able restore the cytoskeleton network damaged by Hcy through the modulation of acetyl-α-tubulin, tyrosinated-α-tubulin, and phosphorylation of the tubulin-binding protein Tau...
November 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27848250/pharmacological-effects-of-active-components-of-chinese-herbal-medicine-in-the-treatment-of-alzheimer-s-disease-a-review
#9
Zhi-Yong Wang, Jian-Gang Liu, Hao Li, Hui-Ming Yang
Alzheimer's disease (AD), the most common neurodegenerative disorder associated with dementia, not only severely decreases the quality of life for its victims, but also brings a heavy economic burden to the family and society. Unfortunately, few chemical drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far, and combined with their significant side-effects, there is therefore an urgent need for new strategies to be developed for AD treatment. Traditional Chinese Medicine has accumulated many experiences in the treatment of dementia during thousands of years of practice; modern pharmacological studies have confirmed the therapeutic effects of many active components derived from Chinese herbal medicines (CHM)...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27827937/effects-of-light-intensity-on-the-growth-photosynthetic-characteristics-and-flavonoid-content-of-epimedium-pseudowushanense-b-l-guo
#10
Junqian Pan, Baolin Guo
Epimedium pseudowushanense B.L.Guo is used in traditional medicine as an aphrodisiac and to strengthen muscles and bones. Several recent reports have shown that flavonoids from Epimedium also significantly affect the treatment of breast cancer, liver cancer, and leukemia. However, few studies have examined the medicinal-ingredient yield of Epimedium, a light-demanding shade herb, under different light intensities. To investigate the effects of light intensity on medicinal-ingredient yields, Epimedium was exposed to five levels of light intensity until harvest time...
November 4, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27810280/-1-h-nmr-based-metabonomic-study-on-the-effects-of-epimedium-on-glucocorticoid-induced-osteoporosis
#11
Sina Pan, Ali Chen, Zhihui Han, Yaling Wang, Xin Lu, Yongxia Yang
Glucocorticoids are widely used in clinical practice for the treatment of many immune-mediated and inflammatory diseases, and glucocorticoid-induced osteoporosis (GIO) is the most common type of secondary osteoporosis. Epimedium is one of the most commonly used traditional Chinese medicines for treating osteoporosis. In the present study, we systematically analysed the metabonomic characteristics of GIO model rats and elucidated the therapeutic effect of Epimedium by using a (1)H NMR-based metabonomic approach in conjunction with multivariate data analysis...
December 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27778023/icariin-protects-against-mpp-induced-neurotoxicity-in-mes23-5-cells
#12
Ai-Li Xu, Ming-Chun Jiang, Xiao-Han Chen, Wen-Fang Chen
Icariin is the major bioactive component of Epimedium and has been demonstrated to be a potential drug for age-related diseases. The present study was aimed to investigate the neuroprotective properties of icariin against 1-methyl-4-phenylpyridinium ion (MPP(+))-induced neurotoxicity in MES23.5 cells and the possible mechanisms. MTT assay showed that treatment with MPP(+) attenuated the cell viability in a dose-dependent manner in MES23.5 cells. Icariin pretreatment resulted in an enhancement of survival. Immunocytochemistry analysis revealed that icariin treatment attenuated MPP(+)-induced loss of tyrosine hydroxylase (TH) positive cells...
October 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/27748966/geographical-classification-of-epimedium-based-on-hplc-fingerprint-analysis-combined-with-multi-ingredients-quantitative-analysis
#13
Ning Xu, Guofu Zhou, Xiaojuan Li, Heng Lu, Fanyun Meng, Huaqiang Zhai
A reliable and comprehensive method for identifying the origin and assessing the quality of Epimedium has been developed. The method is based on analysis of HPLC fingerprints, combined with similarity analysis, hierarchical cluster analysis (HCA), principal component analysis (PCA) and multi-ingredients quantitative analysis. Nineteen batches of Epimedium, collected from different areas in the western regions of China, were used to establish the fingerprints and 18 peaks were selected for the analysis. Similarity analysis, HCA and PCA all classified the 19 areas into three groups...
October 17, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27733858/leaf-like-sepals-induced-by-ectopic-expression-of-a-short-vegetative-phase-svp-like-mads-box-gene-from-the-basal-eudicot-epimedium-sagittatum
#14
Zhineng Li, Shaohua Zeng, Yanbang Li, Mingyang Li, Erik Souer
Epimedium L. (Berberidaceae, Ranales), a perennial traditional Chinese medicinal herb, has become a new popular landscape plant for ground cover and pot culture in many countries based on its excellent ornamental characteristics and, distinctive and diverse floral morphology. However, little is known about the molecular genetics of flower development in Epimedium sagittatum. Here, we describe the characterization of EsSVP that encodes a protein sharing 68, 54, and 35% similarity with SVP, AGAMOUS-like 24 (AGL24) and SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) in Arabidopsis, respectively...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27690633/a-new-flavonol-glycoside-from-the-aerial-parts-of-epimedium-koreanum-nakai
#15
Fubo Han, Ik-Soo Lee
A new prenylated flavonol glycoside (1) was isolated from a 95% methanol extract of the dried and powdered aerial parts of Epimedium koreanum Nakai (Herba Epimedii), along with seven previously known flavonoids (2-8). The chemical structure of the new compound (1) was established to be 5-hydroxy-4'-methoxy-8-(2-hydroxy-3-methyl-3-butenyl)flavone 3-O-α-l-rhamnopyranosyl-7-O-β-D-gluco pyranoside on the basis of spectroscopic methods. The antioxidant activities of these compounds were determined by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay and kaempferitrin (8) showed a high reactivity with DPPH...
October 3, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27677719/botanicals-and-their-bioactive-phytochemicals-for-women-s-health
#16
REVIEW
Birgit M Dietz, Atieh Hajirahimkhan, Tareisha L Dunlap, Judy L Bolton
Botanical dietary supplements are increasingly popular for women's health, particularly for older women. The specific botanicals women take vary as a function of age. Younger women will use botanicals for urinary tract infections, especially Vaccinium macrocarpon (cranberry), where there is evidence for efficacy. Botanical dietary supplements for premenstrual syndrome (PMS) are less commonly used, and rigorous clinical trials have not been done. Some examples include Vitex agnus-castus (chasteberry), Angelica sinensis (dong quai), Viburnum opulus/prunifolium (cramp bark and black haw), and Zingiber officinale (ginger)...
October 2016: Pharmacological Reviews
https://www.readbyqxmd.com/read/27667512/epimedium-koreanum-nakai-and-its-main-constituent-icariin-suppress-lipid-accumulation-during-adipocyte-differentiation-of-3t3-l1-preadipocytes
#17
Yunk-Yung Han, Mi-Young Song, Min-Sub Hwang, Ji-Hye Hwang, Yong-Ki Park, Hyo-Won Jung
Obesity is associated with a number of metabolic abnormalities such as type 2 diabetes and has become a major health problem worldwide. In the present study, we investigated the effects of Epimedium koreanum Nakai (Herba Epimedii, HE) and its main constituent icariin on the adipocyte differentiation in 3T3-L1 preadipocytes. HE extract and icariin significantly reduced lipid accumulation and suppressed the expressions of PPARγ, C/EBPα, and SREBP-1c in 3T3-L1 adipocytes. They also inhibited fatty acid synthase (FAS), acyl-Co A synthase (ACS1), and perilipin...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27620672/metabolism-profiles-of-icariin-in-rats-using-ultra-high-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-tandem-mass-spectrometry-and-in-vitro-enzymatic-study
#18
Tao Cheng, Tingting Sheng, Yaxiong Yi, Tong Zhang, Han Han
Icariin (ICA), the major constituent of Epimedium brevicornu Maxim, is recognized as an effective agent for the treatment of osteoporosis. In our previous report, the relatively short half-life (74min) and poor bioavailability (approximately 0.1%) of ICA in rats suggested that not only ICA itself but also its metabolites could be responsible for the observed osteoporosis treatment effect. Therefore, the present study aimed at identifying the metabolites of ICA in rat plasma, bile, urine, and feces after the administration of a single oral dose of ICA (150mg/kg)...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27610184/icariin-attenuates-ogd-r-induced-autophagy-via-bcl-2-dependent-cross-talk-between-apoptosis-and-autophagy-in-pc12-cells
#19
Zhen-Tao Mo, Wen-Na Li, Yu-Rong Zhai, Qi-Hai Gong
Icariin (ICA), an active component of Epimedium brevicornum Maxim, exerts a variety of neuroprotective effects such as antiapoptosis. However, the mechanisms underlying antiapoptosis of ICA in neurons exposed to oxygen-glucose deprivation and reperfusion (OGD/R) are unclear. The B-cell lymphoma-2 (Bcl-2) protein family plays an important role in the regulation of apoptosis and autophagy through Bcl-2-dependent cross talk. Bcl-2 suppresses apoptosis by binding to Bax and inhibits autophagy by binding to Beclin-1 which is an autophagy related protein...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27537398/antitumoral-action-of-icaritin-in-lncap-prostate-cancer-cells-by-regulating-pea3-her2-ar-signaling
#20
Jimeng Hu, Wenhui Zhu, Bingbing Wei, Hui Wen, Shanhua Mao, Hua Xu, Mengbo Hu, Tian Yang, Haowen Jiang
Human epidermal growth factor receptor type 2 (HER2) and androgen receptor (AR) are critical factors for prostate cancer (PCa) progression. These factors regulate tumor cell survival and proliferation, and remain as crucial drivers of castration-resistant PCa progression. Icaritin (ICT) is a prenyl flavonoid derived from the Epimedium genus, which has many biological and pharmacological effects. Using androgen-sensitive human prostate carcinoma LNCaP cell lines, we found that 35 μg/ml of ICT could inhibit more than 50% of cell proliferation, induce cell apoptosis, and lead to a strong G1 phase arrest by targeting cyclin-related proteins and suppressing the ability of cell invasion...
November 2016: Anti-cancer Drugs
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