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https://www.readbyqxmd.com/read/29150385/igf-1r-mrna-expression-is-increased-in-obese-children
#1
Rafaela Cristina Ricco, Rubens Garcia Ricco, Mariangela Carletti Queluz, Mariana Teresa Sarti de Paula, Patricia Volpon Atique, Rodrigo José Custódio, Hugo Tourinho Filho, Raphael Del Roio Liberatori, Carlos Eduardo Martinelli
OBJECTIVES: Obese children are often taller than age-matched subjects. Reports on GH and IGF-I levels in obese individuals are controversial, with normal and reduced GH-IGF-I levels having been reported in this group of patients. Thus, the aim of this study was to analyse insulin-like growth factor type 1 receptor (IGF-IR) mRNA expression in obese children. METHODS: Forty-seven pre-pubertal children were included in this study: 29 were obese and taller than their target height, and 18 were normal eutrophic controls...
November 11, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29149959/urinary-tissue-inhibitor-of-metalloproteinase-and-insulin-like-growth-factor-7-as-early-biomarkers-of-delayed-graft-function-after-kidney-transplantation
#2
J Yang, S Y Lim, M-G Kim, C-W Jung, W-Y Cho, S-K Jo
BACKGROUND: Recently, urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-7 (IGFBP-7), markers for G1 cell cycle arrest, have been identified and validated in predicting the development of acute kidney injury in critically ill patients. It is unknown, however, whether these two biomarkers could predict the development of delayed graft function (DGF) after kidney transplantation (KT). METHODS: This is a single-center, prospective, observational study...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149730/divergence-of-insulin-superfamily-ligands-receptors-and-igf-binding-proteins-in-marine-versus-freshwater-stickleback-evidence-of-selection-in-known-and-novel-genes
#3
Tim Pellissier, Hend Al Nafea, Sara V Good
Three-spine stickleback (Gasterosteus aculeatus) is a teleost model for understanding genetic, physiological and morphological changes accompanying freshwater (FW) adaptation. There is growing evidence that the insulin superfamily plays important roles in traits involved in marine and FW adaptation. We performed a candidate gene analysis to look for evidence of selection on 33 insulin superfamily ligand-receptor genes and insulin-like growth factor binding proteins (Igfbp's) in stickleback. Using genotype data from 11 marine and 10 FW populations, we calculated the number of SNPs per site in regulatory and intronic regions, the number of synonymous and nonsynonymous mutations in coding regions, Wright's fixation index (Fst), and performed t-tests to identify SNPs with divergent genotype frequencies between marine/FW versus Atlantic/Pacific populations...
November 10, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29144802/lipid-accumulation-product-visceral-adiposity-index-and-chinese-visceral-adiposity-index-as-markers-of-cardiometabolic-risk-in-adult-growth-hormone-deficiency-patients-a-cross-sectional-study
#4
Xin Xie, Qing Li, Lingmin Zhang, Wei Ren
OBJECTIVE: Adult growth hormone deficiency (AGHD) is associated with cardiometabolic risk factors. Given that cardiovascular disease (CVD) is an important cause of morbidity and mortality in the AGHD population, there is a need for alternative, non-invasive methods of assessing cardiometabolic risk in this population. Chinese visceral adiposity index (CVAI) is a new marker of visceral fat dysfunction that is based on age, body mass index (BMI), waist circumference (WC) and metabolic parameters...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29136343/pharmacokinetics-pharmacodynamics-and-safety-of-a-long-acting-human-growth-hormone-mod-4023-in-healthy-japanese-and-caucasian-adults
#5
William G Kramer, Michal Jaron-Mendelson, Ronit Koren, Oren Hershkovitz, Gili Hart
Daily injections of growth hormone (GH) as replacement therapy in GH-deficient (GHD) patients may cause poor compliance and inconvenience. C-terminal peptide-modified human GH (MOD-4023) has been developed for once-weekly administration in GHD adults and children. In the present study, the pharmacokinetics (PK) and pharmacodynamics (PD) of a single subcutaneous dose of MOD-4023 were evaluated in healthy Caucasian and Japanese adults, using a phase 1 double-blind, vehicle-controlled, randomized study design...
November 14, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29130588/effects-of-astragalus-extract-mixture-ht042-on-height-growth-in-children-with-mild-short-stature-a-multicenter-randomized-controlled-trial
#6
Donghun Lee, Sun Haeng Lee, Jungbin Song, Hee-Jung Jee, Sung Ho Cha, Gyu Tae Chang
HT042 is a standardized functional food ingredient approved by Korean Food and Drug Administration with a claim 'HT042 can help height growth of children'. We aimed to evaluate the safety and efficacy of HT042 on height growth in children with mild short stature. A multicenter, randomized, double-blind, placebo-controlled parallel study was performed on children aged 6-8 years with height ranked below the 25th percentile. In 129 children, height gain was significantly higher in HT042 group than placebo group after 24 weeks (mean difference, 0...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29129118/gene-expression-of-insulin-receptor-insulin-like-growth-factor-increases-and-insulin-like-growth-factor-binding-protein-3-reduces-with-increase-in-prostate-size-in-benign-prostatic-hyperplasia
#7
Karli Sreenivasulu, Hanumanthappa Nandeesha, Lalgudi Narayanan Dorairajan, Medha Rajappa, Vickneshwaran Vinayagam, Cleetus Cherupanakkal
INTRODUCTION: Although the role of insulin in the development of benign prostatic hyperplasia (BPH) is well established, there are no studies regarding alteration in the gene expression of components of insulin-signaling pathway and their association with prostate size in BPH. Hence, the study was designed to analyze the gene and protein expression of insulin receptor and its related components in patients with BPH. MATERIALS AND METHODS: Twenty-seven BPH patients aged between 55 and 75 years were recruited in the study and prostatic tissues were obtained after transurethral resection of the prostate...
November 12, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29123408/the-matrix-metalloproteinase-and-insulin-like-growth-factor-system-in-oral-cancer-a-prospective-clinical-study
#8
Eik Schiegnitz, Peer W Kämmerer, Holger Schön, Christoph Gülle, Manfred Berres, Keyvan Sagheb, Bilal Al-Nawas
Aim: The absence of reliable single serum biomarkers for oral premalignant lesion (OPL) and oral squamous cell carcinoma (OSCC) limits early diagnosis, monitoring of advanced disease, and prediction of prognosis. Methods: In this prospective study, serum levels of matrix metalloproteinase (MMP)-2, MMP-3, MMP-13, insulin-like growth factor (IGF)-1, and IGF-binding protein (IGFBP)-3 were measured in 81 untreated OSCC patients, 49 healthy subjects, and 75 individuals with OPLs, and correlated with clinicopathological parameters...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29113370/serum-insulin-like-growth-factor-1-and-its-binding-protein-3-as-prognostic-factors-for-the-incidence-progression-and-outcome-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#9
Jing Wang, Yu-Chuan Li, Min Deng, Hai-Yin Jiang, Li-Hua Guo, Wen-Juan Zhou, Bing Ruan
Purpose: Previous studies have supported an association between serum insulin-like growth factor-1 (IGF1) and IGF-binding protein 3 (IGFBP3) levels and hepatocellular carcinoma (HCC), but the results were inaccurate. It has recently been proposed that IGF1 and IGFBP3 play roles in the time-to-progression (TTP) and overall survival (OS) of HCC patients. Our results revealed that serum IGF1 level is predictive of the progression and survival of HCC patients. Results: HCC was associated with a significant reduction in serum IGF-1 and IGFBP-3 levels compared to cirrhosis (p = 0...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29112184/insulin-like-growth-factor-system-in-remission-and-flare-of-inflammatory-bowel-diseases
#10
Małgorzata Krakowska-Stasiak, Dorota Cibor, Renata Domagała-Rodacka, Kinga Sałapa, Katarzyna Szczeklik, Danuta Owczarek
INTRODUCTION    Insulin-like growth factor-1 (IGF-1) is involved in the modulation of immunity and inflammation. It also plays a role in regulating the migration of endothelial cells and production of vasoactive agents.  OBJECTIVES    This study assessed IGF-1 and insulin-like growth factor bind protein-3 (IGFBP-3) concentrations and their relationships to disease activity in patients with inflammatory bowel disease (IBD). PATIENTS AND METHODS    A total of 129 adult patients with IBD (69 with Crohn's disease [CD] and 60 with ulcerative colitis [UC]) were involved in the study...
November 3, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29112142/igfbp-3-interacts-with-the-vitamin-d-receptor-in-insulin-signaling-associated-with-obesity-in-visceral-adipose-tissue
#11
Inmaculada Moreno-Santos, Daniel Castellano-Castillo, María Fernanda Lara, Jose Carlos Fernandez-Garcia, Francisco Jose Tinahones, Manuel Macias-Gonzalez
Adipose tissue has traditionally only been considered as an energy storage organ. Nevertheless, the importance of this tissue in systemic physiology and, especially, in systemic inflammation has been highlighted in recent years. Adipose tissue expresses proteins related to vitamin D (VD) metabolism, and it has been proposed that it can act as a VD storage tissue. The active form of VD, 1,25-dihydroxyvitamin D3 (1,25(OH)₂D₃), is able to modify adipocyte and adipose tissue physiology via the VD receptor (VDR), decreasing the expression of pro-inflammatory cytokines in adipose tissue...
November 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29108028/decreased-plasma-concentrations-of-bdnf-and-igf-1-in-abstinent-patients-with-alcohol-use-disorders
#12
Nuria García-Marchena, Daniel Silva-Peña, Ana Isabel Martín-Velasco, María Ángeles Villanúa, Pedro Araos, María Pedraz, Rosa Maza-Quiroga, Pablo Romero-Sanchiz, Gabriel Rubio, Estela Castilla-Ortega, Juan Suárez, Fernando Rodríguez de Fonseca, Antonia Serrano, Francisco Javier Pavón
The identification of growth factors as potential biomarkers in alcohol addiction may help to understand underlying mechanisms associated with the pathogenesis of alcohol use disorders (AUDs). Previous studies have linked growth factors to neural plasticity in neurocognitive impairment and mental disorders. In order to further clarify the impact of chronic alcohol consumption on circulating growth factors, a cross-sectional study was performed in abstinent AUD patients (alcohol group, N = 91) and healthy control subjects (control group, N = 55) to examine plasma concentrations of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-1 binding protein-3 (IGFBP-3)...
2017: PloS One
https://www.readbyqxmd.com/read/29103133/recombinant-growth-hormone-therapy-for-prepubertal-children-with-idiopathic-short-stature-in-korea-a-phase-iii-randomized-trial
#13
J Kim, B-K Suh, C W Ko, K-H Lee, C H Shin, J S Hwang, H S Kim, W Y Chung, C J Kim, H-S Han, N Y Kwon, S Y Cho, H-W Yoo, D-K Jin
PURPOSE: Several studies have evaluated the effects of growth hormone (GH) on auxological and biochemical parameters in children with non-GH-deficient, idiopathic short stature (ISS). This study evaluated the efficacy and safety of Growtropin(®)-II (recombinant human GH) in Korean patients with ISS. METHODS: This was a 1-year, open-label, multicenter, phase III randomized trial of Growtropin(®)-II in Korean patients with ISS. In total, 70 prepubertal subjects (39 males, 31 females) between 4 and 12 years of age were included in the study...
November 4, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29100429/association-study-of-igfbp1-and-igfbp3-polymorphisms-with-hypertension-and-cardio-cerebral-vascular-diseases-in-a-chinese-han-population
#14
Zhengmei Fang, Song Yang, Lijun Zhu, Ying Li, Yanchun Chen, Yuelong Jin, Xianghai Zhao, Hailong Zhao, Xiaotian Chen, Yanping Zhao, Chong Shen, Yingshui Yao
Previous studies have showed that insulin-like growth factor (IGF) axis is involved in the development of hypertension. It is unclear whether genetic variants in the IGF-binding proteins (IGFBPs) contribute to the susceptibility to hypertension. Three single-nucleotide polymorphisms (SNPs) in IGFBP1 and four SNPs in IGFBP3 were selected for genotyping in 2,012 hypertension cases and 2,210 healthy controls and 4,128 subjects were followed up for a median of 5.01 years. Multiple logistic regression and Cox regression were performed to evaluate the association of these seven SNPs with hypertension and cardio-cerebral vascular disease (CCVD)...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29081797/the-clinical-values-of-insulin-like-growth-factor-1-and-insulin-like-growth-factor-binding-protein-3-levels-in-blood-and-thyroid-nodules
#15
Ayfer Altas, Fatih Kuzu, Dilek Arpaci, Mustafa Unal, Murat Can, Figen Barut, Furuzan Kokturk, Sevil Uygun Ilikhan, Taner Bayraktaroglu
AIM: Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases. MATERIALS AND METHODS: In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29067463/igfbp-rp1-acts-as-a-potential-tumor-suppressor-via-the-suppression-of-erk-signaling-pathway-in-endometrial-cancer-cells
#16
Yu Ma, Jue Jiang, Yan Zhang, Yi Ding, Ting Xu, Bingjian Lu
Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) is a potential tumor‑suppressor gene in various cancers. However, its biological role and underlying mechanism has not been well investigated in endometrial cancer yet. The aim of the present study aimed to investigate the role and underlying molecular mechanisms of IGFBP‑rP1 in endometrial cancer cells in vitro. The authors used transfection of IGFBP‑rP1 or small interfering (si)RNA in endometrial cancer HEC‑1A or Ishikawa cells, respectively...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29051031/inflammatory-molecules-and-neurotrophic-factors-as-biomarkers-of-neuropsychomotor-development-in-preterm-neonates-a-systematic-review
#17
REVIEW
Rafael C Magalhães, Letícia P Pimenta, Izabela G Barbosa, Janaina M Moreira, João L V M de Barros, Antônio L Teixeira, Ana C Simões E Silva
OBJECTIVE: To provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. DATA SOURCE: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth...
October 16, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29044306/biomarkers-of-renal-recovery-after-acute-kidney-injury
#18
Sérgio Mina Gaião, José Artur Osório de Carvalho Paiva
Novel biomarkers can be suitable for early acute kidney injury diagnosis and the prediction of the need for dialysis. It remains unclear whether such biomarkers may also play a role in the prediction of recovery after established acute kidney injury or in aiding the decision of when to stop renal support therapy. PubMed, Web of Science and Google Scholar were searched for studies that reported on the epidemiology of renal recovery after acute kidney injury, the risk factors of recovery versus non-recovery after acute kidney injury, and potential biomarkers of acute kidney injury recovery...
July 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29040592/the-association-between-igf-i-and-igfbp-3-and-incident-diabetes-in-an-older-population-of-men-and-women-in-the-cardiovascular-health-study
#19
Chino S Aneke-Nash, Xiaonan Xue, Qibin Qi, Mary L Biggs, Anne Cappola, Lewis Kuller, Michael Pollak, Bruce M Psaty, David Siscovick, Kenneth Mukamal, Howard D Strickler, Robert C Kaplan
Context: Insulin like growth factor-I (IGF-I) has structural/functional similarities with insulin and may play a role in glucose homeostasis, along with IGF binding protein-3 (IGFBP-3), which binds the majority of circulating IGF-I. Objective: To assess whether IGF-I and IGFBP-3 are associated with higher risk of incident diabetes in older adults. Design: Participants in the Cardiovascular Health Study (n=3133), a cohort of adults aged ≥65 years, were observed for 16 years (n=3133) for the development of incident diabetes...
October 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29039467/insulin-like-growth-factor-binding-protein-6-released-from-human-mesenchymal-stem-cells-confers-neuronal-protection-through-igf-1r-mediated-signaling
#20
Hyo-Jin Jeon, Jihye Park, Joo-Hyun Shin, Mi-Sook Chang
Human bone marrow‑derived mesenchymal stem cells (hMSCs) are a desirable cell source for cell‑based therapy to treat nervous system injuries due to their ability to differentiate into specific cell types. In addition to their multipotency, hMSCs render the tissue microenvironment more favorable for tissue repair by secreting various growth factors. Our previous study demonstrated that hMSCs secrete several growth factors, including several insulin‑like growth factor binding proteins (IGFBPs). Among these, IGFBP‑6 binds with high affinity and inhibits insulin growth factor‑2 (IGF‑2) to inhibit the growth of IGF‑2‑dependent tumors...
October 5, 2017: International Journal of Molecular Medicine
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