Hai Huang, Junkoo Yi, Song Park, Haibo Zhang, Eungyung Kim, Sijun Park, Wookbong Kwon, Soyoung Jang, Xiujuan Zhang, Hanyong Chen, Seong-Kyoon Choi, Sung-Hyun Kim, Kangddong Liu, Zigang Dong, Mee-Hyun Lee, Zaeyoung Ryoo, Myoung Ok Kim
Melanoma is the most common type of skin cancer and its incidence is rapidly increasing. AKT, and its related signaling pathways, are highly activated in many cancers including lung, colon, and esophageal cancers. Costunolide (CTD) is a sesquiterpene lactone that has been reported to possess neuroprotective, anti-inflammatory, and anti-cancer properties. However, the target and mechanism underlying its efficacy in melanoma have not been identified. In this study, we elucidated the mechanism behind the anti-cancer effect of CTD in melanoma in vitro and in vivo by identifying CTD as an AKT inhibitor...
2021: American Journal of Cancer Research