Alexandre M Sorlin, Marina López-Álvarez, Sarah J Rabbitt, Aryn A Alanizi, Rebecca Shuere, Kondapa Naidu Bobba, Joseph Blecha, Sasank Sakhamuri, Michael J Evans, Kenneth W Bayles, Robert R Flavell, Oren S Rosenberg, Renuka Sriram, Tom Desmet, Bernd Nidetzky, Joanne Engel, Michael A Ohliger, James S Fraser, David M Wilson
Chemoenzymatic techniques have been applied extensively to pharmaceutical development, most effectively when routine synthetic methods fail. The regioselective and stereoselective construction of structurally complex glycans is an elegant application of this approach, that is seldom applied to positron emission tomography (PET) tracers. We sought a method to dimerize 2-deoxy-[ 18 F]-fluoro-D-glucose ([ 18 F]FDG), the most common tracer used in clinical imaging, to form [ 18 F]-labeled disaccharides for detecting microorganisms in vivo based on their bacteria-specific glycan incorporation...
May 20, 2023: bioRxiv