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Discitis AND Pet

A M McGauvran, A L Kotsenas, F E Diehn, J T Wald, C M Carr, J M Morris
BACKGROUND AND PURPOSE: Imaging findings in patients with a combination of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) are often misinterpreted as discitis/osteomyelitis or metastases, resulting in multiple biopsies and delayed diagnosis. We have incidentally noted a semicircular morphology in vertebral body imaging in several cases of SAPHO syndrome with vertebral involvement. Our goal was to evaluate the prevalence of this distinctive morphology in these patients...
August 2016: AJNR. American Journal of Neuroradiology
Tahir Wissanji, Olivier Fouard, Dominique Herman, Philippe Hermans, Christophe Vindevogel
A 52-year-old man was admitted in the emergency department for deteriorating mental status and suspicion of discitis. Computed tomography and positron emission tomography scan showed evidence of localized infection of the aortic bifurcation and blood cultures were positive for Staphylococcus aureus. Ten years ago, the patient underwent placement of covered metal stents on each common iliac artery due to arteritic stenosis. The infected material was removed and aortic bifurcation repaired using an autologous femoral vein graft...
April 2016: Annals of Vascular Surgery
A S Khorsandi, H K Su, W F Mourad, M L Urken, M S Persky, C L Lazarus, A S Jacobson
OBJECTIVE: To study MRI and positron emission tomography (PET)/CT imaging of osteoradionecrosis (ORN) of the subaxial cervical spine, a serious long-term complication of radiation therapy (RT) for head and neck cancers that can lead to pain, vertebral instability, myelopathy and cord compression. METHODS: This is a single-institution retrospective review of patients diagnosed and treated for ORN of the subaxial cervical spine following surgery and radiation for head and neck cancer...
January 2015: British Journal of Radiology
M Revest, S Patrat-Delon, A Devillers, P Tattevin, C Michelet
The diagnosis of some infectious diseases is sometimes difficult to make and new diagnostic tools have been regularly assessed to that end. 18fluoro-deoxyglucose ((18)FDG) positron-emission tomography (PET) coupled with computed tomography (CT) is one of these new procedures. It has been evaluated for numerous infectious diseases with uneven results. A literature review allowed drawing some conclusions. First, (18)FDG-PET/CT is not currently a first-line procedure for infectious diseases. Second, it has proved useful for the evaluation of patients presenting with fever of unknown origin (FUO)...
June 2014: Médecine et Maladies Infectieuses
R Ghermandi, A Mesfin, S Terzi, S Colangeli, E Zamparini, A Gasbarrini
Familial dysautomonia (FD, or Riley-Day syndrome) is a rare but fatal autosomal recessive peripheral neuropathy caused by a point mutation in I-κ-B kinase complex associated protein (IKBCAP) gene. The disease, that affects primarily people of Ashkenazi Jewish origin, prejudices the development of primary sensory neurons determining depletion of autonomic and sensory neurons. Musculoskeletal problems include: spinal deformities, foot deformities, fractures and arthopathies. In this article we review a case of a 34 years old male of non-Jewish origin affected by FD presenting L2-L3 kyphosis and inability to walk due to chronic L2-L3 spondylodiscitis not surgically treated 14 years before as acute disease...
2014: European Review for Medical and Pharmacological Sciences
P Jutte, E Lazzeri, L M Sconfienza, V Cassar-Pullicino, A Trampuz, N Petrosillo, A Signore
Infections of the bone, spine and prosthetic joints are serious and complex conditions to diagnose and to treat. Structured diagnostic workup may very well improve the accuracy and speed of diagnosis, thereby improving the outcome since treatment may very well be more successful and less harmful if timely management is started. Literature shows no uniform advise on diagnosis. The EANM organized a consensus meeting with representatives from the involved disciplines in order to develop common flowcharts for the diagnosis of osteomyelitis, spondylodiscitis and prosthetic joint infections...
March 2014: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Michael L Prodromou, Panayiotis D Ziakas, Loukia S Poulou, Petros Karsaliakos, Loukas Thanos, Eleftherios Mylonakis
PURPOSE: Spondylodiscitis is a rare infectious entity that requires multimodal diagnostic procedures. We evaluated the diagnostic performance of 18F-FDG PET on suspected spondylodiscitis based on published literature. PATIENTS AND METHODS: We searched the PubMed and EMBASE for pertinent studies up to July 2013. We implemented a patient-based meta-analysis of diagnostic data for FDG PET (the index test) against clinical, laboratory, and/or radiologic evidence of disease (the reference standard)...
April 2014: Clinical Nuclear Medicine
Stefan Hungenbach, Karl-Stefan Delank, Markus Dietlein, Peer Eysel, Alexander Drzezga, Matthias C Schmidt
BACKGROUND: Infections of the spine are rare and often discovered late, but they can have a severe outcome with hospital case fatality rates of up to 17%. Efficient and early diagnosis is important, because early diagnosis and therapy improve outcome. The aim of the current study was to evaluate the clinical value of F-fluorodeoxyglucose (18F-FDG) uptake pattern in PET as a diagnostic modality for the detection of spondylodiscitis. MATERIALS AND METHODS: 18F-FDG-PET examinations of the spine were performed in 42 patients with suspected spondylodiscitis...
November 2013: Nuclear Medicine Communications
A Skanjeti, D Penna, A Douroukas, A Cistaro, V Arena, G Leo, G Longo, A Traverso, S Belloro, E Pelosi
AIM: The role of 18F-fluorodeoxyglucose-positron-emission tomography (FDG-PET) in the clinical management of patients with inflammatory diseases (e.g., chronic inflammatory diseases, fever of unknown origin, ostemyelitis, prosthesis infections) is still under investigation. The aim of the present study was to evaluate the usefulness of PET in the diagnostic work-up of patients with spondylodiscitis and to compare it with magnetic resonance imaging (MRI). METHODS: This retrospective study included 33 patients with suspected/confirmed spondylodiscitis...
December 2012: Quarterly Journal of Nuclear Medicine and Molecular Imaging
David Fuster, Oriol Solà, Alex Soriano, Anna Monegal, Xavier Setoain, Xavier Tomás, Sebastià Garcia, Josep Mensa, Domenico Rubello, Francesca Pons
PURPOSE: This study aimed to prospectively evaluate the usefulness of PET/CT using F-FDG in comparison to bone scan and Ga in the diagnosis of spondylodiskitis. MATERIAL AND METHODS: This prospective study included 34 patients (15 women and 19 men) aged 59 (18) years with clinical symptoms of spondylodiskitis. Whole-body PET/CT and bone scan combined with planar and SPECT/CT Ga was performed in all patients. Diagnosis of spondylodiskitis was made by microbiology and/or on the basis of clinical and laboratory findings and imaging follow-up...
September 2012: Clinical Nuclear Medicine
Cristina Nanni, Luca Boriani, Caterina Salvadori, Eleonora Zamparini, Giada Rorato, Valentina Ambrosini, Alessandro Gasbarrini, Fabio Tumietto, Francesco Cristini, Luigia Scudeller, Stefano Boriani, Pierluigi Viale, Stefano Fanti
PURPOSE: Antibiotic therapy in patients affected by discitis is often empirical. Therefore, early evaluation of response to therapy is important. In many patients inflammatory indexes are low during all the phases of the diseases or are altered by concomitant diseases. The aim of the study was to assess the possible role of FDG PET/CT for the early evaluation of response to therapy in patients affected by infective discitis, in comparison to C-reactive protein (CRP) serum levels. METHODS: Enrolled in the study were 38 patients diagnosed with haematogenous infective discitis...
October 2012: European Journal of Nuclear Medicine and Molecular Imaging
G Treglia, C Focacci, C Caldarella, M V Mattoli, M Salsano, S Taralli, A Giordano
BACKGROUND: The diagnosis of spondylodiscitis can be difficult, because the patients history, subjective symptoms and physical findings are often inconclusive, particularly in the early stages. AIM: To perform an overview on the role of nuclear medicine procedures with single photon emission tomography (SPET) and positron emission tomography (PET) tracers in the diagnosis of spondylodiscitis. MATERIALS AND METHODS: A literature review about bone scintigraphy, Gallium-67-citrate scintigraphy, labeled leukocytes scintigraphy and PET was performed...
April 2012: European Review for Medical and Pharmacological Sciences
T Seifen, L Rettenbacher, C Thaler, J Holzmannhofer, M Mc Coy, C Pirich
OBJECTIVE: This study aimed at investigating the diagnostic value of ¹⁸F-FDG PET/CT in cases of suspected spondylodiscitis after inconclusive results in initial diagnostic imaging. PATIENTS, METHODS: We analysed 38 consecutive cases of suspected spondylodiscitis (mean age: 67 ± 14 years) with chronic back pain referred to our Department during a four-year-period after inconclusive results in MRI or other conventional modalities. Clinical histories were retrospectively worked up and results of ¹⁸F-FDG PET/CT and MRI were analysed and related to the results of biopsy, blood culture and a one-year clinical follow-up...
2012: Nuklearmedizin. Nuclear Medicine
Alberto Di Martino, Nicola Papapietro, Angela Lanotte, Fabrizio Russo, Gianluca Vadalà, Vincenzo Denaro
BACKGROUND: Spinal infections are an important clinical problem that often require aggressive medical therapy, and sometimes even surgery. Known risk factors are advanced age, diabetes mellitus, rheumatoid arthritis, immunosuppression, alcoholism, long-term steroid use, concomitant infections, poly-trauma, malignant tumor, and previous surgery or invasive procedures (discography, chemonucleolysis, and surgical procedures involving or adjacent to the intervertebral disc space). The most common level of involvement is at the lumbar spine, followed by the thoracic, cervical and sacral levels: lesions at the thoracic spine tend to lead more frequently to neurological symptoms...
May 2012: Current Medical Research and Opinion
Fidel J Vos, Bart Jan Kullberg, Patrick D Sturm, Paul F M Krabbe, Arie P J van Dijk, Geert J A Wanten, Wim J G Oyen, Chantal P Bleeker-Rovers
Early detection of metastatic infection in patients with Gram-positive bacteremia is important as morbidity and mortality are higher in the presence of these foci, probably due to incomplete eradication of clinically silent foci during initial treatment. We performed a prospective study in 115 patients with Staphylococcus aureus or Streptococcus species bacteremia with at least 1 risk factor for the development of metastatic foci, such as community acquisition, treatment delay, persistently positive blood cultures for >48 hours, and persistent fever >72 hours after initiation of treatment...
March 2012: Medicine (Baltimore)
Andor W J M Glaudemans, Ana Maria Quintero, Alberto Signore
No abstract text is available yet for this article.
May 2012: European Journal of Nuclear Medicine and Molecular Imaging
Enrique Guerado, Ana María Cerván
CONCEPT: Spondylodiscitis refers to an infection affecting the intervertebral disk, the vertebral body or the posterior arch of the vertebra being aetiologically, pyogenic, granulomatous (tuberculosis, brucellosis, or fungal infection) or parasitic. DIAGNOSIS: Spondylodiscitis diagnosis is based on clinical symptoms, a combination of erythrocyte sedimentation rate with C-reactive protein (CRP) tests and, less useful, leukocytosis. Blood culture is also a very cost-effective method of identifying organisms...
February 2012: International Orthopaedics
W Y Cheung, Keith D K Luk
Pyogenic spondylitis is a neurological and life threatening condition. It encompasses a broad range of clinical entities, including pyogenic spondylodiscitis, septic discitis, vertebral osteomyelitis, and epidural abscess. The incidence though low appears to be on the rise. The diagnosis is based on clinical, radiological, blood and tissue cultures and histopathological findings. Most of the cases can be treated non-operatively. Surgical treatment is required in 10-20% of patients. Anterior decompression, debridement and fusion are generally recommended and instrumentation is acceptable after good surgical debridement with postoperative antibiotic cover...
February 2012: International Orthopaedics
A Gasbarrini, L Boriani, C Nanni, E Zamparini, G Rorato, R Ghermandi, C Salvadori, V Allegri, S Bandiera, G Barbanti-Brodano, S Colangeli, A Corghi, S Terzi, L Babbi, L Amendola, F Cristini, G Marinacci, F Tumietto, R Ciminari, M C Malaguti, E Rimondi, M Difiore, R Bacchin, F Facchini, J Frugiuele, A Morigi, U Albisinni, S Bonarelli, S Fanti, P Viale, S Boriani
Spine infections require a multidisciplinary approach to be treated and solved. A guide line to drive physicians in the deep complexity of such a disease is extremely helpful. SIMP suggests a flow-chart built up on clear concepts such as right and well managed antibiotic therapy, sound stability of the spine, correct and smart use of the standard and functional imaging techniques, such as f18 FDG PET/CT. In 16 months a total of 41 patients have been treated for spondylodiscitis, discitis and vertebral osteomyelitis by our team of physicians and 25 patients have been enrolled in a prospective study whose target is the assessment of the SIMP flow-chart and of every single aspect that characterize it...
January 2011: International Journal of Immunopathology and Pharmacology
M Fisk, L F Peck, K Miyagi, M J Steward, S F Lee, M B Macrae, S Morris-Jones, A I Zumla, D J B Marks
No abstract text is available yet for this article.
February 2012: QJM: Monthly Journal of the Association of Physicians
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