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https://www.readbyqxmd.com/read/28436681/psychometric-validation-of-the-geriatric-suicide-ideation-scale-gsis-among-older-adults-with-bipolar-disorder
#1
Norm O'Rourke, Marnin J Heisel, Sarah L Canham, Andrew Sixsmith, Hamed Yaghoubi-Shahir, David B King
OBJECTIVES: Across age groups, bipolar disorder (BD) carries the greatest risk of death by suicide of all psychiatric conditions; 25%-50% of those with BD will make one or more suicide attempt. Psychometrically sound instruments are required to reliably measure suicide ideation and risk of self-harm for older adults with BD. For this study, we validate the geriatric suicide ideation scale (GSIS) with adults 50+ years with BD. METHODS: We recruited a global sample of 220 older adults with BD (M = 58...
April 24, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28428742/a-set-based-mixed-effect-model-for-gene-environment-interaction-and-its-application-to-neuroimaging-phenotypes
#2
Changqing Wang, Jianping Sun, Bryan Guillaume, Tian Ge, Derrek P Hibar, Celia M T Greenwood, Anqi Qiu
Imaging genetics is an emerging field for the investigation of neuro-mechanisms linked to genetic variation. Although imaging genetics has recently shown great promise in understanding biological mechanisms for brain development and psychiatric disorders, studying the link between genetic variants and neuroimaging phenotypes remains statistically challenging due to the high-dimensionality of both genetic and neuroimaging data. This becomes even more challenging when studying gene-environment interaction (G×E) on neuroimaging phenotypes...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28421479/understanding-medical-students-experience-with-stress-and-its-related-constructs-a-focus-group-study-from-singapore
#3
Julia Farquhar, Desiree Lie, Angelique Chan, Mandy Ow, Arpana Vidyarthi
OBJECTIVE: In order to protect medical students from burnout and its untoward psychiatric effects, it is imperative to understand their stress, burnout, coping, and resilience experiences. This study aimed to derive collective definitions from the medical student perspective, to identify common themes of students' experiences, and to distinguish pre-clinical and clinical year students' experiences relating to these four constructs. METHODS: The authors conducted focus groups of medical students in Singapore across 4 years using a semi-structured question guide...
April 18, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28414133/complexity-of-weighted-graph-a-new-technique-to-investigate-structural-complexity-of-brain-activities-with-applications-to-aging-and-autism
#4
Mehran Ahmadlou, Hojjat Adeli
In recent years complexity of the brain structure in healthy and disordered subjects has been studied increasingly. But to the best of the authors' knowledge, researchers so far have investigated the structural complexity only in the context of two restricted networks known as Small-World and Scale-free networks; whereas other aspects of the structural complexity of brain activities may be affected by aging and neurodegenerative disorders such as the Alzheimer's disease and autism spectrum disorder. In this study, two general complexity metrics of graphs, Graph Index Complexity and Offdiagonal Complexity are proposed as general measures of complexity, not restricted to SWN only...
April 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28413369/evaluation-of-quality-indicators-of-integrated-care-in-a-regional-psychiatry-budget-a-pre-post-comparison-by-secondary-data-analysis
#5
Anne Berghöfer, Svenja Hubmann, Thomas Birker, Torsten Hejnal, Felix Fischer
The Regional Psychiatry Budget (RPB), as a special arrangement within the German Federal Hospital Refund Regulation, is based on the capitation principle. A lump sum is allocated to a major inpatient care provider in a large region on a yearly basis. Under this model, the provider is free to offer all forms of treatment and to construct individual models of integrated care that specifically suit the region and the needs of community members. The present study aimed to evaluate selected aspects that represent a change in the psychiatric health status of patients in the covered region under the conditions of the RPB...
December 31, 2016: International Journal of Integrated Care
https://www.readbyqxmd.com/read/28407748/the-role-of-ethnicity-in-pathways-to-emergency-psychiatric-services-for-clients-with-psychosis
#6
Martin Rotenberg, Andrew Tuck, Rachel Ptashny, Kwame McKenzie
BACKGROUND: This study investigates the role of ethnicity in pathways to emergency mental health care in Toronto for clients with psychosis, while taking into account neighborhood factors. Previous literature has focused on Afro-Caribbean clients, reporting an increased risk of accessing mental health care through negative pathways. METHODS: A retrospective chart review for clients from 6 different ethnic origin groups presenting with psychosis - East Asian, South Asian, Black African, Black Caribbean, White European, and White North American - was undertaken in a psychiatric emergency department (ED)...
April 13, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28401275/dimensionality-of-dsm-5-posttraumatic-stress-disorder-and-its-association-with-suicide-attempts-results-from-the-national-epidemiologic-survey-on-alcohol-and-related-conditions-iii
#7
Chiung M Chen, Young-Hee Yoon, Thomas C Harford, Bridget F Grant
BACKGROUND: Emerging confirmatory factor analytic (CFA) studies suggest that posttraumatic stress disorder (PTSD) as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) is best characterized by seven factors, including re-experiencing, avoidance, negative affect, anhedonia, externalizing behaviors, and anxious and dysphoric arousal. The seven factors, however, have been found to be highly correlated, suggesting that one general factor may exist to explain the overall correlations among symptoms...
April 11, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28395527/assessing-cognitive-related-disability-in-schizophrenia-reliability-validity-and-underlying-factors-of-the-evaluation-of-cognitive-processes-involved-in-disability-in-schizophrenia-scale
#8
Christine Passerieux, Virginie Bulot, Marie-Christine Hardy-Baylé, Paul Roux
PURPOSE: We have developed a new scale that assesses disability caused by cognitive impairments in schizophrenia, in order to evaluate the functional impact of schizophrenia and help the prescription of rehabilitation interventions. The aim of the study was to assess its psychometrical properties. MATERIALS AND METHODS: Mental healthcare professionals and relatives of individuals with schizophrenia developed and rated the evaluation of cognitive processes involved in disability in schizophrenia scale, which included 13 items...
April 11, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28388259/the-utility-of-mmpi-2-rf-scale-scores-in-the-differential-diagnosis-of-schizophrenia-and-major-depressive-disorder
#9
Tayla T C Lee, John R Graham, Paul A Arbisi
This study was designed to determine whether scores on selected Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) scales could be used to differentiate between individuals diagnosed with schizophrenia (SCZ) and major depressive disorder (MDD). The sample was drawn from 2 psychiatric inpatient hospitals and included data from 199 individuals with SCZ and 808 individuals with MDD. A series of multivariate analyses of variance, analyses of variance, and odds ratios were calculated to determine which MMPI-2-RF scales provide the best differentiation between individuals presenting with these 2 disorders...
April 7, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28386179/the-research-of-constructing-dynamic-cognition-model-based-on-brain-network
#10
Fang Chunying, Li Haifeng, Ma Lin
Estimating the functional interactions and connections between brain regions to corresponding process in cognitive, behavioral and psychiatric domains is a central pursuit for understanding the human connectome. Few studies have examined the effects of dynamic evolution on cognitive processing and brain activation using brain network model in scalp electroencephalography (EEG) data. Aim of this study was to investigate the brain functional connectivity and construct dynamic programing model from EEG data and to evaluate a possible correlation between topological characteristics of the brain connectivity and cognitive evolution processing...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28384524/reliability-and-validity-of-the-dsm-5-anxious-distress-specifier-interview
#11
Mark Zimmerman, Heather Clark, Patrick McGonigal, Lauren Harris, Carolina Guzman Holst, Jacob Martin
BACKGROUND: To acknowledge the clinical significance of anxiety in depressed patients, DSM-5 included an anxious distress specifier for major depressive disorder (MDD). In the present report we describe the reliability and validity of a semi-structured interview assessing the features of the anxious distress specifier. Our goal was to develop an instrument that could be used for both diagnostic and outcome measurement purposes. METHODS: One hundred seventy-three psychiatric patients with MDD were interviewed by a trained diagnostic rater who administered the Structured Clinical Interview for DSM-IV (SCID) supplemented with questions from the DSM-5 Anxious Distress Specifier Interview (DADSI)...
March 2, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28381230/validation-of-the-world-health-organization-disability-assessment-schedule-in-people-with-severe-mental-disorders-in-rural-ethiopia
#12
Kassahun Habtamu, Atalay Alem, Girmay Medhin, Abebaw Fekadu, Michael Dewey, Martin Prince, Charlotte Hanlon
BACKGROUND: The World Health Organization Disability Assessment Schedule (WHODAS-2.0) has been adapted and validated in several cultures, but data on performance in the African context are lacking. The aim of the study was to evaluate the validity and psychometric properties of the WHODAS-2.0 among people with severe mental disorders (SMD) and their caregivers in a rural African setting. METHODS: The content validity of the 36 item WHODAS was assessed using free listing and pile sorting in 36 community members...
April 5, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28377991/animal-models-in-psychiatric-research-the-rdoc-system-as-a-new-framework-for-endophenotype-oriented-translational-neuroscience
#13
REVIEW
Elmira Anderzhanova, Thomas Kirmeier, Carsten T Wotjak
The recently proposed Research Domain Criteria (RDoC) system defines psychopathologies as phenomena of multilevel neurobiological existence and assigns them to 5 behavioural domains characterizing a brain in action. We performed an analysis on this contemporary concept of psychopathologies in respect to a brain phylogeny and biological substrates of psychiatric diseases. We found that the RDoC system uses biological determinism to explain the pathogenesis of distinct psychiatric symptoms and emphasises exploration of endophenotypes but not of complex diseases...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28374657/dsm-disorders-and-their-criteria-how-should-they-inter-relate
#14
K S Kendler
While the changes in psychiatric diagnosis introduced by Diagnostic and Statistical Manual third edition (DSM-III) have had major benefits to the field of psychiatry, the reification of its diagnostic criteria and the widespread adoption of diagnostic literalism have been problematic. I argue that, at root, these developments can be best understood by contrasting two approaches to the relationship between DSM disorders and their criteria. In a constitutive relationship, criteria definitively define the disorder...
April 4, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28373800/the-effects-of-occupational-therapy-and-psychosocial-interventions-on-interpersonal-functioning-and-personal-and-social-performance-levels-of-corresponding-patients
#15
Soner Çakmak, Hüzün Süt, Sibel Öztürk, Lut Tamam, Ufuk Bal
INTRODUCTION: In this study, we aimed to investigate the effects of occupational therapy and psychosocial interventions on the interpersonal functioning and individual and social performance levels of corresponding patients under the heading of psychosocial treatment approaches in psychiatry clinics as well as the attitudes of the patients in regard to those interventions. METHODS: In 2013, out of psychotic (schizophrenia, bipolar disorder/mania) and nonpsychotic (depression, obsessive compulsive disorder, alcohol dependence) inpatients in our clinic, 48 patients who participated in occupational activities were included in the study group and 43 patients who did not participate in these activities were included in the control group...
September 2016: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28367379/the-sensed-presence-questionnaire-senpq-initial-psychometric-validation-of-a-measure-of-the-sensed-presence-experience
#16
Joseph M Barnby, Vaughan Bell
BACKGROUND: The experience of 'sensed presence'-a feeling or sense that another entity, individual or being is present despite no clear sensory or perceptual evidence-is known to occur in the general population, appears more frequently in religious or spiritual contexts, and seems to be prominent in certain psychiatric or neurological conditions and may reflect specific functions of social cognition or body-image representation systems in the brain. Previous research has relied on ad-hoc measures of the experience and no specific psychometric scale to measure the experience exists to date...
2017: PeerJ
https://www.readbyqxmd.com/read/28362142/elucidating-the-association-between-the-self-harm-inventory-and-several-borderline-personality-measures-in-an-inpatient-psychiatric-sample
#17
Martin Sellbom, Randy A Sansone, Douglas A Songer
OBJECTIVE: The current study evaluated the utility of the self-harm inventory (SHI) as a proxy for and screening measure of borderline personality disorder (BPD) using several diagnostic and statistical manual of mental disorders (DSM)-based BPD measures as criteria. METHODS: We used a sample of 145 psychiatric inpatients, who completed the SHI and a series of well-validated, DSM-based self-report measures of BPD. RESULTS: Using a series of latent trait and latent class analyses, we found that the SHI was substantially associated with a latent construct representing BPD, as well as differentiated latent classes of 'high' vs...
March 31, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28353222/application-of-proteomic-techniques-for-improved-stratification-and-treatment-of-schizophrenia-patients
#18
Johann Steiner, Paul C Guest, Daniel Martins-de-Souza
For major psychiatric disorders such as schizophrenia, there have been shortcomings in the translation of scientific findings into new treatments and this has led to diminished interest for large pharmaceutical companies. This chapter describes how incorporation of proteomic approaches into the clinical pipeline can lead to identification and implementation of biomarker tests for improved patient characterization, prediction of treatment response and monitoring treatment effects to help revitalize efforts in this important area...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28350844/isolation-and-characterization-of-alternatively-spliced-variants-of-the-mouse-sigma1-receptor-gene-sigmar1
#19
Ling Pan, David A Pasternak, Jin Xu, Mingming Xu, Zhigang Lu, Gavril W Pasternak, Ying-Xian Pan
The sigma1 receptor acts as a chaperone at the endoplasmic reticulum, associates with multiple proteins in various cellular systems, and involves in a number of diseases, such as addiction, pain, cancer and psychiatric disorders. The sigma1 receptor is encoded by the single copy SIGMAR1 gene. The current study identifies five alternatively spliced variants of the mouse sigma1 receptor gene using a polymerase chain reaction cloning approach. All the splice variants are generated by exon skipping or alternative 3' or 5' splicing, producing the truncated sigma1 receptor...
2017: PloS One
https://www.readbyqxmd.com/read/28347350/the-association-between-age-of-onset-of-opioid-use-and-comorbidity-among-opioid-dependent-patients-receiving-methadone-maintenance-therapy
#20
Leen Naji, Brittany Burns Dennis, Monica Bawor, Michael Varenbut, Jeff Daiter, Carolyn Plater, Guillaume Pare, David C Marsh, Andrew Worster, Dipika Desai, James MacKillop, Lehana Thabane, Zainab Samaan
BACKGROUND: Opioid use disorder (OUD) affects approximately 21.9 million people worldwide. This study aims to determine the association between age of onset of opioid use and comorbid disorders, both physical and psychiatric, in patients receiving methadone maintenance treatment (MMT) for OUD. Understanding this association may inform clinical practice about important prognostic factors of patients on MMT, enabling clinicians to identify high-risk patients. METHODS: This study includes data collected between June 2011 and August 2016 for the Genetics of Opioid Addiction research collaborative between McMaster University and the Canadian Addiction Treatment Centers...
March 28, 2017: Addiction Science & Clinical Practice
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