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https://www.readbyqxmd.com/read/29218388/correlation-of-sociodemographic-and-clinical-parameters-with-depression-and-distress-in-patients-with-hematologic-malignancies
#1
Amanda J Shreders, Shehzad K Niazi, David O Hodge, Nicolette T Chimato, Megha Kureti, Navya Kirla, Ankit Agrawal, Abhisek Swaika, Elaine Gustetic, Renee Foster, Kimberly A Nelson, Prachi Jani, Asher A Chanan-Khan, Sikander Ailawadhi
A quarter of cancer patients struggle with distress or depression during their illness. Multiple organizations including the National Comprehensive Cancer Network recommend universal screening for distress and depression. Herein, we describe a universal screening program in patients with hematologic malignancies and factors associated with distress and depression. Between December 2013 and February 2015, patients with hematologic malignancies took the Patient Health Questionnaire 9 (PHQ-9) and Distress Thermometer (DT) prior to receiving their first outpatient parenteral chemotherapy...
December 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29217835/bayesian-prediction-intervals-for-assessing-p-value-variability-in-prospective-replication-studies
#2
Olga Vsevolozhskaya, Gabriel Ruiz, Dmitri Zaykin
Increased availability of data and accessibility of computational tools in recent years have created an unprecedented upsurge of scientific studies driven by statistical analysis. Limitations inherent to statistics impose constraints on the reliability of conclusions drawn from data, so misuse of statistical methods is a growing concern. Hypothesis and significance testing, and the accompanying P-values are being scrutinized as representing the most widely applied and abused practices. One line of critique is that P-values are inherently unfit to fulfill their ostensible role as measures of credibility for scientific hypotheses...
December 8, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29215901/introduction-of-the-dsm-5-levels-of-personality-functioning-questionnaire
#3
Steven K Huprich, Sharon M Nelson, Kevin B Meehan, Caleb J Siefert, Gregory Haggerty, James Sexton, V Barry Dauphin, Matthew Macaluso, Jennifer Jackson, Rosey Zackula, Lyle Baade
With the introduction in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) of a hybrid system of personality disorder assessment, the ability to assess patients' traits, as well as their level of personality functioning, has become increasingly important. To assess this criterion, the DSM-5 Levels of Personality Functioning Questionnaire (DLOPFQ) was developed. The DLOPFQ assesses individuals' self-impairments and other impairments in several domains (self-direction, identity, empathy, and intimacy) and across 2 contexts (work/school and relationships)...
December 7, 2017: Personality Disorders
https://www.readbyqxmd.com/read/29215805/development-of-the-suicide-risk-scale-for-medical-inpatients
#4
Sang Won Park, Jong Ha Lee, Eun Kyoung Lee, Jae Jun Song, Hong Seok Park, Soon Young Hwang, Moon Soo Lee
BACKGROUND: Inpatient suicide is one of the major issues related with hospital patient safety. Although there are many studies addressing suicide in the psychiatric unit, little is known about suicide in a medical setting. This study included the development and validation of a screening tool for the assessment of suicide risk, specialized for medical inpatients. METHODS: The preliminary questionnaire was based on review of previous suicide ideation scales, mood scales, and clinical experiences of psychiatrists and clinical psychologists in Korea...
January 15, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29203264/identification-of-genes-regulating-gabaergic-interneuron-maturation
#5
Keita Fukumoto, Kota Tamada, Tsuyoshi Toya, Tasuku Nishino, Yuchio Yanagawa, Toru Takumi
During embryonic development, GABAergic interneurons, a main inhibitory component in the cerebral cortex, migrate tangentially from the ganglionic eminence (GE) to cerebral cortex. After reaching the cerebral cortex, they start to extend their neurites for constructing local neuronal circuits around the neonatal stage. Aberrations in migration or neurite outgrowth are implicated in neurological and psychiatric disorders such as epilepsy, schizophrenia and autism. Previous studies revealed that in the early phase of cortical development the neural population migrates tangentially from the GE in the telencephalon and several genes have been characterized as regulators of migration and specification of GABAergic interneurons...
December 1, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29195773/cognitive-deficits-in-bipolar-disorders-implications-for-emotion
#6
REVIEW
Isabela M M Lima, Andrew D Peckham, Sheri L Johnson
Prominent cognitive deficits have been documented in bipolar disorder, and multiple studies suggest that these deficits can be observed among non-affected first-degree relatives of those with bipolar disorder. Although there is variability in the degree of cognitive deficits, these deficits are robustly relevant for functional outcomes. A separate literature documents clear difficulties in emotionality, emotion regulation, and emotion-relevant impulsivity within bipolar disorder, and demonstrates that these emotion-relevant variables are also central to outcome...
November 21, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29195597/organizational-readiness-for-change-orc-test-used-in-the-implementation-of-assessment-instruments-and-treatment-methods-in-a-swedish-national-study
#7
Johan Billsten, Mats Fridell, Robert Holmberg, Andréas Ivarsson
Organizational climate and related factors are associated with outcome and are as such of vital interest for healthcare organizations. Organizational Readiness for Change (ORC) is the questionnaire used in the present study to assess the influence of organizational factors on implementation success. The respondents were employed in one of 203 Swedish municipalities within social work and psychiatric substance/abuse treatment services. They took part in a nationwide implementation project organized by the Swedish Association of Local Authorities and Regions (SALAR), commissioned by the Swedish National Board of Health and Welfare...
January 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29194697/observed-interactions-in-families-of-adolescent-suicide-attempters
#8
Christine S Aiken, Barry M Wagner, J Benjamin Hinnant
Family interactions of 71 adolescents hospitalized following a suicide attempt were compared with those of 29 psychiatric controls, using observational methods and a 2-year prospective, longitudinal design. Parent-adolescent dyadic interactions were coded for emotional validation and invalidation, and problem-solving constructiveness. There were no between-group differences for parents. However, adolescents who had attempted suicide displayed more emotional invalidation than controls. Within the suicide attempt group, maternal constructive problem solving predicted greater declines in youth suicide ideation, and a similar trend was observed for fathers...
December 1, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29187730/genome-wide-analysis-in-uk-biobank-identifies-four-loci-associated-with-mood-instability-and-genetic-correlation-with-major-depressive-disorder-anxiety-disorder-and-schizophrenia
#9
Joey Ward, Rona J Strawbridge, Mark E S Bailey, Nicholas Graham, Amy Ferguson, Donald M Lyall, Breda Cullen, Laura M Pidgeon, Jonathan Cavanagh, Daniel F Mackay, Jill P Pell, Michael O'Donovan, Valentina Escott-Price, Daniel J Smith
Mood instability is a core clinical feature of affective and psychotic disorders. In keeping with the Research Domain Criteria approach, it may be a useful construct for identifying biology that cuts across psychiatric categories. We aimed to investigate the biological validity of a simple measure of mood instability and evaluate its genetic relationship with several psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD), schizophrenia, attention deficit hyperactivity disorder (ADHD), anxiety disorder and post-traumatic stress disorder (PTSD)...
November 30, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29183829/the-rodent-versus-wild-snake-paradigm-as-a-model-for-studying-anxiety-and-panic-like-behaviors-face-construct-and-predictive-validities
#10
Tatiana Paschoalin-Maurin, Tayllon Dos Anjos-Garcia, Luiz Luciano Falconi-Sobrinho, Renato Leonardo de Freitas, Jade Pissamiglio Cysne Coimbra, Carlos Júlio Laure, Norberto Cysne Coimbra
Using an innovative approach to study the neural bases of psychiatric disorders, this study investigated the behavioral, morphological and pharmacological bases of panic attack-induced responses in a prey-versus-coral snake paradigm. Mesocricetus auratus was chronically treated with intraperitoneal administration of the selective serotonin uptake inhibitor paroxetine or the gamma aminobutyric acid (GABA)/benzodiazepine receptor agonist alprazolam at three different doses and were then confronted with a venomous coral snake (Micrurus frontalis, Reptilia, Colubridae)...
November 25, 2017: Neuroscience
https://www.readbyqxmd.com/read/29183418/defending-psychiatry-or-defending-the-trivial-effects-of-therapeutic-interventions-a-citation-content-analysis-of-an-influential-paper
#11
I A Cristea, F Naudet
AIMS: Leucht et al. in 2012 described an overview of meta-analyses of the efficacy of medication in psychiatry and general medicine, concluding that psychiatric drugs were not less efficacious than other drugs. Our goal was to explore the dissemination of this highly cited paper, which combined a thought provoking message with a series of caveats. METHODS: We conducted a prospectively registered citation content analysis. All papers published before June 1st citing the target paper were independently rated by two investigators...
November 29, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29179570/a-narrow-view-the-conceptualization-of-sexual-problems-in-human-sexuality-textbooks
#12
Monika Stelzl, Brittany Stairs, Hannah Anstey
This study examined the ways in which the meaning of 'sexual problems' is constructed and defined in undergraduate human sexuality textbooks. Drawing on feminist and critical discourse frameworks, the dominant as well as the absent/marginalized discourses were identified using critical discourse analysis. Sexual difficulties were largely framed by the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders. Thus, medical discourse was privileged. Alternative conceptualizations and frameworks, such as the New View of Women's Sexual Problems, were included marginally and peripherally...
November 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/29179142/the-relationship-of-person-specific-eveningness-chronotype-greater-seasonality-and-less-rhythmicity-to-suicidal-behavior-a-literature-review
#13
REVIEW
Meredith E Rumble, Daniel Dickson, W Vaughn McCall, Andrew D Krystal, Doug Case, Peter B Rosenquist, Ruth M Benca
BACKGROUND: Epidemiological data have demonstrated seasonal and circadian patterns of suicidal deaths. Several reviews and meta-analyses have confirmed the relationship between sleep disturbance and suicidality. However, these reviews/meta-analyses have not focused on seasonal and circadian dysfunction in relation to suicidality, despite the common presence of this dysfunction in patients with mood disorders. Thus, the current literature review analyzed studies investigating person-specific chronotype, seasonality, and rhythmicity in relation to suicidal thoughts and behaviors...
November 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29173570/-refusal-of-care-by-a-hiv-positive-adolescent-role-of-the-cross-cultural-approach
#14
Nora Bouaziz, Alice Titia Rizzi
The refusal of treatment is frequent in human immunodeficiency virus-positive adolescents. The clinical history of a teenage girl presenting severe immunodepression secondary to the virus, a depressive disorder and a refusal of treatment, illustrates the benefit of combined paediatric, child psychiatric and cross-cultural care as proposed by the Cochin-Paris Adolescent Centre. Working on the meaning of the refusal was a prerequisite for the construction of a care project forming part of a life project, as the psychopathological work could only begin once somatic care ensuring the patient's protection was in place...
November 2017: Soins. Psychiatrie
https://www.readbyqxmd.com/read/29173238/toward-a-two-dimensional-model-of-social-cognition-in-clinical-neuropsychology-a-systematic-review-of-factor-structure-studies
#15
Aurore Etchepare, Antoinette Prouteau
OBJECTIVE: Social cognition has received growing interest in many conditions in recent years. However, this construct still suffers from a considerable lack of consensus, especially regarding the dimensions to be studied and the resulting methodology of clinical assessment. Our review aims to clarify the distinctiveness of the dimensions of social cognition. METHOD: Based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements, a systematic review was conducted to explore the factor structure of social cognition in the adult general and clinical populations...
November 27, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29172600/what-features-of-psychopathy-might-be-central-a-network-analysis-of-the-psychopathy-checklist-revised-pcl-r-in-three-large-samples
#16
Bruno Verschuere, Sophia van Ghesel Grothe, Lourens Waldorp, Ashley L Watts, Scott O Lilienfeld, John F Edens, Jennifer L Skeem, Arjen Noordhof
Despite a wealth of research, the core features of psychopathy remain hotly debated. Using network analysis, an innovative and increasingly popular statistical tool, the authors mapped the network structure of psychopathy, as operationalized by the Psychopathy Checklist-Revised (PCL-R; Hare, 2003) in two large U.S. offender samples (nNIMH = 1559; nWisconsin = 3954), and 1 large Dutch forensic psychiatric sample (nTBS = 1937). Centrality indices were highly stable within each sample, and indicated that callousness/lack of empathy was the most central PCL-R item in the 2 U...
November 27, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29172592/non-suicidal-self-injury-and-suicidal-thoughts-and-behaviors-a-study-of-the-explanatory-roles-of-the-interpersonal-theory-variables-among-military-service-members-and-veterans
#17
Carol Chu, Melanie A Hom, Ian H Stanley, Anna R Gai, Matthew K Nock, Peter M Gutierrez, Thomas E Joiner
OBJECTIVE: Research has identified non-suicidal self-injury (NSSI) as a robust correlate of suicidal thoughts and behaviors; however, little is known regarding why these constructs may be related. Consistent with the interpersonal theory of suicide, this study investigated thwarted belongingness (TB), perceived burdensomeness (PB), and capability for suicide (CS) as explanatory links in the association between NSSI, ideation, and suicide attempt history. METHOD: Military service members and veterans (N = 973; agemean = 29...
November 27, 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29166349/developing-end-of-training-entrustable-professional-activities-for-psychiatry-results-and-methodological-lessons
#18
John Q Young, Caitlin Hasser, Erick H Hung, Martin Kusz, Patricia S O'Sullivan, Colin Stewart, Andrea Weiss, Nancy Williams
PURPOSE: To develop entrustable professional activities (EPAs) for psychiatry and to demonstrate an innovative, validity-enhancing methodology that may be relevant to other specialties. METHOD: A national task force employed a three-stage process from May 2014 to February 2017 to develop EPAs for psychiatry. In stage 1, the task force used an iterative consensus-driven process to construct proposed EPAs. Each included a title, full description, and relevant competencies...
November 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29164351/latent-class-symptom-profiles-of-selective-mutism-identification-and-linkage-to-temperamental-and-social-constructs
#19
Rachele Diliberto, Christopher A Kearney
Selective mutism (SM) is a stable, debilitating psychiatric disorder in which a child fails to speak in most public situations. Considerable debate exists as to the typology of this population, with empirically-based studies pointing to possible dimensions of anxiety, oppositionality, and communication problems, among other aspects. Little work has juxtaposed identified symptom profiles with key temperamental and social constructs often implicated in SM. The present study examined a large, diverse, non-clinical, international sample of children aged 6-10 years with SM to empirically identify symptom profiles and to link these profiles to key aspects of temperament (i...
November 21, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29159767/development-and-validation-of-the-health-of-the-nation-outcome-scales-residential-facility-honos-rf
#20
Laura Pedrini, Mariangela Lanfredi, Clarissa Ferrari, Sonia Andreose, Pasquale Basso, Rossella Beneduce, Rosaria Pioli, Luciana Rillosi, Giuseppe Rossi, Roberta Rossi, Giovanni Battista Tura
The Health of the Nation Outcome Scale (HoNOS) (Lora et al. Epidemiol Psichiatr Soc 10(3):198-212, 2001) is widely used. However, clinicians have expressed concerns about its ability to describe severe mentally ill patients, as it does not consider some relevant clinical aspects. This study aims to develop and validate the HoNOS-Residential Facility (HoNOS-RF) in order to pursue a thorough assessment of patients admitted to psychiatric residential facilities (RFs). The final version of the HoNOS-RF was administered to 409 patients admitted to four RFs...
November 21, 2017: Psychiatric Quarterly
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