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https://www.readbyqxmd.com/read/29351237/bioengineering-of-rfviia-biopharmaceutical-and-structure-characterization-for-biosimilarity-assessment
#1
Othman Montacir, Houda Montacir, Murat Eravci, Andreas Springer, Stephan Hinderlich, Fereidoun Mahboudi, Amirhossein Saadati, Maria Kristina Parr
Eptacog alfa (NovoSeven®) is a vitamin K-dependent recombinant Factor VIIa produced by genetic engineering from baby hamster kidney (BHK) cells as a single peptide chain of 406 residues. After activation, it consists of a light chain (LC) of 152 amino and a heavy chain (HC) of 254 amino acids. Recombinant FVIIa undergoes many post-translational modifications (PTMs). The first ten glutamic acids of the N-terminal moiety are γ-carboxylated, Asn145 and Asn322 are N-glycosylated, and Ser52 and Ser60 are O-glycosylated...
January 19, 2018: Bioengineering
https://www.readbyqxmd.com/read/29350949/collective-longitudinal-polarization-in-relativistic-heavy-ion-collisions-at-very-high-energy
#2
F Becattini, Iu Karpenko
We study the polarization of particles in relativistic heavy-ion collisions at very high energy along the beam direction within a relativistic hydrodynamic framework. We show that this component of the polarization decreases much slower with center-of-mass energy compared to the transverse component, even in the ideal longitudinal boost-invariant scenario with nonfluctuating initial state, and that it can be measured by taking advantage of its quadrupole structure in the transverse momentum plane. In the ideal longitudinal boost-invariant scenario, the polarization is proportional to the gradient of temperature at the hadronization and its measurement can provide important information about the cooling rate of the quark-gluon plasma around the critical temperature...
January 5, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29348734/energy-spectrum-and-dose-enhancement-due-to-the-depth-of-the-lipiodol-position-using-flattened-and-unflattened-beams
#3
Daisuke Kawahara, Shuichi Ozawa, Akito Saito, Tomoki Kimura, Tatsuhiko Suzuki, Masato Tsuneda, Sodai Tanaka, Kazunari Hioki, Takeo Nakashima, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
Aim: Lipiodol was used for stereotactic body radiotherapy combining trans arterial chemoembolization. Lipiodol used for tumour seeking in trans arterial chemoembolization remains in stereotactic body radiation therapy. In our previous study, we reported the dose enhancement effect in Lipiodol with 10× flattening-filter-free (FFF). The objective of our study was to evaluate the dose enhancement and energy spectrum of photons and electrons due to the Lipiodol depth with flattened (FF) and FFF beams...
January 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29348658/novel-multifunctional-cheese-like-3d-carbon-bn-as-a-highly-efficient-adsorbent-for-water-purification
#4
Zhenya Liu, Yi Fang, Huichao Jia, Chong Wang, Qianqian Song, Lanlan Li, Jing Lin, Yang Huang, Chao Yu, Chengchun Tang
In this paper, a novel three dimensional carbon boron nitride (3D C-BN) was successfully prepared. The obtained material has porous cheese-like structure and pore size ranging from 2 nm to 100 nm. Attractively, the 3D C-BN, which combines the adsorption advantages of BN and carbon together, exhibits excellent adsorption properties for organic dyes, oils and heavy metal ions. The maximum removal capacities of 3D C-BN for methyl blue (MB) and congo red (CR) are 408 mg g-1 and 307 mg g-1, respectively...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348639/evidence-of-local-structural-influence-on-the-shape-driven-magnetic-anisotropy-in-electronically-excited-ni-nanoparticles-embedded-in-sio2-matrix
#5
Debalaya Sarker, Saswata Bhattacharya, H Kumar, Pankaj Srivastava, Santanu Ghosh
The reliance of modern electronic era on ultrafast data recording has made the search for novel tools to tune nano-scale magnetic-anisotropy (MA) never-ending. We demonstrate a strong correlation between the spin-spin interactions, local atomic structure and the MA of Ni nanoparticles (NPs) embedded inside SiO2 matrix under swift heavy ion (SHI) irradiation. In contrast to traditional understandings, MA in Ni NPs along with their aspect ratio, first increases upto 5 × 1013 ions/cm2 SHI fluence (5e13) and gets reduced at highest fluence...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29346028/biophysics-model-of-heavy-ion-degradation-of-neuron-morphology-in-mouse-hippocampal-granular-cell-layer-neurons
#6
Murat Alp, Francis A Cucinotta
Exposure to heavy-ion radiation during cancer treatment or space travel may cause cognitive detriments that have been associated with changes in neuron morphology and plasticity. Observations in mice of reduced neuronal dendritic complexity have revealed a dependence on radiation quality and absorbed dose, suggesting that microscopic energy deposition plays an important role. In this work we used morphological data for mouse dentate granular cell layer (GCL) neurons and a stochastic model of particle track structure and microscopic energy deposition (ED) to develop a predictive model of high-charge and energy (HZE) particle-induced morphological changes to the complex structures of dendritic arbors...
January 18, 2018: Radiation Research
https://www.readbyqxmd.com/read/29345546/enhanced-biosorption-of-transition-metals-by-living-chlorella-vulgaris-immobilized-in-ca-alginate-beads
#7
Ashfaq Ahmad, A H Bhat, Azizul Buang
In this study freely suspended and Ca-alginate immobilized C. vulgaris cells were used for the biosorption of Fe(II), Mn(II), and Zn(II) ions, from the aqueous solution. Experimental data showed that biosorption capacity of algal cells was strongly dependent on the operational condition such as pH, initial metal ions concentration, dosages, contact time and temperature. The maximum biosorption of Fe(II) 43.43, Mn(II) 40.98 and Zn(II) 37.43 mg/g was achieved with Ca-alginate immobilized algal cells at optimum pH of 6...
January 18, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29343841/microdosimetric-modeling-of-biological-effectiveness-for-boron-neutron-capture-therapy-considering-intra-and-intercellular-heterogeneity-in-10b-distribution
#8
Tatsuhiko Sato, Shin-Ichiro Masunaga, Hiroaki Kumada, Nobuyuki Hamada
We here propose a new model for estimating the biological effectiveness for boron neutron capture therapy (BNCT) considering intra- and intercellular heterogeneity in 10B distribution. The new model was developed from our previously established stochastic microdosimetric kinetic model that determines the surviving fraction of cells irradiated with any radiations. In the model, the probability density of the absorbed doses in microscopic scales is the fundamental physical index for characterizing the radiation fields...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29341747/-3-1-d-quasiparticle-anisotropic-hydrodynamics-for-ultrarelativistic-heavy-ion-collisions
#9
Mubarak Alqahtani, Mohammad Nopoush, Radoslaw Ryblewski, Michael Strickland
We present the first comparisons of experimental data with phenomenological results from (3+1)D quasiparticle anisotropic hydrodynamics (aHydroQP). We compare particle spectra, average transverse momentum, and elliptic flow. The dynamical equations used for the hydrodynamic stage utilize aHydroQP, which naturally includes both shear and bulk viscous effects. The (3+1)D aHydroQP evolution obtained is self-consistently converted to hadrons using anisotropic Cooper-Frye freeze-out. Hadron production and decays are modeled using a customized version of therminator 2...
July 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29340401/a-nanopaper-based-artificial-tongue-a-ratiometric-fluorescent-sensor-array-on-bacterial-nanocellulose-for-chemical-discrimination-applications
#10
Samira Abbasi-Moayed, Hamed Golmohammadi, M Reza Hormozi-Nezhad
In the present study, a ratiometric fluorescent sensor array as an artificial tongue has been developed on a nanopaper platform for chemical discrimination applications. The bacterial cellulose (BC) nanopaper was utilized for the first time as a novel, flexible, and transparent substrate in the optical sensor arrays for developing high-performance artificial tongues. To fabricate this platform, the hydrophobic walls on the BC nanopaper substrates were successfully created using a laser printing technology. In addition, we have used the interesting photoluminescence (PL) properties of an immobilized ratiometric probe (carbon dot-Rhodamine B (CD-RhB) nanohybrids) on the nanopaper platform to improve the visual discrimination analysis...
January 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29339607/batch-and-fixed-bed-column-study-for-p-nitrophenol-methylene-blue-and-u-vi-removal-by-polyvinyl-alcohol-graphene-oxide-macroporous-hydrogel-bead
#11
Dan Chen, Jun Zhou, Hongyu Wang, Kai Yang
There is an increasing need to explore effective and clean approaches for hazardous contamination removal from wastewaters. In this work, a novel bead adsorbent, polyvinyl alcohol-graphene oxide (PVA-GO) macroporous hydrogel bead was prepared as filter media for p-nitrophenol (PNP), dye methylene blue (MB), and heavy metal U(VI) removal from aqueous solution. Batch and fixed-bed column experiments were carried out to evaluate the adsorption capacities of PNP, MB, and U(VI) on this bead. From batch experiments, the maximum adsorption capacities of PNP, MB, and U(VI) reached 347...
January 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29339227/a-novel-biphenolic-ligand-for-selective-mg2-and-zn2-ions-sensing-followed-by-colorimetric-spectroscopic-and-cell-imaging-methods
#12
Palanisamy Uma Maheswari, Duraisamy Renuga, H L Jeeva Kumari, Kandasamy Ruckmani
The (E)-2-((2-hydrohy-5-methylphenylimino) methyl) phenol ligand was synthesized. The receptor was characterized by IR, 1H and 13C NMR and CHN analysis. The ligand exhibits colorimetric and fluorometric sensing of Zn2+ and Mg2+ ions in semi-aqueous medium (DMSO-H2O). The receptor was tested with series of transition metal ions (Cr2+, Fe2+, Ni2+, Co2+, Cu2+, Zn2+) and heavy metal ions (Sn2+, Pd2+, Ce2+, Hg2+, Cd2+) and the essential human body elements like Ca2+, Mg2+, Na+ and K+ ions. The naked eye colorimetric sensing was absorbed only for Zn2+ and Mg2+...
January 12, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29335517/a-versatile-mof-based-trap-for-heavy-metal-ion-capture-and-dispersion
#13
Yaguang Peng, Hongliang Huang, Yuxi Zhang, Chufan Kang, Shuangming Chen, Li Song, Dahuan Liu, Chongli Zhong
Current technologies for removing heavy metal ions are typically metal ion specific. Herein we report the development of a broad-spectrum heavy metal ion trap by incorporation of ethylenediaminetetraacetic acid into a robust metal-organic framework. The capture experiments for a total of 22 heavy metal ions, covering hard, soft, and borderline Lewis metal ions, show that the trap is very effective, with removal efficiencies of >99% for single-component adsorption, multi-component adsorption, or in breakthrough processes...
January 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29335513/optimal-ranges-of-variables-for-an-effective-adsorption-of-lead-ii-by-the-agricultural-waste-pomelo-citrus-grandis-peels-using-doehlert-designs
#14
Xiao-Lan Yu, Yong He
The capacity of pomelo peels' adsorption on lead(II) from aqueous solutions without modifications was investigated and confirmed. Four variables in this study, pH, temperature, time and initial concentration of lead(II), significantly affected the adsorption rate of pomelo peels. The prediction model and optimal ranges of optimized variables were given by Doehlert designs, which made the selection of variables rapid, flexible and effortless to obtain an adsorption rate reaching 99.9% and 20 mg/L for initial lead(II) concentration, 3 for pH, 50 °C for temperature and 210 min for time was a choice...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335457/an-equation-of-state-meter-of-quantum-chromodynamics-transition-from-deep-learning
#15
Long-Gang Pang, Kai Zhou, Nan Su, Hannah Petersen, Horst Stöcker, Xin-Nian Wang
A primordial state of matter consisting of free quarks and gluons that existed in the early universe a few microseconds after the Big Bang is also expected to form in high-energy heavy-ion collisions. Determining the equation of state (EoS) of such a primordial matter is the ultimate goal of high-energy heavy-ion experiments. Here we use supervised learning with a deep convolutional neural network to identify the EoS employed in the relativistic hydrodynamic simulations of heavy ion collisions. High-level correlations of particle spectra in transverse momentum and azimuthal angle learned by the network act as an effective EoS-meter in deciphering the nature of the phase transition in quantum chromodynamics...
January 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29332797/electrodialytic-in-line-preconcentration-for-ionic-solute-analysis
#16
Shin-Ichi Ohira, Takayuki Yamasaki, Takumi Koda, Yuko Kodama, Kei Toda
Preconcentration is an effective way to improve analytical sensitivity. Many types of methods are used for enrichment of ionic solute analytes. However, current methods are batchwise and include procedures such as trapping and elution. In this manuscript, we propose in-line electrodialytic enrichment of ionic solutes. The method can enrich ionic solutes within seconds by quantitative transfer of analytes from the sample solution to the acceptor solution under an electric field. Because of quantitative ion transfer, the enrichment factor (the ratio of the concentration in the sample and to that in the obtained acceptor solution) only depends on the flow rate ratio of the sample solution to the acceptor solution...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29332280/hydrogeochemical-processes-and-influence-of-seawater-intrusion-in-coastal-aquifers-south-of-chennai-tamil-nadu-india
#17
G Kanagaraj, L Elango, S G D Sridhar, G Gowrisankar
Seawater intrusion promotes the salinity of groundwater, and it poses a great environmental impact on a global scale. The present study was carried out to determine the hydrogeochemical processes and influence of seawater intrusion in the coastal aquifers using geophysical, geochemical, and stable isotope techniques. The true resistivity value ranges from 0.5 to 8008.5 Ω-m which has been measured using vertical electrical sounding (VES) based on the Schlumberger method. About 33 groundwater samples were collected during post-monsoon (POM) (January 2012) and pre-monsoon (PRM) (June 2012) seasons from open and bore wells and were analyzed for major ions and stable isotopes...
January 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29330185/the-mgte-homolog-fici-acts-as-a-secondary-ferrous-iron-importer-in-shewanella-oneidensis-strain-mr-1
#18
Brittany D Bennett, Kaitlyn E Redford, Jeffrey A Gralnick
The transport of metals into and out of cells is necessary for the maintenance of appropriate intracellular concentrations. Metals are needed for incorporation into metalloproteins but become toxic at higher concentrations. Many metal transport proteins have been discovered in bacteria, including the Mg2+ transporter-E (MgtE) family of passive Mg2+/Co2+ cation-selective channels. Low sequence identity exists between members of the MgtE family, indicating that substrate specificity may differ among MgtE transporters...
January 12, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29329014/nanoadsorbents-based-on-conducting-polymer-nanocomposites-with-main-focus-on-polyaniline-and-its-derivatives-for-removal-of-heavy-metal-ions-dyes-a-review
#19
REVIEW
Ehsan Nazarzadeh Zare, Ahmad Motahari, Mika Sillanpää
Water contamination by toxic heavy metal ions and dyes remains a serious public health problem for humans, so attention on specific methods and technologies to remove heavy metal ions and dyes from wastewaters/aqueous solutions are desired. Numerous adsorbents have been reported for the removal of heavy metal ions/dyes from wastewaters/aqueous solutions. Polyaniline (PANI) and its derivatives, as conducting polymers, are good adsorbents to remove various kinds of heavy metal ions and dyes from wastewaters/aqueous solutions...
January 9, 2018: Environmental Research
https://www.readbyqxmd.com/read/29327161/effects-of-channel-blocking-on-information-transmission-and-energy-efficiency-in-squid-giant-axons
#20
Yujiang Liu, Yuan Yue, Yuguo Yu, Liwei Liu, Lianchun Yu
Action potentials are the information carriers of neural systems. The generation of action potentials involves the cooperative opening and closing of sodium and potassium channels. This process is metabolically expensive because the ions flowing through open channels need to be restored to maintain concentration gradients of these ions. Toxins like tetraethylammonium can block working ion channels, thus affecting the function and energy cost of neurons. In this paper, by computer simulation of the Hodgkin-Huxley neuron model, we studied the effects of channel blocking with toxins on the information transmission and energy efficiency in squid giant axons...
January 11, 2018: Journal of Computational Neuroscience
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