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Diabetes regeneration

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https://www.readbyqxmd.com/read/29782416/acellular-flowable-matrix-in-the-treatment-of-tunneled-or-cavity-ulcers-in-diabetic-feet-a-preliminary-report
#1
Ferdinando Campitiello, Manfredi Mancone, Angela Della Corte, Raffaella Guerniero, Silvestro Canonico
OBJECTIVE: The authors aimed to explore the feasibility and safety of an advanced, acellular, flowable wound matrix (FWM) in patients with diabetes-related cavity or tunnel lesions involving deep structures. METHODS: Patients with diabetic foot ulcers were hospitalized at the General and Geriatric Surgery Unit of the University of Campania in Naples, Italy, between March 2015 and December 2015. Twenty-three patients with tunneled or cavity ulcers were treated. The lesions were filled with the FWM...
June 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29776414/glp-i-secretion-in-healthy-and-diabetic-wistar-rats-in-response-to-aqueous-extract-of-momordica-charantia
#2
Gulzar Ahmad Bhat, Haseeb A Khan, Abdullah S Alhomida, Poonam Sharma, Rambir Singh, Bilal Ahmad Paray
BACKGROUND: Diabetes mellitus is one of the major global health disorders increasing at an alarming rate in both developed and developing countries. The objective of this study was to assess the effect of aqueous extract of Momordica charantia (AEMC) on fasting blood glucose (FBG), tissue glycogen, glycosylated haemoglobin, plasma concentrations of insulin and GLP-1 hormone (glucagon-like peptide 1) in healthy and diabetic wistar rats. METHODS: Male Wistar rats (both normal and diabetic) were treated with AEMC by gavaging (300 mg/kg body wt/day for 28 days)...
May 18, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29774455/semaphorin-3a-promotes-osteogenic-differentiation-of-bmsc-from-type-2-diabetes-mellitus-rats
#3
Qiao Qiao, Xiaoru Xu, Yingliang Song, Shuang Song, Wenzhong Zhu, Fenglan Li
Bone regeneration is impaired in patients with type 2 diabetes mellitus (T2DM), which leads to non-healing after bone loss. The decreased osteogenic capacity of bone mesenchymal stem cells (BMSCs) might be a main reason. Sema3A, as a powerful protein promoting osteocyte differentiation, shows potential for bone regeneration treatment. BMSCs may be a therapeutic solution. In this study, we divided BMSCs from T2DM rats (BMSCs-D) and normal rats (BMSCs-N), identified their ability to differentiate into different cell types...
May 17, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29770834/advances-in-drug-discovery-for-human-beta-cell-regeneration
#4
REVIEW
Esra Karakose, Courtney Ackeifi, Peng Wang, Andrew F Stewart
The numbers of insulin-secreting pancreatic beta cells are reduced in people with type 1 and type 2 diabetes. Driving beta cell regeneration in the pancreases of people with diabetes would be an attractive approach to reversing diabetes. While adult human beta cells have long been believed to be terminally differentiated and, therefore, irreversibly quiescent, it has become clear over recent years that this is not true. More specifically, both candidate and unbiased high-throughput screen approaches have revealed several classes of molecules that are clearly able to induce human beta cell proliferation...
May 16, 2018: Diabetologia
https://www.readbyqxmd.com/read/29770323/dental-mesenchymal-stem-cell-based-translational-regenerative-dentistry-from-artificial-to-biological-replacement
#5
REVIEW
Mona K Marei, Rania M El Backly
Dentistry is a continuously changing field that has witnessed much advancement in the past century. Prosthodontics is that branch of dentistry that deals with replacing missing teeth using either fixed or removable appliances in an attempt to simulate natural tooth function. Although such "replacement therapies" appear to be easy and economic they fall short of ever coming close to their natural counterparts. Complications that arise often lead to failures and frequent repairs of such devices which seldom allow true physiological function of dental and oral-maxillofacial tissues...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29769672/pancreas-regeneration
#6
REVIEW
Qiao Zhou, Douglas A Melton
The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone insulin. Human islets possess limited regenerative ability; loss of islet β-cells in diseases such as type 1 diabetes requires therapeutic intervention. The leading strategy for restoration of β-cell mass is through the generation and transplantation of new β-cells derived from human pluripotent stem cells. Other approaches include stimulating endogenous β-cell proliferation, reprogramming non-β-cells to β-like cells, and harvesting islets from genetically engineered animals...
May 2018: Nature
https://www.readbyqxmd.com/read/29764859/activation-of-nrf2-is-required-for-normal-and-chrebp%C3%AE-augmented-glucose-stimulated-%C3%AE-cell-proliferation
#7
Anil Kumar, Liora S Katz, Anna M Schulz, Misung Kim, Lee B Honig, Lucy Li, Bennett Davenport, Dirk Homann, Adolfo Garcia-Ocaña, Mark A Herman, Cole M Haynes, Jerry E Chipuk, Donald K Scott
Patients with both major forms of diabetes would benefit from therapies that increase β-cell mass. Glucose is a natural mitogen that drives adaptive β-cell mass expansion by promoting β-cell proliferation. We previously demonstrated that carbohydrate response element binding protein (ChREBPα) is required for glucose-stimulated β-cell proliferation, and that overexpression of ChREBPα amplifies the proliferative effect of glucose. Here we found that ChREBPα reprogrammed anabolic metabolism to promote proliferation...
May 15, 2018: Diabetes
https://www.readbyqxmd.com/read/29763605/inos-inhibits-hair-regeneration-in-obese-diabetic-ob-ob-mice
#8
Mari Sasaki, Shohei Shinozaki, Hironobu Morinaga, Masao Kaneki, Emi Nishimura, Kentaro Shimokado
Previous studies have shown that androgenic alopecia is associated with metabolic syndrome and diabetes. However, the detailed mechanism whereby diabetes causes alopecia still remains unclear. We focused on the inflammatory response that is caused by diabetes or obesity, given that inflammation is a risk factor for hair loss. Inducible nitric oxide synthase (iNOS) is known to be upregulated under conditions of acute or chronic inflammation. To clarify the potential role of iNOS in diabetes-related alopecia, we generated obese diabetic iNOS-deficient (ob/ob; iNOS-KO mice)...
May 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29754258/glycerol-induced-injury-as-a-new-model-of-muscle-regeneration
#9
REVIEW
Mohamed A A Mahdy
Skeletal muscle regenerates efficiently following injuries and diseases. However, muscle regeneration is compromised in several conditions by adipocyte infiltration and excessive collagen deposition. Adipocyte infiltration is a characteristic feature of sarcopenia, diabetes, cachexia, muscular dystrophies and advanced cases of Duchenne muscular dystrophy (DMD), while excessive collagen deposition is a hallmark of muscular dystrophies and severe muscle injuries, such as lacerations, contusions and strains. Muscle adipogenesis and fibrosis are major causes of muscle weakness that impairs muscle function...
May 12, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29752867/topical-application-of-culture-expanded-cd34-umbilical-cord-blood-cells-from-frozen-units-accelerates-healing-of-diabetic-skin-wounds-in-mice
#10
Jennifer Whiteley, Theresa Chow, Hibret Adissu, Armand Keating, Ian M Rogers
Chronic and nonhealing wounds are constant health issues facing patients with type 2 diabetes. As the incidence of type 2 diabetes mellitus (T2DM) increases, the incidence of chronic wounds and amputations will rise. T2DM is associated with peripheral arterial occlusive disease, which leads to the development of nonhealing skin ulcers after minor trauma. Patients develop severe pain limiting their mobility and ability to work and take care of themselves thus putting a significant burden on the family and society...
May 12, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29750992/transcriptome-analysis-of-dorsal-root-ganglia-s-diabetic-neuropathy-reveals-mechanisms-involved-in-pain-and-regeneration
#11
Maria Carolina Pedro Athie, Andre Schwambach Vieira, Juliana Maia Teixeira, Gilson Gonçalves Dos Santos, Elayne Vieira Dias, Claudia Herrera Tambeli, Cesar Renato Sartori, Carlos A Parada
Peripheral diabetic neuropathy (DN) manifests in nearly 60% of diabetic patients, being pain its most debilitating symptom. Although electrophysiological and morphological aspects are well described, little is known about its development and progression, undermining effective therapies. Hyperglycemia and insulin signaling impairment are considered the triggering events of oxidative stress observed in the dying nerves, however there are still many gaps in the knowledge of intracellular plastic changes it generates...
May 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/29749986/-urtica-dioica-distillate-regenerates-pancreatic-beta-cells-in-streptozotocin-induced-diabetic-rats
#12
Ali Gohari, Ali Noorafshan, Masoumeh Akmali, Fahimeh Zamani-Garmsiri, Atefeh Seghatoleslam
Background: Urtica dioica is known as an anti-hyperglycemic plant. Urtica dioica distillate (UD) is a traditional Iranian drink, locally known as "aragh gazaneh". In spite of its widespread consumption in Iran, according to traditional Iranian medicine, there is no scientific report on the usefulness of UD for diabetic patients. This survey was designed to evaluate its protective effects for the recovery from diabetes by determining the serum insulin, blood glucose, volume of pancreatic islets, and the number and volume of β-cells in diabetic rats...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749025/photobiomodulation-induces-antinociception-recovers-structural-aspects-and-regulates-mitochondrial-homeostasis-in-peripheral-nerve-of-diabetic-mice
#13
Victória Regina da Silva de Oliveira, Diego Pulzatto Cury, Laura Basílio Yamashita, Marcos Vinicius Esteca, Ii-Sei Watanabe, Yoko Fee Bergmann, Elaine Flamia Toniolo, Camila Squarzoni Dale
Diabetic Peripheral Neuropathy (DPN) is a nervous disorder caused by diabetes mellitus, affecting about 50% of patients in clinical medicine. Chronic pain is one of the major and most unpleasant symptoms developed by those patients, and conventional available treatments for the neuropathy, including the associated pain, are still unsatisfactory and benefit only a small number of patients. Photobiomodulation (PBM) has been gaining clinical acceptance once it is able to promote early nerve regeneration resulting in significant improvement peripheral nerves disabilities...
May 11, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29745944/pegylated-graphene-oxide-mediated-quercetin-modified-collagen-hybrid-scaffold-for-enhancement-of-mscs-differentiation-potential-and-diabetic-wound-healing
#14
Jing Chu, Panpan Shi, Wenxia Yan, Jinping Fu, Zhi Yang, Chengmin He, Xiaoyuan Deng, Hanping Liu
Nanoscale delivery based on polyethylene glycol (PEG)ylated graphene oxide (GO-PEG) merits attention for biomedical applications owing to its functional surface modification, superior solubility/biocompatibility and controllable drug release capability. However, impaired skin regeneration in applications of these fascinating nanomaterials in diabetes is still limited, and critical issues need to be addressed regarding insufficient collagen hyperplasia and inadequate blood supply. Therefore, a high-performance tissue engineering scaffold with biocompatible and biodegradable properties is essential for diabetic wound healing...
May 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/29737242/bms-493-modulates-retinoic-acid-induced-differentiation-during-expansion-of-human-hematopoietic-progenitor-cells-for-islet-regeneration
#15
Ruth Marise Elgamal, Gillian I Bell, Sarah Krause, David A Hess
Cellular therapies are emerging as a novel treatment strategy for diabetes. Thus, the induction of endogenous islet regeneration in situ represents a feasible goal for diabetes therapy. Umbilical cord blood (UCB)-derived hematopoietic progenitor cells (HPC) isolated by high aldehyde dehydrogenase activity (ALDH<sup>hi</sup>) have previously been shown to reduce hyperglycemia after intrapancreatic (iPan) transplantation into streptozotocin (STZ)-treated non-obese diabetic (NOD) severe combined immunodeficient (SCID) mice...
May 8, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29736712/cell-based-methods-to-identify-inducers-of-human-pancreatic-beta-cell-proliferation
#16
Courtney A Ackeifi, Ethan A Swartz, Peng Wang
Diabetes is the result of the insufficiency or dysfunction of pancreatic beta cells alone or in combination with insulin resistance. The replacement or regeneration of beta cells can effectively reverse diabetes in humans and rodents. Therefore, the identification of novel small molecules that promote pancreatic beta-cell proliferation is an attractive approach for diabetic therapy. While numerous hormones, small molecules, and growth factors are able to drive rodent beta cells to replicate, only a few small molecules have demonstrated the ability to stimulate human beta-cell proliferation...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29735923/the-spleen-as-an-optimal-site-for-islet-transplantation-and-a-source-of-mesenchymal-stem-cells
#17
REVIEW
Naoaki Sakata, Gumpei Yoshimatsu, Shohta Kodama
This review demonstrates the unique potential of the spleen as an optimal site for islet transplantation and as a source of mesenchymal stem cells. Islet transplantation is a cellular replacement therapy used to treat severe diabetes mellitus; however, its clinical outcome is currently unsatisfactory. Selection of the most appropriate transplantation site is a major factor affecting the clinical success of this therapy. The spleen has long been studied as a candidate site for islet transplantation. Its advantages include physiological insulin drainage and regulation of immunity, and it has recently also been shown to contribute to the regeneration of transplanted islets...
May 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29735591/the-alchemist-s-nightmare-might-mesenchymal-stem-cells-that-are-recruited-to-repair-the-injured-heart-be-transformed-into-fibroblasts-rather-than-cardiomyocytes
#18
REVIEW
Milton Packer
The injection of mesenchymal stem cells into the injured myocardium to induce cardiac regeneration has yielded disappointing results, conceivably because cells with cardioreparative potential must be supplied for long periods of time to produce a salutary effect. Accordingly, investigators have devised ways of directing such cells to the heart on an ongoing basis: by enhancing the action of endogenous peptides that function as cardiac homing signals (eg, stromal cell-derived factor-1). Stromal cell-derived factor-1 is released during acute cardiac injury and heart failure, but it has a short half-life because of degradation by dipeptidyl peptidase-4...
May 8, 2018: Circulation
https://www.readbyqxmd.com/read/29731442/effect-of-aerobic-exercise-combined-with-ginkgo-polysaccharide-on-weight-blood-glucose-and-glycosylated-serum-protein-in-diabetic-rats
#19
Rongkun Zhu, Jun Xie
Streptozotocin copied diabetic rats model were studied through aerobic exercise combined with ginkgo polysaccharide. Aimed to offering the updating experimental basis to prevent diabetic through aerobic exercise combined with ginkgo polysaccharide, the effect of aerobic exercise combined with ginkgo polysaccharide were discussed on the weight, blood glucose, glucosylated serum protein and the secretion ability of islet β cells, oral glucose tolerance test, islet cell pathological morophological changes and positive expression of Bax and Bcl-2...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29720269/acidic-preconditioning-of-endothelial-colony-forming-cells-ecfc-promote-vasculogenesis-under-proinflammatory-and-high-glucose-conditions-in-vitro-and-in-vivo
#20
Hebe Agustina Mena, Paula Romina Zubiry, Blandine Dizier, Mirta Schattner, Catherine Boisson-Vidal, Soledad Negrotto
BACKGROUND: We have previously demonstrated that acidic preconditioning of human endothelial colony-forming cells (ECFC) increased proliferation, migration, and tubulogenesis in vitro, and increased their regenerative potential in a murine model of hind limb ischemia without baseline disease. We now analyze whether this strategy is also effective under adverse conditions for vasculogenesis, such as the presence of ischemia-related toxic molecules or diabetes, one of the main target diseases for cell therapy due to their well-known healing impairments...
May 2, 2018: Stem Cell Research & Therapy
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