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Insulin regeneration

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https://www.readbyqxmd.com/read/28621713/gpe-promotes-the-proliferation-and-migration-of-mouse-embryonic-neural-stem-cells-and-their-progeny-in-vitro
#1
Cristina Almengló, Pablo Devesa, Jesús Devesa, Víctor M Arce
This study was designed to investigate a possible role of the N-terminal tripeptide of insulin-like growth factor-1 (IGF-I), Gly-Pro-Glu (GPE), physiologically generated in neurons following IGF-I-specific cleavage, in promoting neural regeneration after an injury. Primary cultures of mouse neural stem cells (NSCs), obtained from 13.5 Days post-conception (dpc) mouse embryos, were challenged with either GPE, growth hormone (GH), or GPE + GH and the effects on cell proliferation, migration, and survival were evaluated both under basal conditions and in response to a wound healing assay...
June 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28601648/sequential-igf-1-and-bmp-6-releasing-chitosan-alginate-plga-hybrid-scaffolds-for-periodontal-regeneration
#2
Tuğba Duruel, Anıl Sera Çakmak, Abdullah Akman, Rahime M Nohutcu, Menemşe Gümüşderelioğlu
The goal of periodontal tissue engineering is to repair or regenerate the destructed or lost periodontium by improving functions of cells in the remaining tissue. For continuty of cell growth process, two group of growth factors, i.e. competence factors and progression factors, are needed to act together. However, the short biological half-life of these factors limits their effects on cells and their clinical efficacy. The purpose of this study is to develop different microparticles-loaded chitosan carriers/scaffolds for controlled and sequential delivery of a competence factor, insulin-like growth factor (IGF-1), and progression factor, bone morphogenetic factor-6 (BMP-6)...
June 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28577185/light-emitting-diode-modulates-carbohydrate-metabolism-by-pancreatic-duct-regeneration
#3
José Carlos Tatmatsu-Rocha, Cynthia Aparecida de Castro, Marcela Sene-Fiorese, Nivaldo Antonio Parizotto
Pancreatic lesions can produce metabolic disorders. Light-emitting diode (LED) has been used as a safe and effective phototherapy for cell proliferation and regeneration. We investigate the effects of phototherapy using LED irradiation on the pancreas after the injection of streptozotocin (STZ) to induce experimental diabetes and evaluate that the β cells can regenerate in the pancreas in an in vivo model and observe its implications on the control of carbohydrate metabolism. Twenty Wistar rats were randomized into three groups: non-diabetic control, diabetic control, and diabetic treated with LED...
June 3, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28576774/aff-1-fusogen-can-rejuvenate-the-regenerative-potential-of-adult-dendritic-trees-via-self-fusion
#4
Veronika Kravtsov, Meital Oren-Suissa, Benjamin Podbilewicz
The aging brain undergoes structural changes, affecting brain homeostasis, neuronal function and consequently cognition. The complex architecture of dendritic arbors poses a challenge to understanding age-dependent morphological alterations, behavioral plasticity and remodeling following brain injury. Here, we use the PVD polymodal neurons of C. elegans as a model to study how aging affects neuronal plasticity. Using confocal live imaging of C. elegans PVD neurons, we demonstrate age-related progressive morphological alterations of intricate dendritic arbors...
June 2, 2017: Development
https://www.readbyqxmd.com/read/28576138/changes-in-pancreatic-histology-insulin-secretion-and-oxidative-status-in-diabetic-rats-following-treatment-with-ficus-deltoidea-and-vitexin
#5
Samsulrizal Nurdiana, Yong Meng Goh, Hafandi Ahmad, Sulaiman Md Dom, Nur Syimal'ain Azmi, Noor Syaffinaz Noor Mohamad Zin, Mahdi Ebrahimi
BACKGROUND: The potential application of Ficus deltoidea and vitexin for the management of symptomatologies associated with diabetes mellitus (DM) has gained much attention. However, less firm evidence comes from data to augment our understanding of the role of F. deltoidea and vitexin in protecting pancreatic β-cells. The aim of this study was to assess histological and oxidative stress changes in the pancreas of streptozotocin (STZ)-induced diabetic rats following F. deltoidea extract and vitexin treatment...
June 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28568977/reproductive-performance-and-expression-of-imprinted-genes-in-somatic-cell-cloned-boars
#6
Tatsuo Kawarasaki, Satoko Enya, Masayoshi Otake, Masatoshi Shibata, Satoshi Mikawa
To assess the performance of boars derived by somatic cell cloning, we analyzed various aspects of their reproductive characteristics and the expression of two imprinted genes. Cloned boars (cloned Duroc × Jinhua) were analyzed for birth weight, growth rate, age at first ejaculation, semen characteristics and fertility, in comparison with naturally bred control boars of the same strain. The expression of imprinted genes was analyzed using the microsatellite marker SWC9 for the paternally expressed gene insulin-like growth factor -2 (IGF2) and with single nucleotide polymorphisms (SNPs) for the gene maternally expressed 3 (MEG3)...
June 1, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28559136/intradiencephalon-injection-of-histamine-inhibited-the-recovery-of-locomotor-function-of-spinal-cord-injured-zebrafish
#7
Shu-Bing Huang, Hou-De Zhao, Lin-Fang Wang, Meng-Fei Sun, Ying-Li Zhu, Yi-Bo Wu, Yi-Da Xu, Shi-Xiao Peng, Chun Cui, Yan-Qin Shen
Human spinal cord injury (SCI) usually causes irreversible disability beneath the injured site due to poor neural regeneration. On the contrary, zebrafish show significant regenerative ability after SCI, thus is usually worked as an animal model for studying neuroregeneration. Most of the previous SCI studies focused on the local site of SCI, the supraspinal-derived signals were rarely mentioned. Here we showed that intradiencephalon injection of histamine (HA) inhibited the locomotor recovery in adult zebrafish post-SCI...
May 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28552218/epigenetics-and-type-1-diabetes-mechanisms-and-translational-applications
#8
REVIEW
Alberto Zullo, Linda Sommese, Gianfranco Nicoletti, Francesco Donatelli, Francesco P Mancini, Claudio Napoli
Type 1 diabetes (T1D) is an irreversible degenerative disease with severe complications such as heart disease, nephropathy, neuropathy, and retinopathy. Although exogenous insulin administration is a life-saving therapy, it does not cure the disease. This review addresses the epigenetic mechanisms responsible for the development of T1D and discusses epigenetic-based strategies for prevention and treatment of the disease. We describe novel epigenetic biomarkers for the identification of susceptible individuals and the establishment of innovative therapies with epidrugs and cell therapy to regenerate the lost β-cells...
May 18, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28516218/a-high-fat-diet-can-affect-bone-healing-in-growing-rats
#9
Jéssica Suzuki Yamanaka, Gabriela Rezende Yanagihara, Bruna Leonel Carlos, Júnia Ramos, Brígida Batista Brancaleon, Ana Paula Macedo, João Paulo Mardegan Issa, Antônio Carlos Shimano
A high-fat diet (HFD) can have a negative effect on bone quality in young and old people. Although bone healing in children is normally efficient, there is no evidence that children who have a diet rich in fat have compromised bone fracture regeneration compared with children with recommended dietary fat levels. The purpose of the present study was to evaluate the effects of an HFD on bone healing in growing female rats. Twenty-six postweaning female Wistar rats were divided into two groups (13 animals per group): a standard diet (SD) group and an HFD (with 60% of energy from fat) group...
May 17, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28502255/a-moist-edge-environment-aids-the-regeneration-of-traumatic-tympanic-membrane-perforations
#10
Z C Lou, Z H Lou
OBJECTIVE: To review the history of moist therapy used to regenerate traumatic tympanic membrane perforations. STUDY DESIGN: Literature review. METHODS: The literature on topical agents used to treat traumatic tympanic membrane perforations was reviewed, and the advantages and disadvantages of moist therapy were analysed. RESULTS: A total of 76 studies were included in the analysis. Topical applications of certain agents (e...
July 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28486025/efficacy-and-persistence-of-allogeneic-adipose-derived-mesenchymal-stem-cells-combined-with-hyaluronic-acid-in-osteoarthritis-after-intra-articular-injection-in-a-sheep-model
#11
Chenchen Feng, Xuan Luo, Na He, Huitang Xia, Xiaoteng Lv, Xue Zhang, Dan Li, Fei Wang, Jiaping He, Li Zhang, Xiangming Lin, Liping Lin, Huabin Yin, Jiyin He, Jinwu Wang, Wei Cao, Richard Wang, Guangdong Zhou, Wen Wang
Although a number of studies have reported efficacy of autologous adipose-derived mesenchymal stem cells (AD-MSCs) in treating osteoarthritis (OA), no reliable evidences demonstrate whether allogeneic AD-MSCs can efficiently block OA progression in a large animal model. The current study explored the efficacy and survival of allogeneic AD-MSCs combined with hyaluronic acid (HA) after intra-articular (IA) injection in a sheep OA model, which were conventionally established by anterior cruciate ligament resection and medial meniscectomy...
May 9, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28485389/egfr-dependent-tor-independent-endocycles-support-drosophila-gut-epithelial-regeneration
#12
Jinyi Xiang, Jennifer Bandura, Peng Zhang, Yinhua Jin, Hanna Reuter, Bruce A Edgar
Following gut epithelial damage, epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) signalling triggers Drosophila intestinal stem cells to produce enteroblasts (EBs) and enterocytes (ECs) that regenerate the gut. As EBs differentiate into ECs, they become postmitotic, but undergo extensive growth and DNA endoreplication. Here we report that EGFR/RAS/MAPK signalling is required and sufficient to drive damage-induced EB/EC growth. Endoreplication occurs exclusively in EBs and newborn ECs that inherit EGFR and active MAPK from fast-dividing progenitors...
May 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28480759/gad65-a-prospective-vaccine-for-treating-type-1-diabetes
#13
Johnny Ludvigsson
In spite of modern techniques, the burden for patients with type 1 diabetes (T1D) will not disappear and T1D remains a life-threatening disease causing severe complications and increased mortality. We have to learn how to preserve residual insulin secretion or even increase beta cell regeneration. This would give a milder disease, simpler treatment and perhaps even cure. Thus, there are good reasons to try therapies that may preserve beta cell function. Areas covered: In this review the author reviews the literature and registered ongoing trials using GAD-alum put in relation to the high number of published different immune interventions...
May 25, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28480220/culture-of-ipscs-derived-pancreatic-%C3%AE-like-cells-in-vitro-using-decellularized-pancreatic-scaffolds-a-preliminary-trial
#14
Jian Wan, Yan Huang, Pengcheng Zhou, Yibing Guo, Cen Wu, Shajun Zhu, Yao Wang, Lei Wang, Yuhua Lu, Zhiwei Wang
Diabetes mellitus is a disease which has affected 415 million patients in 2015. In an effort to replace the significant demands on transplantation and morbidity associated with transplantation, the production of β-like cells differentiated from induced pluripotent stem cells (iPSCs) was evaluated. This approach is associated with promising decellularized scaffolds with natural extracellular matrix (ECM) and ideal cubic environment that will promote cell growth in vivo. Our efforts focused on combining decellularized rat pancreatic scaffolds with mouse GFP(+)-iPSCs-derived pancreatic β-like cells, to evaluate whether decellularized scaffolds could facilitate the growth and function of β-like cells...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28474557/the-possible-hypoglycemic-mechanisms-of-echinochrome
#15
Ayman Saber Mohamed, Amel Mahmoud Soliman, Mohamed-Assem Said Marie
BACKGROUND: Diabetes mellitus is a main reason of morbidity and mortality worldwide. In recent years great attention has been paid to bioactivity of natural products due to their potential pharmacological utilization. Echinochrome is natural compound isolated from sea urchins and possesses many biological effects. The hypoglycemic activity of echinochrome reported in many recent experiments. OBJECTIVE: In our study, we tried to collect all the possible the hypoglycemic mechanism of echinochrome...
May 5, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28471324/the-structure-function-relationships-of-insulin-like-growth-factor-1-ec-in-c2c12-cells
#16
Qian Yi, Jianguo Feng, Ling He, Rongxue Wan, Hui Zeng, Li Yang, Shiyong Wu, Liling Tang
Insulin-like growth factor 1 (IGF1) is a crucial growth factor, that regulates skeletal muscles development during cell growth and repair. Recently, its alternative splicing variant, named IGF1Ec, also named mechano-growth factor (MGF), has gained attentions as a new damage repair factor. However, the structure-function relationships of IGF1Ec have not been fully clarified due to contradictory reports. In this study, we systematically investigated physiologic responses of C2C12 muscle cells to IGF1Ec, IGF1 and MGF E peptide...
May 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28448039/surgical-ablation-assay-for-studying-eye-regeneration-in-planarians
#17
Jacob M Morton, Marwa A Saad, Wendy S Beane
In the study of adult stem cells and regenerative mechanisms, planarian flatworms are a staple in vivo model system. This is due in large part to their abundant pluripotent stem cell population and ability to regenerate all cell and tissue types after injuries that would be catastrophic for most animals. Recently, planarians have gained popularity as a model for eye regeneration. Their ability to regenerate the entire eye (comprised of two tissue types: pigment cells and photoreceptors) allows for the dissection of the mechanisms regulating visual system regeneration...
April 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447755/gene-expression-profile-in-human-induced-pluripotent-stem-cells-chondrogenic-differentiation-in-vitro-part-a
#18
Wiktoria Maria Suchorska, Ewelina Augustyniak, Magdalena Richter, Tomasz Trzeciak
Human induced pluripotent stem cells (hiPSCs) offer promise in regenerative medicine, however more data are required to improve understanding of key aspects of the cell differentiation process, including how specific chondrogenic processes affect the gene expression profile of chondrocyte‑like cells and the relative value of cell differentiation markers. The main aims of the present study were as follows: To determine the gene expression profile of chondrogenic-like cells derived from hiPSCs cultured in mediums conditioned with HC‑402‑05a cells or supplemented with transforming growth factor β3 (TGF‑β3), and to assess the relative utility of the most commonly used chondrogenic markers as indicators of cell differentiation...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28411170/the-critical-role-of-phosphatidylcholine-and-phosphatidylethanolamine-metabolism-in-health-and-disease
#19
REVIEW
Jelske N van der Veen, John P Kennelly, Sereana Wan, Jean E Vance, Dennis E Vance, René L Jacobs
Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co-workers performed groundbreaking research that established the general outline of many of the pathways of phospholipid biosynthesis. In recent years, the importance of phospholipid metabolism in regulating lipid, lipoprotein and whole-body energy metabolism has been demonstrated in numerous dietary studies and knockout animal models. The purpose of this review is to highlight the unappreciated impact of phospholipid metabolism on health and disease...
April 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28405581/angiogenesis-in-newly-regenerated-bone-by-secretomes-of-human-mesenchymal-stem-cells
#20
Wataru Katagiri, Takamasa Kawai, Masashi Osugi, Yukiko Sugimura-Wakayama, Kohei Sakaguchi, Taku Kojima, Tadaharu Kobayashi
BACKGROUND: For an effective bone graft for reconstruction of the maxillofacial region, an adequate vascular network will be required to supply blood, osteoprogenitor cells, and growth factors. We previously reported that the secretomes of bone marrow-derived mesenchymal stem cells (MSC-CM) contain numerous growth factors such as insulin-like growth factor (IGF)-1, transforming growth factor (TGF)-β1, and vascular endothelial growth factor (VEGF), which can affect the cellular characteristics and behavior of regenerating bone cells...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
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