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https://www.readbyqxmd.com/read/28922723/protective-effects-of-mirtazapine-and-chrysin-on-experimentally-induced-testicular-damage-in-rats
#1
Alaa E El-Sisi, Magda E El-Sayad, Nermine M Abdelsalam
Mirtazapine is an antidepressant with prominent antioxidant effects. Chrysin, a natural flavone, exhibits multiple pharmacological actions. This study was designed to investigate the potential protective effects of chrysin and mirtazapine against nitrofurazone-induced testicular damage in rats. Possible underlying mechanisms such as oxidative stress, inflammation and apoptosis were also investigated. Testicular damage was induced by oral administration of nitrofurazone (50mg/kg/day) for two weeks. Chrysin (25 and 50mg/kg/day, p...
September 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28918178/using-imaging-to-predict-treatment-response-in-genitourinary-malignancies
#2
REVIEW
Amir H Lebastchi, Matthew J Watson, Christopher M Russell, Arvin K George, Alon Z Weizer, Baris Turkbey
CONTEXT: Over the previous2 decades, there have been numerous advancements in the diagnostic evaluation, therapeutic management, and postoperative assessment of genitourinary malignancies. OBJECTIVE: To present a review of current and novel imaging modalities and their utility in the assessment of therapeutic response in the systemic management of renal, testicular, and prostate cancers. EVIDENCE ACQUISITION: A PubMed/Medline search of the current published literature inclusive of prospective and retrospective original research, systematic reviews, and meta-analyses was conducted evaluating imaging modalities for renal cell carcinoma, prostate cancer, and testicular cancer...
September 13, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28916336/renal-tubular-and-adrenal-medullary-tumors-in-the-2-year-rat-study-with-canagliflozin-confirmed-to-be-secondary-to-carbohydrate-glucose-malabsorption-in-the-15-month-mechanistic-rat-study
#3
Sandra De Jonghe, Mark D Johnson, Rao N V S Mamidi, Petra Vinken, Bianca Feyen, Godelieve Lammens, Jim Proctor
During preclinical development of canagliflozin, an SGLT2 inhibitor, treatment-related pheochromocytomas, renal tubular tumors (RTT), and testicular Leydig cell tumors were reported in the 2-year rat toxicology study. In a previous 6-month rat mechanistic study, feeding a glucose free diet prevented canagliflozin effects on carbohydrate malabsorption as well as the increase in cell proliferation in adrenal medulla and kidneys, implicating carbohydrate malabsorption as the mechanism for tumor formation. In this chronic study male Sprague-Dawley rats were dosed orally with canagliflozin at high dose-levels (65 or 100 mg/kg/day) for 15 months and received either a standard diet or a glucose-free diet...
September 12, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28903372/myosin-va-plays-essential-roles-in-maintaining-normal-mitosis-enhancing-tumor-cell-motility-and-viability
#4
Yan-Ruide Li, Ai Zhong, Han Dong, Lu-Han Ni, Fu-Qing Tan, Wan-Xi Yang
Myosin Va, a member of Class V myosin, functions in organelle motility, spindle formation, nuclear morphogenesis and cell motility. The purpose of this study is to explore the expression and localization of myosin Va in testicular cancer and prostate cancer, and its specific roles in tumor progression including cell division, migration and proliferation. We detected myosin Va in testicular and prostate tumor tissues using sqRT-PCR, western blot, and immunofluorescence. Tumor samples showed an increased expression of myosin Va, abnormal actin and myosin Va distribution...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28893722/parental-occupational-exposure-to-organic-solvents-and-testicular-germ-cell-tumors-in-their-offspring-nord-test-study
#5
Charlotte Le Cornet, Béatrice Fervers, Eero Pukkala, Tore Tynes, Maria Feychting, Johnni Hansen, Kayo Togawa, Karl-Christian Nordby, Susanne Oksbjerg Dalton, Sanni Uuksulainen, Pernilla Wiebert, Torill Woldbæk, Niels E Skakkebæk, Ann Olsson, Joachim Schüz
BACKGROUND: Testicular germ cell tumors (TGCT) were suggested to have a prenatal environmentally related origin. The potential endocrine disrupting properties of certain solvents may interfere with the male genital development in utero. OBJECTIVES: We aimed to assess the association between maternal and paternal occupational exposures to organic solvents during the prenatal period and TGCT risk in their offspring. METHODS: This registry-based case control study included TGCT cases aged 14-49 y (n=8,112) diagnosed from 1978 to 2012 in Finland, Norway, and Sweden...
June 30, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28891799/-paratesticular-sarcoma-with-synchronous-renal-carcinoma
#6
Juan Astigueta, Milagros Abad-Licham, Lenin Fernández, Marisabel Huerta, Juan Terrones, Mariela Pow-Sang
OBJETIVE: Primary undifferentiated pleomorphic sarcoma (UPS) of the testicular tunics is rare, and synchronism with other malignancies of the urinary tract is uncommon, and may complicate the staging and therapeutic approach. We report the case of a patient diagnosed with primary paratesticular UPS with synchronous Renal Carcinoma. METHODS: Patient presenting with intrascrotal tumor who underwent left radical orchiectomy. In staging work up studies a second urologic neoplasia was found in the kidney...
September 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28886318/new-insights-into-the-expression-profile-of-microrna-34c-and-p53-in-infertile-men-spermatozoa-and-testicular-tissue
#7
S Rahbar, M G Novin, E Alizadeh, V Shahnazi, F Pashaei-Asl, Y A AsrBadr, L Farzadi, E Ebrahimie, M Pashaiasl
Spermatogenesis is proliferation and differentiation processes of stem spermatogonia into mature spermatozoa controlled by the genes responsible for transcription and post transcription levels. MicroRNAs (miRNA) are  the key factors during gene expression in RNA silencing and post-transcriptional regulation. They play main roles in regulation of early and late spermatogenesis, and reproduction. In this study, we investigate the role of miRNAs in infertile males.The patients were assigned to five groups based on semen analysis (n=55), including normozoospermic (N), moderate oligoasthenoteratozoospermic (MOAT), severe oligoasthenoteratozoospermic (SOAT), obstructive azoospermia (OA) and non-obstructive azoospermia (NOA)...
August 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28883750/effect-of-etoricoxib-on-experimental-oxidative-testicular-ischemia-reperfusion-damage-in-rats-induced-with-torsion-detorsion
#8
Turgut Yapanoglu, Fatih Ozkaya, Ali Haydar Yilmaz, Renad Mammadov, Ferda Keskin Cimen, Erkan Hirik, Durdu Altuner
Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD-50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG) animals were given single oral doses of distilled water as a solvent...
September 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28881587/mgmt-and-calca-promoter-methylation-are-associated-with-poor-prognosis-in-testicular-germ-cell-tumor-patients
#9
Camila Maria da Silva Martinelli, André van Helvoort Lengert, Flavio Mavignier Cárcano, Eduardo Caetano Albino Silva, Mariana Brait, Luiz Fernando Lopes, Daniel Onofre Vidal
Testicular germ cell tumors (TGCT) represent the second main cause of cancer-related death in young men. Despite high cure rates, refractory disease results in poor prognosis. Epigenetic reprogramming occurs during the development of seminomas and non-seminomas. Understanding the molecular and genetic basis of these tumors would represent an important advance in the search for new TGCT molecular markers. Hence the frequency of methylation of a gene panel (VGF, MGMT, ADAMTS1, CALCA, HOXA9, CDKN2B, CDO1 and NANOG) was evaluated in 72 primary TGCT by quantitative methylation specific PCR...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28879515/testicular-adrenal-rest-tumors-in-congenital-adrenal-hyperplasia-cross-sectional-study-of-51-croatian-male-patients
#10
Miroslav Dumic, Vlatko Duspara, Zorana Grubic, Sasa Kralik Oguic, Veselin Skrabic, Vesna Kusec
Testicular adrenal rest tumors (TARTs) are common cause of infertility in males with congenital adrenal hyperplasia (CAH). We studied the role of genotype and disease regulation on TART development, their impact on gonadal function, and frequency in 47 21-hydroxylase deficiency (21-OHD) and four 11-hydroxylase deficiency (11-OHD) male patients. Testicular ultrasound (TU), genotype, hormonal measurement in 51, and spermiogram in five patients were performed. TARTs were detected in 14 SW21-OHD and one 11-OHD patient: 1/8 patients aged <7 years (1...
September 6, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28873352/immunophenotypic-comparison-of-testicular-sclerosing-sertoli-cell-tumors-and-sertoli-cell-tumors-not-otherwise-specified
#11
Hector Mesa, Chen Zhang, Juan C Manivel, Thomas M Ulbright
Testicular Sertoli cell tumors (SCT) are rare and most fall into the category of SCT-not otherwise specified (SCT-NOS). Only a few additional types of SCT are recognized. Sclerosing SCT (S-SCT), originally described in 1991, comprises a small fraction of SCTs and was considered a specific entity until the 2016 revision of the World Health Organization classification of non-germ cell tumors, where it was classified as a morphologic variant of SCT-NOS. In a recent study, differences in expression of PAX2/PAX8, inhibin, androgen receptor and S100 protein between SCT-NOS and S-SCT were noted in a small number of cases...
September 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/28871003/association-between-rassf1a-promoter-methylation-and-testicular-germ-cell-tumor-a-meta-analysis-and-a-cohort-study
#12
Dora Markulin, Aleksandar Vojta, Ivana Samaržija, Marija Gamulin, Ivona Bečeheli, Irena Jukić, Čedomir Maglov, Vlatka Zoldoš, Aleksandra Fučić
BACKGROUND: The RAS association domain family protein 1a (RASSF1A) is a prominent tumor suppressor gene showing altered promoter methylation in testicular germ cell tumors (TGCT). RASSF1A promoter hypermethylation might represent an early event in TGCT tumorigenesis. We investigated whether the RASSF1A promoter methylation in peripheral blood of TGCT patients can be associated with testicular cancer risk. MATERIALS AND METHODS: Following a meta-analysis, we performed a cohort study including 32 testicular cancer patients and 32 healthy controls...
September 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28862048/a-precious-diagnostic-pearl-the-necklace-pattern-in-germ-cell-tumors-of-the-testis
#13
Justin Snow, Juan Miguel Mosquera, Theresa Scognamiglio, Brian D Robinson, Francesca Khani
Diffuse embryoma is a rare pattern of nonseminomatous germ cell tumor of the testis originally described in 1983. We report a case with this predominant pattern in an 18-year-old male with a painless palpable testicular mass. Although it is relatively common to see a diffuse embryoma pattern focally in mixed nonseminomatous germ cell tumors of the testis, it is rarely the predominant pattern and can represent a diagnostic pitfall on routine hematoxylin and eosin stain. We emphasize the importance of recognizing the individual components within the diffuse embryoma pattern, review the literature, and briefly discuss the ancillary immunohistochemical stains that may be utilized to help support the diagnosis...
August 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28851995/melatonin-ameliorates-restraint-stress-induced-oxidative-stress-and-apoptosis-in-testicular-cells-via-nf-%C3%AE%C2%BAb-inos-and-nrf2-ho-1-signaling-pathway
#14
Ying Guo, Junyan Sun, Ting Li, Qiuwan Zhang, Shixia Bu, Qian Wang, Dongmei Lai
Decline in semen quality has become a global public health concern. Psychological stress is common in the current modern society and is associated with semen decline. Increasing evidence demonstrated that melatonin has anti-apoptotic and antioxidant functions. Whether melatonin can ameliorate the damage in testes induced by psychological stress has never been investigated. Here, a mouse model of restraint stress demonstrated that melatonin normalized the sperm density decline, testicular cells apoptosis, and testicular oxidative stress in stressed male mice...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845050/preservation-of-fertility-or-ovarian-function-in-patients-with-breast-cancer-or-gynecologic-and-internal-malignancies
#15
Angrit Stachs, Steffi Hartmann, Bernd Gerber
Because of the efficacy of systemic therapies, neoplasias which occur in pediatric and adolescent patients and in young adults have high cure rates. This means that fulfilling their wish to have children has become a more pressing concern, particularly among young women with malignant tumors. Premature ovarian failure is also a not insignificant problem as it has a lasting detrimental effect on quality of life. Every oncology patient who may potentially wish to have children should be informed about their options for preserving fertility prior to starting treatment...
August 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28838999/animacroxam-a-novel-dual-mode-compound-targeting-histone-deacetylases-and-cytoskeletal-integrity-of-testicular-germ-cell-cancer-cells
#16
Gustav Steinemann, Alexandra Dittmer, Weronika Kuzyniak, Björn Hoffmann, Mark Schrader, Rainer Schobert, Bernhard Biersack, Bianca Nitzsche, Michael Hoepfner
Novel approaches for the medical treatment of advanced solid tumors including testicular germ cell tumors (TGCT) are desperately needed. Especially, TGCT patients not responding to cisplatin-based therapy need therapeutic alternatives, as there is no effective medical treatment available for this particular subgroup. Here, we studied the suitability of the novel dual mode compound animacroxam for TGCT treatment. Animacroxam consists of a HDAC-inhibitory hydroxamate moiety coupled to a 4,5-diarylimidazole with inherent cytoskeleton disrupting potency...
August 24, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28835760/testicular-adrenal-rests-tumors-and-testicular-microlithiasis-in-a-brazilian-case-series-with-classic-congenital-adrenal-hyperplasia
#17
Laura Ohana Marques Coelho de Carvalho, Raymundo Miguel Garcia Lora, Claudia Renata Rezende Penna, Izabel Calland Ricarte Beserra
BACKGROUND: Testicular adrenal rest tumors are a benign condition characterized by the presence of remnants of adrenal tissue within the testes that can lead to infertility. Testicular microlithiasis are calculus deposits within the seminiferous tubules. Both are described in congenital adrenal hyperplasia. OBJECTIVES: Describe the frequency of testicular adrenal rest tumors and testicular microlithiasis in a Brazilian case series of patients with classic congenital adrenal hyperplasia and to also relate these changes to disease control and hypothalamic-pituitary-gonadal axis disorders...
January 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28834365/spontaneous-testicular-atrophy-occurs-despite-normal-spermatogonial-proliferation-in-a-tp53-knockout-rat
#18
M S Dai, S J Hall, M M Vantangoli Policelli, K Boekelheide, D J Spade
The tumor suppressor protein p53 (TP53) has many functions in cell cycle regulation, apoptosis, and DNA damage repair and is also involved in spermatogenesis in the mouse. To evaluate the role of p53 in spermatogenesis in the rat, we characterized testis biology in adult males of a novel p53 knockout rat (SD-Tp53(tm1sage) ). p53 knockout rats exhibited variable levels of testicular atrophy, including significantly decreased testis weights, atrophic seminiferous tubules, decreased seminiferous tubule diameter, and elevated spermatocyte TUNEL labeling rates, indicating a dysfunction in spermatogenesis...
August 22, 2017: Andrology
https://www.readbyqxmd.com/read/28828589/diagnostic-and-prognostic-value-of-18f-fdg-pet-ct-in-recurrent-germinal-tumor-carcinoma
#19
Pierpaolo Alongi, Laura Evangelista, Federico Caobelli, Marianna Spallino, Luigi Gianolli, Massimo Midiri, Maria Picchio
AIM: The aim of this bicentric retrospective study was to assess the diagnostic performance, the prognostic value, the incremental prognostic value and the impact on therapeutic management of (18)F-FDG PET/CT in patients with suspected recurrent germinal cell testicular carcinoma (GCT). MATERIALS AND METHODS: From the databases of two centers including 31,500 (18)F-FDG PET/CT oncological studies, 114 patients affected by GCT were evaluated in a retrospective study...
August 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28816282/-long-term-follow-up-experience-of-comprehensive-treatment-of-testicular-mixed-germ-cell-tumors
#20
J F Ye, B Wang, L L Ma, L Zhao, G L Wang, K Hong
OBJECTIVE: Testicular mixed germ cell tumor is mixed with embryonal carcinoma, choriocarcinoma, yolk sac tumor, teratoma, seminoma and other two or more components of the testicular tumor, the clinical is relatively rare and high degree of malignancy, this article will summarize its clinical features and optimize its treatment. METHODS: A retrospective analysis of the clinical data of 22 patients with testicular tumor mixed germ cell in Peking University Third Hospital from May 1994 to November 2016 was conducted using a combination of statistical analysis and discussion of the relevant literature...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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