Saima Aslam, Dwayne Roach, Mikeljon P Nikolich, Biswajit Biswas, Robert T Schooley, Kimberley A Lilly-Bishop, Gregory K Rice, Regina Z Cer, Theron Hamilton, Matthew Henry, Tiffany Luong, Ann-Charlott Salabarria, Laura Sisk-Hackworth, Andrey A Filippov, Francois Lebreton, Lindsey Hall, Ran Nir-Paz, Hadil Onallah, Gilat Livni, Eran Shostak, Anat Wieder-Finesod, Dafna Yahav, Ortal Yerushalmy, Sivan Alkalay-Oren, Ron Braunstein, Leron Khalifa, Amit Rimon, Daniel Gelman, Ronen Hazan
Left ventricular assist devices (LVAD) are increasingly used for management of heart failure; infection remains a frequent complication. Phage therapy has been successful in a variety of antibiotic refractory infections and is of interest in treating LVAD infections. We performed a retrospective review of four patients that underwent five separate courses of intravenous (IV) phage therapy with concomitant antibiotic for treatment of endovascular Pseudomonas aeruginosa LVAD infection. We assessed phage susceptibility, bacterial strain sequencing, serum neutralization, biofilm activity, and shelf-life of phage preparations...
March 12, 2024: Antimicrobial Agents and Chemotherapy