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https://www.readbyqxmd.com/read/28091360/collagen-peptide-ingestion-alters-lipid-metabolism-related-gene-expression-and-the-unfolded-protein-response-in-mouse-liver
#1
Chisa Tometsuka, Yoh-Ichi Koyama, Tomoko Ishijima, Tsudoi Toyoda, Miki Teranishi, Kazushige Takehana, Keiko Abe, Yuji Nakai
Ingestion of collagen peptide (CP) elicits beneficial effects on the body, including improvement in blood lipid profiles, but the underlying mechanisms remain unclear. The purpose of this study was to investigate the effects of CP ingestion on the liver, which controls lipid metabolism in the body. Male BALB/cCrSlc mice were bred with the AIN-93M diet containing 14 % casein or the AIN-93M-based low-protein diet containing 10 % casein or a diet containing 6 % casein+4 % CP for 10 weeks (n 12/group). Total, free and esterified cholesterol levels in the blood decreased in the CP group...
January 16, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28089892/algerian-propolis-extracts-chemical-composition-bactericidal-activity-and-in-vitro-effects-on-gilthead-seabream-innate-immune-responses
#2
El-Khamsa Soltani, Rebeca Cerezuela, Noureddine Charef, Samia Mezaache-Aichour, Maria Angeles Esteban, Mohamed Mihoub Zerroug
Propolis has been used as a medicinal agent for centuries. The chemical composition of four propolis samples collected from four locations of the Sétif region, Algeria, using gas chromatography-mass spectrometry was determined. More than 20 compounds and from 30 to 35 compounds were identified in the aqueous and ethanolic extracts, respectively. Furthermore, the antimicrobial activity of the propolis extracts against two marine pathogenic bacteria was evaluated. Finally, the in vitro effects of propolis on gilthead seabream (Sparus aurata L...
January 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28089164/low-median-nerve-palsy-as-initial-manifestation-of-churg-strauss-syndrome
#3
Young Hak Roh, Young Do Koh, Jung Ho Noh, Hyun Sik Gong, Goo Hyun Baek
Anterior interosseous nerve (AIN) syndrome is typically characterized by forearm pain and partial or complete dysfunction of the AIN-innervated muscles. Although the exact etiology and pathophysiology of the disorder remain unclear, AIN syndrome is increasingly thought to be an inflammatory condition of the nerve rather than a compressive neuropathy because the symptoms often resolve spontaneously following prolonged observation. However, peripheral neuropathy can be 1 of the first symptoms of systemic vasculitis that needs early systemic immunotherapy to prevent extensive nerve damage...
January 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28077485/persistent-anterior-interosseous-nerve-palsy-following-forearm-crutch-use
#4
Peter Macneal, Christopher Robert Crome, Scarlett McNally
A 43-year-old man presented with weakness of the interphalageal joint of his right thumb following the use of forearm crutches. On examination he was unable to oppose his thumb and index finger to form the 'ok' sign. Nerve conduction showed anterior interosseous nerve (AIN) damage along its path to the flexor pollicis longus. The patient was managed conservatively with little clinical improvement seen at 4 months. AIN palsies are very rare and account for <1% of all upper limb lesions. Although AIN palsies resulting from other causes such as surgery and blunt trauma are more common, we report the second case of AIN palsy following crutch use, and the first case in which clinical identification was confirmed using electrodiagnosis...
January 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28076863/adverse-renal-effects-of-immune-checkpoint-inhibitors-a-narrative-review
#5
Rimda Wanchoo, Sabine Karam, Nupur N Uppal, Valerie S Barta, Gilbert Deray, Craig Devoe, Vincent Launay-Vacher, Kenar D Jhaveri
BACKGROUND: Cancer immunotherapy, such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death 1 (PD-1), has revolutionized the treatment of malignancies by engaging the patient's own immune system against the tumor rather than targeting the cancer directly. These therapies have demonstrated a significant benefit in the treatment of melanomas and other cancers. SUMMARY: In order to provide an extensive overview of the renal toxicities induced by these agents, a Medline search was conducted of published literature related to ipilimumab-, pembrolizumab-, and nivolumab-induced kidney toxicity...
January 12, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28072766/the-impact-of-body-composition-parameters-on-ipilimumab-toxicity-and-survival-in-patients-with-metastatic-melanoma
#6
Louise E Daly, Derek G Power, Áine O'Reilly, Paul Donnellan, Samantha J Cushen, Kathleen O'Sullivan, Maria Twomey, David P Woodlock, Henry P Redmond, Aoife M Ryan
BACKGROUND: Body composition is an important predictor of drug toxicity and outcome. Ipilimumab (Ipi), a monoclonal antibody used to treat metastatic melanoma, has specific toxicities. No validated biomarkers that predict Ipi toxicity and efficacy exist. Also, the impact of Ipi on body composition has not been established. METHODS: Patients with metastatic melanoma treated with Ipi between 2009 and 2015 were included. Body composition was assessed by computed tomography at baseline and after four cycles of Ipi...
January 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28070233/complete-rectal-prolapse-in-young-egyptian-males-is-schistosomiasis-really-condemned
#7
Ahmed A Abou-Zeid, Islam H ElAbbassy, Ahmed M Kamal, Dina A Somaie
AIM: To investigate the assumption that schistosomiasis is the main cause of rectal prolapse in young Egyptian males. METHODS: Twenty-one male patients between ages of 18 and 50 years with complete rectal prolapse were included in the study out of a total 29 patients with rectal prolapse admitted for surgery at Colorectal Surgery Unit, Ain Shams University hospitals between the period of January 2011 and April 2014. Patients were asked to fill out a specifically designed questionnaire about duration of the prolapse, different bowel symptoms and any past or present history of schistosomiasis...
December 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28070214/youth-traffic-related-injuries-a-prospective-study
#8
Michal Grivna, Hani O Eid, Fikri M Abu-Zidan
BACKGROUND: Traffic-related injuries are the most common cause of morbidity and mortality of the youth. Our aim was to study epidemiology, risk factors and outcome of hospitalized youth patients injured in road traffic collisions in order to give recommendations for prevention. METHODS: We prospectively studied all youth (15-24 years) patients having traffic-related injuries who were admitted to Al Ain or Tawam Hospitals, Al Ain City, or who died after arrival to these hospitals during an 18 months period...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28069542/hemispheric-asymmetries-in-the-transition-from-action-preparation-to-execution
#9
Valentina Sulpizio, Giuliana Lucci, Marika Berchicci, Gaspare Galati, Sabrina Pitzalis, Francesco Di Russo
Flexible and adaptive behavior requires the ability to contextually stop inappropriate actions and select the right one as quickly as possible. Recently, it has been proposed that three brain regions, i.e., the inferior frontal gyrus (iFg), the anterior insula (aIns), and the anterior intraparietal sulcus (aIPs), play an important role in several processing phases of perceptual decision tasks, especially in the preparation, perception and action phases, respectively. However, little is known about hemispheric differences in the activation of these three areas during the transition from perception to action...
January 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/28062418/103-year-old-on-dialysis-was-it-worth-it
#10
Alvin Shrestha, Aine Burns
It is increasingly common for nephrologists to be faced with the question of whether starting dialysis on an elderly patient is appropriate. We present an extraordinary case of a 103-year-old person who has become the oldest patient in our unit, reportedly the world, to not only remain on haemodialysis, but to thrive on it. This case adds to the compelling literature, which suggests that it is indeed the number and severity of comorbidities that is more likely to impact survival than age alone.
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28049927/hypolipidemic-and-hypocholesterolemic-effect-of-roselle-hibiscus-sabdariffa-l-seeds-oil-in-experimental-male-rats
#11
Rehab F M Ali, Ayman M El-Anany
The current investigation aimed to evaluate the influence of roselle seeds oil (RSO), coconut oil (CNO) and binary mixture of them on serum lipids of experimental rats. Fatty acid composition of native and blended oils was determined. Thirty five male Albino rats (145- 160 g) were used throughout this study. The rats were fed AIN-93G diet containing 10% fat from CNO, RSO, B1 (25%RSO+ 75 %CNO), B2 (50 %RSO+ 50 %CNO or B3 (75 %RSO+ 25 % CNO) for eight weeks. Blood samples were collected at the beginning, every two weeks during the experiment, and at the end of the experiment...
2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28039800/back-to-the-future-a-practice-led-transition-program-from-assistant-in-nursing-to-enrolled-nurse
#12
Annette Faithfull-Byrne, Lorraine Thompson, Tony Welch, Moira Williamson, Keppel Schafer, Claire Hallinan
Continuing professional development is an essential element in professional nursing practice. In our Hospital and Health service, a gap in existing nursing pathways was identified for Assistants in Nursing (AINs), who wished to further their career in nursing and progress to Enrolled Nurse (EN). There is also little in the literature that addresses Assistants in Nursing wishing to progress their career to Enrolled Nurses. This article describes a quality improvement project designed to address this gap. The project was a collaborative venture between a Queensland Hospital and Health Service and an Institute of Tertiary and Further Education (TAFE)...
November 21, 2016: Nurse Education in Practice
https://www.readbyqxmd.com/read/28035952/high-dietary-fructose-intake-on-cardiovascular-disease-related-parameters-in-growing-rats
#13
SooYeon Yoo, Hyejin Ahn, Yoo Kyoung Park
The objective of this study was to determine the effects of a high-fructose diet on cardiovascular disease (CVD)-related parameters in growing rats. Three-week-old female Sprague Dawley rats were randomly assigned to four experimental groups; a regular diet group (RD: fed regular diet based on AIN-93G, n = 8), a high-fructose diet group (30Frc: fed regular diet with 30% fructose, n = 8), a high-fat diet group (45Fat: fed regular diet with 45 kcal% fat, n = 8) or a high fructose with high-fat diet group (30Frc + 45Fat, fed diet 30% fructose with 45 kcal% fat, n = 8)...
December 26, 2016: Nutrients
https://www.readbyqxmd.com/read/28032320/no-medium-term-spinocerebellar-input-plasticity-in-deep-cerebellar-nuclear-neurons-in-vivo
#14
Hannes Mogensen, Fredrik Bengtsson, Henrik Jörntell
The existence of input plasticity in the deep cerebellar nuclear (DCN) cells of the adult cerebellum could have profound implications for our understanding of cerebellar function. Whereas the existence of plastic changes in mossy fiber (mf) synaptic responses in DCN neurons has been demonstrated in juvenile slices, there has so far been no direct demonstration of this form of plasticity in the adult cerebellum in vivo. In the present paper, we recorded from neurons in the anterior interposed nucleus (AIN) and stimulated the spinocerebellar tracts (SCT) directly or via the skin to obtain mf activation and the inferior olive to activate climbing fibers (cfs) in the nonanesthetized, adult, decerebrated cat...
December 28, 2016: Cerebellum
https://www.readbyqxmd.com/read/28028457/metal-to-phosphorus-stoichiometries-for-freshwater-phytoplankton-in-three-remote-lakes
#15
Aine M Gormley-Gallagher, Richard W Douglas, Brian Rippey
Simultaneous measurements of changes in phytoplankton biomass and the metal and phosphorus (P) content of cells have been captured to attest to metal to P stoichiometries for freshwater phytoplankton. Three Scottish lakes that had received high, medium or low metal contamination from the atmosphere were selected for study. Phytoplankton cells were collected and Inductively Coupled Plasma-Mass Spectrometry was used to measure their lead (Pb), cadmium (Cd), mercury (Hg), copper (Cu), zinc (Zn), nickel (Ni), chromium (Cr), manganese (Mn), cobalt (Co) and P content...
2016: PeerJ
https://www.readbyqxmd.com/read/28018334/molecular-and-proteomic-analysis-of-levofloxacin-and-metronidazole-resistant-helicobacter-pylori
#16
Aimi Hanafi, Woon Ching Lee, Mun Fai Loke, Xinsheng Teh, Ain Shaari, Mojdeh Dinarvand, Philippe Lehours, Francis Mégraud, Alex Hwong Ruey Leow, Jamuna Vadivelu, Khean Lee Goh
Antibiotic resistance in bacteria incurs fitness cost, but compensatory mechanisms may ameliorate the cost and sustain the resistance even under antibiotics-free conditions. The aim of this study was to determine compensatory mechanisms of antibiotic resistance in H. pylori. Five strains of levofloxacin-sensitive H. pylori were induced in vitro to develop resistance. In addition, four pairs of metronidazole-sensitive and -resistant H. pylori strains were isolated from patients carrying dual H. pylori populations that consist of both sensitive and resistant phenotypes...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28003825/endometrial-volume-measured-by-vocal-compared-to-office-hysteroscopy-for-diagnosis-of-endometrial-polyps-in-premenopausal-women-with-abnormal-uterine-bleeding
#17
Mohamed Laban, Sherif H Hussain, Alaa S Hassanin, Waleed M Khalaf, Mohamed K Etman, Mohammed S E Elsafty, Ahmed M Bahaa Eldin, Ahmad S Hasanien, Noha A Sakna, Mohammed Taema, Mohammed H Mostafa, Marwa M Eisa
The aim is to compare hysteroscopy, two-dimensional transvaginal ultrasound (2D TVUS), and three-dimensional (3D) Virtual Organ Computer-aided AnaLysis™ (VOCAL) to detect endometrial polyps (EPs) in premenopausal women with abnormal uterine bleeding (AUB). This prospective study was done at Ain Shams Maternity Hospital, Egypt, from March 5, 2015, to December 30, 2015, enrolling 118 premenopausal women with AUB. 2D TVUS, 3D VOCAL, and hysteroscopy were done. 109 patients reached final analysis. 36 women (33%) were diagnosed with EP by 2D TVUS...
2016: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/28001088/glioblastoma-in-the-elderly-treatment-patterns-and-survival
#18
Jean-Aine Pretanvil, Isaac Q Salinas, David E Piccioni
AIM: The optimal treatment for elderly glioblastoma patients is unclear. We conducted a retrospective review of the California Cancer Registry to examine treatment patterns and survival by age. METHODS: We identified 2670 adult patients from the California Cancer Registry with glioblastoma. We compared the extent of resection, treatment type and modality. RESULTS: Elderly patients had the greatest overall survival (OS) with combined surgery, radiation and chemotherapy...
December 21, 2016: CNS Oncology
https://www.readbyqxmd.com/read/28000476/neuroprotective-effect-of-sapucaia-nuts-lecythis-pisonis-on-rats-fed-with-high-fat-diet
#19
Marcos Vidal Martins, Izabela Maria Montezano de Carvalho, Mônica Maria Magalhães Caetano, Renata Celi Lopes Toledo, Antônio Avelar Xavier, José Humberto De Queiroz
BACKGROUND: Lecythis pisonis Cambess is commonly known as "castanha de sapucaia" in Brazil. Chemical composition studies revealed that this nut is an excellent source of anti-oxidant minerals and of essential lipids. OBJECTIVE: The aim of the present study is to assess the anti-oxidant and anti-inflammatory effect of Lecythis pisonis Cambess on the brain tissue of Wistar rats. MATERIAL AND METHODS: The animals were divided in four experimental groups (n = 6), total of forty-eight rats...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27999694/a-case-of-pulmonary-renal-syndrome-leading-to-the-diagnosis-of-legionnaires-disease
#20
Erasmia Sabani, Pantelis A Sarafidis, Antonios Lazaridis, Theodora Kouloukourgiotou, Konstantinos Stylianou, Afroditi Pantzaki, Aikaterini Papagianni, Georgios Efstratiadis
We report a case of a 51-year-old Caucasian man referred at our department due to acute renal failure (ARF) complicating respiratory failure during hospitalization in a regional hospital. The patient was previously started on steroids due to the suspicion of rapidly progressive glomerulonephritis (RPGN) in the context of Goodpasture syndrome. However, clinical and laboratory findings did not support this diagnosis; instead a careful evaluation limited differential diagnosis of the renal insult to acute tubular necrosis or acute interstitial nephritis (AIN) following respiratory infection...
2016: Case Reports in Nephrology
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