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https://www.readbyqxmd.com/read/28725902/impact-of-grape-pomace-consumption-on-the-blood-lipid-profile-and-liver-genes-associated-with-lipid-metabolism-of-young-rats
#1
Jianmei Yu, Rishipal R Bansode, Ivy N Smith, Steven L Hurley
Herein, we investigated the effects of grape pomace (GP) in diet on body weight, blood lipid profile, and expression of liver genes associated with lipid metabolism using a young rat model. In this study, twenty female Sprague-Dawley rats at 7 weeks of age were randomly divided into 4 groups, which were fed modified AIN-93G diets containing 0% (control), 6.9%, 13.8%, and 20.7% of GP for 10 weeks. Feed consumption and body weight were weekly determined. Blood samples were obtained at the beginning and end of the feeding period for cholesterol, alanine aminotransferase (ALT), and glucose analysis...
July 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28716797/a-pragmatic-phase-iii-multisite-double-blind-placebo-controlled-parallel-arm-dose-increment-randomised-trial-of-regular-low-dose-extended-release-morphine-for-chronic-breathlessness-breathlessness-exertion-and-morphine-sulfate-beams-study-protocol
#2
David Currow, Gareth John Watts, Miriam Johnson, Christine F McDonald, John O Miners, Andrew A Somogyi, Linda Denehy, Nicola McCaffrey, Danny J Eckert, Philip McCloud, Sandra Louw, Lawrence Lam, Aine Greene, Belinda Fazekas, Katherine C Clark, Kwun Fong, Meera R Agar, Rohit Joshi, Sharon Kilbreath, Diana Ferreira, Magnus Ekström
INTRODUCTION: Chronic breathlessness is highly prevalent and distressing to patients and families. No medication is registered for its symptomatic reduction. The strongest evidence is for regular, low-dose, extended- release (ER) oral morphine. A recent large phase III study suggests the subgroup most likely to benefit have chronic obstructive pulmonary disease (COPD) and modified Medical Research Council breathlessness scores of 3 or 4. This protocol is for an adequately powered, parallel-arm, placebo-controlled, multisite, factorial, block-randomised study evaluating regular ER morphine for chronic breathlessness in people with COPD...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28714589/meg-biomarker-of-alzheimer-s-disease-absence-of-a-prefrontal-generator-during-auditory-sensory-gating
#3
Sanja Josef Golubic, Cheryl J Aine, Julia M Stephen, John C Adair, Janice E Knoefel, Selma Supek
Magnetoencephalography (MEG), a direct measure of neuronal activity, is an underexplored tool in the search for biomarkers of Alzheimer's disease (AD). In this study, we used MEG source estimates of auditory gating generators, nonlinear correlations with neuropsychological results, and multivariate analyses to examine the sensitivity and specificity of gating topology modulation to detect AD. Our results demonstrated the use of MEG localization of a medial prefrontal (mPFC) gating generator as a discrete (binary) detector of AD at the individual level and resulted in recategorizing the participant categories in (1) controls with mPFC generator localized in response to both the standard and deviant tones; (2) a possible preclinical stage of AD participants (a lower functioning group of controls) in which mPFC activation was localized to the deviant tone only; and (3) symptomatic AD in which mPFC activation was not localized to either the deviant or standard tones...
July 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28710003/amelioration-of-atherosclerotic-inflammation-and-plaques-via-endothelial-adrenoceptor-targeted-enos-gene-delivery-using-redox-sensitive-polymer-bearing-l-arginine
#4
Qurrat Ul Ain, Hyunji Chung, Jee Young Chung, Jae-Hoon Choi, Yong-Hee Kim
Endothelial dysfunction combined with inflammation leads to atherosclerosis. Endothelium-specific delivery of therapeutic agents at the cellular level-specifically in vivo-is still a difficult task for proper management of atherosclerosis. We designed a redox-sensitive poly(oligo-l-arginine) (rsPOLA) playing dual roles as an endothelium α-2 adrenoceptors(α-2ARs)-targeted gene carrier and as a substrate for endothelial nitric oxide synthase (eNOS). Overexpression of α-2ARs on atherosclerotic endothelial cells was confirmed and the eNOS/rsPOLA nanoplexes following systemic injection demonstrated to 1) enhance eNOS gene delivery into endothelial cells via α-2ARs/l-arginine specific binding, 2) increase intracellular level of nitric oxide, 3) suppress inflammatory response in endothelium and finally 4) reduce atherosclerotic plaque in a Ldlr(-/-) atherosclerotic mouse model...
July 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28706733/the-effect-of-characteristics-of-proteins-fed-during-gestation-and-lactation-on-development-of-metabolic-syndrome-in-dams-and-male-offspring-of-wistar-rats
#5
A Jahan-Mihan, C A Labyak, A Y Arikawa
OBJECTIVE: The objective of the study is to examine the role of characteristics of proteins in maternal and weaning diets on risk of metabolic syndrome in male offspring. METHODS: Pregnant Wistar rats were allocated to two groups (n = 12) and were fed the AIN-93G diets based on either intact protein-based diet (IPD) or mixed amino acid-based diet (AAD) from day 3 of gestation throughout gestation and lactation. Male offspring were weaned to either an IPD or AAD diet for 18 weeks...
June 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/28704522/assessment-of-gut-microbiota-populations-in-lean-and-obese-zucker-rats
#6
Reza Hakkak, Soheila Korourian, Steven L Foley, Bruce D Erickson
Obesity has been on the rise in the US and worldwide for the last several decades. Obesity has been associated with chronic disease development, such as certain types of cancer, type 2 diabetes, cardiovascular disease, and liver diseases. Previously, we reported that obesity promotes DMBA-induced mammary tumor development using the obese Zucker rat model. The intestinal microbiota is composed of a diverse population of obligate and facultative anaerobic microorganisms, and these organisms carry out a broad range of metabolic activities...
2017: PloS One
https://www.readbyqxmd.com/read/28704125/effect-of-feeding-high-gamma-aminobutyric-acid-containing-giant-embryo-black-sticky-rice-oryza-sativa-l-on-anxiety-related-behavior-of-c57bl-6-mice
#7
Woo-Young Jung, Sung-Gon Kim, Jin-Seong Lee, Hyeon-Kyeong Kim, Beung-Gu Son, Jong-Woo Kim, Jae-Won Suh
The aim of this study was to determine the effect of feeding high gamma-aminobutyric acid (GABA)-containing black sticky rice giant embryo (BSRGE, Oryza sativa L.) on anxiety-related behavior of C57BL/6 mice. Experimental feedstuff (BSRGE with high GABA+AIN-76A) and control (AIN-76A) were provided to C57BL/6 mouse for 10 days. Antianxiety effects of BSRGE with high GABA were measured using an elevated plus maze. On day 8, the number of open arm entries by GABA and control groups were 1.10 ± 1.60 (mean ± SD) and 0...
July 13, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28704054/enhanced-systemic-anti-angiogenic-sivegf-delivery-using-pegylated-oligo-d-arginine
#8
Jee Young Chung, Qurrat Ul Ain, Hyun-Lin Lee, So-Mi Kim, Yong-Hee Kim
Angiogenesis mainly mediated by upregulation of vascular endothelial growth factor (VEGF) provides a hallmark of rapidly proliferating tumor cells and an essential component of the tumor growth and microenvironment, making it a targetable process for anti-tumor therapy. RNA interference (RNAi) provides a very effective tool for developing anti-tumor therapies; however, its application to date has been hampered due to the lack of efficient small interfering RNA (siRNA) delivery systems in vivo. Here, we report a polymeric gene carrier system based on PEGylation of a cationic cysteine-ended 9-mer arginine oligopeptide (CR9C), which provides effective siRNA systemic delivery and specifically suppresses VEGF (siVEGF)...
July 13, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28698971/living-with-diabetes-personal-interviews-with-pakistani-women-in-norway
#9
Walaa Abuelmagd, Helle Håkonsen, Khadijah Qurrat-Ul-Ain Mahmood, Najmeh Taghizadeh, Else-Lydia Toverud
The prevalence of Type 2 diabetes (T2D) among Pakistani women in Norway is remarkably high. This study aims to assess how they live with the disease and their response to lifestyle and medical information. 120 Pakistani women living in Norway (mean age: 55.7 years) were personally interviewed about their T2D using a structured questionnaire (response rate: 95%). The participants were first-generation immigrants (mean residence time: 28.7 years) of whom 27% were illiterates. Poor health was reported by one-third, and 71% had developed macrovascular comorbidities...
July 11, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28698610/tomatoes-protect-against-development-of-uv-induced-keratinocyte-carcinoma-via-metabolomic-alterations
#10
Jessica L Cooperstone, Kathleen L Tober, Ken M Riedl, Matthew D Teegarden, Morgan J Cichon, David M Francis, Steven J Schwartz, Tatiana M Oberyszyn
Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin cancer. SKH-1 hairless and immunocompetent mice (n = 180) were fed AIN-93G or AIN-93G + 10% tangerine or red tomato powder for 35 weeks. From weeks 11-20, mice (n = 120) were exposed to 2240 J/m(2) UV-B light, 3x/week, and tumors were tracked weekly...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28687371/body-weight-loss-effective-satiation-and-absence-of-homeostatic-neuropeptide-compensation-in-male-sprague-dawley-rats-schedule-fed%C3%A2-a-protein-crosslinked-diet
#11
Nikki Cassie, Richard L Anderson, Dana Wilson, Anne Pawsey, Julian G Mercer, Perry Barrett
Food structure contributes to the induction of satiation and the maintenance of satiety following intake of a meal. There is evidence from human studies that protein-crosslinking of a milk-protein based meal may enhance satiety, but the mechanism underpinning this effect is unknown. We investigated whether a rat model would respond in a similar manner and might provide mechanistic insight into enhanced satiety by structural modification of a food source. Rats were schedule fed a modified AIN-93M based diet in a liquid form or protein-crosslinked to produce a soft-solid form...
July 5, 2017: Appetite
https://www.readbyqxmd.com/read/28686324/demographics-and-co-occurring-conditions-in-a-clinic-based-cohort-with-down-syndrome-in-the-united-arab-emirates
#12
Jennifer Price Corder, Fatima Jaber Sehmi Al Ahbabi, Hind Saif Al Dhaheri, Fares Chedid
The majority of studies describing demographics and co-occurring conditions in cohorts with Down syndrome come from regions outside of the Middle East, mainly from Europe and North America. This paper describes demographics and co-occurring conditions in a hospital-based cohort of individuals with Down syndrome living in the Middle Eastern country of the United Arab Emirates (UAE). The first dedicated Down syndrome clinic in the UAE was established in 2012 at Tawam Hospital in Al Ain. This paper describes a clinic-based cohort of 221 participants over 4 years from the Gulf Down Syndrome Registry, a new Down syndrome database and contact registry created at Tawam Hospital...
July 7, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28679287/the-safety-of-nivolumab-for-the-treatment-of-metastatic-melanoma
#13
James Larkin, Aine O'Reilly
Nivolumab, a human IgG4 monoclonal antibody directed against PD-1, is a checkpoint inhibitor that is licenced in the treatment of metastatic melanoma either as a monotherapy or in combination with ipilimumab, a CTLA-4 inhibitor. The introduction of immune checkpoint inhibitors to the therapeutic landscape has dramatically altered outcomes in a proportion of patients with metastatic melanoma. Immune checkpoint inhibitors result in a toxicity profile that is distinct from that of chemotherapy or targeted therapy based on their immunomodulatory mechanism and similarly can result in patterns of response that are unique...
July 6, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28667413/management-of-toxic-cyanobacteria-for-drinking-water-production-of-ain-zada-dam
#14
Amel Saoudi, Luc Brient, Sabrine Boucetta, Rachid Ouzrout, Myriam Bormans, Mourad Bensouilah
Blooms of toxic cyanobacteria in Algerian reservoirs represent a potential health problem, mainly from drinking water that supplies the local population of Ain Zada (Bordj Bou Arreridj). The objective of this study is to monitor, detect, and identify the existence of cyanobacteria and microcystins during blooming times. Samples were taken in 2013 from eight stations. The results show that three potentially toxic cyanobacterial genera with the species Planktothrix agardhii were dominant. Cyanobacterial biomass, phycocyanin (PC) concentrations, and microcystin (MC) concentrations were high in the surface layer and at 14 m depth; these values were also high in the treated water...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28665316/erratum-ksiksi-t-et-al-antioxidant-lipoxygenase-and-histone-deacetylase-inhibitory-activities-of-acridocarpus-orientalis-from-al-ain-and-oman-molecules-2012-17-12521-12532
#15
https://www.readbyqxmd.com/read/28659189/clinical-predictors-of-dengue-fever-co-infected-with-leptospirosis-among-patients-admitted-for-dengue-fever-a-pilot-study
#16
Jeyanthi Suppiah, Shie-Yien Chan, Min-Wern Ng, Yam-Sim Khaw, Siew-Mooi Ching, Lailatul Akmar Mat-Nor, Naematul Ain Ahmad-Najimudin, Hui-Yee Chee
BACKGROUND: Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. As a solution, the present work initiated a pilot study to investigate the incidence related to co-infection of leptospirosis among dengue patients. This enables the identification of more parameters to predict the occurrence of co-infection. METHOD: Two hundred sixty eight serum specimens collected from patients that were diagnosed for dengue fever were confirmed for dengue virus serotyping by real-time polymerase chain reaction...
June 28, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28657349/a-new-triterpene-ester-and-other-chemical-constituents-from-the-aerial-parts-of-anodendron-paniculatum-and-their-cytotoxic-activity
#17
Ho Viet Duc, Hoang Thi Nhu Hang, Vo Quoc Hung, Nguyen Minh Hien, Ain Raal, Nguyen Thi Hoai
The aim of the research was to study the active constituents of Anodendron paniculatum Roxb. (Apocynaceae). A new triterpene ester, named anopaniester (1), and cycloartenol (2), ursolic acid (3), esculenic acid (4), bis-(2-ethylhexyl) phthalate (5), desmosterol (6), stigmasterol (7), vaniline (8), and (E)-phytol (9), were isolated from the aerial parts of A. paniculatum. Compounds 3 and 6 showed the significant inhibitory effect (IC50 values ranging from 30.89 ± 3.60 to 44.37 ± 5.40 μg/ml) against tested human cancer cell lines LU-1 and MKN-7...
June 28, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28650930/clozapine-use-in-a-cohort-of-first-episode-psychosis
#18
Roisin Doyle, Caragh Behan, Donal OʼKeeffe, Sarah Masterson, Anthony Kinsella, Aine Kelly, Ann Sheridan, Dolores Keating, Caroline Hynes, Kevin Madigan, Elizabeth Lawlor, Mary Clarke
PURPOSE/BACKGROUND: For approximately one third of individuals treated for psychosis or schizophrenia, antipsychotic medications will have little or no therapeutic benefit. Clozapine remains the sole medication approved for treatment-resistant schizophrenia, and studies have demonstrated its superior efficacy in reducing psychotic symptoms. METHODS/PROCEDURES: Data were collected from the medical records of people who originally presented with a first-episode psychosis between 1995 and 1999 (N = 171)...
June 23, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28650728/minor-constituents-in-rice-bran-oil-and-sesame-oil-play-a-significant-role-in-modulating-lipid-homeostasis-and-inflammatory-markers-in-rats
#19
Poorna C R Yalagala, Dhavamani Sugasini, Talahalli Ravichandra Ramaprasad, Belur Ramaswamy Lokesh
The effects of feeding rats with groundnut oil (GNO), rice bran oil (RBO), and sesame oil (SESO) on serum lipids, liver lipids, and inflammatory markers were evaluated in rats. Male Wistar rats were fed with AIN-93 diet supplemented with 10 wt% of GNO, RBO, and SESO in the form of native (N) and minor constituent-removed (MCR) oils. Rats given RBO and SESO showed significant reduction in serum and liver lipids, 8-hydroxy-2-deoxyguanosine, cytokines in liver, and eicosanoids in leukocytes as compared with the rats given GNO and MCR oils...
July 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28649073/analgesic-anti-inflammatory-and-antipyretic-activity-of-salvia-moorcroftiana
#20
Liaqat Hussain, Muhammad Sajid Hamid Akash, Noorul Ain, Muhammad Imran Qadir
Salvia moorcroftiana is an herbaceous plant commonly known as "Kallijari" in Pakistan and belongs to the family Lamiaceae. This study was carried out to evaluate its scientific base for its traditional use in pain, fever and inflammation. The powdered plant was extracted by the method of cold maceration using aqueous methanol (70:30) as solvents. Hot plate, flick tail and acetic acid induced writhing test were utilized for analgesic assessment. Anti-inflammatory activity was evaluated by carageenan-induced mice paw edema...
March 2017: Pakistan Journal of Pharmaceutical Sciences
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