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https://www.readbyqxmd.com/read/27923406/ameliorative-effects-of-rutin-against-metabolic-biochemical-and-hormonal-disturbances-in-polycystic-ovary-syndrome-in-rats
#1
Sarwat Jahan, Faryal Munir, Suhail Razak, Anam Mehboob, Qurat Ul Ain, Hizb Ullah, Tayyaba Afsar, Ghazala Shaheen, Ali Almajwal
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. The study was commenced to assess the favorable effects of Rutin against metabolic, biochemical, histological, and androgenic aspects of polycystic ovary syndrome in rats. METHODS: Female Sprague-Dawley rats were administered letrozole (1 mg/kg) per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of rutin (100 mg/kg and 150 mg/kg, p...
December 7, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27919495/clinical-characteristics-of-patients-with-multiple-sclerosis-enrolled-in-a-new-registry-in-egypt
#2
Magd Zakaria, Dina A Zamzam, Mohamed A Abdel Hafeez, Mahmoud S Swelam, Shaimaa S Khater, Mai F Fahmy, Ayman Abdel Hady, Mohamed M Fouad, Azza Abdel Nasser, Hany Aref, Mohsen Gadallah
BACKGROUND: Epidemiological studies of multiple sclerosis (MS) are lacking in Egypt. OBJECTIVE: To study the characteristics of Egyptian patients with multiple sclerosis in a new registry in a major tertiary referral centre in Cairo, Egypt. SUBJECT AND METHODS: Patients were from the project MS database of the Multiple Sclerosis Unit at Ain Shams University Hospitals (N=950). We conducted a detailed medical history and examination including the Expanded Disability Status Scale (EDSS)...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27911380/method-for-identifying-small-molecule-inhibitors-of-the-protein-protein-interaction-between-hcn1-and-trip8b
#3
Ye Han, Kyle A Lyman, Matt Clutter, Gary E Schiltz, Quratul-Ain Ismail, Xiangying Cheng, Chi-Hao Luan, Dane M Chetkovich
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed ubiquitously throughout the brain, where they function to regulate the excitability of neurons. The subcellular distribution of these channels in pyramidal neurons of hippocampal area CA1 is regulated by tetratricopeptide repeat-containing Rab8b interacting protein (TRIP8b), an auxiliary subunit. Genetic knockout of HCN pore forming subunits or TRIP8b, both lead to an increase in antidepressant-like behavior, suggesting that limiting the function of HCN channels may be useful as a treatment for Major Depressive Disorder (MDD)...
November 11, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27910786/bioavailability-and-digestibility-of-nutrients-from-the-dried-oyster-culinary-medicinal-mushroom-pleurotus-ostreatus-agaricomycetes-in-vivo-experiments
#4
Julita Regula, Joanna Suliburska, Marek Siwulski
There is a limited number of publications on the bioavailability and digestibility of nutrients contained in macrofungi. The aim of this study was to assess the bioavailability and digestibility of macronutrients using in vivo experiments on laboratory animals. The experiments were conducted with the commercial oyster mushroom Pleurotus ostreatus. Semisynthetic diets were prepared based on the modified AIN-93M diet and were supplemented with 4% and 8% mushroom powder. Between days 4 and 13, apparent digestibility indexes were determined for all animals using the conventional balance method...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27909490/effects-of-atrial-fibrillation-cardioversion-after-percutaneous-mitral-balloon-valvuloplasty-on-echocardiographic-left-and-right-atrial-functions
#5
Ayman Morttada Md, Aly Ramzy Md, Said Khaled Md, Amal Ayoub Md, Sameh Samir Md, Hossam Zaki Md
Amongst patients with mitral stenosis (MS), the most common complication is AF.Our study aimed at evaluating the effect of AF cardioversion after Percutaneous Mitral Balloon Valvuloplasty (PMBV) on echocardiographic atrial functions. The study included 34 patients with MS and AF, presenting to Ain-shams University hospitals, who underwent successful PMBV then randomized into 2 different groups according to AF management strategy. Group-I patients (n=16) received DC cardioversion after amiodarone infusion (within 24 hours post-PMBV) in addition to anticoagulation...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27902998/autoimmune-cytopenias-diagnosis-management
#6
Christian P Nixon, Joseph D Sweeney
The autoimmune cytopenias are a related group of disorders in which differentiated hematopoietic cells are destroyed by the immune system. Single lineage disease is characterized by the production of autoantibodies against red cells (autoimmune hemolytic anemia [AIHA]), platelets (autoimmune thrombocytopenia [ITP]) and neutrophils (autoimmune neutropenia [AIN]) whereas multilineage disease may include various combinations of these conditions. Central to the genesis of this disease is the breakdown of central and/or peripheral tolerance, and the subsequent production of autoantibodies by both tissue and circulating self-reactive B lymphocytes with support from T helper lymphocytes...
December 1, 2016: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/27899478/one-year-prospective-study-on-the-presence-of-chronic-diseases-and-subsequent-cognitive-decline-in-older-adults
#7
Hamzah Bakouni, Samantha Gontijo Guerra, Veronica Chudzinski, Djamal Berbiche, Helen-Maria Vasiliadis
BACKGROUND: The literature is inconsistent regarding the effect of the presence of chronic physical and mental diseases on cognitive decline in older adults. The objectives of this study were to explore the effect of chronic diseases on subsequent cognitive decline assessed via the Mini Mental State Examination (MMSE) in community living older adults. METHODS: We used data from individuals (n = 2010) participating in the ESA (Étude sur la Santé des Aînés) study...
November 29, 2016: Journal of Public Health
https://www.readbyqxmd.com/read/27896155/colonic-atresia-association-with-other-anomalies
#8
Khaled M El-Asmar, Mohammed Abdel-Latif, Abdel-Hamid A El-Kassaby, Mohamed H Soliman, Mosad M El-Behery
BACKGROUND: Colonic atresia (CA) is a rare form of congenital intestinal atresia. Although CA may be isolated, it is more commonly reported in literature in association with other congenital anomalies. MATERIALS AND METHODS: This study is a review of prospectively collected data of all the patients with colonic atresia presented to our center (Ain Shams University) during 2008 to 2016. RESULTS: Twelve patients were enrolled in this study. The atresia was of type I in one case, type II in four cases, type IIIa in six cases, type IV in one case...
October 2016: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/27893491/role-of-low-molecular-weight-heparins-in-prevention-of-thromboembolic-complication-after-transarterial-chemoembolization-in-hepatocellular-carcinoma
#9
Osama Negm, Sabry Abou Saif, Mohamed El Gharib, Mohamed Yousef, Sherief Abd-Elsalam
BACKGROUND AND AIM: Portal vein thrombosis (PVT) is a common complication after transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC). This is the first clinical study to evaluate the role of low-molecular-weight heparins (LMWHs) with TACE in HCC for the prevention of thromboembolism complications (PVT). PATIENTS AND METHODS: This study was carried out on 40 patients with HCC requiring TACE who presented to the Tropical Medicine Department, Tanta University and Interventional Radiology Department of Ain-Shams University Hospitals starting from April 2015...
November 23, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27892543/functional-and-structural-signatures-of-the-anterior-insula-are-associated-with-risk-taking-tendency-of-analgesic-decision-making
#10
Chia-Shu Lin, Hsiao-Han Lin, Shih-Yun Wu
In a medical context, decision-making is associated with complicated assessment of gains, losses and uncertainty of outcomes. We here provide novel evidence about the brain mechanisms underlying decision-making of analgesic treatment. Thirty-six healthy participants were recruited and completed the Analgesic Decision-making Task (ADT), which quantified individual tendency of risk-taking (RPI), as the frequency of choosing a riskier option to relieve pain. All the participants received resting-state (rs) functional magnetic resonance imaging (MRI) and structural MRI...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27890565/three-generation-reproduction-toxicity-study-of-genetically-modified-rice-with-insect-resistant-genes
#11
Yichun Hu, Qin Zhuo, Zhaolong Gong, Jianhua Piao, Xiaoguang Yang
In the present work, we evaluated the three generation reproductive toxicity of the genetically modified rice with insectresistant cry1Ac and sck genes. 120 Sprague-Dawley (SD) rats were divided into three groups which were fed with genetically modified rice diet (GM group), parental control rice diet (PR group) and AIN-93 control diet (both used as negative control) respectively. Bodyweight, food consumption, reproductive data, hematological parameters, serum chemistry, relative organ weights and histopathology for each generation were examined respectively...
November 24, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27886546/biology-oriented-drug-synthesis-biods-in%C3%A2-vitro-%C3%AE-glucuronidase-inhibitory-and-in-silico-studies-on-2-2-methyl-5-nitro-1h-imidazol-1-yl-ethyl-aryl-carboxylate-derivatives
#12
Uzma Salar, Khalid Mohammed Khan, Muhammad Taha, Nor Hadiani Ismail, Basharat Ali, Qurat-Ul-Ain, Shahnaz Perveen, Mehreen Ghufran, Abdul Wadood
Current study is based on the biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl carboxylate derivatives 1-26, by treating metronidazole with different aryl and hetero-aryl carboxylic acids in the presence of 1,1'-carbonyl diimidazole (CDI) as a coupling agent. Structures of all synthetic derivatives were confirmed with the help of various spectroscopic techniques such as EI-MS, (1)H -NMR and (13)C NMR. CHN elemental analyses were also found in agreement with the calculated values...
November 14, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27885386/wrist-denervation-of-the-posterior-interosseous-nerve-through-a-volar-approach-a-new-technique-with-anatomical-considerations
#13
Stephan Grechenig, Surjit Lidder, Manuel Dreu, Claudia Dolcet, Lucy Marguerite Cooper, Georg Feigl
PURPOSE: Full or selective wrist denervation is an effective treatment for chronic wrist pain. In this cadaveric study, a volar approach for prophylactic denervation of the posterior interosseous nerve (PIN) and the anterior interosseous nerve (AIN) was assessed, which can simultaneously be performed during volar approaches for distal radius fracture fixation or in combination with metalwork removal. MATERIALS AND METHODS: In total 40 adult upper limbs, embalmed using Thiel's method, were investigated...
November 24, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27881592/the-c-3%C3%AE-epimer-of-25-hydroxycholecalciferol-from-endogenous-and-exogenous-sources-supports-normal-growth-and-bone-mineral-density-in-weanling-rats
#14
Marija Djekic-Ivankovic, Paula Lavery, Sherry Agellon, Hope A Weiler
BACKGROUND: The C-3α epimer of 25-hydroxycholecalciferol [3-epi-25(OH)D3] is elevated in infants. OBJECTIVES: We tested whether increasing cholecalciferol intake results in a dose-response in plasma 3-epi-25(OH)D3 We also examined bone and mineral metabolism in response to 3-epi-25(OH)D3 treatment. METHODS: Sprague Dawley rats (4 wk old) were randomly assigned (n = 6/group of each sex) to AIN-93G diets with cholecalciferol at 1 (control), 2, or 4 IU/g diet for objective 1 and to diets with 3-epi-25(OH)D3 at 0...
November 23, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27872877/data-on-spermatogenesis-in-rat-males-gestationally-exposed-to-bisphenol-a-and-high-fat-diets
#15
Pheruza Tarapore, Max Hennessy, Dan Song, Jun Ying, Bin Ouyang, Vinothini Govindarajah, Yuet-Kin Leung, Shuk-Mei Ho
This data article contains supporting information regarding the research article entitled "High butter-fat diet and bisphenol A additively impair male rat spermatogenesis" (P. Tarapore, M. Hennessy, D. Song, J. Ying, B. Ouyang, V. Govindarajah, et al.,) [1]. Sprague-Dawley females were fed AIN, high fat butter, 17α-ethinyl estradiol, or high fat butter plus four bisphenol A doses (2500 µg/kg bw-d, 250 µg/kg bw-d, 25 µg/kg bw-d, and 2.5 µg/kg bw-d) before and during pregnancy. All diets were switched to AIN after the pups were born...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27872725/a-case-of-monocephalusrachipagus-tribrachius-tetrapus-in-a-puppy
#16
Adonis Pino, Arlenis Pérez, Aine Seavers, Guillermo Hermo
Caudal duplication (dipygus) is an uncommon pathologic of conjoined twinning. The conjoined malformation is classified according to the nature and site of the union. We report the presence of this malformation in a female crossbreed puppy. The puppy was delivered by caesarean section following a prolonged period of dystocia. External findings showed a single head (monocephalus) and a normal cranium with no fissure in the medial line detected. The thorax displayed a caudal duplication arising from the lumbosacral region (rachipagus)...
2016: Veterinary Research Forum
https://www.readbyqxmd.com/read/27866314/factors-associated-with-health-related-quality-of-life-hrqol-in-adults-with-short-stature-skeletal-dysplasias
#17
Nitasha Dhiman, Alia Albaghdadi, Cheryl K Zogg, Meesha Sharma, Julie E Hoover-Fong, Michael C Ain, Adil H Haider
INTRODUCTION: Numerous factors associate with health disparities. The extent to which such factors influence health-related quality of life (HRQOL) among adults with short stature skeletal dysplasias (SD) is unknown. In an effort to update and clarify knowledge about the HRQOL of adults with SD, this study aimed to quantify HRQOL scores relative to the American average and assess whether specific indicators are associated with lower scores. METHODS: Members (>18 years) of Little People of America were invited to complete an online survey assessing HRQOL using the SF-12 supplemented with indicator-specific questions...
November 19, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27866036/idiopathic-chylous-ascites-simulating-acute-appendicitis-a-case-report-and-literature-review
#18
Qurat Ul Ain, Yasir Bashir, Sean Johnston
No abstract text is available yet for this article.
October 27, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27864399/novel-genetic-loci-associated-with-long-term-deterioration-in-blood-lipid-concentrations-and-coronary-artery-disease-in-european-adults
#19
Tibor V Varga, Azra Kurbasic, Mattias Aine, Pontus Eriksson, Ashfaq Ali, George Hindy, Stefan Gustafsson, Jian'an Luan, Dmitry Shungin, Yan Chen, Christina-Alexandra Schulz, Peter M Nilsson, Göran Hallmans, Inês Barroso, Panos Deloukas, Claudia Langenberg, Robert A Scott, Nicholas J Wareham, Lars Lind, Erik Ingelsson, Olle Melander, Marju Orho-Melander, Frida Renström, Paul W Franks
BACKGROUND: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids. METHODS: Participants from the GLACIER Study (Nmax = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms; replication, fine-mapping regions and wildcard SNPs for lipid traits) were extracted for association tests with 10-year change in total cholesterol (ΔTC) and triglycerides (ΔTG)...
November 17, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27863347/preventive-effects-of-goji-berry-on-dextran-sulfate-sodium-induced-colitis-in-mice
#20
Yifei Kang, Yansong Xue, Min Du, Mei-Jun Zhu
Goji berry (Lycium barbarum) exerts immune modulation and suppresses inflammation in vitro and in vivo. We hypothesized that Goji berry had beneficial effects on dextran sulfate sodium (DSS)-induced colitis in C57BL/6 mice through suppressing inflammation. Six-week-old male C57BL/6 mice were supplemented with a standard AIN-93G diet with or without 1% (w/w) Goji berry for 4 weeks. Then, colitis was induced by supplementing 3% DSS in drinking water for 7 days, followed by 7 days of remission period to mimic ulcerative colitis symptoms...
October 27, 2016: Journal of Nutritional Biochemistry
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