Sultana Monira Hussain, Catherine Robb, Andrew M Tonkin, Paul Lacaze, Trevor T-J Chong, Lawrence J Beilin, Chenglong Yu, Gerald F Watts, Joanne Ryan, Michael E Ernst, Zhen Zhou, Johannes T Neumann, John J McNeil
BACKGROUND: Recent studies have reported associations between high plasma high-density lipoprotein cholesterol (HDL-C) levels and risk of all-cause mortality, age-related macular degeneration, sepsis and fractures, but associations with dementia risk remain unclear. To determine whether high plasma HDL-C levels are associated with increased incident dementia risk in initially-healthy older people. METHODS: We conducted a post-hoc analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial; a double-blind, randomized, placebo-controlled trial of daily low-dose aspirin in healthy older people...
February 2024: The Lancet Regional Health. Western Pacific