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https://www.readbyqxmd.com/read/27759811/ketogenic-diet-for-epilepsy-treatment
#1
Letícia Pereira de Brito Sampaio
The ketogenic diet (KD), a high-fat, low-carbohydrate, and adequate-protein diet is an established, effective nonpharmacologic treatment option for intractable childhood epilepsy. The KD was developed in 1921 and even though it has been increasingly used worldwide in the past decade, many neurologists are not familiar with this therapeutic approach. In the past few years, alternative and more flexible KD variants have been developed to make the treatment easier and more palatable while reducing side effects and making it available to larger group of refractory epilepsy patients...
October 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27647878/modified-atkins-diet-induces-subacute-selective-ragged-red-fiber-lysis-in-mitochondrial-myopathy%C3%A2-patients
#2
Sofia Ahola, Mari Auranen, Pirjo Isohanni, Satu Niemisalo, Niina Urho, Jana Buzkova, Vidya Velagapudi, Nina Lundbom, Antti Hakkarainen, Tiina Muurinen, Päivi Piirilä, Kirsi H Pietiläinen, Anu Suomalainen
Mitochondrial myopathy (MM) with progressive external ophthalmoplegia (PEO) is a common manifestation of mitochondrial disease in adulthood, for which there is no curative therapy. In mice with MM, ketogenic diet significantly delayed progression of the disease. We asked in this pilot study what effects high-fat, low-carbohydrate "modified Atkins" diet (mAD) had for PEO/MM patients and control subjects and followed up the effects by clinical, morphological, transcriptomic, and metabolomic analyses. All of our five patients, irrespective of genotype, showed a subacute response after 1...
November 2, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27603509/evaluation-of-a-simplified-modified-atkins-diet-for-use-by-parents-with-low-levels-of-literacy-in-children-with-refractory-epilepsy-a-randomized-controlled-trial
#3
Suvasini Sharma, Shaiphali Goel, Puneet Jain, Anuja Agarwala, Satinder Aneja
PURPOSE: This study was planned to develop and evaluate a simple, easy-to-understand variation of the modified Atkins diet, for use by parents with low levels of literacy in children with refractory epilepsy. METHODS: This study was conducted in two phases. In the first phase, a simplified version of the modified Atkins diet was developed. In the second phase this was evaluated in children aged 2-14 years who had daily seizures despite the appropriate use of at least two anticonvulsant drugs, in an open-label randomized-controlled-trial...
September 1, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27594893/erratum-to-modified-atkins-diet-in-advanced-malignancies-final-results-of-a-safety-and-feasibility-trial-within-the-veterans-affairs-pittsburgh-healthcare-system
#4
Jocelyn L Tan-Shalaby, Jennifer Carrick, Krystal Edinger, Dana Genovese, Andrew D Liman, Vida A Passero, Rashmikant B Shah
[This corrects the article DOI: 10.1186/s12986-016-0113-y.].
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27525031/modified-atkins-diet-in-advanced-malignancies-final-results-of-a-safety-and-feasibility-trial-within-the-veterans-affairs-pittsburgh-healthcare-system
#5
Jocelyn L Tan-Shalaby, Jennifer Carrick, Krystal Edinger, Dana Genovese, Andrew D Liman, Vida A Passero, Rashmikant B Shah
BACKGROUND: Dysfunctional mitochondrial processes limit malignant cells ability to use energy from fatty acids and ketones. Animal studies using ketogenic diets for cancer show encouraging results. We tested the diet's safety and feasibility in cancer patients across a broad variety of solid tumors. METHODS: We recruited 17 advanced cancer patients who were not on chemotherapy. They consumed 20 to 40 g of carbohydrates daily with evaluations performed weekly until week 4, then every 4 weeks until 16 weeks...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27273526/use-of-modified-atkins-diet-in-glucose-transporter-type-1-deficiency-syndrome
#6
Sofiane Amalou, Domitille Gras, Adina Ilea, Marie-Odile Greneche, Laurent Francois, Vanina Bellavoine, Catherine Delanoe, Stéphane Auvin
AIM: Glucose transporter type 1 deficiency syndrome (GLUT1-DS) results from impaired glucose transport into the brain, and is treated with a ketogenic diet. A few reports have suggested effectiveness of treatment using the modified Atkins diet (MAD). We aimed to assess the efficacy of MAD as a treatment for GLUT1-DS. METHOD: We evaluated the efficacy of MAD in 10 patients (four males, six females; mean age at diagnosis [SD] 6.2y [1.7], min-max: 4mo-12y) with GLUT1-DS...
June 8, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27064917/-national-consensus-on-the-modified-atkins-diet
#7
María Vaccarezza, Ariela Agustinho, M Julia Alberti, Laura Argumedo, Marisa Armeno, Virginia Blanco, Cecilia Bouquet, Analía Cabrera, Roberto Caraballo, Luciana Caramuta, Araceli Cresta, Elizabeth S de Grandis, Martha G DeMartini, Cecilia Diez, Mariana Diz, Corina Dlugoszewski, Nidia Escobal, Hilario Ferrero, Santiago Galicchio, Victoria Gambarini, Beatriz Gamboni, Lara Gonzalez, Silvina Guisande, Amal Hassan, Pablo Matarrese, Graciela Mestre, Laura Pesce, Viviana Rios, Marcos Semprino, Patricia Sosa, Marisol Toma, Rocío Viollaz, Luis Panico
INTRODUCTION: Epilepsy is a chronic disease that affects 0.5-1% of the population. One third of the patients become refractory to antiepileptic drugs. Among the non-pharmacological treatments available, the modified Atkins diet is an effective treatment used since 2003 as another alternative for children and adults with refractory epilepsy. DEVELOPMENT: The Ketogenic Diet National Committee, which depends on the Argentine Society of Pediatric Neurology, elaborated this consensus on the modified Atkins diet, basing itself on a review of the literature and on their clinical experience...
April 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27060389/establishing-an-adult-epilepsy-diet-center-experience-efficacy-and-challenges
#8
Mackenzie C Cervenka, Bobbie J Henry, Elizabeth A Felton, Katlyn Patton, Eric H Kossoff
OBJECTIVES: Over 250 medical centers worldwide offer ketogenic diets to children with epilepsy; however, access to these therapies has been extremely limited for adults until recent years. We examine our 5-year experience creating and implementing a dedicated Adult Epilepsy Diet Center designed to provide adults with epilepsy access to ketogenic diets. MATERIAL AND METHODS: Outpatients seen at the Johns Hopkins Adult Epilepsy Diet Center from August 2010 thru September 2015 age 18years and older were enrolled in a prospective open-label observational study...
May 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26993568/non-pharmacological-medical-treatment-in-pediatric-epilepsies
#9
REVIEW
S Auvin
The ketogenic diet is a high-fat, low-protein, low-carbohydrate diet that has been employed as a non-pharmacologic therapy for refractory epilepsy. Several multicenter and two randomized studies have demonstrated the efficacy of the ketogenic diet and the modified Atkins diet for children and adolescent with pharmacoresitant epilepsy. In order to facilitate patient tolerability and palatability, the diet protocols are gradually modified including changes in ratios of the fat versus non-fat components and the initiation of the diet with or without fasting...
March 2016: Revue Neurologique
https://www.readbyqxmd.com/read/26961268/diet-redux-outcomes-from-reattempting-dietary-therapy-for-epilepsy
#10
Eric H Kossoff, Sarah C Doerrer, Steven P Winesett, Zahava Turner, Bobbie J Henry, Stacey Bessone, Anthony Stanfield, Mackenzie C Cervenka
The outcome for patients attempting dietary therapy for epilepsy a second time is unknown. Twenty-six subjects treated with the ketogenic diet as children who then began either the ketogenic diet or a Modified Atkins Diet (MAD) at least 6 months later were evaluated. The mean age at the first diet trial was 5.6 years and at the second diet trial was 11.5 years. Most restarted dietary therapy because of persistent seizures (65%) or recurrence after seizure freedom (19%). Overall, 77% had a ≥50% seizure reduction with the first diet, and 50% with the second diet, P = ...
July 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/26923720/outcome-of-ketogenic-diets-in-glut1-deficiency-syndrome-in-japan-a-nationwide-survey
#11
Tatsuya Fujii, Yasushi Ito, Satoru Takahashi, Kuriko Shimono, Jun Natsume, Keiko Yanagihara, Hirokazu Oguni
OBJECTIVES: To evaluate the outcome of ketogenic diets (KDs) in patients with glucose transport type 1 deficiency syndrome (GLUT1DS) in Japan. METHODS: A nationwide survey for GLUT1DS was conducted by sending questionnaires to board-certified pediatric neurologists nationwide to obtain clinical and laboratory data. RESULTS: Among 39 patients whose diagnosis was confirmed molecularly or by the 3-O-methylglucose uptake assay, 31 were treated with KDs for longer than 1month...
August 2016: Brain & Development
https://www.readbyqxmd.com/read/26859528/ketogenic-diet-and-other-dietary-treatments-for-epilepsy
#12
REVIEW
Kirsty Martin, Cerian F Jackson, Robert G Levy, Paul N Cooper
BACKGROUND: The ketogenic diet (KD), being high in fat and low in carbohydrates, has been suggested to reduce seizure frequency. It is currently used mainly for children who continue to have seizures despite treatment with antiepileptic drugs. Recently, there has been interest in less restrictive KDs including the modified Atkins diet (MAD) and the use of these diets has extended into adult practice. OBJECTIVES: To review the evidence for efficacy and tolerability from randomised controlled trials regarding the effects of KD and similar diets...
February 9, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26839878/ketogenic-diet-for-children-with-epilepsy-a-practical-meal-plan-in-a-hospital
#13
Eunjoo Lee, Hoon-Chul Kang, Heung Dong Kim
A ketogenic diet (KD) is a dietary approach to treat intractable epilepsy. The KD begins with hospitalization and the child and their parents can adapt to the KD for 1-2 weeks. Recently, various type of dietary intervention such as the modified Atkins diet (MAD) and the low glycemic index treatment (LGIT) have been performed. Since 2010, we carried out the KD, MAD, and LGIT for total of 802 patients; 489 patients (61%) for the KD, 147 patients (18.3%) with the MAD, and 166 patients (20.7%) for the LGIT. In this report, application of these dietary practices in Severance Hospital is shared...
January 2016: Clinical Nutrition Research
https://www.readbyqxmd.com/read/26803281/use-of-dietary-therapies-amongst-patients-with-glut1-deficiency-syndrome
#14
Hannah R Kass, S Parrish Winesett, Stacey K Bessone, Zahava Turner, Eric H Kossoff
PURPOSE: GLUT-1 deficiency syndrome (GLUT1DS) is a neurologic disorder manifesting as epilepsy, abnormal movements, and cognitive delay. The currently accepted treatment of choice is the classic 4:1 ratio ketogenic diet. METHODS: A 2-page survey was distributed to all attendees of a family-centered conference for GLUT1DS in July 2015. The surveys were completed by parents, collected anonymously, and information analyzed in a database. RESULTS: Surveys were received from 92 families, of which 90 (98%) had been treated with dietary therapies...
February 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/26781762/the-challenges-of-vitamin-and-mineral-supplementation-in-children-with-inherited-metabolic-disorders-a-prospective-trial
#15
A Daly, S Evans, S Chahal, I Surplice, S Vijay, S Santra, A MacDonald
BACKGROUND: In order to achieve metabolic stability, dietary treatment of inborn errors of metabolism may require restriction of protein, fat or carbohydrate. Manipulation of dietary intake potentially reduces micronutrient status, and provision of a comprehensive vitamin and mineral supplement becomes an essential adjunct to dietary treatment. AIM: To review the efficacy of a new complete vitamin and mineral supplement [Fruitivits, Vitaflo Ltd] in 14 subjects in an open prospective 26-week study...
August 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/26662710/efficacy-of-the-classic-ketogenic-and-the-modified-atkins-diets-in-refractory-childhood-epilepsy
#16
RANDOMIZED CONTROLLED TRIAL
Jeong A Kim, Jung-Rim Yoon, Eun Joo Lee, Joon Soo Lee, Jeong Tae Kim, Heung Dong Kim, Hoon-Chul Kang
OBJECTIVE: We aimed to compare the efficacy, safety, and tolerability of a modified Atkins diet (MAD) with the classic ketogenic diet (KD) for the treatment of intractable childhood epilepsy. METHODS: From March 2011 to March 2014, 104 patients aged 1-18 years who had refractory epilepsy were randomly assigned to each diet group (ClinicalTrials.gov, number NCT2100501). A seizure diary record was used to compare seizure frequencies with the baseline prediet seizure frequency at the third and sixth months after diet therapy initiation...
January 2016: Epilepsia
https://www.readbyqxmd.com/read/26649186/glycemic-modulation-in-neuro-oncology-experience-and-future-directions-using-a-modified-atkins-diet-for-high-grade-brain-tumors
#17
Roy E Strowd, Mackenzie C Cervenka, Bobbie J Henry, Eric H Kossoff, Adam L Hartman, Jaishri O Blakeley
Dietary glycemic modulation through high-fat, low-carbohydrate diets, which induce a state of systemic ketosis and alter systemic metabolic signaling, have been incorporated into the clinical management of patients with neurological disease for more than a century. Mounting preclinical evidence supports the antitumor, proapoptotic, and antiangiogenic effects of disrupting glycolytic metabolism through dietary intervention. In recent years, interest in incorporating such novel therapeutic strategies in neuro-oncology has increased...
September 2015: Neuro-oncology Practice
https://www.readbyqxmd.com/read/26588588/a-prospective-study-of-the-modified-atkins-diet-for-adults-with-idiopathic-generalized-epilepsy
#18
Magnhild Kverneland, Kaja K Selmer, Karl O Nakken, Per O Iversen, Erik Taubøll
For children with pharmacoresistant epilepsy, the ketogenic diet is an established treatment option worldwide. However, for adults, this treatment is less frequently offered, and its efficacy less well-documented. The aim of this study was to examine efficacy and tolerability of such a diet as an adjuvant therapy to antiepileptic drugs for adult patients with pharmacoresistant generalized epilepsy. Thirteen patients (12 women) aged 16-57 years were included prospectively. They were treated with a modified Atkins diet for 12 weeks...
December 2015: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26198999/dietary-therapy-is-the-best-option-for-refractory-nonsurgical-epilepsy
#19
REVIEW
Elizabeth A Felton, Mackenzie C Cervenka
Ketogenic diet therapies for epilepsy have been described since the fifth century and published in scientific literature since the early 1900s. Since that time, the diet's popularity has waxed and waned as newer drugs and other treatments have been introduced. However, in recent years, dietary therapy for epilepsy has been increasingly accepted by physicians and desired by patients as an alternative to new drugs and neurostimulation. The introduction of less restrictive versions of the classic ketogenic diet, such as the modified Atkins diet (MAD), have led to increased numbers of adult patients with refractory epilepsy who are initiating dietary treatment...
September 2015: Epilepsia
https://www.readbyqxmd.com/read/25864940/treatment-of-paroxysmal-dyskinesias-in-children
#20
Jonathan W Mink
Paroxysmal dyskinesia represents a group of uncommon movement disorders that are characterized by episodes of abnormal movements arising from a baseline of normal or nearly normal movement. Recent advances in the genetics of these disorders have helped provide some unification of classification schemes and better understanding. However, the approach to treatment continues to be based on the phenotype more than the genotype. The treatment approach is primarily based on the factors that precipitate the episodes of abnormal movements...
June 2015: Current Treatment Options in Neurology
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