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osteosarcoma and nuclear medicine

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https://www.readbyqxmd.com/read/27776427/phyllanthus-urinaria-s-inhibition-of-human-osteosarcoma-xenografts-growth-in-mice-is-associated-with-modulation-of-mitochondrial-fission-fusion-machinery
#1
Sheng-Teng Huang, Chao-Chun Huang, Jer-Ming Sheen, Tsu-Kung Lin, Pei-Lin Liao, Wen-Liang Huang, Pei-Wen Wang, Chia-Wei Liou, Jiin-Haur Chuang
Osteosarcoma is an aggressive bone cancer arising from primitive transformed cells of mesenchymal origin to form malignant osteoid. Phyllanthus urinaria [Formula: see text]P. urinaria[Formula: see text] is a widely used folk medicine in cancer treatment, however the mechanism of P. urinaria inhibited human osteosarcoma is unclear. The present study was aimed at investigating the antitumoral effects of an aqueous P. urinaria on human osteosarcoma in vivo and the related underlying mechanisms, mainly focusing on mitochondrial dynamic dysfunction...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27110639/proliferation-apoptosis-and-invasion-effects-of-mistletoe-alkali-on-human-osteosarcoma-u2os-in-vitro
#2
Yan Ge, Yishu Wang, Lei Pang, Lihong Zhang, Yingxian Zhai, Houlan Zhou
OBJECTIVE: To evaluate the effects of mistletoe alkali on human Osteosarcoma cells (U2OS) in vitro. SUMMARY OF BACKGROUND DATA: Osteosarcoma is the most common primary malignant tumor of bone tumor, although there are a lot of therapies such as surgery, radiotherapy and chemotherapy, its prognosis is still very poor. There is increasing interest in the protective biological function of natural antioxidants contained in Chinese medicinal herbs, which are candidates for the prevention of tumors...
April 25, 2016: International Surgery
https://www.readbyqxmd.com/read/26134602/tanshinone-iia-enhances-bystander-cell-killing-of-cancer-cells-expressing-drosophila-melanogaster-deoxyribonucleoside-kinase-in-nuclei-and-mitochondria
#3
Haiyang Jiang, Lei Zhao, Xiaoshen Dong, Anning He, Caiwei Zheng, Magnus Johansson, Anna Karlsson, Xinyu Zheng
Heterologous expression of the Drosophila melanogaster multi-substrate deoxyribonucleoside kinase (Dm-dNK) increases the sensitivity of cancer cells to several cytotoxic nucleoside analogs. Thus, it may be used as a suicide gene in combined gene/chemotherapy treatment of cancer. To further characterize this potential suicide gene, we constructed two retroviral vectors that enabled the expression of Dm-dNK in cancer cells. One vector harbored the wild‑type enzyme that localized to the nucleus. The other vector harbored a mitochondrial localized mutant enzyme that was constructed by deleting the nuclear localization signal and fusing it to a mitochondrial import signal of cytochrome c oxidase...
September 2015: Oncology Reports
https://www.readbyqxmd.com/read/25978954/molecular-mechanisms-of-polyphyllin-i-induced-apoptosis-and-reversal-of-the-epithelial-mesenchymal-transition-in-human-osteosarcoma-cells
#4
Junli Chang, Hongshen Wang, Xianyang Wang, Yongjian Zhao, Dongfeng Zhao, Chenglong Wang, Yimian Li, Zhilie Yang, Sheng Lu, Qinghua Zeng, Jacquelyn Zimmerman, Qi Shi, Yongjun Wang, Yanping Yang
Osteosarcoma is a most common highly malignant bone tumor in children and adolescents. Polyphyllin I (PPI) is an ethanol extraction from Paris polyphylla Smith var.yunnanensis (Franch.) Hand.-Mazz, which belongs to antipyretic-detoxicate family and has been used as a natural medicine in the treatment of infectious disease and cancer in China for centuries. The proteasome activity inhibitory and anti-osteosarcoma effects of PPI have not been known. Here we found PPI exhibited a selective inhibitory effect on proteasomal chymotrypsin (CT)-like activity, both in purified human proteasome and in cultured osteosarcoma cellular proteasome, and caused an accumulation of ubiquitinated proteins...
July 21, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25862967/the-resveratrol-oligomers-cis-and-trans-gnetin-h-from-paeonia-suffruticosa-seeds-inhibit-the-growth-of-several-human-cancer-cell-lines
#5
Ying Gao, Chunnian He, Ran Ran, Dabing Zhang, Dawei Li, Pei-Gen Xiao, Elliot Altman
ETHNOPHARMACOLOGICAL RELEVANCE: Paeonia suffruticosa Andrews (PSE) is a well-known Chinese medicine that has been widely used as an anti-tumor, anti-oxidative and anti-inflammatory agent. cis- and trans-gnetin H are two resveratrol oligomers isolated from the seeds of PSE. Although resveratrol is widely considered to be one of the most valuable natural chemopreventive agents and there are numerous studies on the antitumor activities of resveratrol, little is known about the antitumor properties of cis- and trans-gnetin H...
July 1, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25070229/imaging-evaluation-of-musculoskeletal-tumors
#6
REVIEW
Nicholas Morley, Imran Omar
In this chapter, we review different imaging modalities, including radiography, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, and nuclear medicine scintigraphy, and their application to musculoskeletal neoplasm. Advantages and limitations of each modality are reviewed, and suggestions for imaging approach are provided.
2014: Cancer Treatment and Research
https://www.readbyqxmd.com/read/24314238/the-anti-tumor-effect-of-shikonin-on-osteosarcoma-by-inducing-rip1-and-rip3-dependent-necroptosis
#7
Zeze Fu, Biyong Deng, Yuxin Liao, Liancheng Shan, Fei Yin, Zhuoying Wang, Hui Zeng, Dongqing Zuo, Yingqi Hua, Zhengdong Cai
BACKGROUND: Osteosarcoma is the most frequent primary malignant bone tumor, notorious for its lung metastasis. Shikonin, an effective constituent extracted from Chinese medicinal herb, was demonstrated to induce necroptosis in some cancers. METHODS: MTT assay was performed to detect cell survival rate in vitro. Flow cytometry was used to analyze cell cycle and cell death. Western blot was performed to determine the expression levels of RIP1, RIP3, caspase-3, caspase-6 and PARP...
December 6, 2013: BMC Cancer
https://www.readbyqxmd.com/read/24067459/growth-factors-their-receptor-expression-and-markers-for-proliferation-of-endothelial-and-neoplastic-cells-in-human-osteosarcoma
#8
E Bianchi, M Artico, C Di Cristofano, M Leopizzi, S Taurone, M Pucci, P Gobbi, F Mignini, V Petrozza, I Pindinello, M T Conconi, C Della Rocca
Osteosarcoma is the most common primary malignant tumour of the bone. Although new therapies continue to be reported, osteosarcoma-related morbidity and mortality remain high. Modern medicine has greatly increased knowledge of the physiopathology of this neoplasm. Novel targets for drug development may be identified through an understanding of the normal molecular processes that are deeply modified in pathological conditions. The aim of the present study is to investigate, by immunohistochemistry, the localisation of different growth factors and of the proliferative marker Ki-67 in order to determine whether these factors are involved in the transformation of osteogenic cells and in the development of human osteosarcoma...
July 2013: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/23912183/tetramethylpyrazine-inhibits-osteosarcoma-cell-proliferation-via-downregulation-of-nf-%C3%AE%C2%BAb-in-vitro-and-in-vivo
#9
Yong Wang, Qin Fu, Wei Zhao
Tetramethylpyrazine (TMP) is an effective component of the traditional Chinese medicine Chuanxiong, which has been reported to have beneficial effects in various types of cancer. However, the activity and mechanism of action of TMP in osteosarcoma (OS) have not been elucidated to date. The aim of the present study was to investigate the inhibitory effect of TMP on OS and its underlying mechanism of action. OS cells were treated with various concentrations of TMP for 48 h. BALB/c nude mice with OS were treated with an intraperitoneal injection of TMP at a dose of 100 mg/kg every other day for 28 days...
October 2013: Molecular Medicine Reports
https://www.readbyqxmd.com/read/23673544/osteosarcoma-review-of-the-various-types-with-emphasis-on-recent-advancements-in-imaging
#10
REVIEW
Michael G Fox, Brian M Trotta
Osteosarcoma is the classic malignant osteoid-forming bone tumor. The typical clinical presentation, histology, imaging findings, treatment, and prognosis for each subtype of osteosarcoma is provided. Particular emphasis is placed on more current magnetic resonance imaging and nuclear medicine imaging techniques that may soon improve the ability to determine the most appropriate therapy and ultimately improve patient survival.
April 2013: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/23354363/xiao-jin-wan-a-traditional-chinese-herbal-formula-inhibits-proliferation-via-arresting-cell-cycle-progression-at-the-g2-m-phase-and-promoting-apoptosis-via-activating-the-mitochondrial%C3%A2-dependent-pathway-in-u-2os-human-osteosarcoma-cells
#11
Guangwen Wu, Jianfeng Chu, Zhengrong Huang, Jinxia Ye, Panyu Chen, Chunsong Zheng, Xihai Li, Xianxiang Liu, Mingxia Wu
Xiao Jin Wan (XJW) is a well-known traditional Chinese folk-medicine, which is commonly used for the treatment of various types of diseases including cancers. However, the mechanism of the anticancer activity of XJW against U-2OS human osteosarcoma cells, have not yet been reported. In the present study, we investigated the cellular effects of the XJW on the U-2OS human osteosarcoma cell line. Our results showed that XJW induced cell morphological changes, reduced cell viability in a dose- and time-dependent manner and arrested in the G2/M phase of the cell cycle suggesting that XJW inhibited the proliferation of U-2OS cells...
March 2013: International Journal of Oncology
https://www.readbyqxmd.com/read/23075374/radiopharmaceuticals-for-bone-metastasis-therapy-and-beyond-a-voyage-from-the-past-to-the-present-and-a-look-to-the-future
#12
REVIEW
Sara Ferreira, Irene Dormehl, Maria Filomena Botelho
Bone cancer can be divided into primary and secondary (metastatic) bone cancer. Osteosarcoma is the most common type of primary bone cancer, but still is a rare cancer. The development of bone metastases is a common event for the cancer patient and the main cause of treatment failure and death, being chronic pain syndrome the most important complication. There are currently several therapeutic modalities for the treatment of metastatic bone disease, including radiation therapy. Treatment with radionuclides (β- and α-particle emitters and Auger electron cascades) is a safe and effective tool of medicine...
November 2012: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/22356869/mesenchymal-stem-cells-with-rhbmp-2-inhibits-the-growth-of-canine-osteosarcoma-cells
#13
Rose Eli Grassi Rici, Dayane Alcântara, Paula Fratini, Cristiane Valverde Wenceslau, Carlos Eduardo Ambrósio, Maria Angelica Miglino, Durvanei Augusto Maria
BACKGROUND: The bone morphogenetic proteins (BMPs) belong to a unique group of proteins that includes the growth factor TGF-β. BMPs play important roles in cell differentiation, cell proliferation, and inhibition of cell growth. They also participate in the maturation of several cell types, depending on the microenvironment and interactions with other regulatory factors. Depending on their concentration gradient, the BMPs can attract various types of cells and act as chemotactic, mitogenic, or differentiation agents...
2012: BMC Veterinary Research
https://www.readbyqxmd.com/read/22319200/serine-305-phosphorylation-modulates-estrogen-receptor-alpha-binding-to-a-coregulator-peptide-array-with-potential-application-in-predicting-responses-to-tamoxifen
#14
René Houtman, Renée de Leeuw, Mariska Rondaij, Diana Melchers, Desiree Verwoerd, Rob Ruijtenbeek, John W M Martens, Jacques Neefjes, Rob Michalides
With current techniques, it remains a challenge to assess coregulator binding of nuclear receptors, for example, the estrogen receptor alpha (ERα). ERα is critical in many breast tumors and is inhibited by antiestrogens such as tamoxifen in cancer therapy. ERα is also modified by acetylation and phosphorylation that affect responses to the antiestrogens as well as interactions with coregulators. Phosphorylation of ERα at Ser305 is one of the mechanisms causing tamoxifen resistance. Detection of resistance in patient samples would greatly facilitate clinical decisions on treatment, in which such patients would receive other treatments such as aromatase inhibitors or fulvestrant...
April 2012: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/22197093/imaging-of-primary-bone-tumors-in-veterinary-medicine-which-differences
#15
Maïa Vanel, Laurent Blond, Daniel Vanel
Veterinary medicine is most often a mysterious world for the human doctors. However, animals are important for human medicine thanks to the numerous biological similarities. Primary bone tumors are not uncommon in veterinary medicine and especially in small domestic animals as dogs and cats. As in human medicine, osteosarcoma is the most common one and especially in the long bones extremities. In the malignant bone tumor family, chondrosarcoma, fibrosarcoma and hemangiosarcoma are following. Benign bone tumors as osteoma, osteochondroma and bone cysts do exist but are rare and of little clinical significance...
December 2013: European Journal of Radiology
https://www.readbyqxmd.com/read/20823809/therapeutic-nuclear-medicine-in-pediatric-malignancy
#16
REVIEW
M Schmidt, R P Baum, T Simon, R Howman-Giles
The following review aims to provide contemporary information on therapeutic nuclear medicine procedures in paediatric malignancies. Neuroblastoma is the most common paediatric extra cranial solid cancer characterized by meta-iodobenzylguanidine (mIBG) avidity in >/=90% of patients. There exists approximately a 30-year experience with I-131-mIBG treatment. Ongoing efforts include a more standardized approach including dosimetric data for patient selection and treatment guidance of I-131-mIBG therapy. Neuroendocrine tumours (NETs) are very rare neoplasms in the paediatric population accounting for <1% of all paediatric malignancies...
August 2010: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/20044614/curcumin-induces-cell-cycle-arrest-and-apoptosis-in-human-osteosarcoma-hos-cells
#17
Duk Su Lee, Mi Kyoung Lee, Jeong Hee Kim
BACKGROUND: Curcumin is a major component of Curcuma longa rhizome and has been used as a traditional medicine for centuries. In this study, we showed that curcumin induced cell cycle arrest followed by antiproliferation and apoptosis in human osteosarcoma (HOS) cells. MATERIALS AND METHODS: Antiproliferative activity was measured with the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Nuclear fragmentation was observed with a fluorescence microscope...
December 2009: Anticancer Research
https://www.readbyqxmd.com/read/19725052/nuclear-matrix-protein-prohibitin-was-down-regulated-and-translocated-from-nucleus-to-cytoplasm-during-the-differentiation-of-osteosarcoma-mg-63-cells-induced-by-ginsenoside-rg1-cinnamic-acid-and-tanshinone-iia-rct
#18
Song-Lin Shi, Qi-Fu Li, Qing-Rong Liu, Dong-Hui Xu, Jian Tang, Ying Liang, Zhen-Li Zhao, Li-Ming Yang
Ginsenoside Rg1, cinnamic acid, and tanshinone IIA (RCT) are effective anticancer and antioxidant constituents of traditional Chinese herbal medicines of Ginseng, Xuanseng, and Danseng. The molecular mechanisms of anticancer effects of those constituents and their targets are unknown. Prohibitin, an inner membrane-bound chaperone in mitochondrion involved in the regulation of cell growth, proliferation, differentiation, aging, and apoptosis, was chosen as a candidate molecular target because of its frequent up-regulation in various cancer cells...
November 1, 2009: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/19723088/apoptosis-of-human-primary-osteoclasts-treated-with-molecules-targeting-nuclear-factor-kappab
#19
REVIEW
Roberta Piva, Letizia Penolazzi, Monica Borgatti, Ilaria Lampronti, Elisabetta Lambertini, Elena Torreggiani, Roberto Gambari
Osteoclasts (OCs) are involved in several pathologies associated with bone loss, including rheumatoid arthritis, osteoporosis, bone metastasis of myeloma, osteosarcoma, and breast cancer. In this review we determined the effects of natural compounds, including extracts from medicinal plants, on differentiation and survival of human primary OCs obtained from peripheral blood. We found that OCs from umbilical cord blood and peripheral blood behave differently in response to molecules inducing apoptosis in this experimental system...
August 2009: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/18524012/therapeutic-touch-affects-dna-synthesis-and-mineralization-of-human-osteoblasts-in-culture
#20
Ankur Jhaveri, Stephen J Walsh, Yatzen Wang, MaryBeth McCarthy, Gloria Gronowicz
Complementary and alternative medicine (CAM) techniques are commonly used in hospitals and private medical facilities; however, the effectiveness of many of these practices has not been thoroughly studied in a scientific manner. Developed by Dr. Dolores Krieger and Dora Kunz, Therapeutic Touch is one of these CAM practices and is a highly disciplined five-step process by which a practitioner can generate energy through their hands to promote healing. There are numerous clinical studies on the effects of TT but few in vitro studies...
November 2008: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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