Siyu Xiu, Xiaowei Chi, Zhenyu Jia, Cheng Shi, Xiangyu Zhang, Qi Li, Tongfei Gao, Liangren Zhang, Zhenming Liu
Nuclear receptor-binding SET domain 3, otherwise known as NSD3, is a member of the group of lysine methyltransferases and is involved in a variety of cellular processes, including transcriptional regulation, DNA damage repair, non-histone related functions and several others. NSD3 gene is mutated or loss of function in a variety of cancers, including breast, lung, pancreatic, and osteosarcoma. These mutations produce dysfunction of the corresponding tumor tissue proteins, leading to tumorigenesis, progression, chemoresistance, and unfavorable prognosis, which suggests that the development of NSD3 probe molecules is important for understanding the specific role of NSD3 in disease and drug discovery...
May 9, 2023: European Journal of Medicinal Chemistry