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https://www.readbyqxmd.com/read/28068869/a-regenerative-cardiac-patch-formed-by-spray-painting-of-biomaterials-onto-the-heart
#1
Junnan Tang, Adam Vandergriff, Zegen Wang, Michael Hensley, Jhon Cores, Tyler Allen, Phuong-Uyen Dinh, Jinying Zhang, Thomas Caranasos, Ke Cheng
Layering a regenerative polymer scaffold on the surface of the heart, termed as a cardiac patch, has been proven to be effective in preserving cardiac function after myocardial infarction. However, the placement of such a patch on the heart usually needs open-chest surgery, which is traumatic therefore prevents the translation of this strategy into the clinic. We sought to device a novel method to apply a cardiac patch by spray painting in situ polymerizable biomaterials onto the heart with a minimally invasive procedure...
January 9, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28063720/a-case-of-cardiac-arrest-that-occurred-on-a-high-mountain-in-which-a-favorable-outcome-was-obtained
#2
Youichi Yanagawa, Kazuhiko Omori, Ikuto Takeuchi, Kei Jitsuiki, Toshihiko Yoshizawa, Kouhei Ishikawa, Yumi Kando, Mutsumu Fukata, Hiromichi Ohsaka
A 36-year-old man started to climb Mount Fuji (3776m above sea level: ASL), from the Gotemba new fifth station (2400m ASL). He had no significant medical history, and this was his first attempt to climb such a high mountain. He began feeling chest discomfort but continued to climb. When he reached the ninth station of the mountain (3600mASL), he lost consciousness. One individual immediately provided basic life support using an automated external defibrillator (AED) that was located in the station. After electroshocks, he regained consciousness...
October 24, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28049727/allosteric-transmission-along-a-loosely-structured-backbone-allows-a-cardiac-troponin-c-mutant-to-function-with-only-one-ca2-ion
#3
Mayra de A Marques, Jose Renato Pinto, Adolfo H Moraes, Anwar Iqbal, Mariana T Q de Magalhães, Jamila Monteiro, Murilo M Pedrote, Martha M Sorenson, Jerson L Silva, Guilherme A P de Oliveira
Hypertrophic cardiomyopathy (HCM) is one of the most common cardiomyopathies, and a major cause of sudden death in young athletes. The Ca2+ sensor of the sarcomere, cardiac troponin C (cTnC), plays an important role in regulating muscle contraction. Although several cardiomyopathy-causing mutations have been identified in cTnC, limited information about their structural defects has been mapped to the HCM phenotype. Here, we use high-resolution electron-spray ionization mass spectrometry (ESI-MS), Carr-Purcell-Meiboom-Gill relaxation dispersion (CPMG-RD) and affinity measurements of cTnC for the thin filament in reconstituted papillary muscles to provide evidence of an allosteric mechanism in mutant cTnC that may play a role to the HCM phenotype...
January 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27943590/a-collagen-cardiac-patch-incorporating-alginate-microparticles-permits-the-controlled-release-of-hgf-and-igf-1-to-enhance-cardiac-stem-cell-migration-and-proliferation
#4
Hugh S O'Neill, Janice O'Sullivan, Niamh Porteous, Eduardo Ruiz Hernandez, Helena M Kelly, Fergal J O'Brien, Garry P Duffy
Cardiac Stem Cells (CSCs) represent a logical cell type to exploit as a regenerative treatment option for tissue damage accrued as a result of a myocardial infarction (MI). However, the isolation and expansion of CSCs prior to cell transplantation is time-consuming, costly and invasive, and the reliability of cell expansion may also prove to be a major obstacle in the clinical application of CSC based transplantation therapy after a MI. In order to overcome this, we propose the incorporation of growth factor-eluting alginate microparticles (MPs) into collagen-based scaffolds as an implantable biomaterial to promote the recruitment and expansion of CSCs in the myocardium...
December 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27919455/potential-benefits-and-consequences-of-public-reporting-of-pediatric-cardiac-surgery-outcomes
#5
EDITORIAL
J William Gaynor, Sara K Pasquali, Richard G Ohye, Thomas L Spray
No abstract text is available yet for this article.
October 28, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27869543/direct-bonding-of-chitosan-biomaterials-to-tissues-using-transglutaminase-for-surgical-repair-or-device-implantation
#6
Javier G Fernandez, Suneil Seetharam, Christopher Ding, Juani Feliz, Ed Doherty, Donald E Ingber
Natural biomaterials, such as chitosan and collagen, are useful for biomedical applications because they are biocompatible, mechanically robust, and biodegradable, but it is difficult to rapidly and tightly bond them to living tissues. In this study, we demonstrate that the microbial transglutaminase (mTG), can be used to rapidly (<5 min) bond chitosan and collagen biomaterials to the surfaces of hepatic, cardiac, and dermal tissues, as well as to functionalized polydimethylsiloxane (PDMS) materials that are used in medical products...
December 19, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27834765/a-comparison-of-perioperative-management-of-anomalous-aortic-origin-of-a-coronary-artery-between-an-adult-and-pediatric-cardiac-center
#7
Jeremy L Herrmann, Leah A Goldberg, Abigail M Khan, Sara L Partington, Julie A Brothers, Christopher E Mascio, Thomas L Spray, Yuli Y Kim, Stephanie Fuller
BACKGROUND: Anomalous aortic origin of a coronary artery (AAOCA) presents in varying age-groups. Assuming management algorithms differ between pediatric and adult institutions, we compared the perioperative management of patients with AAOCA at two such centers. METHODS: A retrospective review was conducted at a pediatric and an adult institution of patients 14 years or older who underwent surgical repair of AAOCA between January 2000 and May 2014. RESULTS: Twenty patients from the pediatric center (median age: 16...
November 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27763916/hemodynamic-instability-following-airway-spray-cryotherapy
#8
Alessia Pedoto, Dawn P Desiderio, David Amar, Robert J Downey
BACKGROUND: Spray cryotherapy (SCT) of airway lesions is used to effectively palliate respiratory symptoms related to airway obstruction, but significant intraoperative hemodynamic complications have been noted. We reviewed the experience at a single institution using SCT for the treatment of obstructive airway tumors. METHODS: A retrospective review of a single institution experience with intraoperative and postoperative hemodynamic complications associated with SCT was performed...
November 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27680535/safety-and-pain-in-electrodiagnostic-studies
#9
REVIEW
Zachary N London
Discomfort is an unavoidable part of electrodiagnostic (EDX) studies. The most readily modifiable mediator of electromyography (EMG)-associated pain is muscle selection. Interventions that may reduce pain include vapocoolant spray, ibuprofen, and techniques such as slapping or stretching the skin. Needlestick injuries to health care workers carry the risk of transmitting bloodborne illnesses, but other infectious complications of EDX studies are very rare. EMG probably contributes to asymptomatic hemorrhage in approximately 1% of patients, but clinically significant bleeding has only been reported a few times...
September 28, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27590462/vapocoolant-spray-versus-lidocaine-infiltration-for-radial-artery-cannulation-a-prospective-randomized-controlled-clinical-trial
#10
Dirk Rüsch, Tilo Koch, Florian Seel, Leopold Eberhart
OBJECTIVES: Local infiltration with lidocaine is a frequently used measure to prevent pain during arterial cannulation. Its administration is associated with pain. Vapocoolants like ethyl chloride or alkanes also affect rapid-onset anesthesia. However, their administration causes less discomfort compared with administration of lidocaine. The effectiveness of vapocoolants in mitigating discomfort associated with arterial cannulation never has been studied. The authors therefore compared vapocoolant with lidocaine for reducing discomfort caused by arterial cannulation...
June 8, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27501598/comparison-of-spraying-and-nebulized-lidocaine-in-patients-undergoing-esophago-gastro-duodenoscopy-a-randomized-trial
#11
RANDOMIZED CONTROLLED TRIAL
Papiroon Noitasaeng, Phongthara Vichitvejpaisal, Uaypom Kaosombatwattana, Jaiyen Tassanee, Siriwongsa Suwannee
OBJECTIVE: Esophago-gastro-duodenoscopy (EGD) was performed under the topical anesthesia of the pharynx. However spraying lidocaine was found to be an annoying maneuver to patients, while nebulized lidocaine appeared to efficiently suppress gags and cough reflexes in airway anesthesia. This study aimed to compare the effectiveness of spraying and nebulized lidocaine for patients undergoing EGD. MATERIAL AND METHOD: A total of 110 patients undergoing elective EGD, with a history of neither lidocaine intolerance nor irritable airways due to smoking, chronic obstructive pulmonary disease (COPD), upper respiratory infection, asthma, cardiac and pulmonary diseases and allergy to lidocaine were included...
May 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27344675/transient-complete-heart-block-secondary-to-bed-bug-insecticide-a-case-of-pyrethroid-cardiac-toxicity
#12
Hemindermeet Singh, Faraz Khan Luni, Bharat Marwaha, Syed Sohail Ali, Mohammed Alo
Pyrethroids are the major components of various commercially used insect repellants. These are less toxic to humans due to their slow absorption and rapid metabolism. However, cases of suicidal and accidental poisoning with household insecticides are not uncommon. We report a case of a 59-year-old female who presented with syncope after an accidental exposure to bed bug repellant spray at home. She was found to be in complete heart block and was treated conservatively. There was complete resolution of symptoms and atrioventricular conduction abnormality on day 2 of hospitalization...
June 25, 2016: Cardiology
https://www.readbyqxmd.com/read/27321986/simulator-teaching-of-cardiopulmonary-bypass-complications-a-prospective-randomized-study
#13
Jeremy L C Smelt, Simon Phillips, Colin Hamilton, Paul Fricker, Dominic Spray, Justin L Nowell, Marjan Jahangiri
OBJECTIVE: Complications of cardiopulmonary bypass (CPB) are rare, but life-threatening events that need prompt and rehearsed actions involving a team. This is not adequately taught to cardiothoracic surgical trainees. The objective of this study was to assess the knowledge of cardiothoracic trainees required to manage these events after simulation-based vs. lecture-based teaching. PARTICIPANTS AND DESIGN: Totally, 17 cardiac surgical trainees with no formal teaching in intraoperative complications of CPB management were randomly assigned by computer to either a study group receiving simulation-based complications of CPB teaching via the Orpheus simulator (n = 9) or a control group receiving complications of CPB teaching via a lecture (n = 8)...
November 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27183886/increasing-cumulative-exposure-to-volatile-anesthetic-agents-is-associated-with-poorer-neurodevelopmental-outcomes-in-children-with-hypoplastic-left-heart-syndrome
#14
Laura K Diaz, J William Gaynor, Shannon J Koh, Richard F Ittenbach, Marsha Gerdes, Judy C Bernbaum, Elaine H Zackai, Robert R Clancy, Mohamed A Rehman, Jeffrey W Pennington, Nancy Burnham, Thomas L Spray, Susan C Nicolson
OBJECTIVES: Despite improved survival in children with hypoplastic left heart syndrome (HLHS), significant concern persists regarding their neurodevelopmental (ND) outcomes. Previous studies have identified patient factors, such as prematurity and genetic syndromes, to be associated with worse ND outcomes. However, no consistent relationships have been identified among modifiable management factors, including cardiopulmonary bypass strategies, and ND outcomes after cardiac surgery in infancy...
August 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26914479/improved-assessment-of-outcomes-following-transient-global-cerebral-ischemia-in-mice
#15
Stine Spray, Lars Edvinsson
Mouse models of global cerebral ischemia (GCI) allow experimental examination of cerebral pathophysiology in genetically modified mice and fast screening of new treatment strategies. Various surgical protocols of GCI-induction in mice have been published; however, many of these studies are hindered by limited neurological assessment protocols and present insufficient reporting of the cumulative survival rate. Therefore, we aim at developing a reproducible and easily implementable model of transient GCI in mice with minimal impact on normal mouse behavior...
July 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/26772815/cyp1b1-inhibition-attenuates-doxorubicin-induced-cardiotoxicity-through-a-mid-chain-hetes-dependent-mechanism
#16
Zaid H Maayah, Hassan N Althurwi, Ghada Abdelhamid, Gabriela Lesyk, Paul Jurasz, Ayman O S El-Kadi
Doxorubicin (DOX) has been reported to be a very potent and effective anticancer agent. However, clinical treatment with DOX has been greatly limited due to its cardiotoxicity. Furthermore, several studies have suggested a role for cytochrome P450 1B1 (CYP1B1) and mid-chain hydroxyeicosatetraenoic acids (mid-chain HETEs) in DOX-induced cardiac toxicity. Therefore, we hypothesized that DOX induced cardiotoxicity is mediated through the induction of CYP1B1 and its associated mid-chain HETEs metabolite. To test our hypothesis, Sprague-Dawley rats and RL-14 cells were treated with DOX in the presence and absence of 2,3',4,5'-tetramethoxystilbene (TMS), a selective CYP1B1 inhibitor...
March 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26721465/topical-spraying-of-cefazolin-and-gentamicin-reduces-deep-sternal-wound-infections-after-heart-surgery-a-multicenter-large-volume-retrospective-study
#17
MULTICENTER STUDY
Hiroshi Osawa, Shinpei Yoshii, Samuel J K Abraham, Yuki Okamoto, Shigeru Hosaka, Shoji Fukuda, Koji Tsuchiya, Masato Nakajima, Yoshihiro Honda, Kouki Takizawa
OBJECTIVE: The use of topical antimicrobials applied to the sternum during cardiac procedures in combination with intravenous agents to prevent mediastinitis has been reported to yield good results. The objective of this study is to provide optimal method of topical antimicrobials for the prevention of sternal wound infection after cardiac surgery. METHODS: We retrospectively evaluated the patients undergoing adult cardiac surgery at five institutions between January 1994 and August 2013 for the incidence of deep sternal wound infection (DSWI)...
April 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26526778/-malignant-hypertension-and-cardiac-decompensation-after-overuse-of-nasal-decongestant-a-case-report-and-literature-review
#18
T Novais, M Bourdelin, O Le Vavasseur, H Bontemps
INTRODUCTION: Vasoconstrictors, widely prescribed in the congestive states during acute rhinitis, are responsible for many cases of drug-related iatrogenic disease. CASE REPORT: We report the case of a 40-year-old man, who presented with an episode of malignant hypertensive crisis associated with life-threatening congestive heart decompensation. The patient interview revealed consumption to supra-therapeutic dosage of an association of naphazoline and prednisolone nasal sprays...
June 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/26410159/improving-cardiac-surgical-site-infection-reporting-and-prevention-by-using-registry-data-for-case-ascertainment
#19
Vaidehi Nayar, Andrea Kennedy, Janine Pappas, Krista D Atchley, Cynthia Field, Sarah Smathers, Eva E Teszner, Julia S Sammons, Susan E Coffin, Jeffrey S Gerber, Thomas L Spray, James M Steven, Louis M Bell, Joan Forrer, Fernando Gonzalez, Albert Chi, William J Nieczpiel, John N Martin, J William Gaynor
BACKGROUND: The use of administrative data for surgical site infection (SSI) surveillance leads to inaccurate reporting of SSI rates [1]. A quality improvement (QI) initiative was conducted linking clinical registry and administrative databases to improve reporting and reduce the incidence of SSI [2]. METHODS: At our institution, The Society of Thoracic Surgeons Congenital Heart Surgery Database (STS-CHSD) and infection surveillance database (ISD) were linked to the enterprise data warehouse containing electronic health record (EHR) billing data...
January 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26295908/lc-ms-ms-and-gc-ms-methods-in-propofol-detection-evaluation-of-the-two-analytical-procedures
#20
COMPARATIVE STUDY
Fabio Vaiano, Giovanni Serpelloni, Martina Focardi, Alessia Fioravanti, Francesco Mari, Elisabetta Bertol
Propofol is a short-acting hypnotic agent that is commonly used to induce and maintain anesthesia. Propofol abuse and its involvement in suicide deaths have increased in recent years, especially among healthcare personnel. An example is the suicide of a 61-year-old nurse found with a propofol drip in his left arm. We describe the postmortem concentration of propofol in various tissues (femoral and cardiac blood, bile, urine, brain, and liver) and in the drip. The toxicological analyses were performed through two analytical methods, differing in derivatization reaction and in instrumentation: silylation for gas chromatograph-mass spectrometer (GC-MS), as routinely performed in our laboratory for this kind of analyses (lower limits of quantification-LLOQ-in urine and blood: 0...
November 2015: Forensic Science International
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