Georgios Georgiopoulos, Simon Kraler, Matthias Mueller-Hennessen, Dimitrios Delialis, Georgios Mavraganis, Kateryna Sopova, Florian A Wenzl, Lorenz Räber, Moritz Biener, Barbara E Stähli, Eleni Maneta, Luke Spray, Juan F Iglesias, Jose Coelho-Lima, Simon Tual-Chalot, Olivier Muller, François Mach, Norbert Frey, Daniel Duerschmied, Harald F Langer, Hugo Katus, Marco Roffi, Giovanni G Camici, Christian Mueller, Evangelos Giannitsis, Ioakim Spyridopoulos, Thomas F Lüscher, Konstantinos Stellos, Kimon Stamatelopoulos
IMPORTANCE: The Global Registry of Acute Coronary Events (GRACE) risk score, a guideline-recommended risk stratification tool for patients presenting with acute coronary syndromes (ACS), does not consider the extent of myocardial injury. OBJECTIVE: To assess the incremental predictive value of a modified GRACE score incorporating high-sensitivity cardiac troponin (hs-cTn) T at presentation, a surrogate of the extent of myocardial injury. DESIGN, SETTING, AND PARTICIPANTS: This retrospectively designed longitudinal cohort study examined 3 independent cohorts of 9803 patients with ACS enrolled from September 2009 to December 2017; 2 ACS derivation cohorts (Heidelberg ACS cohort and Newcastle STEMI cohort) and an ACS validation cohort (SPUM-ACS study)...
August 30, 2023: JAMA Cardiology