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Thomas L Spray

Nikolaj S Winther, Claus L Jensen, Claus M Jensen, Thomas Lind, Henrik M Schrøder, Gunnar Flivik, Michael M Petersen
BACKGROUND: Regenerex is a novel porous titanium construct with a three-dimensional porous structure and biomechanical characteristics close to that of normal trabecular bone. The aim of this study was to compare this novel construct to a well-proven porous plasma sprayed tibial (PPS) implant after total knee arthroplasty. METHODS: Sixty-one patients scheduled for an uncemented TKA were randomized to receive either a novel highly porous titanium construct Regenerex or the PPS tibial component...
October 18, 2016: Knee
Corrado Cancedda, Sheila M Davis, Kerry L Dierberg, Jonathan Lascher, J Daniel Kelly, Mohammed Bailor Barrie, Alimamy Philip Koroma, Peter George, Adikali Alpha Kamara, Ronald Marsh, Manso S Sumbuya, Cameron T Nutt, Kirstin W Scott, Edgar Thomas, Katherine Bollbach, Andrew Sesay, Ahmidu Barrie, Elizabeth Barrera, Kathryn Barron, John Welch, Nahid Bhadelia, Raphael G Frankfurter, Ophelia M Dahl, Sarthak Das, Rebecca E Rollins, Bryan Eustis, Amanda Schwartz, Piero Pertile, Ilias Pavlopoulos, Allan Mayfield, Regan H Marsh, Yusupha Dibba, Danielle Kloepper, Andrew Hall, Karin Huster, Michael Grady, Kimberly Spray, David A Walton, Fodei Daboh, Cora Nally, Sahr James, Gabriel S Warren, Joyce Chang, Michael Drasher, Gina Lamin, Sherry Bangura, Ann C Miller, Annie P Michaelis, Ryan McBain, M Jana Broadhurst, Megan Murray, Eugene T Richardson, Ted Philip, Gary L Gottlieb, Joia S Mukherjee, Paul E Farmer
An epidemic of Ebola virus disease (EVD) beginning in 2013 has claimed an estimated 11 310 lives in West Africa. As the EVD epidemic subsides, it is important for all who participated in the emergency Ebola response to reflect on strengths and weaknesses of the response. Such reflections should take into account perspectives not usually included in peer-reviewed publications and after-action reports, including those from the public sector, nongovernmental organizations (NGOs), survivors of Ebola, and Ebola-affected households and communities...
October 15, 2016: Journal of Infectious Diseases
Ronan Le Cointe, Thomas E Simon, Patrick Delarue, Maxime Hervé, Melen Leclerc, Sylvain Poggi
Reducing our reliance on pesticides is an essential step towards the sustainability of agricultural production. One approach involves the rational use of pesticides combined with innovative crop management. Most control strategies currently focus on the temporal aspect of epidemics, e.g. determining the optimal date for spraying, regardless of the spatial mechanics and ecology of disease spread. Designing innovative pest management strategies incorporating the spatial aspect of epidemics involves thorough knowledge on how disease control affects the life-history traits of the pathogen...
2016: PloS One
Jessica L Waite, Penelope A Lynch, Matthew B Thomas
BACKGROUND: Novel interventions for malaria control are necessary in the face of problems such as increasing insecticide resistance and residual malaria transmission. One way to assess performance prior to deployment in the field is through mathematical modelling. Modelled here are a range of potential outcomes for eave tubes, a novel mosquito control tool combining house screening and targeted use of insecticides to provide both physical protection and turn the house into a lethal mosquito killing device...
2016: Malaria Journal
Felix E Wettstein, Roy Kasteel, Maria F Garcia Delgado, Irene Hanke, Sebastian Huntscha, Marianne E Balmer, Thomas Poiger, Thomas D Bucheli
Pesticide transport from seed dressings toward subsurface tile drains is still poorly understood. We monitored the neonicotinoid insecticides imidacloprid and thiamethoxam from sugar beet seed dressings in flow-proportional drainage water samples, together with spray applications of bromide and the herbicide S-metolachlor in spring and the fungicides epoxiconazole and kresoxim-methyl in summer. Event-driven, high first concentration maxima up to 2830 and 1290 ng/L for thiamethoxam and imidacloprid, respectively, were followed by an extended period of tailing and suggested preferential flow...
August 24, 2016: Journal of Agricultural and Food Chemistry
Bart G J Knols, Marit Farenhorst, Rob Andriessen, Janneke Snetselaar, Remco A Suer, Anne J Osinga, Johan M H Knols, Johan Deschietere, Kija R Ng'habi, Issa N Lyimo, Stella T Kessy, Valeriana S Mayagaya, Sergej Sperling, Michael Cordel, Eleanore D Sternberg, Patrick Hartmann, Ladslaus L Mnyone, Andreas Rose, Matthew B Thomas
In spite of massive progress in the control of African malaria since the turn of the century, there is a clear and recognized need for additional tools beyond long-lasting insecticide-treated bed nets (LLINs) and indoor residual spraying (IRS) of insecticides, to progress towards elimination. Moreover, widespread and intensifying insecticide resistance requires alternative control agents and delivery systems to enable development of effective insecticide resistance management strategies. This series of articles presents a novel concept for malaria vector control, the 'eave tube', which may fulfil these important criteria...
2016: Malaria Journal
James S Tweddell
No abstract text is available yet for this article.
October 2016: Journal of Thoracic and Cardiovascular Surgery
Elizabeth A French, Motoko Mukai, Michael Zurakowski, Bradley Rauch, Gloria Gioia, Joseph R Hillebrandt, Mark Henderson, Ynte H Schukken, Thomas C Hemling
Majority of iodine found in dairy milk comes from the diet and teat disinfection products used during milking process. The objective of this study was to evaluate the effects of 4 iodine-based teat dips on milk iodide concentrations varying in iodine level (0.25% vs. 0.5%, w/w), normal low viscosity dip versus barrier dip, and application method (dip vs. spray) to ensure safe iodine levels in dairy milk when these products are used. The iodine exposure study was performed during a 2-wk period. The trial farm was purged of all iodine-based disinfection products for 21 d during a prestudy "washout period," which resulted in baseline milk iodide range of 145 to 182 ppb...
July 2016: Journal of Food Science
Berna van Wendel de Joode, Benoit Barbeau, Maryse F Bouchard, Ana María Mora, Åsa Skytt, Leonel Córdoba, Rosario Quesada, Thomas Lundh, Christian H Lindh, Donna Mergler
Elevated manganese (Mn) in drinking water has been reported worldwide. While, naturally occurring Mn in groundwater is generally the major source, anthropogenic contamination by Mn-containing fungicides such as mancozeb may also occur. The main objective of this study was to examine factors associated with Mn and ethylenethiourea (ETU), a degradation product of mancozeb, in drinking water samples from villages situated near banana plantations with aerial spraying of mancozeb. Drinking water samples (n = 126) were obtained from 124 homes of women participating in the Infants' Environmental Health Study (ISA, for its acronym in Spanish), living nearby large-scale banana plantations...
August 2016: Environmental Pollution
Laura K Diaz, J William Gaynor, Shannon J Koh, Richard F Ittenbach, Marsha Gerdes, Judy C Bernbaum, Elaine H Zackai, Robert R Clancy, Mohamed A Rehman, Jeffrey W Pennington, Nancy Burnham, Thomas L Spray, Susan C Nicolson
OBJECTIVES: Despite improved survival in children with hypoplastic left heart syndrome (HLHS), significant concern persists regarding their neurodevelopmental (ND) outcomes. Previous studies have identified patient factors, such as prematurity and genetic syndromes, to be associated with worse ND outcomes. However, no consistent relationships have been identified among modifiable management factors, including cardiopulmonary bypass strategies, and ND outcomes after cardiac surgery in infancy...
August 2016: Journal of Thoracic and Cardiovascular Surgery
Xiaofei Wang, Camille M Sultana, Jonathan Trueblood, Thomas C J Hill, Francesca Malfatti, Christopher Lee, Olga Laskina, Kathryn A Moore, Charlotte M Beall, Christina S McCluskey, Gavin C Cornwell, Yanyan Zhou, Joshua L Cox, Matthew A Pendergraft, Mitchell V Santander, Timothy H Bertram, Christopher D Cappa, Farooq Azam, Paul J DeMott, Vicki H Grassian, Kimberly A Prather
With the oceans covering 71% of the Earth, sea spray aerosol (SSA) particles profoundly impact climate through their ability to scatter solar radiation and serve as seeds for cloud formation. The climate properties can change when sea salt particles become mixed with insoluble organic material formed in ocean regions with phytoplankton blooms. Currently, the extent to which SSA chemical composition and climate properties are altered by biological processes in the ocean is uncertain. To better understand the factors controlling SSA composition, we carried out a mesocosm study in an isolated ocean-atmosphere facility containing 3,400 gallons of natural seawater...
June 24, 2015: ACS Central Science
Emilio Dirlikov, Kyle R Ryff, Jomil Torres-Aponte, Dana L Thomas, Janice Perez-Padilla, Jorge Munoz-Jordan, Elba V Caraballo, Myriam Garcia, Marangely Olivero Segarra, Graciela Malave, Regina M Simeone, Carrie K Shapiro-Mendoza, Lourdes Romero Reyes, Francisco Alvarado-Ramy, Angela F Harris, Aidsa Rivera, Chelsea G Major, Marrielle Mayshack, Luisa I Alvarado, Audrey Lenhart, Miguel Valencia-Prado, Steve Waterman, Tyler M Sharp, Brenda Rivera-Garcia
Zika virus is a flavivirus transmitted primarily by Aedes species mosquitoes, and symptoms of infection can include rash, fever, arthralgia, and conjunctivitis (1).* Zika virus infection during pregnancy is a cause of microcephaly and other severe brain defects (2). Infection has also been associated with Guillain-Barré syndrome (3). In December 2015, Puerto Rico became the first U.S. jurisdiction to report local transmission of Zika virus, with the index patient reporting symptom onset on November 23, 2015 (4)...
2016: MMWR. Morbidity and Mortality Weekly Report
Allan H Treiman, David L Bish, David T Vaniman, Steve J Chipera, David F Blake, Doug W Ming, Richard V Morris, Thomas F Bristow, Shaunna M Morrison, Michael B Baker, Elizabeth B Rampe, Robert T Downs, Justin Filiberto, Allen F Glazner, Ralf Gellert, Lucy M Thompson, Mariek E Schmidt, Laetitia Le Deit, Roger C Wiens, Amy C McAdam, Cherie N Achilles, Kenneth S Edgett, Jack D Farmer, Kim V Fendrich, John P Grotzinger, Sanjeev Gupta, John Michael Morookian, Megan E Newcombe, Melissa S Rice, John G Spray, Edward M Stolper, Dawn Y Sumner, Ashwin R Vasavada, Albert S Yen
The Windjana drill sample, a sandstone of the Dillinger member (Kimberley formation, Gale Crater, Mars), was analyzed by CheMin X-ray diffraction (XRD) in the MSL Curiosity rover. From Rietveld refinements of its XRD pattern, Windjana contains the following: sanidine (21% weight, ~Or95); augite (20%); magnetite (12%); pigeonite; olivine; plagioclase; amorphous and smectitic material (~25%); and percent levels of others including ilmenite, fluorapatite, and bassanite. From mass balance on the Alpha Proton X-ray Spectrometer (APXS) chemical analysis, the amorphous material is Fe rich with nearly no other cations-like ferrihydrite...
January 2016: Journal of Geophysical Research. Planets
Sharad Mangal, Felix Meiser, Geoffrey Tan, Thomas Gengenbach, David A V Morton, Ian Larson
OBJECTIVE: In this study, we investigated the applicability of cohesive-adhesive balance (CAB) model to predict the interactive mixing behaviour of small excipient particles. Further, we also investigated the application of this CAB model to predict the flow and compactibility of resultant blends. METHODS: Excipients created by co-spraying polyvinylpyrrolidone (PVP, a model pharmaceutical binder) with various l-leucine concentrations were used for this study. Paracetamol was used as model active pharmaceutical ingredient (API)...
July 2016: European Journal of Pharmaceutics and Biopharmaceutics
Erik Munson, Timothy K Block, Erin J Bowles, Michael Costello, Richard Dern, Thomas R Fritsche, Michael A Helgesen, Joshua L Kropp, Raymond P Podzorski, Karen Siebers, Brian Simmons, Mary A Smith, Frances Spray, Tam T Van, David M Warshauer
BACKGROUND: Antimicrobial resistance presents a threat to quality patient care. Knowledge of localantibacterial susceptibility patterns can guide clinicians in empiric antibacterial administration andassist pharmacists and infectious disease physicians in development of appropriate therapeutic pathways. METHODS: To characterize Wisconsin antibacterial susceptibility patterns and elucidate geographicor temporal variation in antibacterial resistance, a retrospective, observational analysis of antibiogram data was performed...
February 2016: WMJ: Official Publication of the State Medical Society of Wisconsin
Sharad Mangal, Satu Lakio, Thomas Genegenbach, Ian Larson, David A V Morton
In this study, we investigated the influence of deformability of specifically-engineered guest particles on the tensile strength of tablets of interactive mixtures. The binder polyvinylpyrrolidone (PVP) of different molecular weights were spray dried with l-leucine to create guest particle formulations. The guest particle formulations were characterized by their particle size, surface l-leucine concentration and glass transition temperature (Tg). These spray-dried particles were then blended with paracetamol to form interactive mixtures, which were compacted into tablets and tablet tensile strength and elastic recovery were determined...
March 23, 2016: International Journal of Pharmaceutics
Tanya L Russell, Thomas R Burkot, Hugo Bugoro, Allan Apairamo, Nigel W Beebe, Weng K Chow, Robert D Cooper, Frank H Collins, Neil F Lobo
BACKGROUND: There is an urgent need for vector control tools to supplement long-lasting insecticidal nets (LLINs) and indoor residual spraying; particularly in the Solomon Islands where the primary vector, Anopheles farauti, is highly anthropophagic and feeds mainly outdoors and early in the evening. Currently, the only supplementary tool recommended by the World Health Organization is larval source management (LSM). The feasibility and potential effectiveness of LSM requires information on the distribution of anophelines, the productivity of larval habitats and the potential impacts of larval control on adult fitness...
2016: Malaria Journal
Sharad Mangal, Thomas Gengenbach, Doug Millington-Smith, Brian Armstrong, David A V Morton, Ian Larson
In this study, we aimed to investigate the effects cohesion of small surface-engineered guest binder particles on the flow behaviour of interactive mixtures. Polyvinylpyrrolidone (PVP) - a model pharmaceutical binder - was spray-dried with varying l-leucine feed concentrations to create small surface-engineered binder particles with varying cohesion. These spray-dried formulations were characterised by their particle size distribution, morphology and cohesion. Interactive mixtures were produced by blending these spray-dried formulations with paracetamol...
May 2016: European Journal of Pharmaceutics and Biopharmaceutics
Liang Li, Siping Sun, Thaigarajan Parumasivam, John A Denman, Thomas Gengenbach, Patricia Tang, Shirui Mao, Hak-Kim Chan
L-Leucine (LL) has been widely used to enhance the dispersion performance of powders for inhalation. LL can also protect powders against moisture, but this effect is much less studied. The aim of this study was to investigate whether LL could prevent moisture-induced deterioration in in vitro aerosolization performances of highly hygroscopic spray-dried powders. Disodium cromoglycate (DSCG) was chosen as a model drug and different amounts of LL (2-40% w/w) were added to the formulation, with the aim to explore the relationship between powder dispersion, moisture protection and physicochemical properties of the powders...
May 2016: European Journal of Pharmaceutics and Biopharmaceutics
Tanya L Russell, Nigel W Beebe, Hugo Bugoro, Allan Apairamo, Weng K Chow, Robert D Cooper, Frank H Collins, Neil F Lobo, Thomas R Burkot
BACKGROUND: The effectiveness of vector control on malaria transmission by long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) depends on the vectors entering houses to blood feed and rest when people are inside houses. In the Solomon Islands, significant reductions in malaria have been achieved in the past 20 years with insecticide-treated bed nets, IRS, improved diagnosis and treatment with artemisinin combination therapies; despite the preference of the primary vector, Anopheles farauti, to feed outdoors and early in the evening and thereby avoid potential exposure to insecticides...
2016: Malaria Journal
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