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Octreotide diabetes

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https://www.readbyqxmd.com/read/27910739/overview-on-therapeutic-applications-of-microparticulate-drug-delivery-systems
#1
Swarna Bale, Amit Khurana, A Shiva Shankar Reddy, Mandip Singh, Chandraiah Godugu
Research in novel drug delivery systems is being explored competitively in order to attain maximum therapeutic effect while minimizing the adverse effects. Despite several advancements in pharmaceutical formulations, one of the major challenges still persisting is sustained drug release. Microencapsulation enacts as an intelligent approach with a strong therapeutic impact and is in demand globally in medical technology due to its specific and attractive properties, including biocompatibility, stability, target specificity, uniform encapsulation, better compliance, and controlled and sustained release patterns that are responsible for diminishing the toxicity and dosage frequency...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27802864/glucokinase-mutation-a-rare-cause-of-recurrent-hypoglycemia-in-adults-a-case-report-and-literature-review
#2
Oluremi N Ajala, David M Huffman, Ibrahim I Ghobrial
BACKGROUND: Hypoglycemia occurs frequently in patients both in the inpatient and outpatient settings. While most hypoglycemia unrelated to diabetes treatment results from excessive endogenous insulin action, rare cases involve functional and congenital mutations in glycolytic enzymes of insulin regulation. CASE: A 21-year-old obese woman presented to the emergency department with complaints of repeated episodes of lethargy, syncope, dizziness, and sweating. She was referred from an outside facility on suspicion of insulinoma, with severe hypoglycemia unresponsive to repeated dextrose infusions...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27775943/physiological-uptake-in-the-pancreatic-head-on-somatostatin-receptor-scintigraphy-using-111in-dtpa-octreotide-incidence-and-mechanism
#3
Tessa Brabander, Jaap Teunissen, Dik Kwekkeboom
PURPOSE: Physiological uptake in the uncinate process or pancreatic head has been described with Ga-labeled PET tracers for somatostatin receptor imaging. In-DTPA-octreotide is the only registered radiopharmaceutical for the imaging of neuroendocrine tumors. We studied the uptake in this region of the pancreatic head on somatostatin receptor scintigraphy (SRS) using In-DTPA-octreotide in a large group of patients. Furthermore, known physiological and clinical characteristics are discussed in an attempt to elucidate this phenomenon...
October 21, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27633684/peptide-therapeutics-and-the-pharmaceutical-industry-barriers-encountered-translating-from-the-laboratory-to-patients
#4
John Rafferty, Hema Nagaraj, Alice P McCloskey, Rawan Huwaitat, Simon Porter, Alyaa Albadr, Garry Laverty
Peptides are receiving increasing interest as clinical therapeutics. These highly tunable molecules can be tailored to achieve desirable biocompatibility and biodegradability with simultaneously selective and potent therapeutic effects. Despite challenges regarding up-scaling and licensing of peptide products, their vast clinical potential is reflected in the 60 plus peptide-based therapeutics already on the market, and the further 500 derivatives currently in developmental stages. Peptides are proving effective for a multitude of disease states including: type 2 diabetes (controlled using the licensed glucagon-like peptide-1 receptor liraglutide); irritable bowel syndrome managed with linaclotide (currently at approval stages); acromegaly (treated with octapeptide somostatin analogues lanreotide and octreotide); selective or broad spectrum microbicidal agents such as the Gram-positive selective PTP-7 and antifungal heliomicin; anticancer agents including goserelin used as either adjuvant or monotherapy for prostate and breast cancer, and the first marketed peptide derived vaccine against prostate cancer, sipuleucel-T...
September 9, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27286364/vegf-as-a-survival-factor-in-ex-vivo-models-of-early-diabetic-retinopathy
#5
Rosario Amato, Martina Biagioni, Maurizio Cammalleri, Massimo Dal Monte, Giovanni Casini
PURPOSE: Growing evidence indicates neuroprotection as a therapeutic target in diabetic retinopathy (DR). We tested the hypothesis that VEGF is released and acts as a survival factor in the retina in early DR. METHODS: Ex vivo mouse retinal explants were exposed to stressors similar to those characterizing DR, that is, high glucose (HG), oxidative stress (OS), or advanced glycation end-products (AGE). Neuroprotection was provided using octreotide (OCT), a somatostatin analog, and pituitary adenylate cyclase activating peptide (PACAP), two well-documented neuroprotectants...
June 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27117887/serial-follow-up-of-presurgical-treatment-using-pasireotide-long-acting-release-with-or-without-octreotide-long-acting-release-for-na%C3%A3-ve-active-acromegaly
#6
Jan-Shun Chang, Ham-Min Tseng, Tien-Chun Chang
The aim of the present study was to evaluate the serial changes of GH and IGF-1 in seven patients with naïve, active acromegaly following presurgical treatment of the somatostatin analog pasireotide long-acting release (LAR) and octreotide LAR. The patients were treated with pasireotide LAR with or without octreotide LAR for two years and underwent transsphenoidal adenomectomy. After treatment with the somatostatin analogs, the surgical cure rate was similar to that in patients who underwent transsphenoidal surgery alone...
April 22, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27087264/fluoxetine-induced-hypoglycaemia-in-a-patient-with-congenital-hyperinsulinism-on-lanreotide-therapy
#7
Dinesh Giri, Victoria Price, Zoe Yung, Mohammed Didi, Senthil Senniappan
Antidepressant drugs are reported to cause alterations in blood glucose homeostasis in adults with diabetes mellitus. We report a patient with persistent congenital hyperinsulinism (CHI) who developed recurrent hypoglycaemia following fluoxetine therapy. This 15-year-old girl was initially managed with diazoxide therapy. She developed troublesome hypertrichosis, which affected her quality of life adversely. Diazoxide was then slowly weaned and stopped with the introduction of octreotide, to which she responded well...
September 1, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/26890290/metformin-with-everolimus-and-octreotide-in-pancreatic-neuroendocrine-tumor-patients-with-diabetes
#8
Sara Pusceddu, Roberto Buzzoni, Claudio Vernieri, Laura Concas, Sara Marceglia, Luca Giacomelli, Massimo Milione, Livia Leuzzi, Daniela Femia, Barbara Formisano, Vincenzo Mazzaferro, Filippo de Braud
A bidirectional relationship seems to exist between diabetes mellitus and development of pancreatic tumors. Metformin, the most widely used drug in the treatment of Type 2 diabetes mellitus, has recently emerged as a potentially active agent in cancer chemoprevention and treatment. In this article, we discuss the potential correlation between glycemic status, administration of antiglycemic treatments, such as metformin or insulin, and prognosis of pancreatic neuroendocrine tumors patients treated with everolimus and octreotide, on the basis of existing evidence and our experience...
May 2016: Future Oncology
https://www.readbyqxmd.com/read/26834850/pediatric-obesity-causes-symptoms-prevention-and-treatment
#9
Shumei Xu, Ying Xue
Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21-24% children and adolescents are overweight, and 16-18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethnic groups. Obesity increases the risk of heart diseases in children and adults. Childhood obesity predisposes the individual to insulin resistance and type 2 diabetes, hypertension, hyperlipidemia, liver and kidney diseases and causes reproductive dysfunction in adults...
January 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26811671/pasireotide-a-novel-treatment-for-patients-with-acromegaly
#10
REVIEW
Daniel Cuevas-Ramos, Maria Fleseriu
Morbidity and mortality rates in patients with active acromegaly are higher than the general population. Adequate biochemical control restores mortality to normal rates. Now, medical therapy has an increasingly important role in the treatment of patients with acromegaly. Somatostatin receptor ligands (SRLs) are considered the standard medical therapy, either after surgery or as a first-line therapy when surgery is deemed ineffective or is contraindicated. Overall, octreotide and lanreotide are first-generation SRLs and are effective in ~20%-70% of patients...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/26792348/-impact-of-octreotide-on-pancreatic-fistula-after-pancreaticoduodenectomy-a-prospective-study
#11
RANDOMIZED CONTROLLED TRIAL
Rui Kong, Jisheng Hu, Le Li, Gang Wang, Hua Chen, Xuewei Bai, Yongwei Wang, Linfeng Wu, Hongchi Jiang, Bei Sun
OBJECTIVE: To investigate the effect of utilizing octreotide during perioperative period on pancreatic fistula after pancreaticoduodenectomy (PD). METHODS: Three hundreds and six patients admitted from January 2010 to October 2014, who prepared to undergo pancreaticoduodenectomy (PD) were randomly divided into octreotide group (147 cases) and control group (159 cases). In octreotide group, octreotide was used in subcutaneous injection instantly after PD, each 8 hours until postoperative 10(th) day, and patients in control group were injected with the same volume of saline...
January 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/26679960/clinical-and-economic-burden-of-commercially-insured-patients-with-acromegaly-in-the-united-states-a-retrospective-analysis
#12
Hilary Placzek, Yaping Xu, Yunming Mu, Susan M Begelman, Maxine Fisher
BACKGROUND: Acromegaly is a chronic disorder characterized by excess growth hormone secretion and elevated insulin-like growth factor-1 levels most often caused by a pituitary adenoma. Clinical presentation of the disease includes coarsening of the facial features, soft-tissue swelling of the hands and feet, and overgrowth of the frontal skull and protrusion of the jaw, as well as joint symptoms. Acromegaly is associated with several comorbidities, including diabetes, cardiovascular disease, and arthropathy, which, if left untreated, can lead to early mortality...
December 2015: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/26653333/daily-fasting-blood-glucose-rhythm-in-male-mice-a-role-of-the-circadian-clock-in-the-liver
#13
Hitoshi Ando, Kentaro Ushijima, Shigeki Shimba, Akio Fujimura
Fasting blood glucose (FBG) and hepatic glucose production are regulated according to a circadian rhythm. An early morning increase in FBG levels, which is pronounced among diabetic patients, is known as the dawn phenomenon. Although the intracellular circadian clock generates various molecular rhythms, whether the hepatic clock is involved in FBG rhythm remains unclear. To address this issue, we investigated the effects of phase shift and disruption of the hepatic clock on the FBG rhythm. In both C57BL/6J and diabetic ob/ob mice, FBG exhibited significant daily rhythms with a peak at the beginning of the dark phase...
February 2016: Endocrinology
https://www.readbyqxmd.com/read/26537065/outcomes-of-first-line-long-acting-octreotide-treatment-in-non-functional-advanced-gastroenteropancreatic-neuroendocrine-tumors
#14
Sezer Saglam, Hulya Hacisahinogullari, Nakiye Ozturk, Yersu Kapran, Mine Gulluoglu, Cuneyt Turkmen, Isik Adalet, Ali Orhan Bilge, Numan Cem Balci
PURPOSE: Benefits of somatostatin analogues have been mostly studied in mixed samples of patients including both functional and non-functional neuroendocrine tumors. This study aimed to examine the response of patients with non-functional metastatic or inoperable gastroenteropancreatic neuroendocrine tumors (GEP-NETs) that received first-line treatment with the somatostatin analogue octreotide LAR. METHODS: The medical records of 23 patients with locally inoperable or metastatic non-functional neuroendocrine tumors who received octreotide LAR (long acting release) treatment were retrospectively reviewed for clinical data and disease course...
September 2015: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/26361517/glycemic-profile-in-patients-with-acromegaly-treated-with-somatostatin-analogue
#15
A Valea, M Carsote, C Ghervan, C Georgescu
HYPOTHESIS: The growth hormone (GH) excess displayed in acromegaly induces insulin resistance up to diabetes mellitus (DM). The somatostatin analogues (as octreotide LAR) are useful in controlling the GH levels but disturbances of glucose metabolism might be seen. OBJECTIVE: This study evaluates the acromegalic glycemic profile under octreotide. METHODS & RESULTS: Out of the total number of patients (N=34) diagnosed with active acromegaly, only some were followed (N=25; male/ female ratio: 6/ 19; mean age: 51...
2015: Journal of Medicine and Life
https://www.readbyqxmd.com/read/26266036/glp1-and-glucagon-co-secreting-pancreatic-neuroendocrine-tumor-presenting-as-hypoglycemia-after-gastric-bypass
#16
Marta Guimarães, Pedro Rodrigues, Sofia S Pereira, Mário Nora, Gil Gonçalves, Nicolai Wewer Albrechtsen, Bolette Hartmann, Jens Juul Holst, Mariana P Monteiro
UNLABELLED: Post-prandial hypoglycemia is frequently found after bariatric surgery. Although rare, pancreatic neuroendocrine tumors (pNET), which occasionally are mixed hormone secreting, can lead to atypical clinical manifestations, including reactive hypoglycemia. Two years after gastric bypass surgery for the treatment of severe obesity, a 54-year-old female with previous type 2 diabetes, developed post-prandial sweating, fainting and hypoglycemic episodes, which eventually led to the finding by ultrasound of a 1...
2015: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/26236746/delta-cell-hyperplasia-in-adult-goto-kakizaki-gk-moltac-diabetic-rats
#17
Lukáš Alán, Tomáš Olejár, Monika Cahová, Jaroslav Zelenka, Zuzana Berková, Magdalena Smětáková, František Saudek, Radoslav Matěj, Petr Ježek
Reduced beta cell mass in pancreatic islets (PI) of Goto-Kakizaki (GK) rats is frequently observed in this diabetic model, but knowledge on delta cells is scarce. Aiming to compare delta cell physiology/pathology of GK to Wistar rats, we found that delta cell number increased over time as did somatostatin mRNA and delta cells distribution in PI is different in GK rats. Subtle changes in 6-week-old GK rats were found. With maturation and aging of GK rats, disturbed cytoarchitecture occurred with irregular beta cells accompanied by delta cell hyperplasia and loss of pancreatic polypeptide (PPY) positivity...
2015: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26198989/a-maintenance-hemodialysis-diabetic-patient-with-unexplained-pulmonary-and-gastrointestinal-involvement
#18
Anand Yuvaraj, Georgi Abraham, Abraham Kurien, Priyanka Koshy, Sanjeev Nair, Sudhakshina Ghosh
A 50-year-old man with diabetes mellitus with diabetic retinopathy, peripheral neuropathy, hypertension, and end-stage renal disease on maintenance hemodialysis, presented with persistent cough and hiccups, continued to be unwell with weight loss, poor appetite, and recurrent respiratory symptoms such as wheezing and cough. Whole body positron emission tomography-computed tomography scan showed metabolically active lesions in liver, stomach/lesser sac, pancreas, and left sixth rib. As he had repeated bilateral transudative pleural effusion, left mini thoracotomy with pleural biopsy showed no evidence of granuloma or malignancy...
January 2016: Hemodialysis International
https://www.readbyqxmd.com/read/26121441/clinical-presentation-and-long-term-outcome-of-patients-with-ectopic-acth-syndrome-due-to-bronchial-carcinoid-tumors-a-one-center-experience
#19
Sofia Tsirona, Marinella Tzanela, Efi Botoula, Ion Belenis, D Rondogianni, Stylianos Tsagarakis
OBJECTIVE: To describe the diagnostic features and long-term outcome of patients with bronchial carcinoid tumors with ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS), treated in our department. METHODS: We studied 10 cases with EAS and histologically confirmed bronchial carcinoid tumors, diagnosed from 1992 until 2006. Diagnosis was based upon blood, urine, radiologic, and interventional tests. Disease status at the time of the last follow-up was the primary outcome measure...
October 2015: Endocrine Practice
https://www.readbyqxmd.com/read/26025695/octreotide-for-hypoglycemia-caused-by-sulfonylurea-and-dpp-4-inhibitor
#20
Suguru Yamaguchi, Midori Ikejima, Asami Furukawa, Masanori Abe, Mitsuhiro Nakazaki, Hisamitsu Ishihara
We describe a type 2 diabetes patient with persistent hypoglycemia caused by sulfonylurea misuse on top of a DPP-4 inhibitor. Hyperinsulinemia was exaggerated by dextrose administration, but was successfully treated with octreotide. Since many patients are currently treated with DPP-4 inhibitors, the importance of octreotide has been increasing. For refractory sulfonylurea-induced hypoglycemia, especially when the patient is also being given an incretin-based therapy, octreotide should be considered.
August 2015: Diabetes Research and Clinical Practice
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