keyword
https://read.qxmd.com/read/37966353/tranexamic-acid-in-cardiac-surgery-a-case-report-of-an-infrequent-adverse-reaction-to-a-common-medication
#21
JOURNAL ARTICLE
Lisa Sanchez Salcedo, Federico Manuel Baloira, Alejo Adrover, Juan C Bianco, Maria Eugenia Garcia Guzzo
Life-threatening anaphylaxis to tranexamic acid (TXA) is rare but critical in cardiac surgery. A 76-year-old patient undergoing elective ascending aorta replacement developed severe anaphylactic shock shortly after anesthesia induction. Subsequent skin prick tests confirmed a positive TXA reaction. While TXA and lysine derivatives were avoided in the second surgery, the patient experienced hyperfibrinolysis. Guided by rotational thromboelastometry, hemostatic therapy led to a successful outcome with minimal postoperative bleeding...
November 1, 2023: A&A Practice
https://read.qxmd.com/read/37962201/intramuscular-administration-of-tranexamic-acid-in-a-large-swine-model-of-hemorrhage-with-hyperfibrinolysis
#22
JOURNAL ARTICLE
Christopher J Haberkorn, Carter C Severance, Nathan C Wetmore, Walker G West, Patrick C Ng, Francesca Cendali, Christopher Pitotti, Steven G Schauer, Joseph K Maddry, Vikhyat S Bebarta, Tara B Hendry-Hofer
BACKGROUND: Traumatic injury with subsequent hemorrhage is one of the leading causes of mortality among military personnel and civilians alike. Post traumatic hemorrhage accounts for 40-50% of deaths in severe trauma patients occurring secondary to direct vessel injury or the development of trauma induced coagulopathy (TIC). Hyperfibrinolysis plays a major role in TIC and its presence increases a patient's risk of mortality. Early therapeutic intervention with intravenous (IV) tranexamic acid (TXA) prevents development of hyperfibrinolysis and subsequent TIC leading to decreased mortality...
November 13, 2023: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/37944982/evaluation-of-cerebral-infarction-by-carotid-doppler-ultrasound-combined-with-cysteine-d-dimer-and-other-indexes
#23
JOURNAL ARTICLE
Yuliang Yin, Letao Yu
BACKGROUND: Cerebral infarction, formerly known as ischemic stroke, refers to localized ischemic necrosis or softening caused by disorders of blood supply to the brain, ischemia, or hypoxia. Cerebral infarction is characterized by high mortality and morbidity. Therefore, early and accurate diagnosis of cerebral infarction is of great significance to the selection of treatment and prognosis of patients. Electrocardiogram (ECG) is the traditional method for diagnosing myocardial infarction...
November 10, 2023: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/37839099/thromboembolic-complications-following-perioperative-tranexamic-acid-administration
#24
JOURNAL ARTICLE
Ella C Eisinger, Liam Forsythe, Sarah Joergensen, Shyam Murali, Jeremy W Cannon, Patrick M Reilly, Patrick K Kim, Elinore J Kaufman
INTRODUCTION: The antifibrinolytic tranexamic acid (TXA) may reduce death in trauma; however, outcomes associated with TXA use in patients without proven hyperfibrinolysis remain unclear. We analyzed the associations of empirically administered TXA, hypothesizing that TXA use would correlate to lower transfusion totals but increased thromboembolic complications. METHODS: This retrospective cohort study compared trauma patients started on massive transfusion protocol at a Level I trauma center from 2016 to 2021 who either did or did not receive TXA...
January 2024: Journal of Surgical Research
https://read.qxmd.com/read/37837820/fibrinogen-fragment-x-mediates-endothelial-barrier-disruption-via-suppression-of-ve-cadherin
#25
JOURNAL ARTICLE
Sarah A Olson, Baron K Osborn, Madeline E Cotton, Joseph D Krocker, Hiroyuki Koami, Nathan White, Jessica C Cardenas
INTRODUCTION: Major traumatic injury is associated with early hemorrhage-related and late-stage deaths due to multiple organ failure (MOF). While improvements to hemostatic resuscitation have significantly reduced hemorrhage-related deaths, the incidence of MOF among trauma patients remains high. Dysregulation of vascular endothelial cell (EC) barrier function is a central mechanism in the development of MOF; however, the mechanistic triggers remain unknown. Accelerated fibrinolysis occurs in a majority of trauma patients, resulting in high circulating levels of fibrin(ogen) degradation products, such as fragment X...
January 2024: Journal of Surgical Research
https://read.qxmd.com/read/37802703/analysis-of-fibrinolytic-shutdown-in-trauma-patients-with-traumatic-brain-injury
#26
JOURNAL ARTICLE
L Favors, K Harrell, V Miles, R C Hicks, M Rippy, H Parmer, A Edwards, C Brown, K Stewart, L Day, A Wilson, R Maxwell
BACKGROUND: Coagulation profiles following major trauma vary depending on injury pattern and degree of shock. The physiologic mechanisms involved in coagulation function at any given time are varied and remain poorly understood. Thromboelastography (TEG) has been used evaluate coagulation profiles in the trauma population with some reports demonstrating a spectrum of fibrinolysis to fibrinolytic shutdown on initial presentation. The objective of this study was to evaluate the fibrinolytic profile of patients with TBI using thromboelastography (TEG)...
September 26, 2023: American Journal of Surgery
https://read.qxmd.com/read/37756519/impaired-fibrinolysis-and-increased-clot-strength-are-potential-risk-factors-for-thrombosis-in-lymphoma
#27
JOURNAL ARTICLE
Søren T Bønløkke, Christian Fenger-Eriksen, Hans Beier Ommen, Anne-Mette Hvas
Thrombosis and bleeding are significant contributors to morbidity and mortality in patients with hematological cancer, and the impact of altered fibrinolysis on bleeding and thrombosis risk is poorly understood. In this prospective cohort study, we investigated the dynamics of fibrinolysis in hematological cancer patients. Fibrinolysis was investigated prior to treatment and three months after treatment initiation. A dynamic clot formation and lysis assay was performed beyond the measurement of plasminogen activator inhibitor 1, tissue- and urokinase-type plasminogen activators (tPA and uPA), plasmin-antiplasmin complexes (PAP), α-2-antiplasmin activity, and plasminogen activity...
September 27, 2023: Blood Advances
https://read.qxmd.com/read/37722532/mechanisms-and-management-of-the-coagulopathy-of-trauma-and-sepsis-trauma-induced-coagulopathy-sepsis-induced-coagulopathy-and-disseminated-intravascular-coagulation
#28
JOURNAL ARTICLE
Toshiaki Iba, Julie Helms, Matthew D Neal, Jerrold H Levy
Disseminated intravascular coagulation can occur due to different causes but commonly following sepsis. Trauma-induced coagulopathy (TIC) occurs on hospital arrival in approximately 25% of seriously injured patients who initially presents with impaired hemostasis and a bleeding phenotype that can later progress to a prothrombotic phase. Following traumatic injury, ineffective hemostasis is driven by massive blood loss, tissue damage, and hyperfibrinolysis. This initial impaired hemostasis continues until surgical or other management strategies not only to stop the causes of hemorrhage but also progresses to a prothrombotic and hypofibrinolytic state, also termed fibrinolytic shutdown...
December 2023: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/37700441/association-of-fibrinolysis-phenotype-with-patient-outcomes-following-traumatic-brain-injury
#29
JOURNAL ARTICLE
Samantha Durbin, Alexandra Brito, Alicia Johnson, Bryan Cotton, Susan Rowell, Martin Schreiber
BACKGROUND: Impaired coagulation is associated with elevated risk of mortality in trauma patients. Prior studies have demonstrated increased mortality in patients with hyperfibrinolysis (HF) and fibrinolysis shutdown (SD). Additionally, prior studies have demonstrated no effect of tranexamic acid (TXA) on fibrinolysis phenotypes. We examined the association of admission fibrinolysis phenotype with traumatic brain injury (TBI) patient outcomes. METHODS: Data were extracted from a placebo-controlled multicenter clinical trial...
September 13, 2023: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/37601774/the-effect-of-sequential-perioperative-intravenous-tranexamic-acid-in-reducing-postoperative-blood-loss-and-hidden-blood-loss-after-posterior-lumbar-interbody-fusion-a-randomized-controlled-trial
#30
JOURNAL ARTICLE
Wei Dong, Yi Liang, Dongxu Li, Zhaoxin Ma, Minghuang Cheng, Xiaojun Zhang, Jieliang Shen, Nian Zhou, Jie Hao, Wei Jiang, Zhenming Hu
BACKGROUND: Tranexamic acid (TXA) has previously been shown to be effective in reducing intraoperative blood loss (IBL) and transfusion requirements in spine surgery. A conventional TXA regimen is a simple preoperative or intraoperative administration. However, the hyperfibrinolysis caused by surgical trauma lasts at least 24 h, and a single dose of TXA cannot cover the whole process of hyperfibrinolysis. Moreover, its ability to control postoperative blood loss (PBL) may be insufficient...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37517207/a-retrospective-validation-of-rotem-algorithms-for-detecting-hyperfibrinolysis-demonstrates-poor-agreement-for-prediction-of-in-hospital-mortality-and-transfusion-requirement-in-a-general-non-cardiac-surgical-population
#31
JOURNAL ARTICLE
Leon Rosebery, Matthew Miller, Peter Loizou, Shir Jing Ho, Keith J Adkins, Kush Deshpande
INTRODUCTION: Hyperfibrinolysis diagnosed on Rotational Thromboelastography (ROTEM) is associated with increased transfusion requirements and mortality in trauma. The diagnosis and significance of hyperfibrinolysis in a mixed, non-cardiac, general surgical population has not been investigated. We aimed to measure agreement between four ROTEM algorithms for diagnosing hyperfibrinolysis and transfusion requirements and mortality in general surgical patients. These algorithms mostly incorporate measures of early or late clot amplitude reduction on the Extrinsic Clotting Pathway Test with Tissue Factor (EXTEM) channel...
July 19, 2023: Thrombosis Research
https://read.qxmd.com/read/37485730/angiogenesis-coagulation-and-fibrinolytic-markers-in-acute-promyelocytic-leukemia-nb4-an-evaluation-of-melatonin-effects
#32
JOURNAL ARTICLE
Mohammad Reza Amirzargar, Fahimeh Shahriyary, Minoo Shahidi, Ahmad Kooshari, Mahshid Vafajoo, Reza Nekouian, Mohammad Faranoush
Melatonin is a powerful biological agent that has been shown to inhibit angiogenesis and also exert anti-inflammatory effects. It is well known that new blood vessel formation (angiogenesis) has become an urgent issue in leukemia as well as solid tumors. Acute promyelocytic leukemia (APL) is a form of liquid cancer that manifests increased angiogenesis in the bone marrow of patients. Despite high-rate curable treatment with all trans retinoic acid (ATRA) and recently arsenic trioxide (ATO), early death because of hemorrhage, coagulopathy, and Disseminated intravascular coagulation (DIC) remains still a concerning issue in these patients...
July 24, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37450381/tissue-factor-activates-coagulation-in-mouse-models-of-acute-promyelocytic-leukemia
#33
JOURNAL ARTICLE
Yohei Hisada, Tomohiro Kawano, Sierra J Archibald, John S Welch, Brandi N Reeves, Nigel Mackman
Acute promyelocytic leukemia (APL) is associated with a high risk of bleeding and thrombosis. The coagulopathy involves activation of coagulation, hyperfibrinolysis and thrombocytopenia. APL cells express tissue factor (TF), which is the receptor and cofactor for factor VII/VIIa. This study had two goals. First, we measured biomarkers of activation of coagulation and fibrinolysis as well as platelet counts and bleeding in both mouse xenograft and allograft models of APL. Second, we determined the effect of inhibiting TF on the activation of coagulation in these models...
July 14, 2023: Blood Advances
https://read.qxmd.com/read/37446351/experimental-models-of-traumatic-injuries-do-they-capture-the-coagulopathy-and-underlying-endotheliopathy-induced-by-human-trauma
#34
REVIEW
Liam Barrett, Nicola Curry, Jeries Abu-Hanna
Trauma-induced coagulopathy (TIC) is a major cause of morbidity and mortality in patients with traumatic injury. It describes the spectrum of coagulation abnormalities that occur because of the trauma itself and the body's response to the trauma. These coagulation abnormalities range from hypocoagulability and hyperfibrinolysis, resulting in potentially fatal bleeding, in the early stages of trauma to hypercoagulability, leading to widespread clot formation, in the later stages. Pathological changes in the vascular endothelium and its regulation of haemostasis, a phenomenon known as the endotheliopathy of trauma (EoT), are thought to underlie TIC...
July 6, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37415401/sensitivity-and-specificity-of-thromboelastography-for-hyperfibrinolysis-comparison-of-teg-5000-and-teg-6s-ck-ly30-systems
#35
JOURNAL ARTICLE
Christine Fuja, Timothy C Carll, Krzysztof Mikrut, Geoffrey D Wool
OBJECTIVES: The sensitivity and specificity of clot lysis at 30 minutes after maximum clot strength (LY30), as measured by thromboelastography (TEG), for clinically significant hyperfibrinolysis have not been compared across the 2 US Food and Drug Administration-approved instruments (the TEG 5000 and TEG 6s [Haemonetics]). METHODS: We performed a retrospective, single-center analysis of these 2 instruments using the kaolin (CK) reagent. RESULTS: Local verification studies showed that the TEG 5000 and TEG 6s CK LY30 upper limits of normal (ULNs) were distinct (5...
July 7, 2023: American Journal of Clinical Pathology
https://read.qxmd.com/read/37393235/spontaneous-intramuscular-hemorrhage-in-cancer-associated-dermatomyositis-a-case-and-literature-review
#36
REVIEW
Rui Xing, Fenfen Xiang, Lingli Dong, Guifen Shen
BACKGROUND: Spontaneous intramuscular hemorrhage (SIH) is a rare but life-threatening complication of dermatomyositis (DM). The pathogenetic mechanism and management of intramuscular hematoma in these patients remains unclear. Here we discuss a case of recurrent hemorrhage in a patient with cancer-associated DM, and review the relevant literature for timely diagnosis and treatment. CASE PRESENTATION: A 53-year-old male patient presented with rashes, muscle weakness, and dysphagia and was diagnosed with DM...
July 1, 2023: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/37390313/ilich-a-gernsheimer-tb-triulzi-dj-et%C3%A2-al-absence-of-hyperfibrinolysis-may-explain-lack-of-efficacy-of-tranexamic-acid-in-hypoproliferative-thrombocytopenia-blood-adv-2023-7-6-900-908
#37
JOURNAL ARTICLE
https://read.qxmd.com/read/37388112/retracted-expression-and-significance-of-d-dimer-and-fibrinogen-in-hyperfibrinolysis-of-elderly-patients-with-bleeding-after-bph-operation
#38
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2022/9387484.].
2023: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/37381810/the-impact-of-thromboelastography-on-patients-with-penetrating-abdominal-trauma-requiring-intensive-care
#39
JOURNAL ARTICLE
M Hannington, D Nel, M Miller, A Nicol, P Navsaria
BACKGROUND: Trauma-induced coagulopathy (TIC) is a complex multifaceted process which contributes to higher mortality rates in severely injured trauma patients. Thromboelastography (TEG) is effective in detecting TIC which assists in instituting goal-directed therapy as part of damage control resuscitation. METHODS: This retrospective study included all adult patients over a 36-month period with penetrating abdominal trauma who required a laparotomy, blood products and admission for critical care...
June 2023: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://read.qxmd.com/read/37326149/plasma-d-dimer-and-interleukin-6-are-associated-with-treatment-response-and-progression-free-survival-in-advanced-nsclc-patients-on-anti-pd-1-therapy
#40
JOURNAL ARTICLE
Chong Chen, Huaru Yin, Yu Zhang, Huan Chen, Jie Xu, Li Ren
BACKGROUND/AIMS: Response to therapy after using immune checkpoint inhibitors (ICIs) is unpredictable due to significant interindividual variation in efficacy among advanced non-small cell lung cancer (NSCLC) patients. The current study centered on the identification of perivascular blood biomarkers for predicting the effectiveness of anti-programmed cell death protein 1 (anti-PD-1) treatment and progression-free survival (PFS) in advanced NSCLC patients, that could be applied to help determine how to change treatment plans therapeutic regimens for optimizing clinical benefits...
June 16, 2023: Cancer Medicine
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