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JOURNAL ARTICLE
Saikat Ghosh, Rohan Lalani, Kuntal Maiti, Shubhadeep Banerjee, Vivek Patel, Subhas Bhowmick, Ambikanandan Misra
Aim: To improve the efficacy of poly-ethylene glycol (PEG)ylated liposomes coloaded with doxorubicin and vincristine against triple-negative breast cancer (TNBC) and non-small-cell lung cancer (NSCLC). Methods: The combinatorial index of the drugs was established using the Chou-Talalay method in MDA-MB-231 and A549 cell lines. The most effective ratio was co-encapsulated in factorial design optimized nanoliposomes which were characterized for similarity to clinical standard and evaluated in-vitro and in-vivo for therapeutic efficacy...
October 22, 2020: Nanomedicine
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JOURNAL ARTICLE
Saikat Ghosh, Rohan Lalani, Kuntal Maiti, Shubhadeep Banerjee, Himanshu Bhatt, Yamini Shankar Bobde, Vivek Patel, Swati Biswas, Subhas Bhowmick, Ambikanandan Misra
The current work aims to explore the biological characteristics of Vincristine synergistic co-loading into pegylated liposomal doxorubicin in non-indicated modalities of non-small cell lung cancer (NSCLC) and triple negative breast cancer (TNBC). The combinatorial liposome prepared by active co-loading of the drugs against modified ammonium ion gradient exhibited 95% encapsulation of both drugs. The cellular uptake studies using confocal microscopy and flowcytometry showed significantly increased uptake of dual drug formulation as against liposomal doxorubicin...
October 16, 2020: Nanomedicine: Nanotechnology, Biology, and Medicine
#23
REVIEW
Monique T Barakat, Subhas Banerjee
After outbreaks of duodenoscope-transmitted infection with multidrug-resistant organisms, it has become clear that institutions must optimize their endoscope reprocessing programs. Standard endoscope reprocessing practices may not represent the ideal approach for preventing transmission of infection related to endoscopy. We discuss multiple approaches to enhance and optimize reprocessing, drying, and storage of standard duodenoscopes. The optimal enhanced duodenoscope reprocessing modality remains to be determined...
October 2020: Gastrointestinal Endoscopy Clinics of North America
#24
Subha Mondal, Nilanjan Adhikari, Suvankar Banerjee, Sk Abdul Amin, Tarun Jha
No abstract text is available yet for this article.
August 1, 2020: European Journal of Medicinal Chemistry
#25
JOURNAL ARTICLE
Monique T Barakat, Subhas Banerjee
BACKGROUND AND AIMS: ERCP is a high-risk endoscopic procedure, yet reports of ERCP-related adverse events are largely limited to early adverse events, based on immediate postprocedure assessment. We hypothesize that immediate/1-day follow-up underestimates the true adverse event rate, and later follow-up calls may enable a more accurate assessment of adverse events, leading to enhanced postprocedural patient care. METHODS: Consecutive patients undergoing ERCP at our tertiary care academic medical center from 2018 to 2019 were analyzed...
July 25, 2020: Gastrointestinal Endoscopy
#26
JOURNAL ARTICLE
Alexander Podboy, George Cholankeril, Lisa Cianfichi, Edward Guzman, Aijaz Ahmed, Subhas Banerjee
No abstract text is available yet for this article.
October 2020: Gastroenterology
#27
JOURNAL ARTICLE
Sharareh Moraveji, Adarsh M Thaker, V Raman Muthusamy, Subhas Banerjee
No abstract text is available yet for this article.
October 2020: Gastroenterology
#28
JOURNAL ARTICLE
Mandeep S Sawhney, Mohammad Bilal, Heiko Pohl, Vladimir M Kushnir, Mouen A Khashab, Allison R Schulman, Tyler M Berzin, Prabhleen Chahal, V Raman Muthusamy, Shyam Varadarajulu, Subhas Banerjee, Gregory G Ginsberg, Gottumukkala S Raju, Joseph D Feuerstein
BACKGROUND AND AIMS: There is a lack of consensus on which GI endoscopic procedures should be performed during the COVID-19 pandemic, and which procedures could be safely deferred without having a significant impact on outcomes. METHODS: We selected a panel of 14 expert endoscopists. We identified 41 common indications for advanced endoscopic procedures from the ASGE Appropriate Use of GI Endoscopy guidelines. Using a modified Delphi method, we first achieved consensus on the patient-important outcome for each procedural indication...
September 2020: Gastrointestinal Endoscopy
#29
REVIEW
Subha Mondal, Nilanjan Adhikari, Suvankar Banerjee, Sk Abdul Amin, Tarun Jha
Matrix metalloproteinases (MMPs) are zinc dependent proteolytic metalloenzyme. MMP-9 is one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to degrade the extracellular matrix (ECM) components and has important role in the pathophysiological functions. Overexpression and dysregulation of MMP-9 is associated with various diseases. Thus, regulation and inhibition of MMP-9 is an important therapeutic approach for combating various diseases including cancer. Inhibitors of MMP-9 can be used as anticancer agents...
May 15, 2020: European Journal of Medicinal Chemistry
#30
JOURNAL ARTICLE
Monique T Barakat, Mohit Girotra, Robert J Huang, Abhishek Choudhary, Nirav C Thosani, Shivangi Kothari, Saurabh Sethi, Subhas Banerjee
BACKGROUND: Biliary cannulation is readily achieved in > 85% of patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). When standard cannulation techniques fail, salvage techniques utilized include the needle knife precut, double wire technique, and Goff septotomy. METHODS: Records of patients undergoing ERCP from 2005 to 2016 were retrospectively examined using a prospectively maintained endoscopy database. Patients requiring salvage techniques for biliary access were analyzed together with a control sample of 20 randomly selected index ERCPs per study year...
February 12, 2020: Digestive Diseases and Sciences
#31
JOURNAL ARTICLE
Amrita Sethi, Amy Tyberg, Adam Slivka, Douglas G Adler, Amit P Desai, Divyesh V Sejpal, Douglas K Pleskow, Helga Bertani, Seng-Ian Gan, Raj Shah, Urban Arnelo, Paul R Tarnasky, Subhas Banerjee, Takao Itoi, Jong Ho Moon, Dong Choon Kim, Monica Gaidhane, Isaac Raijman, Bret T Peterson, Frank G Gress, Michel Kahaleh
BACKGROUND: Visual characteristics seen during digital single-operator cholangioscopy (DSOC) have not been validated. The aim of this 2-phase study was to define terminology by consensus for the visual diagnosis of biliary lesions to develop a model for optimization of the diagnostic performance of DSOC. MATERIALS AND METHODS: In phase 1 (criteria identification), video-cholangioscopy clips were reviewed by 12 expert biliary endoscopists, who were blinded to the final diagnosis...
February 1, 2022: Journal of Clinical Gastroenterology
#32
JOURNAL ARTICLE
Mohit Girotra, Saurabh Sethi, Monique T Barakat, Robert J Huang, Shai Friedland, Uri Ladabaum, Subhas Banerjee
BACKGROUND: Rates of incomplete colonoscopy in non-expert settings range up to 13%. Expert colonoscopists can complete ~ 95% colonoscopies when other endoscopists fail; however, a small number remain incomplete even in expert hands, typically due to bowel fixity. AIMS: Pentax Retroview™ (EC-3490TLi) is a new slim colonoscope with a short turning radius (STR) and greater tip deflection (210°), which allows easy maneuverability across sharply angulated/fixed colonic bends...
October 19, 2019: Digestive Diseases and Sciences
#33
JOURNAL ARTICLE
Subhas Banerjee
No abstract text is available yet for this article.
September 2019: Endoscopy
#34
JOURNAL ARTICLE
Monique T Barakat, Subhas Banerjee
No abstract text is available yet for this article.
May 4, 2019: Digestive Diseases and Sciences
#35
JOURNAL ARTICLE
Sachin Wani, Samuel Han, Violette Simon, Matthew Hall, Dayna Early, Eva Aagaard, Wasif M Abidi, Subhas Banerjee, Todd H Baron, Michael Bartel, Erik Bowman, Brian C Brauer, Jonathan M Buscaglia, Linda Carlin, Amitabh Chak, Hemant Chatrath, Abhishek Choudhary, Bradley Confer, Gregory A Coté, Koushik K Das, Christopher J DiMaio, Andrew M Dries, Steven A Edmundowicz, Abdul Hamid El Chafic, Ihab El Hajj, Swan Ellert, Jason Ferreira, Anthony Gamboa, Ian S Gan, Lisa Gangarosa, Bhargava Gannavarapu, Stuart R Gordon, Nalini M Guda, Hazem T Hammad, Cynthia Harris, Sujai Jalaj, Paul Jowell, Sana Kenshil, Jason Klapman, Michael L Kochman, Sri Komanduri, Gabriel Lang, Linda S Lee, David E Loren, Frank J Lukens, Daniel Mullady, Raman V Muthusamy, Andrew S Nett, Mojtaba S Olyaee, Kavous Pakseresht, Pranith Perera, Patrick Pfau, Cyrus Piraka, John M Poneros, Amit Rastogi, Anthony Razzak, Brian Riff, Shreyas Saligram, James M Scheiman, Isaiah Schuster, Raj J Shah, Rishi Sharma, Joshua P Spaete, Ajaypal Singh, Muhammad Sohail, Jayaprakash Sreenarasimhaiah, Tyler Stevens, James H Tabibian, Demetrios Tzimas, Dushant S Uppal, Shiro Urayama, Domenico Vitterbo, Andrew Y Wang, Wahid Wassef, Patrick Yachimski, Sergio Zepeda-Gomez, Tobias Zuchelli, Rajesh N Keswani
BACKGROUND AND AIMS: Minimum EUS and ERCP volumes that should be offered per trainee in "high quality" advanced endoscopy training programs (AETPs) are not established. We aimed to define the number of procedures required by an "average" advanced endoscopy trainee (AET) to achieve competence in technical and cognitive EUS and ERCP tasks to help structure AETPs. METHODS: American Society for Gastrointestinal Endoscopy (ASGE)-recognized AETPs were invited to participate; AETs were graded on every fifth EUS and ERCP examination using a validated tool...
June 2019: Gastrointestinal Endoscopy
#36
REVIEW
Saikat Ghosh, Rohan Lalani, Vivek Patel, Denish Bardoliwala, Kuntal Maiti, Shubhadeep Banerjee, Subhas Bhowmick, Ambikanandan Misra
Hematological cancers are a group of malignancies affecting human hematopoietic and lymphoid tissues. Although the patients respond to treatment regimen during initial phases, the hematoma tumor heterogeneity results in the presence of some minimal disease residue thereby exhibiting remission, relapses or refractoriness in disease conditions leading to poor overall survival period. The current therapeutic standard practices involve blending of conventional agents with novel targeting agents or immune-therapeutics in a cocktail to effectively reap the benefits of drugs acting through multiple signaling pathways...
January 18, 2019: Journal of Controlled Release
#37
JOURNAL ARTICLE
Indranil Banerjee, Manjarika De, Goutam Dey, Rashmi Bharti, Sankha Chattopadhyay, Nahid Ali, Partha Chakrabarti, Rui L Reis, Subhas C Kundu, Mahitosh Mandal
Melanoma is a highly aggressive skin cancer. A paclitaxel formulation of solid lipid nanoparticles modified with Tyr-3-octreotide (PSM) is employed to treat melanoma that highly expresses somatostatin receptors (SSTRs). PSM exerts more apoptotic and anti-invasive effects in B16F10 mice melanoma cells as compared to dacarbazine (DTIC), an approved chemotherapeutic drug for treating aggressive melanoma. Besides, PSM induces one of the biomarkers of immunogenic cell death in vitro and in vivo as confirmed by calreticulin exposure on the B16F10 cell surface...
January 17, 2019: Biomaterials Science
#38
JOURNAL ARTICLE
Monique T Barakat, Aditi Mithal, Robert J Huang, Alka Sehgal, Amrita Sehgal, Gurkirpal Singh, Subhas Banerjee
BACKGROUND: The Affordable Care Act (ACA) with Medicaid expansion implemented in 2014, extended health insurance to >20-million previously uninsured individuals. However, it is unclear whether enhanced primary care access with Medicaid expansion decreased emergency department (ED) visits and hospitalizations for gastrointestinal (GI)/pancreatic/liver diseases. METHODS: We evaluated trends in GI/pancreatic/liver diagnosis-specific ED/hospital utilization over a 5-year period leading up to Medicaid expansion and a year following expansion, in California (a state that implemented Medicaid expansion) and compare these with Florida (a state that did not)...
October 3, 2018: Journal of Clinical Gastroenterology
#39
MULTICENTER STUDY
Robert J Huang, Monique T Barakat, Mohit Girotra, Jennifer S Lee, Subhas Banerjee
BACKGROUND & AIMS: We have few population-level data on the performance of endoscopic retrograde cholangiopancreatography (ERCP) in the United States. We investigated the numbers of unplanned hospital encounters (UHEs), patient and facility factors associated with UHEs, and variation in quality and outcomes in the performance of ERCP in 3 large American states. METHODS: We collected data on 68,642 ERCPs, performed at 635 facilities in California, Florida, and New York from 2009 through 2014...
January 2019: Gastroenterology
#40
JOURNAL ARTICLE
Monique T Barakat, Robert J Huang, Subhas Banerjee
BACKGROUND AND AIMS: Residual fluid within endoscope working channels after reprocessing may promote growth of pathogens. Current reprocessing guidelines therefore recommend endoscope drying with administration of forced filtered air; however, the duration and modality of administered air are not specified. The new DriScope Aid device enables automated administration of filtered air at controlled pressure through all internal endoscope channels. We systematically compared, for the first time, the impact of manual drying and automated drying on retained working channel fluid and bioburden after reprocessing...
January 2019: Gastrointestinal Endoscopy
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