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Delay discounting

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https://www.readbyqxmd.com/read/28101922/a-second-type-of-magnitude-effect-reinforcer-magnitude-differentiates-delay-discounting-between-substance-users-and-controls
#1
Alexandra M Mellis, Alina E Woodford, Jeffrey S Stein, Warren K Bickel
Basic research on delay discounting, examining preference for smaller-sooner or larger-later reinforcers, has demonstrated a variety of findings of considerable generality. One of these, the magnitude effect, is the observation that individuals tend to exhibit greater preference for the immediate with smaller magnitude reinforcers. Delay discounting has also proved to be a useful marker of addiction, as demonstrated by the highly replicated finding of greater discounting rates in substance users compared to controls...
January 2017: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/28088471/effects-of-group-i-metabotropic-glutamate-receptor-antagonists-on-sensitivity-to-reinforcer-magnitude-and-delayed-reinforcement-in-a-delay-discounting-task-in-rats-contribution-of-delay-presentation-order
#2
Justin R Yates, Katherine K Rogers, Benjamin T Gunkel, Nicholas A Prior, Mallory N Hughes, Sara M Sharpe, Hunter L Campbell, Anthony B Johnson, Margaret G Keller, Kerry A Breitenstein, Hansen N Shults
Metabotropic glutamate receptor 1 (mGluR1) blockade has been shown to decrease impulsive choice, as measured in delay discounting. However, several variables are known to influence an animal's discounting, including sensitivity to delayed reinforcement and sensitivity to reinforcer magnitude. The goal of this experiment was to determine the effects of mGluR1, as well as mGluR5, antagonism on these parameters. Forty Sprague Dawley rats were trained in delay discounting, in which consistently choosing a small, immediate reward reflects impulsive choice...
January 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28087369/multidimensional-assessment-of-impulsivity-in-relation-to-obesity-and-food-addiction
#3
Lauren VanderBroek-Stice, Monika K Stojek, Steven R H Beach, Michelle R vanDellen, James MacKillop
Based on similarities between overconsumption of food and addictive drugs, there is increasing interest in "food addiction," a compulsive eating pattern defined using symptoms parallel to substance use disorders. Impulsivity, a multidimensional construct robustly linked to drug addiction, has been increasingly examined as an obesity determinant, but with mixed findings. This study sought to clarify relations between three major domains of impulsivity (i.e., impulsive personality traits, discounting of delayed rewards, and behavioral inhibition) in both obesity and food addiction...
January 10, 2017: Appetite
https://www.readbyqxmd.com/read/28077716/the-attraction-effect-modulates-reward-prediction-errors-and-intertemporal-choices
#4
Sebastian Gluth, Jared M Hotaling, Jörg Rieskamp
: Classical economic theory contends that the utility of a choice option should be independent of other options. This view is challenged by the attraction effect, in which the relative preference between two options is altered by the addition of a third, asymmetrically dominated option. Here, we leveraged the attraction effect in the context of intertemporal choices to test whether both decisions and reward prediction errors (RPE) in the absence of choice violate the independence of irrelevant alternatives principle...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28066708/right-inferior-frontal-cortex-activity-correlates-with-tolcapone-responsivity-in-problem-and-pathological-gamblers
#5
Andrew S Kayser, Taylor Vega, Dawn Weinstein, Jan Peters, Jennifer M Mitchell
Failures of self-regulation in problem and pathological gambling (PPG) are thought to emerge from failures of top-down control, reflected neurophysiologically in a reduced capacity of prefrontal cortex to influence activity within subcortical structures. In patients with addictions, these impairments have been argued to alter evaluation of reward within dopaminergic neuromodulatory systems. Previously we demonstrated that augmenting dopamine tone in frontal cortex via use of tolcapone, an inhibitor of the dopamine-degrading enzyme catechol-O-methyltransferase (COMT), reduced delay discounting, a measure of impulsivity, in healthy subjects...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28063134/how-can-pricing-and-reimbursement-policies-improve-affordable-access-to-medicines-lessons-learned-from-european-countries
#6
REVIEW
Sabine Vogler, Valérie Paris, Alessandra Ferrario, Veronika J Wirtz, Kees de Joncheere, Peter Schneider, Hanne Bak Pedersen, Guillaume Dedet, Zaheer-Ud-Din Babar
This article discusses pharmaceutical pricing and reimbursement policies in European countries with regard to their ability to ensure affordable access to medicines. A frequently applied pricing policy is external price referencing. While it provides some benchmark for policy-makers and has been shown to be able to generate savings, it may also contribute to delay in product launch in countries where medicine prices are low. Value-based pricing has been proposed as a policy that promotes access while rewarding useful innovation; however, implementing it has proven quite challenging...
January 6, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28057530/effects-of-nucleus-accumbens-amphetamine-administration-on-performance-in-a-delay-discounting-task
#7
Caitlin A Orsini, Marci R Mitchell, Sara C Heshmati, Kristy G Shimp, Megan S Spurrell, Jennifer L Bizon, Barry Setlow
Chronic administration of cocaine can cause pronounced and enduring cognitive alterations such as increases in impulsive choice. Chronic cocaine can also result in enhanced dopamine (DA) release in the nucleus accumbens (NAc) in response to reward-related cues. It is possible that this enhanced DA release in the NAc is a mechanism by which cocaine increases impulsive choice. To date, however, the specific role of DA in the NAc in impulsive choice is unclear. To begin to address this, rats received acute microinjections of the indirect DA agonist amphetamine directly into the NAc prior to testing in a delay discounting task in which rats chose between a small, immediate and a large, delayed food reward...
January 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28040671/decisional-impulsivity-and-the-associative-limbic-subthalamic-nucleus-in-obsessive-compulsive-disorder-stimulation-and-connectivity
#8
Valerie Voon, Fabien Droux, Laurel Morris, Stephan Chabardes, Thierry Bougerol, Olivier David, Paul Krack, Mircea Polosan
Why do we make hasty decisions for short-term gain? Rapid decision-making with limited accumulation of evidence and delay discounting are forms of decisional impulsivity. The subthalamic nucleus is implicated in inhibitory function but its role in decisional impulsivity is less well-understood. Here we assess decisional impulsivity in subjects with obsessive compulsive disorder who have undergone deep brain stimulation of the limbic and associative subthalamic nucleus. We show that stimulation of the subthalamic nucleus is causally implicated in increasing decisional impulsivity with less accumulation of evidence during probabilistic uncertainty and in enhancing delay discounting...
December 31, 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28033718/maintained-physical-activity-induced-changes-in-delay-discounting
#9
Michael J Sofis, Ale Carrillo, David P Jarmolowicz
Those who discount the subjective value of delayed rewards less steeply are more likely to engage in physical activity. There is limited research, however, showing whether physical activity can change rates of delay discounting. In a two-experiment series, treatment and maintenance effects of a novel, effort-paced physical activity intervention on delay discounting were evaluated with multiple baseline designs. Using a lap-based method, participants were instructed to exercise at individualized high and low effort levels and to track their own perceived effort...
December 1, 2016: Behavior Modification
https://www.readbyqxmd.com/read/28017930/commentary-delay-discounting-and-smoking-robust-correlation-but-uncertain-causation
#10
James MacKillop, Marcus R Munafò
No abstract text is available yet for this article.
December 25, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28010126/quantifying-impatience-using-models-of-delay-discounting-in-substance-use-disorders
#11
Suzanne H Mitchell
No abstract text is available yet for this article.
December 23, 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28009473/temporal-discounting-across-three-psychiatric-disorders-anorexia-nervosa-obsessive-compulsive-disorder-and-social-anxiety-disorder
#12
Joanna E Steinglass, Karolina M Lempert, Tse-Hwei Choo, Marcia B Kimeldorf, Melanie Wall, B Timothy Walsh, Abby J Fyer, Franklin R Schneier, H Blair Simpson
BACKGROUND: Temporal discounting refers to the tendency for rewards to lose value as the expected delay to receipt increases. Individuals with anorexia nervosa (AN) have been found to show reduced temporal discounting rates, indicating a greater preference for delayed rewards compared to healthy peers. Obsessive-compulsive disorder (OCD) and social anxiety disorder (SAD) commonly co-occur with AN, and anxiety has been related to development and prognosis of AN. We examined whether reduced temporal discounting is present across these potentially related disorders, and explored the relationship between temporal discounting and anxiety transdiagnostically...
December 23, 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/28008322/the-relationship-between-impulsivity-and-problem-gambling-in-adolescence
#13
Roberto Secades-Villa, Victor Martínez-Loredo, Aris Grande-Gosende, José R Fernández-Hermida
Gambling has become one of the most frequently reported addictive behaviors among young people. Understanding risk factors associated with the onset or maintenance of gambling problems in adolescence has implications for its prevention and treatment. The main aim of the present study was to examine the potential relationships between impulsivity and problem gambling in adolescence. Participants were 874 high school students (average age: 15 years old) who were surveyed to provide data on gambling and impulsivity...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/28004949/effects-of-endothelin-induced-prefrontal-cortical-lesions-on-delay-discounting-in-the-rat
#14
Robert A Déziel, R Andrew Tasker
Stroke is one of the most prominent causes of neurological disability, and the number of stroke cases worldwide is expected to grow due to increases in both average life span and population. As such, new methods for both acute treatment and poststroke rehabilitation will be increasingly necessary. Although a number of approaches to restoring motor function poststroke are in development, there are few methods to alleviate the cognitive deficits caused by this disease. As well, there are very few preclinical models of stroke with a specific focus on higher-order cognitive functions...
December 22, 2016: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28003245/impulsivity-moderates-subjective-responses-to-alcohol-in-alcohol-dependent-individuals
#15
Jonathan G Westman, Spencer Bujarski, Lara A Ray
AIMS: Studies of social drinkers indicate that subjective response (SR) to alcohol and impulsivity are risk factors for the development of alcohol use disorder which may be related. It is unclear, however, whether there are significant relationships between SR and impulsivity among individuals with alcohol dependence. Using data from an intravenous (IV) alcohol challenge study, the present study is the first to explore the relationship between impulsivity and SR during alcohol administration among alcohol-dependent individuals...
December 20, 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28000083/impulsivity-in-rodents-with-a-genetic-predisposition-for-excessive-alcohol-consumption-is-associated-with-a-lack-of-a-prospective-strategy
#16
David N Linsenbardt, Michael P Smoker, Sarine S Janetsian-Fritz, Christopher C Lapish
Increasing evidence supports the hypothesis that impulsive decision-making is a heritable risk factor for an alcohol use disorder (AUD). Clearly identifying a link between impulsivity and AUD risk, however, is complicated by the fact that both AUDs and impulsivity are heterogeneous constructs. Understanding the link between the two requires identifying the underlying cognitive factors that lead to impulsive choices. Rodent models have established that a family history of excessive drinking can lead to the expression of a transgenerational impulsive phenotype, suggesting heritable alterations in the decision-making process...
December 20, 2016: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/27991822/quick-delay-questionnaire-reliability-validity-and-relations-to-functional-impairments-in-adults-with-attention-deficit-hyperactivity-disorder-adhd
#17
Lisa B Thorell, Douglas Sjöwall, Gabry W Mies, Anouk Scheres
The Quick Delay Questionnaire (QDQ) is a self-report measure of delay-related behaviors in adults, and the present study aimed at investigating the psychometric properties of QDQ scores, how well they can discriminate between ADHD adults and both clinical and nonclinical controls, as well as their relations to measures of functional impairments. In the present study, QDQ ratings, a laboratory measure of delay discounting, and ratings of functional impairments were collected from adults diagnosed with attention-deficit/hyperactivity disorder (ADHD; n = 51), a clinical control group with other psychiatric disorders (n = 46), and a nonclinical control group (n = 105)...
December 19, 2016: Psychological Assessment
https://www.readbyqxmd.com/read/27976705/comparison-of-impulsivity-in-non-problem-at-risk-and-problem-gamblers
#18
Wan-Sen Yan, Ran-Ran Zhang, Yan Lan, Yong-Hui Li, Nan Sui
As a non-substance addiction, gambling disorder represents the model for studying the neurobiology of addiction without toxic consequences of chronic drug use. From a neuropsychological perspective, impulsivity is deemed as a potential construct responsible in the onset and development of drug addiction. The objective of this study was to investigate the associations between impulsivity and gambling status in young adults with varying severity of gambling. A sample of 1120 college students, equally divided into non-problem, at-risk and problem gamblers, were administered multiple measures of impulsivity including the UPPSP Impulsive Behaviors Scale (UPPSP), the Barratt Impulsiveness Scale-11 (BIS-11), and the Delay-discounting Test (DDT)...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27958761/delay-discounting-risk-taking-and-rejection-sensitivity-among-individuals-with-internet-and-video-gaming-disorders
#19
Aviv Weinstein, Hodaya Ben Abu, Ayelet Timor, Yaniv Mama
Background and aims There is a previous evidence for impulsivity in individuals with Internet and Video Gaming Disorders. The aim of this study was to examine whether Internet and video game addictions are associated with experiential delay discounting, risk-taking, and sensitivity to social rejection using computerized tasks and questionnaires. Methods Twenty participants (mean age 24, SD = 1.55) with high score on the Problematic Online Gaming Questionnaire (POGQ) were compared with 20 participants (mean age 24...
December 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/27943064/investigating-the-impact-of-cognitive-load-and-motivation-on-response-control-in-relation-to-delay-discounting-in-children-with-adhd
#20
Mary K Martinelli, Stewart H Mostofsky, Keri S Rosch
Attention-deficit/hyperactivity disorder (ADHD) is characterized by deficits in impulse control across a range of behaviors, from simple actions to those involving complex decision-making (e.g., preference for smaller-sooner versus larger later rewards). This study investigated whether changes in motor response control with increased cognitive load and motivational contingencies are associated with decision-making in the form of delay discounting among 8-12 year old children with and without ADHD. Children with ADHD (n = 26; 8 girls) and typically developing controls (n = 40; 11 girls) completed a standard go/no-go (GNG) task, a GNG task with motivational contingencies, a GNG task with increased cognitive load, and two measures of delay discounting: a real-time task in which the delays and immediately consumable rewards are experienced in real-time, and a classic task involving choices about money at longer delays...
December 12, 2016: Journal of Abnormal Child Psychology
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