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Gynecological endocrinology

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https://www.readbyqxmd.com/read/29454146/matching-trends-for-the-fellowship-in-minimally-invasive-gynecologic-surgery-fmigs-since-participation-in-the-national-residency-match-program-nrmp
#1
Maria V Vargas, Magdy P Milad
OBJECTIVE: To describe the level of interest in the fellowship in minimally invasive gynecologic surgery (FMIGS) using data from National Residency Match Program (NRMP) over the past 4 years. DESIGN: Retrospective report (Canadian Task Force Classification II-2) SETTING: Publically reported data from the NRMP PARTICIPANTS: Applicants using the NRMP to match into fellowship training. INTERVENTIONS: Reporting matching trends for the gynecologic surgical subspecialty programs starting in 2014, when the FMIGS programs started participating in the NRMP...
February 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29429350/-steroid-21-hydroxylase-deficiency-the-most-frequent-cause-of-congenital-adrenal-hyperplasia
#2
Márton Doleschall, Dóra Török, Katalin Mészáros, Andrea Luczay, Zita Halász, Krisztina Németh, Nikolette Szücs, Róbert Kiss, Judit Tőke, János Sólyom, György Fekete, Attila Patócs, Péter Igaz, Miklós Tóth
Congenital adrenal hyperplasia is a group of genetic diseases due to the disablement of 7 genes; one of them is steroid 21-hydroxylase deficiency. The genes of congenital adrenal hyperplasia encode enzymes taking part in the steroidogenesis of adrenal gland. Steroid 21-hydroxylase deficiency is an autosomal recessive disorder caused by mutations of the steroid 21-hydroxylase gene. The mutations of steroid 21-hydroxylase gene cause 95% of the congenital adrenal hyperplasia cases. Although the non-classic steroid 21-hydroxylase deficiency with mild symptoms is seldom diagnosed, the classic steroid 21-hydroxylase deficiency may lead to life-threatening salt-wasting and adrenal crises due to the insufficient aldosterone and cortisol serum levels...
February 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29408736/diagnostic-evaluation-comorbidity-screening-and-treatment-of-polycystic-ovary-syndrome-in-adolescents-in-three-specialty-clinics
#3
Meghna R Sebastian, Constance M Wiemann, Fida Bacha, Sharonda J Alston-Taylor
STUDY OBJECTIVE: A polycystic ovary syndrome (PCOS) diagnosis in adolescence can have significant long-term health implications. The criteria for its diagnosis in adolescents have been subject to much debate. This study aimed to characterize the variability in diagnosis and management among different pediatric specialties. DESIGN, SETTINGS, PARTICIPANTS, AND INTERVENTIONS: This is a retrospective review of electronic medical records of females (11 - 21 years old) who presented to three specialties (adolescent medicine (AM), pediatric endocrinology (ENDO), and gynecology (GYN)), with a post-visit diagnosis of PCOS, menstrual disorders, or hirsutism, at a large tertiary care center, from November 1, 2011- October 31, 2012...
January 31, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29388179/the-pcos-patients-differ-in-lipid-profile-according-to-their-phenotypes
#4
Magdalena Spałkowska, Sandra Mrozińska, Anna Gałuszka-Bednarczyk, Katarzyna Gosztyła, Agnieszka Przywara, Justyna Guzik, Marek Janeczko, Tomasz Milewicz, Anna Wojas-Pelc
Polycystic ovary syndrome (PCOS) affects 4-18% of women of reproductive age. The number of reports exploring the lipid profiles among PCOS patients and number of studied patients are limited. The aim of our study was to assess the lipid profile separately in lean and non-lean women with polycystic ovary syndrome divided according to hyperandrogenemia, defined as free androgen index (FAI)≥5. The second aim was to compare the lipid profiles among lean and non-lean PCOS patients with respect to hyperandrogenemia and regularity of menstruation cycles...
January 31, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29343557/dicer1-and-associated-conditions-identification-of-at-risk-individuals-and-recommended-surveillance-strategies
#5
Kris Ann P Schultz, Gretchen M Williams, Junne Kamihara, Douglas R Stewart, Anne K Harris, Andrew J Bauer, Joyce Turner, Rachana Shah, Katherine Schneider, Kami Wolfe Schneider, Ann Garrity Carr, Laura A Harney, Shari Baldinger, A Lindsay Frazier, Daniel Orbach, Dominik T Schneider, David Malkin, Louis P Dehner, Yoav H Messinger, Ashley Hill
Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome with a variety of manifestations. In addition to conferring increased cancer risks for pleuropulmonary blastoma (PPB) and ovarian sex cord-stromal tumors, particularly Sertoli-Leydig cell tumor, individuals with pathogenic germline DICER1 variants may also develop lung cysts, cystic nephroma, renal sarcoma and Wilms tumor, nodular hyperplasia of the thyroid, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, genitourinary embryonal rhabdomyosarcoma and brain tumors including pineoblastoma and pituitary blastoma...
January 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29197313/variation-in-use-of-prophylactic-antibiotics-in-gynecologic-procedures-before-and-after-an-educational-intervention
#6
Emily Wu, Jessica Langsjoen, Jessica Pruszynski, Thomas J Kuehl, Wilma I Larsen
OBJECTIVES: Guidelines for use of prophylactic antibiotics in gynecologic procedures are outlined by the American Congress of Obstetricians and Gynecologists. There remains, however, a high rate of unindicated administration of antibiotics for surgeries. A retrospective study performed at our institution in 2012-2013 demonstrated that unindicated prophylactic antibiotics were administered over half the time. This study aimed to examine variations in the use of prophylactic antibiotics in patients undergoing gynecologic surgery at Scott and White Memorial Hospital and determine whether an educational intervention to gynecology physicians was associated with a significant decrease in unindicated prophylactic antibiotics...
December 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/29171893/should-clinicians-set-limits-on-reproductive-autonomy
#7
Louise P King
As a gynecologic surgeon with a focus on infertility, I frequently hold complex discussions with patients, exploring with them the risks and benefits of surgical options. In the past, we physicians may have expected our patients to simply defer to our expertise and choose from the options we presented. In our contemporary era, however, patients frequently request options not favored by their physicians and even some they've found themselves online. In reproductive endocrinology and infertility, the range of options that may be offered or that patients may themselves seek out is continuously widening...
December 2017: Hastings Center Report
https://www.readbyqxmd.com/read/29083441/measuring-active-and-healthy-ageing-applying-a-generic-interdisciplinary-assessment-model-incorporating-icf
#8
P Stute, N Bitterlich, J Bousquet, F Meissner, M von Wolff, D Poethig
OBJECTIVES: In this study we compared the chronological and bio-functional age between two German speaking cohorts 30 years apart applying a comprehensive and generic Active and Healthy Aging (AHA) assessment model incorporating ICF. METHODS: Single-centre, cross-sectional, observational, non-interventional, non-randomized trial at an University based women's hospital, division of Gynecological Endocrinology and Reproductive Medicine. All participants followed a standardized, holistic battery of biopsychosocial assessments consisting of bio-functional status (BFS), bio-functional age (BFA) and additional validated psychometric questionnaires...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29050164/-comparisons-of-prevalence-and-clinical-and-environmental-characteristics-between-tibetan-and-han-women-with-polycystic-ovarian-syndrome-in-tibetan-plateau
#9
K L Zhai, G Zhuo, H B Chi, Z Lan
Objective: By the preliminary comparison study on the constituent ratio and clinical characteristics of polycystic ovary syndrome (PCOS) in Tibetan and Han women in Tibetan Plateau, we aimed to find the relevance of its pathogenic factors, and to guide the treatment of PCOS in the plateau region and improve the prognosis. Methods: The general situation and clinical data of 165 patients who were diagnosed with PCOS from December 1, 2015 to November 30, 2016 in the Department of Obstetrics and Gynecology of the People's Hospital of Tibet Autonomous Region were analyzed retrospectively...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29046513/history-and-practice-of-thyroid-fine-needle-aspiration-in-china-based-on-retrospective-study-of-the-practice-in-shandong-university-qilu-hospital
#10
REVIEW
Zhiyan Liu, Dongge Liu, Bowen Ma, Xiaofang Zhang, Peng Su, Li Chen, Qingdong Zeng
Cytology in China developed from nothing and underwent a long journey from gynecologic cytology to that of all organs, laying a solid foundation for new developments in the 21st century. Thyroid fine-needle aspiration (FNA) was primarily developed in an endocrinology department and then in the clinical laboratory department or pathology department in the 1970-80s. Wrights staining is popular in endocrine and clinical laboratory departments, while hematoxylin and eosin staining is common in pathology. Liquid based cytology is not common in thyroid FNA cytology, while BRAF V600E mutation analysis has been the most popular molecular test...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28950844/effect-of-simvastatin-on-monocyte-chemoattractant-protein-1-expression-in-endometriosis-patients-a-randomized-controlled-trial
#11
Wanwisa Waiyaput, Somphoch Pumipichet, Sawaek Weerakiet, Sasivimol Rattanasiri, Areepan Sophonsritsuk
BACKGROUND: Simvastatin is a promising new drug for the treatment of endometriosis. It is a cholesterol-lowering drug that acts by inhibiting HMG-CoA reductase, resulting in a decrease in mevalonate, a precursor of cholesterol and monocyte chemoattractant protein-1 (MCP-1). This study investigated the effect of pre-operative oral simvastatin administration on MCP-1 gene expression and serum MCP-1 protein levels in patients with endometriosis. METHODS: A prospective, randomized, controlled study was conducted at the Reproductive Endocrinology Unit of the Department of Obstetrics and Gynecology at the Faculty of Medicine Ramathibodi Hospital...
September 26, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28854581/unexplained-recurrent-miscarriages-are-associated-with-an-aberrant-sperm-protamine-mrna-content
#12
Nina Rogenhofer, Johannes Ott, Adrian Pilatz, Julia Wolf, Christian J Thaler, Lisa Windischbauer, Undraga Schagdarsurengin, Klaus Steger, Viktoria von Schönfeldt
STUDY QUESTION: Are unexplained recurrent miscarriages associated with abnormal protamine-1 and protamine-2 mRNA levels in spermatozoa? SUMMARY ANSWER: Both protamine-1 and protamine-2 mRNA levels as well as the protamine-1 to protamine-2 mRNA ratio in spermatozoa from men whose female partners experienced two or more consecutive miscarriages were significantly different compared to those from both healthy control men and subfertile couples undergoing IVF/ICSI. WHAT IS KNOWN ALREADY: Aberrant sperm protamine ratios are known to be associated with male-factor infertility...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28789706/small-leucine-rich-proteoglycans-slrps-in-the-endometrium-of-polycystic-ovary-syndrome-women-a-pilot-study
#13
Ricardo Santos Simões, José Maria Soares-Jr, Manuel J Simões, Helena B Nader, Maria Cândida P Baracat, Gustavo Arantes R Maciel, Paulo C Serafini, Ricardo Azziz, Edmund C Baracat
BACKGROUND: Small leucine-rich proteoglycans (SLRPs) play an important role in tissue homeostasis and cell proliferation since these proteoglycans sequester multiple growth factors. However, the content of SLRPs in the endometrium of polycystic ovary syndrome (PCOS) women is unknown. Our purpose was to test the hypothesis that excessive endometrial proliferation in PCOS may be partly related to abnormalities in SLRPs. METHODS: In a cross section study a total of 20 endometrial samples were collected from 10 patients with PCOS and 10 ovulatory women during their proliferative (pre-ovulatory) phase...
August 8, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28690863/fertility-preservation-training-for-obstetrics-and-gynecology-fellows-a-highly-desired-but-non-standardized-experience
#14
Elizabeth J N Miller, Lisa M Cookingham, Teresa K Woodruff, Ginny L Ryan, Karen M Summers, Laxmi A Kondapalli, Divya K Shah
BACKGROUND: Despite a large body of data suggesting that delivery of fertility care to cancer patients is inconsistent and frequently insufficient, there is a paucity of literature examining training in fertility preservation for those physicians expected to discuss options or execute therapy. The study objective was to compare fertility preservation training between Reproductive Endocrinology & Infertility (REI) and Gynecologic Oncology (GYN ONC) fellows and assess the need for additional education in this field...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/28672734/subclinical-hypothyroidism-does-not-influence-the-metabolic-and-hormonal-profile-of-women-with-pcos
#15
Eftihios Trakakis, Vasilios Pergialiotis, Erifili Hatziagelaki, Periklis Panagopoulos, Ioannis Salloum, Nikolaos Papantoniou
Background Subclinical hypothyroidism (SCH) is present in 5%-10% of polycystic ovary syndrome (PCOS) patients. To date, its impact on the metabolic and hormonal profile of those women remains controversial. The purpose of our study is to evaluate the impact of SCH on the glycemic, lipid and hormonal profile of PCOS patients. Materials and methods We conducted a prospective case control study of patients that attended the Department of Gynecological Endocrinology of our hospital. Results Overall, 280 women with PCOS were enrolled during a time period of 7 years (2009-2015)...
June 23, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28557237/disorders-of-sex-development-dsd-clinical-service-delivery-in-the-united-states
#16
Aimee M Rolston, Melissa Gardner, Kathleen van Leeuwen, Lauren Mohnach, Catherine Keegan, Emmanuèle Délot, Eric Vilain, David E Sandberg
Following the principles of care recommended in the 2006 Consensus Statement on Disorders of Sex Development (DSD), along with input from representatives of peer support and advocacy groups, this study surveyed DSD clinical management practices at healthcare facilities in the United States. DSD are congenital conditions in which development of chromosomal, gonadal, or anatomic sex is atypical. Facilities providing care for patients with DSD were targeted for participation. Specialty providers completed a survey with questions in six broad categories: Institution Information, Nomenclature and Care Guidelines, Interdisciplinary Services, Staff and Community Education, DSD Management, and Research...
June 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28546817/clinical-and-biochemical-characteristics-in-pcos-women-with-menstrual-abnormalities
#17
Vasiliki Christodoulopoulou, Eftihios Trakakis, Vasilios Pergialiotis, Melpomeni Peppa, Charalampos Chrelias, Dimitrios Kassanos, Nikolaos Papantoniou
Objective: The purpose of the present study was to examine the impact of menstrual cycle abnormalities among patients with polycystic ovary syndrome (PCOS) on biochemical and anthropometric characteristics. Materials and methods: We conducted a prospective observational study of patients 17-35 years of age with PCOS that attended the department of Gynecological Endocrinology of our hospital. Results: A total of 309 women with PCOS participated in the study. In total, 72.2% suffered from menstrual cycle disorders...
December 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28508615/a-multidisciplinary-approach-to-puberty-and-fertility-in-girls-with-turner-syndrome
#18
Johanna Viau Colindres, Krista J Childress, Marni Axelrad, Laurence B McCullough, Yunru Shao, Charles Macias, Jennifer Loveless, Sheila K Gunn, Jennifer Bercaw-Pratt, Reid Sutton, Lefkothea P Karaviti, Jennifer E Dietrich
Women with Turner Syndrome (TS) have a variety of medical needs throughout their lives; however, the peripubertal years are particularly challenging. From a medical perspective, the burden of care increases during this time due to growth optimization strategies, frequent health screenings, and puberty induction. Psychologically, girls begin to comprehend the long-term implications of the condition, including their diminished fertility potential. Unfortunately, clear guidelines for how to best approach this stage have not been established...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28473852/inositol-s-from-bench-to-bedside-in-endocrinology-and-gynecology
#19
EDITORIAL
Vittorio Unfer, John E Nestler, Zdravko A Kamenov, Nikos Prapas, Fabio Facchinetti
No abstract text is available yet for this article.
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28315665/physician-scientists-in-obstetrics-and-gynecology-predictors-of-success-in-obtaining-independent-research-funding
#20
Ijeoma Okeigwe, Cynthia Wang, Joseph A Politch, Linda J Heffner, Wendy Kuohung
BACKGROUND: Obstetrics and gynecology departments receive the smallest amount of National Institutes of Health research funding and have significantly lower application success rates compared to pediatric, internal medicine, and surgery departments. The development of mentored early career development training grants (K awards) has been one strategy implemented by the National Institutes of Health to help aspiring physician-scientists establish independent research careers. OBJECTIVE: The purpose of this study is to describe the cohort of obstetrics and gynecology physician-scientists who were K08, K12, and K23 recipients from 1988 through 2015 and to identify predictors of success in obtaining independent federal funding, as defined by acquisition of an R01, R21, R34, U01, U54, P01, or P50 award...
July 2017: American Journal of Obstetrics and Gynecology
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