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JOURNAL ARTICLE
Norah P Saarman, Jae Hak Son, Hongyu Zhao, Luciano V Cosme, Yong Kong, Mo Li, Shiyu Wang, Brian L Weiss, Richard Echodu, Robert Opiro, Serap Aksoy, Adalgisa Caccone
The primary vector of the trypanosome parasite causing human and animal African trypanosomiasis in Uganda is the riverine tsetse fly Glossina fuscipes fuscipes (Gff). Our study improved the Gff genome assembly with whole genome 10× Chromium sequencing of a lab reared pupae, identified autosomal versus sex-chromosomal regions of the genome with ddRAD-seq data from 627 field caught Gff, and identified SNPs associated with trypanosome infection with genome-wide association (GWA) analysis in a subset of 351 flies...
September 12, 2023: Infection, Genetics and Evolution
#22
JOURNAL ARTICLE
E Aprile, K Abe, F Agostini, S Ahmed Maouloud, L Althueser, B Andrieu, E Angelino, J R Angevaare, V C Antochi, D Antón Martin, F Arneodo, L Baudis, A L Baxter, M Bazyk, L Bellagamba, R Biondi, A Bismark, E J Brookes, A Brown, S Bruenner, G Bruno, R Budnik, T K Bui, C Cai, J M R Cardoso, D Cichon, A P Cimental Chavez, A P Colijn, J Conrad, J J Cuenca-García, J P Cussonneau, V D'Andrea, M P Decowski, P Di Gangi, S Di Pede, S Diglio, K Eitel, A Elykov, S Farrell, A D Ferella, C Ferrari, H Fischer, M Flierman, W Fulgione, C Fuselli, P Gaemers, R Gaior, A Gallo Rosso, M Galloway, F Gao, R Glade-Beucke, L Grandi, J Grigat, H Guan, M Guida, R Hammann, A Higuera, C Hils, L Hoetzsch, N F Hood, J Howlett, M Iacovacci, Y Itow, J Jakob, F Joerg, A Joy, N Kato, M Kara, P Kavrigin, S Kazama, M Kobayashi, G Koltman, A Kopec, F Kuger, H Landsman, R F Lang, L Levinson, I Li, S Li, S Liang, S Lindemann, M Lindner, K Liu, J Loizeau, F Lombardi, J Long, J A M Lopes, Y Ma, C Macolino, J Mahlstedt, A Mancuso, L Manenti, F Marignetti, T Marrodán Undagoitia, K Martens, J Masbou, D Masson, E Masson, S Mastroianni, M Messina, K Miuchi, K Mizukoshi, A Molinario, S Moriyama, K Morå, Y Mosbacher, M Murra, J Müller, K Ni, U Oberlack, B Paetsch, J Palacio, R Peres, C Peters, J Pienaar, M Pierre, V Pizzella, G Plante, J Qi, J Qin, D Ramírez García, R Singh, L Sanchez, J M F Dos Santos, I Sarnoff, G Sartorelli, J Schreiner, D Schulte, P Schulte, H Schulze Eißing, M Schumann, L Scotto Lavina, M Selvi, F Semeria, P Shagin, S Shi, E Shockley, M Silva, H Simgen, A Takeda, P-L Tan, A Terliuk, D Thers, F Toschi, G Trinchero, C Tunnell, F Tönnies, K Valerius, G Volta, C Weinheimer, M Weiss, D Wenz, C Wittweg, T Wolf, V H S Wu, Y Xing, D Xu, Z Xu, M Yamashita, L Yang, J Ye, L Yuan, G Zavattini, M Zhong, T Zhu
We report on the first search for nuclear recoils from dark matter in the form of weakly interacting massive particles (WIMPs) with the XENONnT experiment, which is based on a two-phase time projection chamber with a sensitive liquid xenon mass of 5.9 ton. During the (1.09±0.03) ton yr exposure used for this search, the intrinsic ^{85}Kr and ^{222}Rn concentrations in the liquid target are reduced to unprecedentedly low levels, giving an electronic recoil background rate of (15...
July 28, 2023: Physical Review Letters
#23
JOURNAL ARTICLE
Yordi J van de Vegte, Ruben N Eppinga, M Yldau van der Ende, Yanick P Hagemeijer, Yuvaraj Mahendran, Elias Salfati, Albert V Smith, Vanessa Y Tan, Dan E Arking, Ioanna Ntalla, Emil V Appel, Claudia Schurmann, Jennifer A Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina Mononen, Kirsi Auro, Anne U Jackson, Lawrence F Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Müller-Nurasyid, Carolina Roselli, Weihua Zhang, Marcus E Kleber, Xiuqing Guo, Henry J Lin, Francesca Pavani, Tessel E Galesloot, Raymond Noordam, Yuri Milaneschi, Katharina E Schraut, Marcel den Hoed, Frauke Degenhardt, Stella Trompet, Marten E van den Berg, Giorgio Pistis, Yih-Chung Tham, Stefan Weiss, Xueling S Sim, Hengtong L Li, Peter J van der Most, Ilja M Nolte, Leo-Pekka Lyytikäinen, M Abdullah Said, Daniel R Witte, Carlos Iribarren, Lenore Launer, Susan M Ring, Paul S de Vries, Peter Sever, Allan Linneberg, Erwin P Bottinger, Sandosh Padmanabhan, Bruce M Psaty, Nona Sotoodehnia, Ivana Kolcic, David O Arnar, Daniel F Gudbjartsson, Hilma Holm, Beverley Balkau, Claudia T Silva, Christopher H Newton-Cheh, Kjell Nikus, Perttu Salo, Karen L Mohlke, Patricia A Peyser, Heribert Schunkert, Mattias Lorentzon, Jari Lahti, Dabeeru C Rao, Marilyn C Cornelis, Jessica D Faul, Jennifer A Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie Waldenberger, Moritz F Sinner, Konstantin Strauch, Graciela E Delgado, Kent D Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renée de Mutsert, Eco J C de Geus, Åsa Johansson, Peter K Joshi, Lars Lind, Andre Franke, Peter W Macfarlane, Kirill V Tarasov, Nicholas Tan, Stephan B Felix, E-Shyong Tai, Debra Q Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia Lindgren, Andrew P Morris, Olli T Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur Gudnason, Nicholas J Timpson, Alanna C Morrison, Patricia B Munroe, David P Strachan, Niels Grarup, Ruth J F Loos, Susan R Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif Groop, Nicholas J Wareham, Cornelia M van Duijn, Mary F Feitosa, Christopher J O'Donnell, Mika Kähönen, Markus Perola, Michael Boehnke, Sharon L R Kardia, Jeanette Erdmann, Colin N A Palmer, Claes Ohlsson, David J Porteous, Johan G Eriksson, Claude Bouchard, Susanne Moebus, Peter Kraft, David R Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kääb, Annette Peters, John C Chambers, Jaspal S Kooner, Winfried März, Jerome I Rotter, Andrew A Hicks, J Gustav Smith, Lambertus A L M Kiemeney, Dennis O Mook-Kanamori, Brenda W J H Penninx, Ulf Gyllensten, James F Wilson, Stephen Burgess, Johan Sundström, Wolfgang Lieb, J Wouter Jukema, Mark Eijgelsheim, Edward L M Lakatta, Ching-Yu Cheng, Marcus Dörr, Tien-Yin Wong, Charumathi Sabanayagam, Albertine J Oldehinkel, Harriette Riese, Terho Lehtimäki, Niek Verweij, Pim van der Harst
Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci...
August 2, 2023: Nature Communications
#24
JOURNAL ARTICLE
Judith Weiss, Regina Steil, Kathlen Priebe, Petra Lindauer, Nikolaus Kleindienst, Thomas Fydrich, Meike Müller-Engelmann
Many women with posttraumatic stress disorder (PTSD) after child sexual abuse (CSA) suffer from sexual problems. However, little is known about the frequency of female sexual dysfunctions (FSD) as defined by DSM-5 among women with PTSD due to CSA. Furthermore, factors related to FSD in this patient population are understudied. To assess prevalence rates and clinical correlates of FSD according to DSM-5 criteria in women with PTSD after CSA, a structured clinical interview for sexual dysfunctions according to DSM-5 criteria was administered in a sample of 137 women with PTSD after CSA...
July 19, 2023: Archives of Sexual Behavior
#25
JOURNAL ARTICLE
E Aprile, K Abe, S Ahmed Maouloud, L Althueser, B Andrieu, E Angelino, J R Angevaare, V C Antochi, D Antón Martin, F Arneodo, L Baudis, A L Baxter, M Bazyk, L Bellagamba, R Biondi, A Bismark, E J Brookes, A Brown, S Bruenner, G Bruno, R Budnik, T K Bui, C Cai, J M R Cardoso, D Cichon, A P Cimental Chavez, M Clark, A P Colijn, J Conrad, J J Cuenca-García, J P Cussonneau, V D'Andrea, M P Decowski, P Di Gangi, S Di Pede, S Diglio, K Eitel, A Elykov, S Farrell, A D Ferella, C Ferrari, H Fischer, M Flierman, W Fulgione, C Fuselli, P Gaemers, R Gaior, A Gallo Rosso, M Galloway, F Gao, R Glade-Beucke, L Grandi, J Grigat, H Guan, M Guida, R Hammann, A Higuera, C Hils, L Hoetzsch, N F Hood, J Howlett, M Iacovacci, Y Itow, J Jakob, F Joerg, A Joy, N Kato, M Kara, P Kavrigin, S Kazama, M Kobayashi, G Koltman, A Kopec, F Kuger, H Landsman, R F Lang, L Levinson, I Li, S Li, S Liang, S Lindemann, M Lindner, K Liu, J Loizeau, F Lombardi, J Long, J A M Lopes, Y Ma, C Macolino, J Mahlstedt, A Mancuso, L Manenti, F Marignetti, T Marrodán Undagoitia, K Martens, J Masbou, D Masson, E Masson, S Mastroianni, M Messina, K Miuchi, K Mizukoshi, A Molinario, S Moriyama, K Morå, Y Mosbacher, M Murra, J Müller, K Ni, U Oberlack, B Paetsch, J Palacio, Q Pellegrini, R Peres, C Peters, J Pienaar, M Pierre, V Pizzella, G Plante, T R Pollmann, J Qi, J Qin, D Ramírez García, R Singh, L Sanchez, J M F Dos Santos, I Sarnoff, G Sartorelli, J Schreiner, D Schulte, P Schulte, H Schulze Eißing, M Schumann, L Scotto Lavina, M Selvi, F Semeria, P Shagin, S Shi, E Shockley, M Silva, H Simgen, A Takeda, P-L Tan, A Terliuk, D Thers, F Toschi, G Trinchero, C Tunnell, F Tönnies, K Valerius, G Volta, C Weinheimer, M Weiss, D Wenz, C Wittweg, T Wolf, V H S Wu, Y Xing, D Xu, Z Xu, M Yamashita, L Yang, J Ye, L Yuan, G Zavattini, M Zhong, T Zhu
Multiple viable theoretical models predict heavy dark matter particles with a mass close to the Planck mass, a range relatively unexplored by current experimental measurements. We use 219.4 days of data collected with the XENON1T experiment to conduct a blind search for signals from multiply interacting massive particles (MIMPs). Their unique track signature allows a targeted analysis with only 0.05 expected background events from muons. Following unblinding, we observe no signal candidate events. This Letter places strong constraints on spin-independent interactions of dark matter particles with a mass between 1×10^{12} and 2×10^{17} GeV/c^{2}...
June 30, 2023: Physical Review Letters
#26
JOURNAL ARTICLE
Maximilian Kugler, Mirjam Dellinger, Felix Kartnig, Lena Müller, Teresa Preglej, Leonhard X Heinz, Elisabeth Simader, Lisa Göschl, Stephan E Puchner, Sebastian Weiss, Lisa E Shaw, Matthias Farlik, Wolfgang Weninger, Giulio Superti-Furga, Josef S Smolen, Guenter Steiner, Daniel Aletaha, Hans P Kiener, Myles J Lewis, Costantino Pitzalis, Anela Tosevska, Thomas Karonitsch, Michael Bonelli
INTRODUCTION: Structural reorganisation of the synovium with expansion of fibroblast-like synoviocytes (FLS) and influx of immune cells is a hallmark of rheumatoid arthritis (RA). Activated FLS are increasingly recognised as a critical component driving synovial tissue remodelling by interacting with immune cells resulting in distinct synovial pathotypes of RA. METHODS: Automated high-content fluorescence microscopy of co-cultured cytokine-activated FLS and autologous peripheral CD4+ T cells from patients with RA was established to quantify cell-cell interactions...
September 2023: Annals of the Rheumatic Diseases
#27
JOURNAL ARTICLE
V Martín-Gorgojo, M C Blasco Mollá, F Forriol Brocal, Á Aguilar Hernández, A M Olivas Marín, M Sánchez González, A Guillot Ferriols
BACKGROUND AND AIM: Müller-Weiss disease (MWD) is a rare anomaly of the tarsal scaphoid. Maceira and Rochera proposed the most commonly accepted aetiopathogenic theory, in which dysplastic, mechanical, and socioeconomic environmental factors would be involved. The aim is to describe the clinical and sociodemographic characteristics of patients with MWD in our setting, corroborate their association with the socioeconomic factors previously described, estimate the influence of other factors involved in the development of MWD, and describe the treatment carried out...
June 11, 2023: Revista Española de Cirugía Ortopédica y Traumatología
#28
JOURNAL ARTICLE
Wellington Farias Molina, Monica Paschoal Nogueira, Fernando Salgueiro Alvo, Lourenço Galizia Heitzmann
PURPOSE: Evaluate the functional health status and quality of life of patients diagnosed with Müller-Weiss disease and, secondarily, determine the influence of factors such as gender, social status, race, body mass index, and surgical and non-surgical treatment in patient outcome. METHODS: This study included 30 affected feet (18 patients) with follow-up from 2002 to 2016. Five patients were excluded from reassessment, resulting in 20 feet (13 patients). Questionnaires for functional and quality of life assessments were administered, and statistical analysis was performed...
June 9, 2023: International Orthopaedics
#29
JOURNAL ARTICLE
Nina Müller, Carina Lorenz, Jenny Ostendorp, Felix S Heisel, Ulrich P Friese, Maria Cartolano, Dennis Plenker, Hannah L Tumbrink, Alena Heimsoeth, Philipp Baedeker, Sandra Ortiz-Cuaran, Jonathan Weiss, Reinhard Büttner, Martin Peifer, Roman K Thomas, Martin L Sos, Johannes Berg, Johannes Brägelmann
The emergence of resistance to targeted therapies restrains their efficacy. The development of rational-ly guided drug combinations could overcome this currently insurmountable clinical challenge. However, our limited understanding of the trajectories that drive the outgrowth of resistant clones in cancer cell populations precludes design of drug combinations to forestall resistance. Here, we propose an iterative treatment strategy coupled with genomic profiling and genome-wide CRISPR activation screening to systematically extract and define pre-existing resistant subpopulations in an EGFR-driven lung cancer cell line...
June 8, 2023: Cancer Research
#30
JOURNAL ARTICLE
Javier Carrascoso, Manuel Monteagudo, Eva Llopis, Mar Jiménez, Manuel Recio, Ernesto Maceira
Müller-Weiss disease (MWD) is the result of a dysplasia of the tarsal navicular bone. Over the adult years, the dysplastic bone leads to the development of an asymmetric talonavicular arthritis with the talar head shifting laterally and plantarly, thus driving the subtalar joint into varus. From a diagnostic point of view, the condition may be difficult to differentiate from an avascular necrosis or even a stress fracture of the navicular, but fragmentation is the result of a mechanical impairment rather than a biological dysfunction...
June 2023: Seminars in Musculoskeletal Radiology
#31
JOURNAL ARTICLE
John Wong-Chung, Andrew Walls, Matthew Lynch-Wong, Roslyn Cassidy, Raymond McKenna, Alistair Wilson, Michael Stephens
BACKGROUND: The single existing classification of Müller-Weiss Disease (MWD), based solely upon Méary's angle, serves neither as guide for prognosis nor treatment. This accounts for lack of gold standard in its management. METHODS: Navicular compression, medial extrusion, metatarsal lengths, Kite's, lateral and dorsoplantar talo-first metatarsal angles were measured in 95 feet with MWD. Joints involved, presence and location of navicular fracture were recorded...
July 2023: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
#32
JOURNAL ARTICLE
Andreas Stallmach, Lutz von Müller, Martin Storr, Alexander Link, Peter C Konturek, Philipp Christoph Solbach, Karl Heinz Weiss, Steffen Wahler, Maria J G T Vehreschild
INTRODUCTION: Fecal microbiota transfer (FMT) is a treatment to modulate the gastrointestinal microbiota. Its use in recurrent Clostridioides difficile infection (rCDI) is established throughout Europe and recommended in national and international guidelines. In Germany, the FMT is codeable in the hospital reimbursement system. A comprehensive survey on the frequency of use based on this coding is missing so far. MATERIAL AND METHODOLOGY: Reports of the Institute for Hospital Remuneration (InEK), the Federal Statistical Office (DESTATIS), and hospital quality reports 2015-2021 were examined for FMT coding and evaluated in a structured expert consultation...
May 15, 2023: Zeitschrift Für Gastroenterologie
#33
JOURNAL ARTICLE
Martin B Müller, Clemens Stihl, Annika Schmid, Simon Hirschberger, Rea Mitsigiorgi, Martin Holzer, Martin Patscheider, Bernhard G Weiss, Christoph Reichel, Max Hübner, Bernd Uhl
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by recurrent episodes of upper airway obstruction and subsequent hypoxia. In patients with OSA, severity and number of these hypoxic events positively correlate with the extent of associated cardiovascular pathology. The molecular mechanisms underlying intermittent hypoxia (IH)-driven cardiovascular disease in OSA, however, remain poorly understood-partly due to the lack of adequate experimental models. Here, we present a novel experimental approach that utilizes primary human endothelial cells cultivated under shear stress...
2023: Frontiers in Physiology
#34
JOURNAL ARTICLE
Manuel Besendörfer, Laurin Langer, Roman Carbon, Christel Weiss, Hanna Müller, Sonja Diez
BACKGROUND: Therapeutic principles of fistula-in-ano (FIA) are lacking evidence-based consensus on treatment options. Non-cutting, sphincter-sparing options have not been published for infancy and childhood FIA. PATIENTS AND METHODS: We are presenting retrospective data on FIA treatment with non-cutting seton placement between 2011 and 2020. Data were collected based on medical records and complemented by patients' contact for follow-up analyses between November 2021 and October 2022...
2023: Frontiers in Surgery
#35
JOURNAL ARTICLE
Wenbo Bai, Yinghao Li, Guodong Shen, Hongning Zhang, Xue Li, Yongzhan Zhu
BACKGROUND: There is no gold standard for the operative treatment of patients with Müller-Weiss disease (MWD). This study reports the mid-term follow-up results for at least 5 years following talonavicular-cuneiform (TNC) arthrodesis for Müller-Weiss disease. METHODS: A total of 15 patients undergoing TNC arthrodesis for MWD were retrospectively reviewed between January 2015 and August 2017. Two senior doctors assessed the radiographic results twice at each visit (preoperative, three months after the operation, and final follow-up)...
March 10, 2023: BMC Musculoskeletal Disorders
#36
JOURNAL ARTICLE
Víctor Martín-Gorgojo, María Carmen Blasco Mollá, Francisco Forriol Brocal, Ángel Aguilar Hernández, Ana María Olivas Marín, María Sánchez González, Anna Guillot Ferriols
UNLABELLED: [Introduction and aim: Müller-Weiss disease (MWD) is a rare anomaly of the tarsal scaphoid. Maceira and Rochera proposed the most commonly accepted etiopathogenic theory, in which dysplastic, mechanical, and socioeconomic environmental factors would be involved. The aim is to describe the clinical and sociodemographic characteristics of patients with MWD in our setting, corroborate their association with the socioeconomic factors previously described, estimate the influence of other factors involved in the development of MWD, and describe the treatment carried out...
February 15, 2023: Revista Española de Cirugía Ortopédica y Traumatología
#37
JOURNAL ARTICLE
Jonas Maier, A Kandulski, N E Donlon, J M Werner, A Mehrl, M Müller, A Doenecke, H J Schlitt, M Hornung, A R R Weiss
BACKGROUND: Anastomotic leakages after esophagectomies continue to constitute significant morbidity and mortality. Intrathoracic anastomoses pose a high risk for mediastinitis, sepsis, and death, if a leak is not addressed timely and appropriately. However, there are no standardized treatment recommendations or algorithms as for how to treat these leakages. METHODS: The study included all patients at the University Hospital Regensburg, who developed an anastomotic leakage after esophagectomy with gastric pull-up reconstruction from 2007 to 2022...
February 15, 2023: Langenbeck's Archives of Surgery
#38
JOURNAL ARTICLE
Beatriz F Côrte-Real, Ibrahim Hamad, Rebeca Arroyo Hornero, Sabrina Geisberger, Joris Roels, Lauren Van Zeebroeck, Aleksandra Dyczko, Marike W van Gisbergen, Henry Kurniawan, Allon Wagner, Nir Yosef, Susanne N Y Weiss, Klaus G Schmetterer, Agnes Schröder, Luka Krampert, Stefanie Haase, Hendrik Bartolomaeus, Niels Hellings, Yvan Saeys, Ludwig J Dubois, Dirk Brenner, Stefan Kempa, David A Hafler, Johannes Stegbauer, Ralf A Linker, Jonathan Jantsch, Dominik N Müller, Markus Kleinewietfeld
FOXP3+ regulatory T cells (Tregs) are central for peripheral tolerance, and their deregulation is associated with autoimmunity. Dysfunctional autoimmune Tregs display pro-inflammatory features and altered mitochondrial metabolism, but contributing factors remain elusive. High salt (HS) has been identified to alter immune function and to promote autoimmunity. By investigating longitudinal transcriptional changes of human Tregs, we identified that HS induces metabolic reprogramming, recapitulating features of autoimmune Tregs...
February 7, 2023: Cell Metabolism
#39
JOURNAL ARTICLE
Federico Perdomo-Celis, Caroline Passaes, Valérie Monceaux, Stevenn Volant, Faroudy Boufassa, Pierre de Truchis, Morgane Marcou, Katia Bourdic, Laurence Weiss, Corinne Jung, Christine Bourgeois, Cécile Goujard, Laurence Meyer, Michaela Müller-Trutwin, Olivier Lambotte, Asier Sáez-Cirión
No abstract text is available yet for this article.
January 17, 2023: Journal of Clinical Investigation
#40
JOURNAL ARTICLE
Laura Griewahn, Madeleine Müller, Lukas Peintner, Manuela Wissler, Martina Weiss, Prisca Brauns-Schubert, Ramin Massoumi, Christoph Borner, Olaf Groß, Monica Yabal, Céline Charvet, Ulrich Maurer
SPATA2 mediates the recruitment of CYLD to immune receptor complexes by bridging the interaction of CYLD with the linear ubiquitylation assembly complex (LUBAC) component HOIP. Whether SPATA2 exhibits functions independently of CYLD is unclear. Here, we show that, while Cyld-/- and Spata2-/- mice are viable, double mutants exhibit highly penetrant perinatal lethality, indicating independent functions of SPATA2 and CYLD. Cyld-/- Spata2-/- fibroblasts show increased M1-linked TNFR1-SC ubiquitylation and, similar to Cyld-/- Spata2-/- macrophages and intestinal epithelial cells, elevated pro-inflammatory gene expression compared with Cyld-/- or Spata2-/- cells...
January 12, 2023: Cell Reports
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