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Primitive reflexes

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https://www.readbyqxmd.com/read/28518104/neurodevelopmental-reflex-testing-in-neonatal-rat-pups
#1
Antoinette T Nguyen, Edward A Armstrong, Jerome Y Yager
Neurodevelopmental reflex testing is commonly used in clinical practice to assess the maturation of the nervous system. Neurodevelopmental reflexes are also referred to as primitive reflexes. They are sensitive and consistent with later outcomes. Abnormal reflexes are described as an absence, persistence, reappearance, or latency of reflexes, which are predictive indices of infants that are at high risk for neurodevelopmental disorders. Animal models of neurodevelopmental disabilities, such as cerebral palsy, often display aberrant developmental reflexes, as would be observed in human infants...
April 24, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28409761/the-question-of-whether-or-not-to-perform-therapeutic-hypothermia-a-case-of-neonatal-spinal-cord-injury
#2
K Yokoi, S Kobayashi, K Muramatsu, S Suzuki, H Gotou
Neonatal spinal cord injury is an extremely rare perinatal complication that often occurs concurrently with hypoxic ischemic encephalopathy (HIE), further complicating diagnosis of spinal cord injury. Although therapeutic hypothermia for moderate to severe HIE is widely recommended in Japan, it is difficult to determine whether it satisfies the neurological findings-related entry criteria in some patients.We describe a female infant with neonatal spinal cord injury after forceps delivery, who underwent therapeutic hypothermia upon diagnosis of HIE...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28343847/global-developmental-delay-and-intellectual-disability-associated-with-a-de-novo-top2b-mutation
#3
Ching-Wan Lam, Wai-Lan Yeung, Chun-Yiu Law
BACKGROUND: More than 100 genes had been identified for autism spectrum disorder (ASD). With the advancement of whole-exome/genome sequencing (WES/WGS), disease-causing gene in ASD can be identified in a holistic and unbiased approach. The identification of new ASD genes can further explore the molecular basis of ASD. METHODS: We report a 15yo girl with developmental delay, intellectual disability, hypotonia, microcephaly and autistic feature. She first presented at 6months old with primitive response to noise...
March 23, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28241263/bridging-knowledge-gaps-to-understand-how-zika-virus-exposure-and-infection-affect-child-development
#4
Bill G Kapogiannis, Nahida Chakhtoura, Rohan Hazra, Catherine Y Spong
Importance: The Zika virus (ZIKV) epidemic has profoundly affected the lives of children and families across the Americas. As the number of children born with ZIKV-related complications continues to grow, the long-term developmental trajectory for these children and the effect on their families remains largely unknown. In September 2016, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and partner National Institutes of Health institutes convened a workshop to develop a research agenda to improve the evaluation, monitoring, and management of neonates, infants, or children affected by ZIKV and its complications...
May 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/27966319/the-frequency-of-buccopalpebral-reflex-in-parkinson-disease
#5
Hülya Eser, Yasemin Ünal, Gülnihal Kutlu, Ruhsen Öcal, Levent Ertuğrul İnan
BACKGROUND/AIM: This study aimed to define the frequency of a primitive reflex, the buccopalpebral reflex (BPR), and its association with the clinical situation in patients with Parkinson disease. MATERIALS AND METHODS: Between May 2010 and May 2011, 222 patients, 115 with Parkinson disease and 107 patients without any sign of neurodegenerative disease, were included in the study. All included patients were examined for BPR and snout reflex and were also evaluated with the Mini Mental State Examination...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27848255/prognostic-predictors-for-ambulation-in-children-with-cerebral-palsy-a-systematic-review-and-meta-analysis-of-observational-studies
#6
Orawan Keeratisiroj, Nuanlaor Thawinchai, Wantana Siritaratiwat, Montana Buntragulpoontawee, Chayanin Pratoomsoot
PURPOSE: The purpose of this study is to investigate the prognostic predictors for ambulation in children with cerebral palsy using meta-analysis of observational studies. METHOD: Electronic searches were conducted in PubMed, SCOPUS, CINAHL, ProQuest, Ovid, Wiley InterScience, and ScienceDirect databases from their start dates to December 2015. RESULTS: Of the 1123 identified articles, 12 met the inclusion criteria for qualitative synthesis, eight of which were deemed appropriate for meta-analysis...
November 16, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27595468/persistent-primary-reflexes-affect-motor-acts-potential-implications-for-autism-spectrum-disorder
#7
Alice Chinello, Valentina Di Gangi, Eloisa Valenza
In typical motor development progress in use of goal-directed actions and communicative gestures depends on the inhibition of several primitive reflexes, especially those that involve the hand or mouth. This study explored the relationship between the persistence of primitive reflexes that involve the hand or mouth and the motor repertoire in a sample of 12- to 17-month-old infants. Moreover, since children with Autism Spectrum Disorders (ASD) often have difficulty in performing skilled movements and show poor gesture repertoire, and since ASD represents the upper extreme of a constellation of traits that may be continuously distributed in the general population, we investigated the relationship between the persistence of primitive reflexes in the same sample of infants and the subclinical autistic traits measured in their parents...
August 29, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27570791/somatic-stimulation-causes-frontoparietal-cortical-changes-in-neonates-a-functional-near-infrared-spectroscopy-study
#8
Nasser H Kashou, Irfaan A Dar, Kathryn A Hasenstab, Ramzi W Nahhas, Sudarshan R Jadcherla
Palmar and plantar grasp are the foremost primitive neonatal reflexes and functions. Persistence of these reflexes in infancy is a sign of evolving cerebral palsy. Our aims were to establish measurement feasibility in a clinical setting and to characterize changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbD) concentration in the bilateral frontoparietal cortex in unsedated neonates at the crib-side using functional near-infrared spectroscopy (fNIRS). We hypothesized that bilateral concentration changes will occur upon somatic central and peripheral somatic stimulation...
January 2017: Neurophotonics
https://www.readbyqxmd.com/read/27196946/movement-assessment-of-children-mac-validity-reliability-stability-and-sensitivity-to-change-in-typically-developing-children
#9
L S Chandler, L Terhorst, J C Rogers, M B Holm
AIM: The purpose of this study was to establish the validity, reliability, stability and sensitivity to change of the family-centred Movement Assessment of Children (MAC) in typically developing infants/toddlers from 2 months (1 month 16 days) to 2 years (24 months 15 days) of age. BACKGROUND: Assessment of infant/toddler motor development is critical so that infants and toddlers who are at-risk for developmental delay or whose functional motor development is delayed can be monitored and receive therapy to improve their developmental outcomes...
July 2016: Child: Care, Health and Development
https://www.readbyqxmd.com/read/27071788/psycho-cognitive-intervention-for-asd-from-cross-species-behavioral-analyses-of-infants-chicks-and-common-marmosets
#10
Mamiko Koshiba, Genta Karino, Koki Mimura, Shun Nakamura, Kunio Yui, Tetsuya Kunikata, Hideo Yamanouchi
Educational treatment to support social development of children with autism spectrum disorder (ASD) is an important topic in developmental psychiatry. However, it remains difficult to objectively quantify the socio-emotional development of ASD children. To address this problem, we developed a novel analytical method that assesses subjects' complex behaviors using multivariate analysis, 'Behavior Output analysis for Quantitative Emotional State Translation' (BOUQUET). Here, we examine the potential for psycho-cognitive ASD therapy based on comparative evaluations of clinical (human) and experimental (animal) models...
2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27027608/prognostic-significance-of-neurological-signs-in-high-risk-infants-a-systematic-review
#11
REVIEW
Elisa G Hamer, Mijna Hadders-Algra
The aim of this paper was to systematically review the literature on the significance of specific neurological signs in infancy, in particular in infants at risk for developmental problems such as cerebral palsy (CP). A literature search was performed using the databases PubMed, Embase, Web of Science, and AMED. Papers on infantile reactions ('primitive reflexes') and postural reactions were included if data were available allowing for calculation of sensitivity, specificity, or positive and negative predictive value for CP or atypical developmental outcome...
March 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/26639955/palmomental-reflex-a-relevant-sign-in-early-alzheimer-s-disease-diagnosis
#12
Audrey Gabelle, Laure-Anne Gutierrez, Jean-François Dartigues, Karen Ritchie, Jacques Touchon, Claudine Berr
BACKGROUND: Sophisticated and expensive biomarkers are proposed for the diagnostic of Alzheimer's disease (AD). The amyloid process seems to be early in AD, and brain amyloid load affects the frontal lobe. OBJECTIVE: To determine if certain simple clinical signs, especially frontal-related signs, could help reach an earlier and better diagnosis. METHODS: In the frame of the 3-City cohort, we conducted a nested case-control study comparing incident cases of AD to controls matched for age, gender, and education...
2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26531285/influence-of-one-year-neurologic-outcome-of-treatment-on-newborns-with-moderate-and-severe-hypoxic-ischemic-encephalopathy-by-rhuep0-combined-with-ganglioside-gm1
#13
X-Y Zhu, M-Y Ye, A-M Zhang, W-D Wang, F Zeng, J-L Li, F Fang
OBJECTIVE: To observe the one-year neurologic prognostic outcome of newborns with moderate and severe hypoxic-ischemic encephalopathy (HIE) who received recombinant human erythropoietin (rhuEPO) combined with exogenous monosialotetrahexosylganglioside (GM1) treatment to provide new guidelines for clinical treatment. PATIENTS AND METHODS: Seventy-six newborns with moderate and severe HIE were selected from February 2011 to February 2014 in our hospital. This study received the informed consent of our hospital's Ethics Committee and the newborns' guardians...
October 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26250756/validation-and-adaptation-of-rapid-neurodevelopmental-assessment-instrument-for-infants-in-guatemala
#14
L Thompson, R A Peñaloza, K Stormfields, R Kooistra, G Valencia-Moscoso, H Muslima, N Z Khan
BACKGROUND: Timely detection of neurodevelopmental impairments in children can prompt referral for critical services that may prevent permanent disability. However, screening of impairments is a significant challenge in low-resource countries. We adapted and validated the rapid neurodevelopmental assessment (RNDA) instrument developed in Bangladesh to assess impairment in nine domains: primitive reflexes, gross and fine motor development, vision, hearing, speech, cognition, behaviour and seizures...
November 2015: Child: Care, Health and Development
https://www.readbyqxmd.com/read/26056310/calcium-activates-the-light-dependent-conductance-in-melanopsin-expressing-photoreceptors-of-amphioxus
#15
Gabriel Peinado, Tomás Osorno, María del Pilar Gomez, Enrico Nasi
Melanopsin, the photopigment of the "circadian" receptors that regulate the biological clock and the pupillary reflex in mammals, is homologous to invertebrate rhodopsins. Evidence supporting the involvement of phosphoinositides in light-signaling has been garnered, but the downstream effectors that control the light-dependent conductance remain unknown. Microvillar photoreceptors of the primitive chordate amphioxus also express melanopsin and transduce light via phospholipase-C, apparently not acting through diacylglycerol...
June 23, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/25981791/behavioral-responses-to-a-repetitive-visual-threat-stimulus-express-a-persistent-state-of-defensive-arousal-in-drosophila
#16
William T Gibson, Carlos R Gonzalez, Conchi Fernandez, Lakshminarayanan Ramasamy, Tanya Tabachnik, Rebecca R Du, Panna D Felsen, Michael R Maire, Pietro Perona, David J Anderson
The neural circuit mechanisms underlying emotion states remain poorly understood. Drosophila offers powerful genetic approaches for dissecting neural circuit function, but whether flies exhibit emotion-like behaviors has not been clear. We recently proposed that model organisms may express internal states displaying "emotion primitives," which are general characteristics common to different emotions, rather than specific anthropomorphic emotions such as "fear" or "anxiety." These emotion primitives include scalability, persistence, valence, and generalization to multiple contexts...
June 1, 2015: Current Biology: CB
https://www.readbyqxmd.com/read/25926068/topography-of-primitive-reflexes-in-dementia-an-f-18-fluorodeoxyglucose-positron-emission-tomography-study
#17
J A Matias-Guiu, M N Cabrera-Martín, M Fernádez-Matarrubia, T Moreno-Ramos, M Valles-Salgado, J Porta-Etessam, J L Carreras, J Matias-Guiu
BACKGROUND AND PURPOSE: Although primitive reflexes (PRs) are inhibited during the first years of childhood, they may reappear with brain injury. PRs have been linked to frontal lobe dysfunction, but their precise topography has not yet been defined. The purpose of this study was to map which regions of the brain display a reduced glucose metabolism in patients with cognitive impairment and PRs. METHODS: A prospective study was conducted to evaluate PRs in a group of patients assessed due to suspected cognitive decline...
August 2015: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/25825125/isolated-subtle-neurological-abnormalities-in-neurologically-and-cognitively-healthy-aging-subjects
#18
Cecilia Camarda, Paola Torelli, Rosolino Camarda, Iacopo Battaglini, Cesare Gagliardo, Roberto Monastero
The aim of this study is to describe the frequency of isolated, subtle, neurological abnormalities (ISNAs) in a large population of neurologically and cognitively healthy subjects and to compare ISNAs to various types of MRI-detected cerebrovascular lesions and subcortical brain atrophy in different age classes. 907 subjects were selected from a large, prospective hospital-based study. At baseline neurological examination, 17 ISNAs were selected. Primitive reflexes were the most common ISNAs (35.8%), while dysphagia was the most rarely encountered (0...
May 2015: Journal of Neurology
https://www.readbyqxmd.com/read/25785487/intrapartum-synthetic-oxytocin-reduce-the-expression-of-primitive-reflexes-associated-with-breastfeeding
#19
COMPARATIVE STUDY
Miguel A Marín Gabriel, Ibone Olza Fernández, Ana M Malalana Martínez, Carmen González Armengod, Valeria Costarelli, Isabel Millán Santos, Aurora Fernández-Cañadas Morillo, Pilar Pérez Riveiro, Francisco López Sánchez, Lourdes García Murillo
AIM: Several synthetic peptide manipulations during the time surrounding birth can alter the specific neurohormonal status in the newborn brain. This study is aimed at assessing whether intrapartum oxytocin administration has any effect on primitive neonatal reflexes and determining whether such an effect is dose-dependent. MATERIALS AND METHODS: A cohort prospective study was conducted at a tertiary hospital. Mother-infant dyads who received intrapartum oxytocin (n=53) were compared with mother-infant dyads who did not receive intrapartum oxytocin (n=45)...
May 2015: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/25782289/-probable-structural-functional-evolution-of-sensory-surface-of-osphradia-of-aquatic-prosobranchian-molluscs
#20
N N Kamardin
At present, in ecotoxicological studies, as biomarkers there are used physiological reactions of invertebrates, based on diverse reflex. The primary chain of the reflex is chemo-, mechano-, and osmoreceptors. The structures are exposed on the surface of body and mantle cavity. Earlier, a hypothesis was put forward, which suggested that the polymodal osphradial organ of the pond snail might participate in adaptive reactions of aquatic molluscs to toxicants. The known homology of osphradial structures allows spreading this suggestion on marine representatives of various subclasses of Mollusca, although diversity of structure, of ways of nutrition, and multiplicity of aquatic molluscs can impede interpretation of future ecotoxicological studies...
November 2014: Zhurnal Evoliutsionnoĭ Biokhimii i Fiziologii
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