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https://www.readbyqxmd.com/read/29452136/neuroprotective-effects-of-valproic-acid-on-brain-ischemia-are-related-to-its-hdac-and-gsk3-inhibitions
#1
Monalisa Ribeiro Silva, Alyne Oliveira Correia, Gabriel Cabral Alencar Dos Santos, Lucas Leimig Telles Parente, Keicy Parente de Siqueira, Danielly Gonçalves Sombra Lima, Jonathan Almeida Moura, Ana Elisa da Silva Ribeiro, Roberta Oliveira Costa, Daniel Luna Lucetti, Elaine Cristina Pereira Lucetti, Kelly Rose Tavares Neves, Glauce Socorro de Barros Viana
Valproic acid (VA) is an antiepileptic that is also used for the treatment of bipolar disorders. The objective was to evaluate the neuroprotective effects of VA on a brain ischemia model. The groups of male Wistar rats were: SO (sham-operated), ischemic and ischemic treated with VA (25, 50 and 100 mg/kg, p.o.). After anesthesia with ketamine and xilazine, the animals were subjected to clamping of carotid arteries (30 min) and reperfusion. Except for the carotid clamping, the SO group was submitted to the same procedure...
February 13, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29442939/photo-induced-multiple-state-memory-behaviour-in-non-volatile-bipolar-resistive-switching-devices
#2
Xuejiao Zhang, Zhiwei Xu, Bai Sun, Jianjun Liu, Yanyan Cao, Haixia Qiao, Yong Huang, Xiaofeng Pang
The recent discovery of non-volatile resistive-switching memory is a promising phenomenon for the semiconductor industry and electronic device technology. In our work, CaWO4 nanoparticles were synthesised through a one-step hydrothermal reaction. A resistive-switching memory device with Ag/CaWO4/fluorine-doped tin oxide structure was prepared. This device presents photo-induced multiple-state memory behaviour at room temperature. This study is valuable for exploring multi-functional materials and their applications in photo-controlled multiple-state non-volatile memories...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29428214/the-effects-of-bilateral-continuous-and-chronic-deep-brain-stimulation-of-the-medial-forebrain-bundle-in-a-rodent-model-of-depression
#3
Stephanie Thiele, Luciano Furlanetti, Lisa-Marie Pfeiffer, Volker A Coenen, Máté D Döbrössy
BACKGROUND: Clinical trials of supra-lateral medial forebrain bundle (MFB) Deep Brain Stimulation (DBS) in treatment resistant major depressive patients have shown rapid and long-term benefits. OBJECTIVE/HYPOTHESIS: The study used Flinders Sensitive Line (FSL) rats with previously identified depressive-like phenotype to assess the range of behavior modification achieved by MFB DBS. METHODS: Male FSL and wild-type Sprague-Dawley rats as Controls were tested on mood/anxiety/exploration, cognitive and motor behaviors...
February 8, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29407766/dopamine-d3-receptor-blockade-rescues-hyper-dopamine-activity-induced-deficit-in-novel-object-recognition-memory
#4
Pi-Kai Chang, Lung Yu, Jin-Chung Chen
Patients afflicted with bipolar disorder demonstrate significant impairments in recognition and episodic memory during acute depressive and manic episodes. These impairments and the related pathophysiology may result from over-activation of the brain dopamine (DA) system. In order to model overactive DA transmission in a well-established novel object recognition (NOR) memory test, we used DA transporter knockdown (DAT-KD) mice, which exhibit reduced DAT expression and display hyper-dopaminergic phenotypes. DAT-KD mice exhibited impaired NOR memory compared to wild-type (WT) mice...
February 1, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29382902/cognitive-impairment-in-treatment-na%C3%A3-ve-bipolar-ii-and-unipolar-depression
#5
Arthur D P Mak, Domily T Y Lau, Alicia K W Chan, Suzanne H W So, Owen Leung, Sheila L Y Wong, Linda Lam, C M Leung, Sing Lee
Cognition dysfunction may reflect trait characteristics of bipolarity but cognitive effects of medications have confounded previous comparisons of cognitive function between bipolar II and unipolar depression, which are distinct clinical disorders with some overlaps. Therefore, we examined the executive function (WCST), attention, cognitive speed (TMT-A) and memory (CAVLT, WMS-Visual reproduction) of 20 treatment-naïve bipolar II patients (BPII), 35 treatment-naïve unipolar depressed (UD) patients, and 35 age/sex/education matched healthy controls...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29363947/probing-the-mechanism-for-bipolar-resistive-switching-in-annealed-graphene-oxide-thin-films
#6
Pooja Saini, Manjri Singh, Jyoti Thakur, Ranjit A Patil, Yuan-Ron Ma, Ram Pal Tandon, Surinder P Singh, Ajit Kumar Mahapatro
The bipolar resistive switching (BRS) between a metallic low resistance state (LRS) and an insulating high resistance state (HRS) is demonstrated for annealed graphene oxide (GO) thin film based device structures with aluminum (Al) as one of the contact electrodes. An optimal switching of ~104 order is recorded for Al/GO(200°C)/ITO among the device structures in metal(M2)/GO(T)/metal(M1) configurations (M1 = Al, Au, ITO, and M2 = Au, Al), fabricated using GO(T)/metal(M1), annealed at different temperatures, T = 100, 200, 300, and 400 °C...
January 24, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29350624/conductive-bridge-random-access-memory-characteristics-of-sicn-based-transparent-device-due-to-indium-diffusion
#7
Dayanand Kumar, Rakesh Aluguri, Umesh Chand, Tseung-Yuen Tseng
In this work, the transparent bipolar resistive switching characteristics of SiCN-based ITO/SiCN/AZO structure due to In diffusion from ITO was studied. SiCN based device is found to be 80 % transparent in the visible wavelength region. This device with AZO as both top and bottom electrodes did not show any RRAM property due to deposition of the high quality O2 free SiCN film. Replacing the AZO top electrode with ITO in this device exhibited good resistive switching(RS) characteristics with high on/off ratio and long retention...
January 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29331931/resting-state-fmri-signals-in-offspring-of-parents-with-bipolar-disorder-at-the-high-risk-and-ultra-high-risk-stages-and-their-relations-with-cognitive-function
#8
Kangguang Lin, Robin Shao, Rui Lu, Kun Chen, Weicong Lu, Ting Li, Jiehua Kong, Kwok-Fai So, Guiyun Xu
BACKGROUND: Bipolar disorder (BD) has been associated with dysfunctional resting-state brain functioning. However, it is still not known whether the aberrant functioning occurs and predict cognitive functioning before illness onset. AIMS: We examined the resting-state regional and network dysfunctioning, and their correlates with neurocognitive performance, in the high-risk (HR) and ultra-high-risk (UHR) stages of bipolar disorder. METHODS: Using amplitude of low-frequency fluctuations (ALFF), region homogeneity (ReHo) and hypothesis-driven region-of-interest (ROI)-based connectivity, we examined resting-state fMRI data of 8- to 25-year-old healthy offspring (HR, n = 28) and offspring with subthreshold syndromes (UHR, n = 22) of a BD parent, and age-matched healthy controls without any personal or family psychopathology (HC, n = 46)...
January 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29331692/memory-performance-predicts-response-to-psychotherapy-for-depression-in-bipolar-disorder-a-pilot-randomized-controlled-trial-with-exploratory-functional-magnetic-resonance-imaging
#9
Thilo Deckersbach, Amy T Peters, Conor Shea, Aishwarya Gosai, Jonathan P Stange, Andrew D Peckham, Kristen K Ellard, Michael W Otto, Scott L Rauch, Darin D Dougherty, Andrew A Nierenberg
OBJECTIVE: This pilot randomized controlled trial compared Cognitive Behavior Therapy (CBT) and Supportive Psychotherapy (SP) for the treatment of depression in bipolar I disorder. We also examined whether exploratory verbal memory, executive functioning, and neural correlates of verbal memory during functional magnetic resonance imaging (fMRI) predicted change in depression severity. METHODS: Thirty-two adults (ages 18-65) with DSM-IV bipolar I disorder meeting current criteria for a major depressive episode were randomized to 18 weeks of CBT or SP...
December 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29329741/sex-differences-of-hippocampal-structure-in-bipolar-disorder
#10
Jing Shi, Hua Guo, Fengmei Fan, Hongzhen Fan, Huimei An, Zhiren Wang, Shuping Tan, Fude Yang, Yunlong Tan
Although differential patterns in clinical characteristics have been consistently noted between male and female patients with bipolar disorder (BD), the effect of sex on the hippocampal structure remains unclear. To address this, the present study investigated the effects of BD and sex on the hippocampal structure, and the relationship between the hippocampal structure and cognitive performance. Morphometric and neurocognitive analyses were performed in 91 subjects (patients with BD: male/female = 33/19; normal controls: male/female = 22/17)...
December 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29328948/psychopathology-and-episodic-future-thinking-a-systematic-review-and-meta-analysis-of-specificity-and-episodic-detail
#11
D J Hallford, D W Austin, K Takano, F Raes
Episodic future thinking (EFT) refers to the mental simulation of future events that might be personally-experienced; a crucial mental process in adaptation. Psychiatric disorders are associated with deficits in recalling episodic memory, however, no study has reviewed the empirical literature to assess for similar deficits in EFT. A systematic review comparing psychiatric groups with control groups on the specificity and episodic detail of EFT returned 19 eligible studies. An overall effect of g = -0.84 (95%CI = -1...
January 5, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29316520/psychosocial-functioning-in-patients-with-psychotic-and-non-psychotic-bipolar-i-disorder-a-comparative-study-with-individuals-with-schizophrenia
#12
Estela Jiménez-López, Eva María Sánchez-Morla, Ana Isabel Aparicio, Ana López-Villarreal, Vicente Martínez-Vizcaíno, Roberto Rodriguez-Jimenez, Eduard Vieta, José Luis Santos
BACKGROUND: More than 50% of individuals with bipolar disorder (BD) do not reach full psychosocial functioning, even during periods of euthymia. It has been suggested that history of psychotic symptoms is one of the factors which are associated with a worse functional outcome. The objective was to compare psychosocial functioning between patients with BD, with (BD-P), and without (BD-NP) a history of psychotic symptoms, and to examine whether the history of psychotic symptoms, or other clinical or neurocognitive variables predict psychosocial functioning...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29314557/assessment-of-cognitive-functions-in-bipolar-i-disorder-a-1-year-naturalistic-follow-up-study
#13
Rajesh Sagar, Anamika Sahu, Raman Deep Pattanayak, Biswadip Chatterjee
OBJECTIVE: Available findings from cross-sectional studies have demonstrated cognitive impairments in bipolar I disorder (BD-I) during various phases of illness. However, very little is known about the longitudinal course of these cognitive impairments. The purpose of the study was to explore the longitudinal pattern of changes in cognitive functioning of BD-I patients. METHODS: A total of 129 BD-I subjects (manic, depressed and euthymic groups) and 49 healthy controls were recruited using predefined selection criteria...
January 4, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29306692/neurocognitive-features-in-clinical-subgroups-of-bipolar-disorder-a-meta-analysis
#14
REVIEW
Emre Bora
OBJECTIVE: There is a significant cognitive heterogeneity in bipolar disorder (BD). The aim of this systematic review was to examine the potential distinctive neuropsychological of features of clinical subgroups of BD. A literature search investigating cognitive differences between potential subtypes of BD was conducted. METHODS: It was possible to conduct a meta-analysis of studies investigating the relationship between cognitive deficits and subgroups of DSM-IV BD (type I (BD-I) and type II (BD-II)), subgroups based on history of psychosis (PBD and NPBD)...
December 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29298279/severe-chronic-lithium-intoxication-in-patient-treated-for-bipolar-disorder
#15
Ivana Stetkarova, Vaclav Bocek, Alsu Gismatullina, Zuzana Svobodova, Tomas Peisker
OBJECTIVE: Lithium has been long used in psychiatry as an adjuvant treatment for bipolar disorder. Chronic lithium intoxication is very rare. DESIGN: We present the case of a 72-year-old female, treated with lithium for more than 10 years for bipolar disorder, who was admitted for gait impairment with weakness of limbs, myoclonus, speech impairment and memory disturbances. RESULTS: Diagnosis of lithium intoxication was based on clinical picture and determination of serum lithium levels...
December 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29251266/a-study-on-the-resistance-switching-of-ag2se-and-ta2o5-heterojunctions-using-structural-engineering
#16
Tae Sung Lee, Nam Joo Lee, Haider Abbas, Quanli Hu, Tae-Sik Yoon, Hyun Ho Lee, Ee Le Shim, Chi Jung Kang
The resistive random access memory (RRAM) devices with heterostuctures have been investigated due to cycling stability, nonlinear switching, complementary resistive switching and self-compliance. The heterostructured devices can modulate the resistive switching (RS) behavior appropriately by bilayer structure with a variety of materials. In this study, the bipolar resistive switching characteristics of the bilayer structures composed of Ta2O5 and Ag2Se, which are transition-metal oxide (TMO) and silver chalcogenide, were investigated...
December 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29245093/neurocognitive-functioning-in-first-episode-bipolar-disorder-relationship-with-functional-status
#17
Alejandro G Szmulewicz, Marina P Valerio, Julieta Lomastro, José M Smith, Virginia Chiappe, Diego J Martino, Ana Igoa
BACKGROUND: The aim of this study was to assess if an association between neurocognitive deficits and psychosocial functioning exists in first-episode BD patients. METHODS: Twenty-five euthymic first-episode BD patients and thirty-seven healthy controls were recruited. History of suicide attempts, psychiatric comorbidities, pharmacological exposure, and previous depressive episodes were investigated. Performances on neurocognitive domains (verbal memory, attention, processing speed, and executive functions) as well as a measure of psychosocial functioning were used as outcomes...
December 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29243543/a-kainate-receptor-gluk4-deletion-protective-against-bipolar-disorder-is-associated-with-enhanced-cognitive-performance-across-diagnoses-in-the-twinsuk-cohort
#18
Maria Koromina, Miles Flitton, Ian Mellor, Helen Miranda Knight
OBJECTIVES: Cognitive deficits are a common feature of neuropsychiatric disorders. We investigated the relationship between cognitive performance and a deletion allele within GluK4 protective against risk for bipolar disorder, in 1642 individuals from the TwinsUK study. METHODS: Cognitive performance was assessed using the National Adult Reading Test, four CANTAB tests (Spatial Working Memory, Paired Associates Learning, Pattern Recognition Memory, and Reaction Time), and two Principal Component Analysis derived factors...
December 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29235143/allostatic-load-but-not-medical-burden-predicts-memory-performance-in-late-life-bipolar-disorder
#19
REVIEW
Sophie R Vaccarino, Tarek K Rajji, Ariel G Gildengers, Sarah E S Waters, Meryl A Butters, Mahesh Menon, Daniel M Blumberger, Aristotle N Voineskos, Dielle Miranda, Benoit H Mulsant
OBJECTIVE: Older patients with bipolar disorder (BD) present with variable degrees of cognitive impairment. Over time, stress, mood episodes, and comorbidities increase the body's allostatic load. We assessed the extent to which allostatic load vs more traditional measures of medical burden account for the heterogeneity in cognition in this population. METHODS: Thirty-five older euthymic patients with BD and 30 age-equated, gender-equated, and education-equated comparison participants were administered a comprehensive assessment including a neuropsychological battery, and 9 physiological measures to determine allostatic load...
December 13, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29234084/nonvolatile-bio-memristor-based-on-silkworm-hemolymph-proteins
#20
Lu Wang, Dianzhong Wen
This paper reports the first successful fabrication of an ITO/silkworm hemolymph/Al bio-memristor using silkworm hemolymph as the active layer. Experiments demonstrate that the silkworm hemolymph bio-memristor is a nonvolatile rewritable bipolar memory device with a current switching ratio exceeding 103. The state of the bio-memristor can be retained for more than 104 seconds and remains stable for at least 500 cycles. Tests of 1/f noise have shown that the resistance switching characteristics of the silkworm hemolymph bio-memristor are related to the formation and breaking of conductive filaments, which result from the migration of oxygen ions and the oxidation and reduction of metal cations in the silkworm hemolymph film...
December 12, 2017: Scientific Reports
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