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https://www.readbyqxmd.com/read/28078883/flexible-multistate-data-storage-devices-fabricated-using-natural-lignin-at-room-temperature
#1
Youngjun Park, Jang-Sik Lee
The growing interests for bioinspired and sustainable electronics have induced research for biocompatible and biodegradable materials. However, conventional electronic devices have been restricted due to its non-biodegradable and sometimes harmful and toxic material, which even cause environmental issues. Here, we report resistive switching memory (ReRAM) device based on lignin, which is a biodegradable waste product of the paper industry. The active layer of the device can be easily formed using a simple solution process on a plastic substrate...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28073491/gray-matter-neuritic-microstructure-deficits-in-schizophrenia-and-bipolar-disorder
#2
Arash Nazeri, Benoit H Mulsant, Tarek K Rajji, Melissa L Levesque, Jon Pipitone, Laura Stefanik, Saba Shahab, Tina Roostaei, Anne L Wheeler, Sofia Chavez, Aristotle N Voineskos
BACKGROUND: Postmortem studies have demonstrated considerable dendritic pathologies among persons with schizophrenia and to some extent among those with bipolar I disorder. Modeling gray matter (GM) microstructural properties is now possible with a recently proposed diffusion-weighted magnetic resonance imaging modeling technique: neurite orientation dispersion and density imaging. This technique may bridge the gap between neuroimaging and histopathological findings. METHODS: We performed an extended series of multishell diffusion-weighted imaging and other structural imaging series using 3T magnetic resonance imaging...
December 8, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28063385/the-effect-of-premorbid-intelligence-on-neurocognitive-and-psychosocial-functioning-in-bipolar-disorder
#3
Diego J Martino, Marina P Valerio, Alejandro G Szmulewicz, Sergio A Strejilevich
BACKGROUND: The aim of this study was to assess if premorbid IQ moderates the association between measures of clinical severity and neurocognitive or psychosocial functioning in euthymic patients with bipolar disorder. METHODS: One hundred and nineteen outpatients and forty healthy controls were included. The length of illness, number of previous hypo/manic and depressive episodes, episode density, and history of psychosis assessed clinical severity. Performances in verbal memory, attention, and executive functions, as well as level of psychosocial functioning were used as outcomes...
January 2, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28045139/chrna7-deficient-mice-manifest-no-consistent-neuropsychiatric-and-behavioral-phenotypes
#4
Jiani Yin, Wu Chen, Hongxing Yang, Mingshan Xue, Christian P Schaaf
The alpha7 nicotinic acetylcholine receptor, encoded by the CHRNA7 gene, has been implicated in various psychiatric and behavioral disorders, including schizophrenia, bipolar disorder, epilepsy, autism, Alzheimer's disease, and Parkinson's disease, and is considered a potential target for therapeutic intervention. 15q13.3 microdeletion syndrome is a rare genetic disorder, caused by submicroscopic deletions on chromosome 15q. CHRNA7 is the only gene in this locus that has been deleted entirely in cases involving the smallest microdeletions...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28040657/neuropsychological-profiles-of-major-depressive-disorder-and-bipolar-disorder-during-euthymia-a-systematic-literature-review-of-comparative-studies
#5
REVIEW
Alejandro G Szmulewicz, Marina P Valerio, José M Smith, Cecilia Samamé, Diego J Martino, Sergio A Strejilevich
Bipolar disorder and major depressive disorder have been shown to be associated with neurocognitive abnormalities during periods of clinical remission. However, at present, there is no consensus on whether these disorders have distinctive cognitive profiles. The aim of this study was to provide an updated systematic review of studies comparing neuropsychological functioning between bipolar disorder and major depressive disorder during remission. Main findings included the following: 1) no differences regarding performances in measures of attention and processing speed, executive functions and theory of mind were found between both patient groups and 2) regarding verbal memory, preliminary evidence points towards a more defective performance in patients with bipolar disorder than those with major depressive disorder...
December 24, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28029429/high-cognitive-reserve-in-bipolar-disorders-as-a-moderator-of-neurocognitive-impairment
#6
I Grande, J Sanchez-Moreno, B Sole, E Jimenez, C Torrent, C M Bonnin, C Varo, R Tabares-Seisdedos, V Balanzá-Martínez, E Valls, I Morilla, A F Carvalho, J L Ayuso-Mateos, E Vieta, A Martinez-Aran
BACKGROUND: Cognitive reserve (CR) reflects the capacity of the brain to endure neuropathology, minimize clinical manifestations and successfully complete cognitive tasks. The present study aims to determine whether high CR may constitute a moderator of cognitive functioning in bipolar disorder (BD). METHODS: 102 patients with BD and 32 healthy controls were enrolled. All patients met DSM-IV criteria for I or II BD and were euthymic (YMRS≤6 and HDRS≤8) during a 6-month period...
October 18, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28029107/modulation-of-nonlinear-resistive-switching-behavior-of-a-taox-based-resistive-device-through-interface-engineering
#7
Zongwei Wang, Jian Kang, Zhizhen Yu, Yichen Fang, Yaotian Ling, Yimao Cai, Ru Huang, Yangyuan Wang
A resistive switching device with inherent nonlinear characteristics through a delicately engineered interfacial layer is an ideal component to be integrated into passive crossbar arrays for the suppression of sneaking current, especially in ultra-dense 3D integration. In this paper, we demonstrated a TaOx-based bipolar resistive switching device with a nearly symmetrical bi-directional nonlinear feature through interface engineering. This was accomplished by introducing an ultra-thin interfacial layer (SiO2-x) with unique features, including a large band gap and a certain level of negative heat of oxide formation between the top electrode (TiN) and resistive layer (TaOx)...
February 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28002634/fkbp5-polymorphisms-influence-pre-learning-stress-induced-alterations-of-learning-and-memory
#8
Phillip R Zoladz, Alison M Dailey, Hannah E Nagle, Miranda K Fiely, Brianne E Mosley, Callie M Brown, Tessa J Duffy, Amanda R Scharf, McKenna B Earley, Boyd R Rorabaugh
FK506 binding protein 51(FKBP5) is a co-chaperone of heat shock protein 90 and significantly influences glucocorticoid receptor sensitivity. Single nucleotide polymorphisms (SNPs) in the FKBP5 gene are associated with altered hypothalamus-pituitary-adrenal (HPA) axis function, changes in the structure and function of several cognitive brain areas, and increased susceptibility to post-traumatic stress disorder, major depression, bipolar disorder, and suicidal events. The mechanisms underlying these associations are largely unknown, but it has been speculated that the influence of these SNPs on emotional memory systems may play a role...
December 21, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27995622/lower-cognitive-functioning-as-a-predictor-of-weight-gain-in-bipolar-disorder-a-12-month-study
#9
D J Bond, I J Torres, S S Lee, J-M Kozicky, L E Silveira, T Dhanoa, R W Lam, L N Yatham
OBJECTIVE: In cross-sectional studies, elevated body mass index (BMI) is associated with cognitive impairment in bipolar disorder (BD). We investigated the direction of this association by prospectively examining changes in BMI and cognition. METHOD: We measured BMI and performance in six cognitive domains over 12 months in 80 adolescent and young adult BD patients and 46 healthy comparison subjects (HS). Ninety-three percent of patients received pharmacotherapy and 84% were euthymic...
December 20, 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27992891/negative-experiences-in-childhood-and-the-development-and-course-of-bipolar-disorder
#10
REVIEW
Paulina Jaworska-Andryszewska, Janusz Rybakowski
The aim of this paper is to review the effects of negative childhood experiences on the development and course of bipolar disorder (BD) and to discuss the involved mechanisms. The negative childhood experiences that may play a role in BD are critical or traumatic events including all kinds of abuse, loss of a parent or parents resulting from death, suicide, separation, divorce or prolonged separation. Previous studies indicate that in BD patients negative childhood events are more frequent than in control group...
October 31, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27992513/permanent-data-storage-in-zno-thin-films-by-filamentary-resistive-switching
#11
Adolfo Henrique Nunes Melo, Marcelo Andrade Macêdo
Resistive memories are considered the most promising candidates for the next generation of non-volatile memory; however, attention has so far been limited to rewritable memory features for applications in resistive random access memories (RRAM). In this article, we provide a new insight into the applicability of resistive memories. The characteristics of non-rewritable resistive memories (NRRM) were investigated. Devices with Pt/ZnO/ITO architecture were prepared using magnetron sputtering, upon which various bipolar and unipolar resistive switching tests were performed...
2016: PloS One
https://www.readbyqxmd.com/read/27979650/the-search-for-neuroimaging-and-cognitive-endophenotypes-a-critical-systematic-review-of-studies-involving-unaffected-first-degree-relatives-of-individuals-with-bipolar-disorder
#12
REVIEW
Kamilla W Miskowiak, Hanne L Kjærstad, Iselin Meluken, Jeff Zarp Petersen, Beatriz R Maciel, Cristiano A Köhler, Maj Vinberg, Lars V Kessing, André F Carvalho
The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-faceted disorder. We included original studies involving unaffected first-degree relatives of BD patients (URs) and a healthy control (HC) comparison group with no first-degree family history of mental disorders, investigating: 'cold' and 'hot' cognition and functional and structural neuroimaging...
December 12, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27976600/clinical-improvements-following-bilateral-anterior-capsulotomy-in-treatment-resistant-depression
#13
L Subramanian, T Bracht, P Jenkins, S Choppin, D E J Linden, G Phillips, B A Simpson
BACKGROUND: The purpose of this study was to evaluate a programme of lesion surgery carried out on patients with treatment-resistant depression (TRD). METHOD: This was a retrospective study looking at clinical and psychometric data from 45 patients with TRD who had undergone bilateral stereotactic anterior capsulotomy surgery over a period of 15 years, with the approval of the Mental Health Act Commission (37 with unipolar depression and eight with bipolar disorder)...
December 15, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27957851/conduction-channel-formation-and-dissolution-due-to-oxygen-thermophoresis-diffusion-in-hafnium-oxide-memristors
#14
Suhas Kumar, Ziwen Wang, Xiaopeng Huang, Niru Kumari, Noraica Davila, John Paul Strachan, David Vine, A L David Kilcoyne, Yoshio Nishi, R Stanley Williams
Transition-metal-oxide memristors, or resistive random-access memory (RRAM) switches, are under intense development for storage-class memory because of their favorable operating power, endurance, speed, and density. Their commercial deployment critically depends on predictive compact models based on understanding nanoscale physicochemical forces, which remains elusive and controversial owing to the difficulties in directly observing atomic motions during resistive switching, Here, using scanning transmission synchrotron X-ray spectromicroscopy to study in situ switching of hafnium oxide memristors, we directly observed the formation of a localized oxygen-deficiency-derived conductive channel surrounded by a low-conductivity ring of excess oxygen...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27951511/prefronto-cerebellar-tdcs-enhances-neurocognition-in-euthymic-bipolar-patients-findings-from-a-placebo-controlled-neuropsychological-and-psychophysiological-investigation
#15
Francesco Saverio Bersani, Amedeo Minichino, Laura Bernabei, Francesco Spagnoli, Alessandra Corrado, Lucilla Vergnani, Daniela Mannarelli, Caterina Pauletti, Francesco Fattapposta, Massimo Biondi, Roberto Delle Chiaie
OBJECTIVES: The present double blind placebo-controlled study aimed at investigating the efficacy of 3-weeks prefronto-cerebellar transcranial direct current stimulation (tDCS) on neurocognitive functioning in euthymic BD patients. METHODS: Forty-two outpatients with BD were randomly assigned to receive either active (n=21) or sham (n=21) prefronto-cerebellar tDCS for 3 consecutive weeks. Neurocognitive abilities were assessed with both neuropsychological testing and psychophysiological evaluation with a P300 novelty task...
February 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27934191/plasma-induced-nonvolatile-resistive-switching-with-extremely-low-set-voltage-in-tioxfy-with-agf-nanoparticles
#16
Xiangyu Sun, Chuangui Wu, Yao Shuai, Xinqiang Pan, Wenbo Luo, Tiangui You, Agnieszka Bogusz, Nan Du, Yanrong Li, Heidemarie Schmidt
Low power consumption is crucial for the application of resistive random access memory. In this work, we present the bipolar resistive switching in an Ag/TiOxFy/Ti/Pt stack with extremely low switch-on voltage of 0.07 V. Operating current as low as 10 nA was also obtained by conductive atomic force microscopy. The highly defective TiOxFy layer was fabricated by plasma treatment using helium, oxygen, and carbon tetrafluoride orderly. During the electroforming process, AgF nanoparticles were formed due to the diffusion of Ag(+) which reacted with the adsorbed F(-) in the TiOxFy layer...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27929612/effects-of-cumulative-herpesviridae-and-toxoplasma-gondii-infections-on-cognitive-function-in-healthy-bipolar-and-schizophrenia-subjects
#17
Nora Hamdani, Claire Daban-Huard, Ophelia Godin, Hakim Laouamri, Stéphane Jamain, Dodji Attiba, Marine Delavest, Jean-Pierre Lépine, Philippe Le Corvoisier, Josselin Houenou, Jean-Romain Richard, Robert H Yolken, Rajagopal Krishnamoorthy, Ryad Tamouza, Marion Leboyer, Faith B Dickerson
OBJECTIVE: Schizophrenia and bipolar disorder are associated with cognitive impairment leading to social disruption. While previous studies have focused on the effect of individual infectious exposure, namely, Herpesviridae viruses or Toxoplasma gondii (T gondii), on cognitive functioning, the objective of the present study was to examine the effect of multiple infections on cognitive functioning in patients with schizophrenia and bipolar disorder and in healthy controls. METHODS: Seropositivity to herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), cytomegalovirus (CMV), and T gondii was related to cognitive status among 423 participants (recruited between 2008 and 2014; 138 patients with bipolar disorder, 105 patients with schizophrenia [DSM-IV criteria], and 180 healthy controls) for episodic verbal memory (California Verbal Learning Test), working memory (Wechsler Adult Intelligence Scale, third edition), and premorbid intelligence quotient (National Adult Reading Test)...
December 6, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27929229/the-mental-status-examination
#18
David Norris, Molly S Clark, Sonya Shipley
The mental status examination includes general observations made during the clinical encounter, as well as specific testing based on the needs of the patient and physician. Multiple cognitive functions may be tested, including attention, executive functioning, gnosia, language, memory, orientation, praxis, prosody, thought content, thought processes, and visuospatial proficiency. Proprietary and open-source clinical examination tools are available, such as the Mini-Mental State Examination and the Mini-Cog...
October 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27924149/differences-in-real-world-executive-function-between-children-with-pediatric-bipolar-disorder-and-children-with-adhd
#19
Alessandra M Passarotti, Nidhi Trivedi, Liza Dominguez-Colman, Manharkumar Patel, Scott A Langenecker
BACKGROUND: Recent research evidence suggests that executive function (EF) is impaired in both pediatric bipolar disorder (PBD) and attention deficit-hyperactivity disorder (ADHD), although the underlying cognitive mechanisms are still unclear. In this study we examined EF, including cognitive and emotional control, in three pediatric groups with overlapping symptoms. METHODS: Sixteen children and adolescents with PBD, 17 children and adolescents with ADHD, Type Combined, and 13 children and adolescents with PBD and comorbid ADHD (PBD+ADHD) (mean age=12...
2016: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27923415/association-of-body-mass-index-related-single-nucleotide-polymorphisms-with-psychiatric-disease-and-memory-performance-in-a-japanese-population
#20
Midori Ninomiya-Baba, Junko Matsuo, Daimei Sasayama, Hiroaki Hori, Toshiya Teraishi, Miho Ota, Kotaro Hattori, Takamasa Noda, Ikki Ishida, Shigenobu Shibata, Hiroshi Kunugi
OBJECTIVE: Obesity is a risk factor for psychiatric diseases. Recently, a number of single nucleotide polymorphisms (SNPs) have been shown to be related to body mass index (BMI). In this study, we investigated the association of BMI-related SNPs with psychiatric diseases and one of their endophenotypes, memory performance, in a Japanese population. METHODS: The subjects were 1624 patients with one of three psychiatric diseases (799 patients with major depressive disorder, 594 with schizophrenia, and 231 with bipolar disorder) and 1189 healthy controls...
December 7, 2016: Acta Neuropsychiatrica
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