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https://www.readbyqxmd.com/read/29045770/treatment-to-enhance-cognition-in-bipolar-disorder-trec-bd-efficacy-of-a-randomized-controlled-trial-of-cognitive-remediation-versus-active-control
#1
Kathryn E Lewandowski, Sarah H Sperry, Bruce M Cohen, Lesley A Norris, Garrett M Fitzmaurice, Dost Ongur, Matcheri S Keshavan
OBJECTIVE: Cognitive dysfunction is a core symptom dimension in bipolar disorder and a strong predictor of functional outcomes. Cognitive remediation (CR) produces moderate, durable effects on cognition in patients with schizophrenia; however, studies of CR in patients with bipolar disorder are sparse and findings have been mixed. Thus, the aim of this study was to evaluate the effects of CR versus active control in patients with bipolar disorder with psychosis. METHODS: Patients with a DSM-IV diagnosis of bipolar disorder with psychosis (n = 75) were randomized to a 70-hour computerized CR program or a dose-matched computer control using a parallel design with 1:1 allocation between July 2011 and November 2015...
October 17, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29034573/memory-encoding-related-anterior-hippocampal-potentials-are-modulated-by-deep-brain-stimulation-of-the-entorhinal-area
#2
Niels Hansen, Leila Chaieb, Marlene Derner, Kevin G Hampel, Christian E Elger, Rainer Surges, Bernhard Staresina, Nikolai Axmacher, Juergen Fell
BACKGROUND: Deep brain stimulation (DBS) of the human entorhinal area using 50 Hz pulses has revealed conflicting results regarding memory performance. Moreover, its impact on memory-related hippocampal potentials has not yet been investigated. METHODS: We recorded data from seven epilepsy patients implanted with depth electrodes in the entorhinal cortex, hippocampus, amygdala and parahippocampal cortex. Entorhinal DBS (bipolar, biphasic 50 Hz pulses, on- and off-cycles of 15 s) was applied with low amplitude (0...
October 16, 2017: Hippocampus
https://www.readbyqxmd.com/read/29033637/cognitive-functioning-in-euthymic-bipolar-patients-on-monotherapy-with-novel-antipsychotics-or-mood-stabilizers
#3
Vesile Şentürk Cankorur, Hilal Demirel, Cem Atbaşoğlu
INTRODUCTION: Bipolar disorder is associated with cognitive dysfunction in several domains. Medication effect is a potential confounder that can only be statistically controlled in many studies. The cognitive profile in bipolar disorder during remission on maintenance antipsychotics or mood stabilizers medication has not been compared before. METHODS: We compared the cognitive profile of bipolar disorder patients euthymic for 2 month or more on monotherapy with novel antipsychotics (AP) (n=16), lithium carbonate (Li) (n=25) or valproic acid (VPA; n=26)...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29027461/nonpolar-resistive-switching-in-ag-tio2-core-shell-nanowires
#4
Hugh G Manning, Subhajit Biswas, Justin D Holmes, John J Boland
Nonpolar resistive switching, a combination of bipolar and unipolar resistive switching, is demonstrated for the first time in a single nanowire system. Exploiting Ag@TiO2 core-shell nanowires synthesized by post-growth shell formation the switching mode is controlled by adjusting the current compliance effectively tailoring the electrical polarity response.. We demonstrate ON/OFF ratios of 10(5) and 10(7) for bipolar and unipolar modes respectively. In the bipolar regime, retention times could be controlled up to 10(3) s and in unipolar mode > 10(6) s were recorded...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28994517/the-impact-of-obesity-on-cognitive-functioning-in-euthymic-bipolar-patients-a-cross-sectional-and-longitudinal-study
#5
Ester Mora, Maria J Portella, Montserrat Martinez-Alonso, Montse Teres, Irene Forcada, Eduard Vieta, Maria Mur
OBJECTIVE: To determine the influence of body mass index (BMI) on cognition in euthymic bipolar patients and healthy matched controls in a post hoc study of 2 cross-sectional and longitudinal exploratory studies. METHOD: A total sample of 121 individuals was examined, which included 52 euthymic bipolar disorder I or II patients (DSM-IV-TR criteria) and 69 healthy controls matched by age and gender, categorized in 2 subgroups in terms of body mass index (BMI-factor): normal weight (BMI: 18...
October 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28971006/dysfunctional-gaze-processing-in-bipolar-disorder
#6
Cristina Berchio, Camille Piguet, Christoph M Michel, Paolo Cordera, Tonia A Rihs, Alexandre G Dayer, Jean-Michel Aubry
Gaze conveys emotional information, and humans present sensitivity to its direction from the earliest days of life. Bipolar disorder is a disease characterized by fluctuating states of emotional and cognitive dysregulation. To explore the role of attentional control on face processing in bipolar patients (BP) we used gaze direction as an emotion modulation parameter in a two-back Working Memory (WM) task while high-density EEG data were acquired. Since gaze direction influences emotional attributions to faces with neutral expressions as well, we presented neutral faces with direct and averted gaze...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28966598/verbal-memory-impairment-in-patients-with-subsyndromal-bipolar-disorder
#7
Tomiki Sumiyoshi, Atsuhito Toyomaki, Naoko Kawano, Tomoko Kitajima, Ichiro Kusumi, Norio Ozaki, Nakao Iwata, Kazuki Sueyoshi, Kazuyuki Nakagome
BACKGROUNDS: Several domains of cognitive function, including learning memory and executive function, are impaired in mood disorders. Also, the relationship between disturbances of these two cognitive domains has been suggested. In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder, the present study was conducted to (1) test the criterion-related validity and test-retest reliability of the California Verbal Learning Test (CVLT)-II Japanese version, and (2) determine if type of word learning tasks (i...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28963521/valence-change-bipolar-resistive-switching-accompanied-with-magnetization-switching-in-cofe2o4-thin-film
#8
Sandeep Munjal, Neeraj Khare
Resistive Switching in oxides has offered new opportunities for developing resistive random access memory (ReRAM) devices. Here we demonstrated bipolar Resistive Switching along with magnetization switching of cobalt ferrite (CFO) thin film using Al/CFO/FTO sandwich structure, which makes it a potential candidate for developing future multifunctional memory devices. The device shows good retention characteristic time (>10(4) seconds) and endurance performance, a good resistance ratio of high resistance state (HRS) and low resistance state (LRS) ~10(3)...
September 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28961594/bipolar-disorder-and-cognitive-dysfunction-a-complex-link
#9
REVIEW
Gabriele Cipriani, Sabrina Danti, Cecilia Carlesi, Davide Maria Cammisuli, Mario Di Fiorino
The aim of this article was to describe the current evidence regarding phenomenon of cognitive functioning and dementia in bipolar disorder (BD). Cochrane Library and PubMed searches were conducted for relevant articles, chapters, and books published before 2016. Search terms used included "bipolar disorder," "cognitive dysfunction," and "dementia." At the end of the selection process, 159 studies were included in our qualitative synthesis. As result, cognitive impairments in BD have been previously considered as infrequent and limited to the affective episodes...
October 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28944813/transparent-amorphous-strontium-titanate-resistive-memories-with-transient-photo-response
#10
Taimur Ahmed, Sumeet Walia, Jeeson Kim, Hussein Nili, Rajesh Ramanathan, Edwin L H Mayes, Desmond W M Lau, Omid Kavehei, Vipul Bansal, Madhu Bhaskaran, Sharath Sriram
Transparent non-volatile memory devices are desirable for realizing visually-clear integrated systems for information storage. Optical transparency provides advantages in applications such as smart glass electronic devices and wearable electronics. However, achieving high transparency limits the choice of active layers as well as the electrodes; thereby, constraining device processing and performance. Here, we demonstrate bilayer transparent memory cells using room temperature deposited amorphous strontium titanate as the functional material and indium tin oxide electrodes...
October 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/28941032/are-patients-with-bipolar-disorder-and-comorbid-attention-deficit-hyperactivity-disorder-more-neurocognitively-impaired
#11
Imma Torres, Brisa Sole, Montse Corrales, Esther Jiménez, Sofia Rotger, Juan Francisco Serra-Pla, Irene Forcada, Vanesa Richarte, Ester Mora, Carlos Jacas, Nuria Gómez, Maria Mur, Francesc Colom, Eduard Vieta, Miquel Casas, Anabel Martinez-Aran, Jose M Goikolea, Josep A Ramos-Quiroga
OBJECTIVE: Research on neurocognitive impairment in adult patients with comorbid bipolar disorder (BD) and attention-deficit hyperactivity disorder (ADHD) is very scarce. This study assessed the neurocognitive profile of a comorbid group (BD+ADHD) compared with that of pure BD (pBD) group, pure ADHD (pADHD) group and healthy controls (HCs). METHODS: This was a three-site study comprising 229 subjects: 70 patients with pBD, 23 with BD+ADHD, 50 with pADHD, and 86 HCs...
September 21, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28940099/influence-of-depressed-patients-expectations-prior-to-electroconvulsive-therapy-on-its-effectiveness-and-tolerability-exp-ect-a-prospective-study
#12
Lisa Krech, Michael Belz, Matthias Besse, Isabel Methfessel, Dirk Wedekind, David Zilles
Electroconvulsive therapy (ECT) is the most effective therapy for severe depressive disorders. Though there are known clinical predictors of response (e.g., higher age, presence of psychotic symptoms), there is a lack of knowledge concerning the impact of patients' expectations on treatment outcome and tolerability in terms of possible placebo/nocebo effects. In 31 patients with unipolar or bipolar depressive disorder, we used a questionnaire to investigate the patients' expectations of ECT effectiveness and tolerability prior to and in the course of the treatment...
September 22, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28912160/dopamine-d2-receptors-modulate-pyramidal-neurons-in-mouse-medial-prefrontal-cortex-through-a-stimulatory-g-protein-pathway
#13
Sarah E Robinson, Vikaas S Sohal
Dopaminergic modulation of prefrontal cortex (PFC) is thought to play key roles in many cognitive functions and to be disrupted in pathological conditions, such as schizophrenia. We have previously described a phenomenon whereby dopamine D2 receptor (D2R) activation elicits afterdepolarizations (ADPs) in subcortically projecting (SC) pyramidal neurons within L5 of the PFC. These D2R-induced ADPs only occur following synaptic input, which activates NMDARs, even when the delay between the synaptic input and ADPs is relatively long (e...
October 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28906586/equivalent-linear-change-in-cognition-between-individuals-with-bipolar-disorder-and-healthy-controls-over-5%C3%A2-years
#14
Kelly A Ryan, Shervin Assari, Kaley Angers, David F Marshall, Kristin Hinrichs, Rebecca Easter, Pallavi Babu, Bethany D Pester, Scott A Langenecker, Melvin G McInnis
OBJECTIVES: Cognitive dysfunction is a key feature of bipolar disorder (BD). However, not much is known about its temporal stability, as some studies have demonstrated a neurodegenerative model in BD while others have shown no change in cognitive functioning over time. Building upon our prior work, which examined the natural course of executive functioning, the current study aimed to investigate the natural course of memory, emotion processing, and fine motor dexterity over a 5-year period in BD and healthy control (HC) samples...
September 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28899881/tet1-overexpression-leads-to-anxiety-like-behavior-and-enhanced-fear-memories-via-the-activation-of-calcium-dependent-cascade-through-egr1-expression-in-mice
#15
Wookbong Kwon, Hyeng-Soo Kim, Jain Jeong, Yonghun Sung, Minjee Choi, Song Park, Jinhee Lee, Soyoung Jang, Sung Hyun Kim, Sanggyu Lee, Myoung Ok Kim, Zae Young Ryoo
Ten-eleven translocation methylcytosine dioxygenase 1 (Tet1) initiates DNA demethylation by converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) at CpG-rich regions of genes, which have key roles in adult neurogenesis and memory. In addition, the overexpression of Tet1 with 5-hmC alteration in patients with psychosis has also been reported, for instance in schizophrenia and bipolar disorders. The mechanism underlying Tet1 overexpression in the brain; however, is still elusive. In the present study, we found that Tet1-transgenic (Tet1-TG) mice displayed abnormal behaviors involving elevated anxiety and enhanced fear memories...
September 12, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28880126/detecting-allocentric-and-egocentric-navigation-deficits-in-patients-with-schizophrenia-and-bipolar-disorder-using-virtual-reality
#16
Alireza Mohammadi, Ehsan Hesami, Mahmoud Kargar, Jamal Shams
Present evidence suggests that the use of virtual reality has great advantages in evaluating visuospatial navigation and memory for the diagnosis of psychiatric or other neurological disorders. There are a few virtual reality studies on allocentric and egocentric memories in schizophrenia, but studies on both memories in bipolar disorder are lacking. The objective of this study was to compare the performance of allocentric and egocentric memories in patients with schizophrenia and bipolar disorder. For this resolve, an advanced virtual reality navigation task (VRNT) was presented to distinguish the navigational performances of these patients...
September 7, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28866718/hypersomnia-and-cognitive-impairment-in-a-patient-with-bipolar-disorder-a-case-report
#17
Katarzyna Szaulińska, Anna Antosik-Wójcińska, Ewa Paszkowska, Łukasz Święcicki, Marek Jarema, Adam Wichniak
OBJECTIVES: Obstructive sleep apnea (OSA) is a common clinical problem that can have serious health consequences and complicate the course of mental disorders. It is estimated that the prevalence of sleep apnea in patients with bipolar disorder can be 21-47.5%. Some symptoms of OSA are the same as the symptoms of depression: daytime drowsiness, cognitive dysfunction, decreased drive, apathy, depressed mood, anhedonia. METHODS: We present a case of a patient whose depressive symptoms persisted despite repeated changes of pharmacological treatment and were exacerbated by severe sleep disorder...
June 18, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28841488/longitudinal-relationship-between-clinical-course-and-neurocognitive-impairments-in-bipolar-disorder
#18
Diego J Martino, Ana Igoa, Eliana Marengo, María Scápola, Sergio A Strejilevich
BACKGROUND: The aim of this study was to estimate the relationship between clinical course and trajectory of neurocognitive functioning during a follow-up period in a sample of euthymic bipolar patients. METHODS: Fifty-one patients with BD performed two-neurocognitive assessment separated by a period of at least 48 months. The clinical course during the follow-up period was documented by: three measures 1) number of affective episodes, 2) time spent ill, and 3) mood instability...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28829959/cognitive-abilities-in-first-degree-relatives-of-individuals-with-bipolar-disorder
#19
Daniela Calafiore, Susan L Rossell, Tamsyn E Van Rheenen
BACKGROUND: Although the study of cognition in first degree relatives (FDRs) is not new, findings in this group are still somewhat inconsistent and much of the research examining FDR populations include individuals under the age of 25, who are arguably still at significant risk to go on to develop BD. The present study aimed to establish the value of cognitive performance as a genuine endophenotypic marker of familial risk for bipolar disorder (BD), by examining cognition in FDRs aged 25 years or older...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28826415/differentiating-bipolar-disorders-from-unipolar-depression-by-applying-the-brief-assessment-of-cognition-in-affective-disorders
#20
C-Y Lee, L-J Wang, Y Lee, C-F Hung, Y-C Huang, M-I Lee, S-Y Lee
BACKGROUND: Scholars continue to argue about whether bipolar disorders (BD) and unipolar depression (UD) are distinguishable with regard to neurocognitive function. This study aims to explore the cognitive profiles of UD and BD by applying the Brief Assessment of Cognition in Affective Disorders (BAC-A) for neuropsychological assessment. METHOD: This cross-sectional study included 68 patients with UD, 67 patients with BD, and 135 healthy control subjects. We evaluated the participants' cognitive functions at euthymic status using the BAC-A, which is made up of six traditional cognitive subtests and the Affective Processing Test...
August 22, 2017: Psychological Medicine
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