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https://www.readbyqxmd.com/read/28332122/cognitive-impairments-and-predominant-polarity-in-bipolar-disorder-a-cross-sectional-study
#1
Gabriel Okawa Belizario, Alexandre Duarte Gigante, Cristiana Castanho de Almeida Rocca, Beny Lafer
BACKGROUND: Bipolar disorder (BD) patients exhibit cognitive impairments during euthymic states. Studies suggest that manic episodes may be correlated to cognitive impairments. The present study investigated the relationship between predominant polarity and the cognitive deficits frequently detected in bipolar patients. We hypothesize that mania predominant polarity (MPP) patients should exhibit greater cognitive impairments in comparison to depressive (DPP) and indefinite predominant polarity (IPP) patients and healthy control (HC) individuals...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28320224/identification-of-common-neural-circuit-disruptions-in-cognitive-control-across-psychiatric-disorders
#2
Lisa M McTeague, Julia Huemer, David M Carreon, Ying Jiang, Simon B Eickhoff, Amit Etkin
OBJECTIVE: Cognitive deficits are a common feature of psychiatric disorders. The authors investigated the nature of disruptions in neural circuitry underlying cognitive control capacities across psychiatric disorders through a transdiagnostic neuroimaging meta-analysis. METHOD: A PubMed search was conducted for whole-brain functional neuroimaging articles published through June 2015 that compared activation in patients with axis I disorders and matched healthy control participants during cognitive control tasks...
March 21, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28291970/neurodevelopmental-versus-neurodegenerative-model-of-schizophrenia-and-bipolar-disorder-comparison-with-physiological-brain-development-and-aging
#3
Massimiliano Buoli, Marta Serati, Alice Caldiroli, Laura Cremaschi, Alfredo Carlo Altamura
Available data support a contribution of both neurodevelopmental and neurodegenerative factors in the etiology of schizophrenia (SCH) and bipolar disorder (BD). Of note, one of the most important issue of the current psychiatric research is to identify the specific factors that contribute to impaired brain development and neurodegeneration in SCH and BD, and especially how these factors alter normal brain development and physiological aging process. Our hypothesis is that only specific damages, taking place in precise brain development stages, are associated with future SCH /BD onset and that neurodegeneration consists of an acceleration of brain aging after SCH /BD onset...
March 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28285254/the-predictive-role-of-daily-cognitive-stimulation-on-executive-functions-in-bipolar-disorder
#4
Charles Cotrena, Laura Damiani Branco, André Ponsoni, Flávio Milman Shansis, Renata Kochhann, Rochele Paz Fonseca
This study aimed to estimate the predictive role of clinical and demographic variables on the three core executive functions (EF) - working memory (WM), inhibitory control (IC) and cognitive flexibility (CF) - in bipolar disorder (BD). The sample consisted of 38 patients with BD type I, 39 with BD type II, and 106 control participants with no mood disorders. Subjects completed the Hayling Test, Trail Making Test, Digit Span Backwards, Sentence Word Span Test, and Stroop Color-Word Test. Composite scores for WM, IC and CF were calculated, and their correlations with clinical and demographic variables were analyzed...
March 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28274831/effects-of-prefrontal-bipolar-and-high-definition-transcranial-direct-current-stimulation-on-cortical-reactivity-and-working-memory-in-healthy-adults
#5
Aron T Hill, Nigel C Rogasch, Paul B Fitzgerald, Kate E Hoy
Transcranial direct current stimulation (tDCS) is a well-recognised neuromodulatory technology which has been shown to induce short-lasting changes in motor-cortical excitability. The recent and rapid expansion of tDCS into the cognitive domain, however, necessitates deeper mechanistic understanding of its neurophysiological effects over non-motor brain regions. The present study utilised transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) to probe the immediate and longer-term effects of both a bipolar (BP-tDCS) and more focal 4×1 High-Definition tDCS (HD-tDCS) montage applied over the left DLPFC on TMS-evoked potentials (TEPs) and oscillations in 19 healthy adult participants...
March 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/28261713/nonvolatile-reconfigurable-sequential-logic-in-a-hfo2-resistive-random-access-memory-array
#6
Ya-Xiong Zhou, Yi Li, Yu-Ting Su, Zhuo-Rui Wang, Ling-Yi Shih, Ting-Chang Chang, Kuan-Chang Chang, Shi-Bing Long, Simon M Sze, Xiang-Shui Miao
Resistive random access memory (RRAM) based reconfigurable logic provides a temporal programmable dimension to realize Boolean logic functions and is regarded as a promising route to build non-von Neumann computing architecture. In this work, a reconfigurable operation method is proposed to perform nonvolatile sequential logic in a HfO2-based RRAM array. Eight kinds of Boolean logic functions can be implemented within the same hardware fabrics. During the logic computing processes, the RRAM devices in an array are flexibly configured in a bipolar or complementary structure...
March 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28243220/executive-function-is-selectively-impaired-in-old-age-bipolar-depression
#7
Leonardo Caixeta, Vânia L D Soares, Renata T Vieira, Cândida D Soares, Victor Caixeta, Sandra B Ferreira, Tales A Aversi-Ferreira
Background: Little is known about the cognitive signature of bipolar disorder (BD) in elderly brains. The neuropsychological features of depressive elderly with early-onset BD are largely unknown. This issue is relevant because cognitive impairment can produce an additional impact on the already compromised functionality of elderly with BD. The aim of this study is to assess executive functions (EFs) in the depressive phase of elderly outpatients with early-onset BD. Methods: Forty-nine elderly outpatients with early-onset BD were assessed with several neuropsychological tests for EF in the depressive phase of the disorder...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28241886/comparison-of-associated-features-and-drug-treatment-between-co-occurring-unipolar-and-bipolar-disorders-in-depressed-eating-disorder-patients
#8
Mei-Chih Meg Tseng, Chin-Hao Chang, Shih-Cheng Liao, Hsi-Chung Chen
BACKGROUND: To examine the differences of associated characteristics and prescription drug use between co-occurring unipolar and bipolar disorders in patients with eating disorders (EDs). METHODS: Patients with EDs and major depressive episode (MDE) were recruited from psychiatric outpatient clinics. They were interviewed and completed self-administered measures assessing eating and general psychopathology. The prescribed drugs at the index outpatient visit were recorded...
February 27, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28229954/nano-cone-resistive-memory-for-ultralow-power-operation
#9
Sungjun Kim, Sunghun Jung, Min-Hwi Kim, Tae-Hyeon Kim, Suhyun Bang, Seongjae Cho, Byung-Gook Park
SiN x -based nano-structure resistive memory is fabricated by fully silicon CMOS compatible process integration including particularly designed anisotropic etching for the construction of a nano-cone silicon bottom electrode (BE). Bipolar resistive switching characteristics have significantly reduced switching current and voltage and are demonstrated in a nano-cone BE structure, as compared with those in a flat BE one. We have verified by systematic device simulations that the main cause of reduction in the performance parameters is the high electric field being more effectively concentrated at the tip of the cone-shaped BE...
March 24, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28219620/brain-structural-correlates-of-executive-and-social-cognition-profiles-in-behavioral-variant-frontotemporal-dementia-and-elderly-bipolar-disorder
#10
Sandra Baez, Clara Pinasco, María Roca, Jesica Ferrari, Blas Couto, Indira García-Cordero, Agustín Ibañez, Francy Cruz, Pablo Reyes, Diana Matallana, Facundo Manes, Marcelo Cetcovich, Teresa Torralva
An early stage of behavioral variant frontotemporal dementia (bvFTD) often displays a mix of behavioral disturbances and personality changes hindering a differential diagnosis from elderly bipolar disorder (BD), making this process a big challenge. However, no studies have compared these pathologies from neuropsychological and neuroanatomical perspectives. The aim of the present study was to compare the executive functions (EF) and social cognition profiles as well as the structural neuroimaging of bvFTD and elderly patients with BD...
February 17, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28215308/releasing-mechanism-of-neurotrophic-factors-via-polysialic-acid
#11
C Sato
Neurotrophins are well-characterized neurologically active molecules in the central nervous system. The regulation of these signaling molecules, which are involved in cell growth, differentiation, and survival, is critical for normal brain function. Among the different types of neurotrophins, brain-derived neurotrophic factor (BDNF) is involved in various brain functions, including memory consolidation, synaptic plasticity, and adult neurogenesis, and is therefore a key molecule for understanding comprehensive brain function and neurodevelopmental and psychiatric diseases...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28168631/cognitive-remediation-for-bipolar-patients-with-objective-cognitive-impairment-a-naturalistic-study
#12
J Veeh, J Kopf, S Kittel-Schneider, J Deckert, A Reif
BACKGROUND: Many bipolar patients (BP) are affected by cognitive impairments and reduced psychosocial function even after complete remission. In the present naturalistic study, we developed a tailored cognitive remediation program (CR) to evaluate the effect on objective and subjective neuropsychological performance, psychosocial functioning and quality of life. METHODS: The CR program used a cognitive training software combined with group sessions to educate cognitive skills...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28139921/atomic-layer-deposited-oxide-based-nanocomposite-structures-with-embedded-coptx-nanocrystals-for-resistive-random-access-memory-applications
#13
Lai-Guo Wang, Zheng-Yi Cao, Xu Qian, Lin Zhu, Da-Peng Cui, Ai-Dong Li, Di Wu
Al2O3- or HfO2-based nanocomposite structures with embedded CoPtx nanocrystals (NCs) on TiN-coated Si substrates have been prepared by combination of thermal atomic layer deposition (ALD) and plasma-enhanced ALD for resistive random access memory (RRAM) applications. The impact of CoPtx NCs and their average size/density on the resistive switching properties has been explored. Compared to the control sample without CoPtx NCs, ALD-derived Pt/oxide/100 cycle-CoPtx NCs/TiN/SiO2/Si exhibits a typical bipolar, reliable, and reproducible resistive switching behavior, such as sharp distribution of RRAM parameters, smaller set/reset voltages, stable resistance ratio (≥10(2)) of OFF/ON states, better switching endurance up to 10(4) cycles, and longer data retention over 10(5) s...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28138157/forebrain-specific-ablation-of-phospholipase-c%C3%AE-1-causes-manic-like-behavior
#14
Y R Yang, J H Jung, S-J Kim, K Hamada, A Suzuki, H J Kim, J H Lee, O-B Kwon, Y K Lee, J Kim, E-K Kim, H-J Jang, D-S Kang, J-S Choi, C J Lee, J Marshall, H-Y Koh, C-J Kim, H Seok, S H Kim, J H Choi, Y-B Choi, L Cocco, S H Ryu, J-H Kim, P-G Suh
Manic episodes are one of the major diagnostic symptoms in a spectrum of neuropsychiatric disorders that include schizophrenia, obsessive-compulsive disorder and bipolar disorder (BD). Despite a possible association between BD and the gene encoding phospholipase Cγ1 (PLCG1), its etiological basis remains unclear. Here, we report that mice lacking phospholipase Cγ1 (PLCγ1) in the forebrain (Plcg1(f/f); CaMKII) exhibit hyperactivity, decreased anxiety-like behavior, reduced depressive-related behavior, hyperhedonia, hyperphagia, impaired learning and memory and exaggerated startle responses...
January 31, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28135335/electrical-study-of-trapped-charges-in-copper-doped-zinc-oxide-films-by-scanning-probe-microscopy-for-nonvolatile-memory-applications
#15
Ting Su, Haifeng Zhang
Charge trapping properties of electrons and holes in copper-doped zinc oxide (ZnO:Cu) films have been studied by scanning probe microscopy. We investigated the surface potential dependence on the voltage and duration applied to the copper-doped ZnO films by Kelvin probe force microscopy. It is found that the Fermi Level of the 8 at.% Cu-doped ZnO films shifted by 0.53 eV comparing to undoped ZnO films. This shift indicates significant change in the electronic structure and energy balance in Cu-doped ZnO films...
2017: PloS One
https://www.readbyqxmd.com/read/28098978/reliable-and-low-power-multilevel-resistive-switching-in-tio2-nanorod-arrays-structured-with-a-tiox-seed-layer
#16
Ming Xiao, Kevin P Musselman, Walter W Duley, Y Norman Zhou
The electrical performance of TiO2 nanorod array (NRA)-based resistive switching memory devices is examined in this paper. The formation of a seed layer on the fluorine-doped tin oxide (FTO) glass substrate after treatment in TiCl4 solution, before the growth of TiO2 NRAs on the FTO substrate via a hydrothermal process, is shown to significantly improve the resistive switching performance of the resulting TiO2 NRA-based device. As fabricated, the Al/TiO2 NRA/TiOx layer/FTO device displayed electroforming-free bipolar resistive switching behavior while maintaining a stable ON/OFF ratio for more than 500 direct sweeping cycles over a retention period of 3 × 10(4) s...
January 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28096869/short-term-psychiatric-rehabilitation-in-major-depressive-and-bipolar-disorders-neuropsychological-psychosocial-outcomes
#17
Giampaolo Perna, Silvia Daccò, Ferdinando Sacco, Wilma Micieli, Paolo Cavedini, Daniela Caldirola
OBJECTIVE: Our pilot study aims to investigate the efficacy of a Short-Term (4 weeks) Psychiatric Rehabilitation Program (S-T PsyRP), without specific cognitive remediation trainings, on the neuropsychological performance and psychosocial functioning of inpatients with Major Depressive Disorder (MDD) or Bipolar Disorder (BD). Published studies with similar aims are lacking. METHODS: Fifty-three inpatients with MDD and 27 with BD (type I/II) were included. The S-T PsyRP was usually performed as clinical practice at Villa San Benedetto Menni Hospital and included a variety of activities aimed at promoting personal autonomies, interpersonal/social skills, and self-care...
January 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28088728/the-association-between-insomnia-related-sleep-disruptions-and-cognitive-dysfunction-during-the-inter-episode-phase-of-bipolar-disorder
#18
Jennifer C Kanady, Adriane M Soehner, Alexandra B Klein, Allison G Harvey
Sleep disturbance and cognitive dysfunction are two domains of impairment during inter-episode bipolar disorder. Despite evidence demonstrating the importance of sleep for cognition in healthy and sleep-disordered samples, this link has been minimally examined in bipolar disorder. The present study tested the association between insomnia-related sleep disruptions and cognitive dysfunction during inter-episode bipolar disorder. Forty-seven participants with bipolar disorder and a comorbid insomnia diagnosis (BD-Insomnia) and 19 participants with bipolar disorder without sleep disturbance in the last six months (BD-Control) participated in the study...
January 5, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28078883/flexible-multistate-data-storage-devices-fabricated-using-natural-lignin-at-room-temperature
#19
Youngjun Park, Jang-Sik Lee
The growing interest in bioinspired and sustainable electronics has induced research on biocompatible and biodegradable materials. However, conventional electronic devices have been restricted due to their nonbiodegradable and sometimes harmful and toxic materials, which can even cause environmental issues. Here, we report a resistive switching random access memory (ReRAM) device based on lignin, which is a biodegradable waste product of the paper industry. The active layer of the device can be easily formed using a simple solution process on a plastic substrate...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28073491/gray-matter-neuritic-microstructure-deficits-in-schizophrenia-and-bipolar-disorder
#20
Arash Nazeri, Benoit H Mulsant, Tarek K Rajji, Melissa L Levesque, Jon Pipitone, Laura Stefanik, Saba Shahab, Tina Roostaei, Anne L Wheeler, Sofia Chavez, Aristotle N Voineskos
BACKGROUND: Postmortem studies have demonstrated considerable dendritic pathologies among persons with schizophrenia and to some extent among those with bipolar I disorder. Modeling gray matter (GM) microstructural properties is now possible with a recently proposed diffusion-weighted magnetic resonance imaging modeling technique: neurite orientation dispersion and density imaging. This technique may bridge the gap between neuroimaging and histopathological findings. METHODS: We performed an extended series of multishell diffusion-weighted imaging and other structural imaging series using 3T magnetic resonance imaging...
December 8, 2016: Biological Psychiatry
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