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https://www.readbyqxmd.com/read/29613943/patient-experience-of-electroconvulsive-therapy-a-retrospective-review-of-clinical-outcomes-and-satisfaction
#1
Sarah K Brown, Rachel B Nowlin, Rebecca Sartorelli, Johan Smith, Karen Johnson
OBJECTIVE: The aim of the study was to explore patient perception and perceived benefit of electroconvulsive therapy (ECT) by assessing the real-world experience of adult patients who received ECT, focusing on clinical outcomes and patient satisfaction. METHODS: This retrospective study analyzed patient self-report of depressive symptoms (Patient Health Questionnaire), perception of physical and cognitive ECT adverse effects (ECT Outcomes Survey) and satisfaction with treatment (Patient Satisfaction Survey)...
April 2, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29545118/cognitive-benefits-of-lithium-chloride-in-app-ps1-mice-are-associated-with-enhanced-brain-clearance-of-%C3%AE-amyloid
#2
Yijun Pan, Jennifer L Short, Stephanie A Newman, Kwok H C Choy, Durgesh Tiwari, Christopher Yap, Danielle Senyschyn, William A Banks, Joseph A Nicolazzo
Epidemiological evidence suggests that people with bipolar disorder prescribed lithium exhibit a lower risk of Alzheimer's disease (AD) relative to those prescribed other mood-stabilizing medicines. Lithium chloride (LiCl) reduces brain β-amyloid (Aβ) levels, and the brain clearance of Aβ is reduced in AD. Therefore, the purpose of this study was to assess whether the cognitive benefits of LiCl are associated with enhanced brain clearance of exogenously-administered Aβ. The brain clearance of intracerebroventricularly (icv) administered125 I-Aβ42 was assessed in male Swiss outbred mice administered daily oral NaCl or LiCl (300 mg/kg for 21 days)...
March 12, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29536533/association-of-intracortical-myelin-and-cognitive-function-in-bipolar-i-disorder
#3
M Sehmbi, C D Rowley, L Minuzzi, F Kapczinski, M Steiner, R B Sassi, N A Bock, B N Frey
OBJECTIVE: Although cognitive dysfunction persists through affective and euthymic states in bipolar disorder (BD), its neurobiological correlates remain undetermined. We explore whole-cortex intracortical myelin (ICM) and cognition in BD-I and controls. METHODS: T1 -weighted images (3T) optimized for ICM measurement were analyzed using a surface-based approach. MRI signal was sampled at cortical mid-depth. Cognitive performance was measured via standardized computerized battery and paper-and-pencil Trails B...
March 13, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29522943/distinct-patterns-of-blood-oxygenation-in-the-prefrontal-cortex-in-clinical-phenotypes-of-schizophrenia-and-bipolar-disorder
#4
Kazuhiko Yamamuro, Sohei Kimoto, Junzo Iida, Naoko Kishimoto, Shohei Tanaka, Michihiro Toritsuka, Daisuke Ikawa, Yasunori Yamashita, Toyosaku Ota, Manabu Makinodan, Hiroki Yoshino, Toshifumi Kishimoto
BACKGROUND: Schizophrenia (SZ) and bipolar disorder (BD) are characterized by different clinical symptoms, and have previously been considered as categorically separate. However, several lines of evidence controversially suggest that these two disorders may run on a continuum. While it is therefore important to evaluate the subtle differences between SZ and BD, few studies have investigated the difference of brain functioning between the two by focusing on the common symptoms of cognitive functioning and impulsivity, rather than positive/negative and mood symptoms...
February 27, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29516092/multivariate-associations-among-behavioral-clinical-and-multimodal-imaging-phenotypes-in-patients-with-psychosis
#5
Dominik A Moser, Gaelle E Doucet, Won Hee Lee, Alexander Rasgon, Hannah Krinsky, Evan Leibu, Alex Ing, Gunter Schumann, Natalie Rasgon, Sophia Frangou
Importance: Alterations in multiple neuroimaging phenotypes have been reported in psychotic disorders. However, neuroimaging measures can be influenced by factors that are not directly related to psychosis and may confound the interpretation of case-control differences. Therefore, a detailed characterization of the contribution of these factors to neuroimaging phenotypes in psychosis is warranted. Objective: To quantify the association between neuroimaging measures and behavioral, health, and demographic variables in psychosis using an integrated multivariate approach...
March 7, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29508115/identity-bipolar-disorder-and-the-problem-of-self-narration-in-kay-redfield-jamison-s-an-unquiet-mind-and-ellen-forney-s-marbles
#6
Bethany Ober Mannon
The field of narrative medicine holds that personal narratives about illness have the potential to give illness meaning and to create order out of disparate facets of experience, thereby aiding a patient's treatment and resisting universalizing medical discourse. Two narratives of bipolar disorder, Kay Redfield Jamison's prose memoir An Unquiet Mind (1995) and Ellen Forney's graphic memoir Marbles (2012) challenge these ideas. These writers demonstrate that one result of bipolar disorder is a rupture to their sense of identity, making straightforward and verbal forms of narrative impossible...
March 6, 2018: Journal of Medical Humanities
https://www.readbyqxmd.com/read/29486955/what-does-the-managing-emotions-branch-of-the-msceit-add-to-the-matrics-consensus-cognitive-battery
#7
Nicole R DeTore, Kim T Mueser, Susan R McGurk
The Managing Emotions branch of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT-ME) was included within the MATRICS Consensus Cognitive Battery (MCCB) as the measure of social cognition, although limited research has examined its associations with psychosocial functioning in people with schizophrenia or other severe mental illnesses. This secondary analysis with 107 participants examined what the MSCEIT-ME contributes to our understanding of functioning in this population, and whether it uniquely predicts psychosocial functioning after controlling for performance on the other MCCB tests and negative symptoms...
February 24, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29480043/prospective-memory-level-of-disability-and-return-to-work-in-severe-mental-illness
#8
Cynthia Z Burton, Lea Vella, Elizabeth W Twamley
OBJECTIVE: Prospective memory (the ability to remember to do things) has clear implications for everyday functioning, including employment, in people with severe mental illnesses (SMI). This study aimed to evaluate prospective memory performance and its relationship to real-world functional variables in an employment-seeking sample of people with SMI (Clinical Trial registration number NCT00895258). METHOD: 153 individuals with DSM-IV diagnosis of depression (n = 58), bipolar disorder (n = 37), or schizophrenia (n = 58) who were receiving outpatient psychiatric care at a university clinic enrolled in a trial of supported employment and completed a baseline assessment...
February 25, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29461331/the-effect-of-electroconvulsive-therapy-on-hypoperfusion-in-psychotic-bipolar-depression-a-case-study
#9
Céline Julie De Smet, Bernard Sabbe, J F E Oldenburg
The pharmacological treatment of bipolar depression has low response rates. Twenty percent to 30% of patients have an insufficient response to medication. The guidelines suggest that electroconvulsive therapy (ECT) is the next step. The aim of this case study is to evaluate the effect of ECT on the perfusion of the brain in bipolar depression, while monitoring effects on mood and cognition. We present a case study of 56-year-old female patient who suffered from a psychotic depression and cognitive impairment...
February 14, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29459824/-egr3-immediate-early-gene-and-the-brain-derived-neurotrophic-factor-in-bipolar-disorder
#10
Bianca Pfaffenseller, Flavio Kapczinski, Amelia L Gallitano, Fábio Klamt
Bipolar disorder (BD) is a severe psychiatric illness with a consistent genetic influence, involving complex interactions between numerous genes and environmental factors. Immediate early genes (IEGs) are activated in the brain in response to environmental stimuli, such as stress. The potential to translate environmental stimuli into long-term changes in brain has led to increased interest in a potential role for these genes influencing risk for psychiatric disorders. Our recent finding using network-based approach has shown that the regulatory unit of early growth response gene 3 ( EGR3 ) of IEGs family was robustly repressed in postmortem prefrontal cortex of BD patients...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29452136/neuroprotective-effects-of-valproic-acid-on-brain-ischemia-are-related-to-its-hdac-and-gsk3-inhibitions
#11
Monalisa Ribeiro Silva, Alyne Oliveira Correia, Gabriel Cabral Alencar Dos Santos, Lucas Leimig Telles Parente, Keicy Parente de Siqueira, Danielly Gonçalves Sombra Lima, Jonathan Almeida Moura, Ana Elisa da Silva Ribeiro, Roberta Oliveira Costa, Daniel Luna Lucetti, Elaine Cristina Pereira Lucetti, Kelly Rose Tavares Neves, Glauce Socorro de Barros Viana
Valproic acid (VA) is an antiepileptic that is also used for the treatment of bipolar disorders. The objective was to evaluate the neuroprotective effects of VA on a brain ischemia model. The groups of male Wistar rats were: SO (sham-operated), ischemic and ischemic treated with VA (25, 50 and 100 mg/kg, p.o.). After anesthesia with ketamine and xilazine, the animals were subjected to clamping of carotid arteries (30 min) and reperfusion. Except for the carotid clamping, the SO group was submitted to the same procedure...
February 13, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29442939/photo-induced-multiple-state-memory-behaviour-in-non-volatile-bipolar-resistive-switching-devices
#12
Xuejiao Zhang, Zhiwei Xu, Bai Sun, Jianjun Liu, Yanyan Cao, Haixia Qiao, Yong Huang, Xiaofeng Pang
The recent discovery of non-volatile resistive-switching memory is a promising phenomenon for the semiconductor industry and electronic device technology. In our work, CaWO4 nanoparticles were synthesised through a one-step hydrothermal reaction. A resistive-switching memory device with Ag/CaWO4/fluorine-doped tin oxide structure was prepared. This device presents photo-induced multiple-state memory behaviour at room temperature. This study is valuable for exploring multi-functional materials and their applications in photo-controlled multiple-state non-volatile memories...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29428214/the-effects-of-bilateral-continuous-and-chronic-deep-brain-stimulation-of-the-medial-forebrain-bundle-in-a-rodent-model-of-depression
#13
Stephanie Thiele, Luciano Furlanetti, Lisa-Marie Pfeiffer, Volker A Coenen, Máté D Döbrössy
BACKGROUND: Clinical trials of supra-lateral medial forebrain bundle (MFB) Deep Brain Stimulation (DBS) in treatment resistant major depressive patients have shown rapid and long-term benefits. OBJECTIVE/HYPOTHESIS: The study used Flinders Sensitive Line (FSL) rats with previously identified depressive-like phenotype to assess the range of behavior modification achieved by MFB DBS. METHODS: Male FSL and wild-type Sprague-Dawley rats as Controls were tested on mood/anxiety/exploration, cognitive and motor behaviors...
February 8, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29407766/dopamine-d3-receptor-blockade-rescues-hyper-dopamine-activity-induced-deficit-in-novel-object-recognition-memory
#14
Pi-Kai Chang, Lung Yu, Jin-Chung Chen
Patients afflicted with bipolar disorder demonstrate significant impairments in recognition and episodic memory during acute depressive and manic episodes. These impairments and the related pathophysiology may result from over-activation of the brain dopamine (DA) system. In order to model overactive DA transmission in a well-established novel object recognition (NOR) memory test, we used DA transporter knockdown (DAT-KD) mice, which exhibit reduced DAT expression and display hyper-dopaminergic phenotypes. DAT-KD mice exhibited impaired NOR memory compared to wild-type (WT) mice...
February 1, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29382902/cognitive-impairment-in-treatment-na%C3%A3-ve-bipolar-ii-and-unipolar-depression
#15
Arthur D P Mak, Domily T Y Lau, Alicia K W Chan, Suzanne H W So, Owen Leung, Sheila L Y Wong, Linda Lam, C M Leung, Sing Lee
Cognition dysfunction may reflect trait characteristics of bipolarity but cognitive effects of medications have confounded previous comparisons of cognitive function between bipolar II and unipolar depression, which are distinct clinical disorders with some overlaps. Therefore, we examined the executive function (WCST), attention, cognitive speed (TMT-A) and memory (CAVLT, WMS-Visual reproduction) of 20 treatment-naïve bipolar II patients (BPII), 35 treatment-naïve unipolar depressed (UD) patients, and 35 age/sex/education matched healthy controls...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29363947/probing-the-mechanism-for-bipolar-resistive-switching-in-annealed-graphene-oxide-thin-films
#16
Pooja Saini, Manjri Singh, Jyoti Thakur, Ranjit A Patil, Yuan-Ron Ma, Ram Pal Tandon, Surinder P Singh, Ajit Kumar Mahapatro
The bipolar resistive switching (BRS) between a metallic low resistance state (LRS) and an insulating high resistance state (HRS) is demonstrated for annealed graphene oxide (GO) thin film based device structures with aluminum (Al) as one of the contact electrodes. An optimal switching of ~104 order is recorded for Al/GO(200°C)/ITO among the device structures in metal(M2)/GO(T)/metal(M1) configurations (M1 = Al, Au, ITO, and M2 = Au, Al), fabricated using GO(T)/metal(M1), annealed at different temperatures, T = 100, 200, 300, and 400 °C...
January 24, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29350624/conductive-bridge-random-access-memory-characteristics-of-sicn-based-transparent-device-due-to-indium-diffusion
#17
Dayanand Kumar, Rakesh Aluguri, Umesh Chand, Tseung-Yuen Tseng
In this work, the transparent bipolar resistive switching characteristics of a SiCN-based ITO/SiCN/AZO structure due to In diffusion from ITO is studied. The SiCN based device is found to be 80% transparent in the visible wavelength region. This device, with AZO as both top and bottom electrodes, does not show any RRAM property due to deposition of the high quality O2 -free SiCN film. Replacing the AZO top electrode with ITO in this device results in good resistive switching (RS) characteristics with a high on/off ratio and long retention...
March 23, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29331931/resting-state-fmri-signals-in-offspring-of-parents-with-bipolar-disorder-at-the-high-risk-and-ultra-high-risk-stages-and-their-relations-with-cognitive-function
#18
Kangguang Lin, Robin Shao, Rui Lu, Kun Chen, Weicong Lu, Ting Li, Jiehua Kong, Kwok-Fai So, Guiyun Xu
BACKGROUND: Bipolar disorder (BD) has been associated with dysfunctional resting-state brain functioning. However, it is still not known whether the aberrant functioning occurs and predict cognitive functioning before illness onset. AIMS: We examined the resting-state regional and network dysfunctioning, and their correlates with neurocognitive performance, in the high-risk (HR) and ultra-high-risk (UHR) stages of bipolar disorder. METHODS: Using amplitude of low-frequency fluctuations (ALFF), region homogeneity (ReHo) and hypothesis-driven region-of-interest (ROI)-based connectivity, we examined resting-state fMRI data of 8- to 25-year-old healthy offspring (HR, n = 28) and offspring with subthreshold syndromes (UHR, n = 22) of a BD parent, and age-matched healthy controls without any personal or family psychopathology (HC, n = 46)...
March 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29331692/memory-performance-predicts-response-to-psychotherapy-for-depression-in-bipolar-disorder-a-pilot-randomized-controlled-trial-with-exploratory-functional-magnetic-resonance-imaging
#19
Thilo Deckersbach, Amy T Peters, Conor Shea, Aishwarya Gosai, Jonathan P Stange, Andrew D Peckham, Kristen K Ellard, Michael W Otto, Scott L Rauch, Darin D Dougherty, Andrew A Nierenberg
OBJECTIVE: This pilot randomized controlled trial compared Cognitive Behavior Therapy (CBT) and Supportive Psychotherapy (SP) for the treatment of depression in bipolar I disorder. We also examined whether exploratory verbal memory, executive functioning, and neural correlates of verbal memory during functional magnetic resonance imaging (fMRI) predicted change in depression severity. METHODS: Thirty-two adults (ages 18-65) with DSM-IV bipolar I disorder meeting current criteria for a major depressive episode were randomized to 18 weeks of CBT or SP...
March 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29329741/sex-differences-of-hippocampal-structure-in-bipolar-disorder
#20
Jing Shi, Hua Guo, Fengmei Fan, Hongzhen Fan, Huimei An, Zhiren Wang, Shuping Tan, Fude Yang, Yunlong Tan
Although differential patterns in clinical characteristics have been consistently noted between male and female patients with bipolar disorder (BD), the effect of sex on the hippocampal structure remains unclear. To address this, the present study investigated the effects of BD and sex on the hippocampal structure, and the relationship between the hippocampal structure and cognitive performance. Morphometric and neurocognitive analyses were performed in 91 subjects (patients with BD: male/female = 33/19; normal controls: male/female = 22/17)...
March 30, 2018: Psychiatry research. Neuroimaging
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