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Memory bipolar

Juliana M Sartori, Ramiro Reckziegel, Ives Cavalcante Passos, Leticia S Czepielewski, Adam Fijtman, Leonardo A Sodré, Raffael Massuda, Pedro D Goi, Miréia Vianna-Sulzbach, Taiane de Azevedo Cardoso, Flávio Kapczinski, Benson Mwangi, Clarissa S Gama
Neuroimaging studies have been steadily explored in Bipolar Disorder (BD) in the last decades. Neuroanatomical changes tend to be more pronounced in patients with repeated episodes. Although the role of such changes in cognition and memory is well established, daily-life functioning impairments bulge among the consequences of the proposed progression. The objective of this study was to analyze MRI volumetric modifications in BD and healthy controls (HC) as possible predictors of daily-life functioning through a machine learning approach...
May 26, 2018: Journal of Psychiatric Research
Alessandra Sussulini, Rachel Ann Hauser-Davis
Biochemical imbalances, provoked by aging or a secondary illness, might directly affect the brain, causing severe problems, such as loss of memory or alteration of behavior patterns. Brain disorders are usually classified as injuries (such as stroke, hematomas, and concussions), tumors, and neurodegenerative (such as Parkinson's and Alzheimer's diseases) and mental (such as depression, bipolar disorder, schizophrenia) diseases. As the pathophysiology of these illnesses is not completely established and multiple factors are involved, metallomics, a bioanalytical strategy that allows the detection of metal ions and metalloproteins in diverse biological matrices, is of extreme relevance in identifying which elements are affected by a disease and/or treatment...
2018: Advances in Experimental Medicine and Biology
Maj Vinberg, Pernille Højman, Bente Klarlund Pedersen, Lars Vedel Kessing, Kamilla W Miskowiak
BACKGROUND: Erythropoietin (EPO) has been suggested to improve metabolism and also cognition, but human studies are scarce. This randomised controlled trial aimed to investigate whether EPO treatment influences body composition and fat and glycated haemoglobin (HbA1c) and fasting glucose, and whether these changes would be associated with previous observed cognitive benefits of EPO. METHOD: In total, 84 non-obese patients with treatment-resistant unipolar depression or bipolar disorder in remission were randomised to 8 weekly EPO (40,000 IU) or saline (NaCl 0...
June 8, 2018: Acta Neuropsychiatrica
Priyanka Bhatia, Ajeet Sidana, Subhash Das, Manoj Kumar Bajaj
Background: A substantial proportion of euthymic bipolar disorder patients have neuropsychological impairment which can have a significant impact on the overall functional recovery. Materials and Methods: A total of 60 bipolar disorder patients, currently in euthymic phase for the last 3 months with minimum duration of illness 2 years and current Young Mania Rating Scale <7 and Hamilton Depression Rating Scale <6, currently on medications were administrated various neuropsychological tests...
May 2018: Indian Journal of Psychological Medicine
Hanlu Ma, Wei Wang, Hai Yang Xu, Zhongqiang Wang, Ye Tao, Peng Chen, Weizhen Liu, Xintong Zhang, Jiangang Ma, Yichun Liu
Hybrid organic-inorganic perovskite, well known as light-absorbing materials in solar cells, have recently attracted considerable interest for applications in resistive switching (RS) memory. A better understanding of the role of interface-state in hybrid perovskite materials on RS behavior is essential for the development of practical devices. Here, we study the influence of interface-state on the RS behavior of an Au/CH3 NH3 PbI3 /FTO memory device using a simple air-exposure method. We observe a transition of RS hysteresis behavior with exposure time...
June 6, 2018: ACS Applied Materials & Interfaces
Véronique Desbeaumes Jodoin, François Richer, Jean-Philippe Miron, Marie-Pierre Fournier-Gosselin, Paul Lespérance
BACKGROUND: Treatment-resistant depression (TRD) is a serious chronic condition disabling patients functionally and cognitively. Chronic vagus nerve stimulation (VNS) is recognized for the management of TRD, but few studies have examined its long-term effects on cognitive dysfunction in unipolar and bipolar resistant depression. OBJECTIVE: The purpose of this study was to assess the course of cognitive functions and clinical symptoms in a cohort of patients treated with VNS for TRD...
June 4, 2018: Journal of ECT
Taeyoon Kim, Gwangho Baek, Seungmo Yang, Jung Yup Yang, Kap Soo Yoon, Soo Gil Kim, Jae Yeon Lee, Hyun Sik Im, Jin Pyo Hong
Recent advances in oxide-based resistive switching devices have made these devices very promising candidates for future nonvolatile memory applications. However, several key issues remain that affect resistive switching. One is the need for generic alternative electrodes with thermally robust resistive switching characteristics in as-grown and high-temperature annealed states. Here, we studied the electrical characteristics of Ta2 O5-x oxide-based bipolar resistive frames for various TaNx bottoms. Control of the nitrogen content of the TaNx electrode is a key factor that governs variations in its oxygen affinity and structural phase...
June 4, 2018: Scientific Reports
Tae Yeon Kim, Gopinathan Anoop, Yeong Jun Son, Soo Hyeon Kim, Eunji Lee, Ji Young Jo
In ferroelectric (FE) polymer-semiconducting polymer blend based organic resistive random access memory devices (ReRAM), the carriers are injected into the semiconductor region of the blend because of the polarization originated internal electric field in the FE polymer. A higher concentration of semiconducting polymer in the FE polymer-semiconducting polymer blends usually generate a high leakage current and degrades the FE characteristics of the FE polymer resulting in a high OFF current and consequently a low ON/OFF ratio...
June 4, 2018: Physical Chemistry Chemical Physics: PCCP
Chih-Ken Chen, Chun-Yi Lee, Yu Lee, Chi-Fa Hung, Yu-Chi Huang, Sheng-Yu Lee, Ming-Chyi Huang, Mian-Yoon Chong, Yi-Chih Chen, Liang-Jen Wang
This study seeks to determine whether the cognition profiles of patients with schizoaffective disorder (SAD), schizophrenia and bipolar I disorder (BD) are distinguishable. A total of 227 participants, comprising 88 healthy control subjects, 50 patients with SAD, 48 patients with schizophrenia and 41 patients with BD, were recruited. The participants' cognitive functions were evaluated using the Brief Assessment of Cognition in Schizophrenia (BACS). A discriminant functions analysis (DFA) was conducted to determine whether using cognitive performance can be used to distinguish these participant groups...
May 24, 2018: Psychiatry Research
Hannah E Brown, Kamber L Hart, Leslie A Snapper, Joshua L Roffman, Roy H Perlis
A measure of planning and impulse control, the delay-discounting (DD) task estimates the extent to which an individual decreases the perceived value of a reward as the reward is delayed. We examined cross-disorder performance between healthy controls (n = 88), individuals with bipolar disorder (n = 23), major depressive disorder (n = 43), and primary psychotic disorders (schizophrenia and schizoaffective disorder; n = 51) on the DD task (using a $10 delayed larger reward), as well as the interaction of DD scores with other symptom domains (cognition, psychosis, and affect)...
May 28, 2018: NPJ Schizophrenia
Moria D Braun, Theresa M Kisko, Débora Dalla Vecchia, Roberto Andreatini, Rainer K W Schwarting, Markus Wöhr
The CACNA1C gene is strongly implicated in the etiology of multiple major neuropsychiatric disorders, such as bipolar disorder, major depression, and schizophrenia, with cognitive deficits being a common feature. It is unclear, however, by which mechanisms CACNA1C variants advance the risk of developing neuropsychiatric disorders. This study set out to investigate cognitive functioning in a newly developed genetic Cacna1c rat model. Specifically, spatial and reversal learning, as well as object recognition memory were assessed in heterozygous Cacna1c+/- rats and compared to wildtype Cacna1c+/+ littermate controls in both sexes...
May 22, 2018: Neurobiology of Learning and Memory
Xinran Cao, Caimin Meng, Jing Li, Jun Wang, Yafei Yuan, Jing Su, Chunmin Liu, Xintong Zhang, Hao Zhang, Jianlu Wang
In this study, bipolar memristive behaviors were systematically characterized in Ag/Sb2Te3/Ag hetero-junctions. By using in situ Raman and photoluminescence spectroscopy, a direct observation of the bonding environment and band structure confirmed that resistive switches are strongly related to the electronic valence changes in Sb2Te3 and the formation of Schottky barriers at Ag/Sb2Te3 interfaces. Band movement of Sb2Te3 acquired by first-principles calculations also supports the electrostatic barrier charging as a memristive mechanism of Ag/Sb2Te3/Ag heterocells...
May 25, 2018: Physical Chemistry Chemical Physics: PCCP
Sung Pyo Park, Young Jun Tak, Hee Jun Kim, Jin Hyeok Lee, Hyukjoon Yoo, Hyun Jae Kim
Resistive random access memory (RRAM) devices are fabricated through a simple solution process using glucose, which is a natural biomaterial for the switching layer of RRAM. The fabricated glucose-based RRAM device shows nonvolatile bipolar resistive switching behavior, with a switching window of 103 . In addition, the endurance and data retention capability of glucose-based RRAM exhibit stable characteristics up to 100 consecutive cycles and 104 s under constant voltage stress at 0.3 V. The interface between the top electrode and the glucose film is carefully investigated to demonstrate the bipolar switching mechanism of the glucose-based RRAM device...
May 15, 2018: Advanced Materials
Jana Wörsching, Frank Padberg, Stephan Goerigk, Irmgard Heinz, Christine Bauer, Christian Plewnia, Alkomiet Hasan, Birgit Ertl-Wagner, Daniel Keeser
BACKGROUND: Transcranial direct current stimulation (tDCS) of the prefrontal cortex (PFC) has been widely applied in cognitive neurosciences and advocated as a therapeutic intervention, e.g. in major depressive disorder. Although several targets and protocols have been suggested, comparative studies of tDCS parameters, particularly electrode montages and their cortical targets, are still lacking. OBJECTIVE: This study investigated a priori hypotheses on specific effects of prefrontal-tDCS montages by using multimodal functional magnetic resonance imaging (fMRI) in healthy participants...
May 4, 2018: Brain Stimulation
Amanda L Rodrigue, Jennifer E McDowell, Neeraj Tandon, Matcheri S Keshavan, Carol A Tamminga, Godfrey D Pearlson, John A Sweeney, Robert D Gibbons, Brett A Clementz
BACKGROUND: Cognitive and structural brain abnormalities range from mild to severe in psychosis. The relation of specific cognitive functions to specific brain structures across the psychosis spectrum is less certain. METHODS: Participants (n = 678) with bipolar, schizoaffective, or schizophrenia psychoses and healthy control subjects were recruited via the Bipolar-Schizophrenia Network for Intermediate Phenotypes. The Schizo-Bipolar Scale was used to create a psychosis continuum (from purely affective to purely nonaffective)...
March 31, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Yalong Ye, Jie Zhao, Li Xiao, Baochang Cheng, Yanhe Xiao, Shuijin Lei
Hybrid nanostructures can show enormous potential in different areas due to their unique structural configurations. Herein, Fe@Al2O3 hybrid nanotubes are constructed via a homogeneous coprecipitation method followed by subsequent annealing at reducing atmosphere. The introduction of zero bandgap Fe nanocrystals in the wall of ultrawide bandgap Al2O3 insulator nanotubes results in the formation of charge trap centers, and correspondingly a single hybrid nanotube-based two-terminal device can show reversible negative resistive switching (RS) characteristics with symmetrical negative differential resistance (NDR) at relatively high operation bias voltages...
May 10, 2018: ACS Applied Materials & Interfaces
Loes M Olde Loohuis, Serghei Mangul, Anil P S Ori, Guillaume Jospin, David Koslicki, Harry Taegyun Yang, Timothy Wu, Marco P Boks, Catherine Lomen-Hoerth, Martina Wiedau-Pazos, Rita M Cantor, Willem M de Vos, René S Kahn, Eleazar Eskin, Roel A Ophoff
The role of the human microbiome in health and disease is increasingly appreciated. We studied the composition of microbial communities present in blood across 192 individuals, including healthy controls and patients with three disorders affecting the brain: schizophrenia, amyotrophic lateral sclerosis, and bipolar disorder. By using high-quality unmapped RNA sequencing reads as candidate microbial reads, we performed profiling of microbial transcripts detected in whole blood. We were able to detect a wide range of bacterial and archaeal phyla in blood...
May 10, 2018: Translational Psychiatry
J Sanchez-Moreno, C M Bonnin, A González-Pinto, B L Amann, B Solé, V Balanzá-Martinez, C Arango, E Jiménez, R Tabarés-Seisdedos, M P Garcia-Portilla, A Ibáñez, J M Crespo, J L Ayuso-Mateos, A Martinez-Aran, C Torrent, E Vieta
OBJECTIVE: The current investigation aimed at studying the sociodemographic, clinical, and neuropsychological variables related to functional outcome in a sample of euthymic patients with bipolar disorder(BD) presenting moderate-severe levels of functional impairment. METHODS: Two-hundred and thirty-nine participants with BD disorders and with Functioning Assessment Short Test(FAST) scores equal or above 18 were administered a clinical and diagnostic interview, and the administration of mood measure scales and a comprehensive neuropsychological battery...
May 3, 2018: Acta Psychiatrica Scandinavica
Paola Magioncalda, Matteo Martino, Samuele Tardito, Bruno Sterlini, Benedetta Conio, Valentina Marozzi, Giulia Adavastro, Laura Capobianco, Daniel Russo, Alessia Parodi, Francesca Kalli, Giorgia Nasi, Tiziana Altosole, Niccolò Piaggio, Georg Northoff, Daniela Fenoglio, Matilde Inglese, Gilberto Filaci, Mario Amore
BACKGROUND: White matter (WM) microstructural abnormalities and, independently, signs of immunological activation were consistently demonstrated in bipolar disorder (BD). However, the relationship between WM and immunological alterations as well as their occurrence in the various phases of BD remain unclear. METHOD: In 60 type I BD patients - 20 in manic, 20 in depressive, 20 in euthymic phases - and 20 controls we investigated: (i) diffusion tensor imaging (DTI)-derived fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (AD) using a tract-based spatial statistics (TBSS) approach; (ii) circulating T cell subpopulations frequencies, as well as plasma levels of different cytokines; (iii) potential relationships between WM and immunological data...
April 30, 2018: Brain, Behavior, and Immunity
Joseph Firth, Josh A Firth, Brendon Stubbs, Davy Vancampfort, Felipe B Schuch, Mats Hallgren, Nicola Veronese, Alison R Yung, Jerome Sarris
Importance: Objective physical fitness measures, such as handgrip strength, are associated with physical, mental, and cognitive outcomes in the general population. Although people with mental illness experience reduced physical fitness and cognitive impairment, the association between muscular strength and cognition has not been examined to date. Objective: To determine associations between maximal handgrip strength and cognitive performance in people with major depression or bipolar disorder and in healthy controls...
April 18, 2018: JAMA Psychiatry
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