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https://www.readbyqxmd.com/read/29759944/testing-assumptions-on-prefrontal-transcranial-direct-current-stimulation-comparison-of-electrode-montages-using-multimodal-fmri
#1
Jana Wörsching, Frank Padberg, Stephan Goerigk, Irmgard Heinz, Christine Bauer, Christian Plewnia, Alkomiet Hasan, Birgit Ertl-Wagner, Daniel Keeser
BACKGROUND: Transcranial direct current stimulation (tDCS) of the prefrontal cortex (PFC) has been widely applied in cognitive neurosciences and advocated as a therapeutic intervention, e.g. in major depressive disorder. Although several targets and protocols have been suggested, comparative studies of tDCS parameters, particularly electrode montages and their cortical targets, are still lacking. OBJECTIVE: This study investigated a priori hypotheses on specific effects of prefrontal-tDCS montages by using multimodal functional magnetic resonance imaging (fMRI) in healthy participants...
May 4, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29751598/informed-consent-decision-making-in-deep-brain-stimulation
#2
REVIEW
Gabriele Mandarelli, Germana Moretti, Massimo Pasquini, Giuseppe Nicolò, Stefano Ferracuti
Deep brain stimulation (DBS) has proved useful for several movement disorders (Parkinson’s disease, essential tremor, dystonia), in which first and/or second line pharmacological treatments were inefficacious. Initial evidence of DBS efficacy exists for refractory obsessive-compulsive disorder, treatment-resistant major depressive disorder, and impulse control disorders. Ethical concerns have been raised about the use of an invasive surgical approach involving the central nervous system in patients with possible impairment in cognitive functioning and decision-making capacity...
May 11, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29726314/effect-of-depression-on-cognition-after-mild-traumatic-brain-injury-in-adults
#3
Douglas P Terry, Michelle Brassil, Grant L Iverson, William J Panenka, Noah D Silverberg
OBJECTIVE: The current study examined the effect of depression on cognitive test performance in a sample of adults seeking treatment for a mild traumatic brain injury (MTBI). We hypothesized that patients with greater depressive symptoms would perform worse on tasks of fluid cognition compared to those without depression, after controlling for potential confounds. METHOD: Patients (N = 76) completed a brief cognitive test battery (NIH Toolbox Cognition Battery; NIHTB-CB) and a depression screening questionnaire (PHQ-9) at 11...
May 4, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29724684/the-neural-bases-of-interoceptive-encoding-and-recall-in-healthy-adults-and-adults-with-depression
#4
Danielle C DeVille, Kara L Kerr, Jason A Avery, Kaiping Burrows, Jerzy Bodurka, Justin Feinstein, Sahib S Khalsa, Martin P Paulus, W Kyle Simmons
BACKGROUND: Theoretical models assert that the brain's interoceptive network links external stimuli with their interoceptive consequences, thereby supporting later recall of these associations to guide the selection of healthy behaviors. If these accounts are correct, previously reported interoceptive abnormalities in major depressive disorder (MDD) should lead to altered recall of associations between external stimuli and their interoceptive (somatic) consequences. To date, the processes underlying interoceptive recall have never been experimentally investigated...
March 27, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29722134/a-novel-pde9-inhibitor-wyq-c36d-ameliorates-corticosterone-induced-neurotoxicity-and-depression-like-behaviors-by-cgmp-creb-related-signaling
#5
Xian-Feng Huang, Wen-Tao Jiang, Li Liu, Fang-Chen Song, Xia Zhu, Gui-Lan Shi, Shu-Ming Ding, Heng-Ming Ke, Wei Wang, James M O'Donnell, Han-Ting Zhang, Hai-Bin Luo, Yi-Qian Wan, Guo-Qiang Song, Ying Xu
BACKGROUND: Major depressive disorder (MDD) is a mental disease characterized by depressed mood, lifetime anxiety, and deficits of learning and memory. Inhibition of phosphodiesterase 9 (PDE9) has been reported to improve rodent cognitive and memory function. However, the role of PDE9 in MDD, in particular its manifestations of depression and anxiety, has not been investigated. METHODS: We examined the protective effects of WYQ-C36D (C36D), a novel PDE9 inhibitor, against corticosterone-induced cytotoxicity, pCREB/CREB and BDNF expression by cell viability, and immunoblot assays in HT-22 cells...
May 2, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29718333/neural-response-after-a-single-ect-session-during-retrieval-of-emotional-self-referent-words-in-depression-a-randomized-sham-controlled-fmri-study
#6
Kamilla W Miskowiak, Julian Macoveanu, Martin B Jørgensen, Mette M Støttrup, Caroline V Ott, Hans M Jensen, Anders Jørgensen, J Harmer, Olaf B Paulson, Lars V Kessing, Hartwig R Siebner
Background: Negative neurocognitive bias is a core feature of depression that is reversed by antidepressant drug treatment. However, it is unclear whether modulation of neurocognitive bias is a common mechanism of distinct biological treatments. This randomized controlled functional magnetic resonance imaging study explored the effects of a single electroconvulsive therapy session on self-referent emotional processing. Methods: Twenty-nine patients with treatment-resistant major depressive disorder were randomized to one active or sham electroconvulsive therapy session at the beginning of their electroconvulsive therapy course in a double-blind, between-groups design...
March 1, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29710135/association-between-muscular-strength-and-cognition-in-people-with-major-depression-or-bipolar-disorder-and-healthy-controls
#7
Joseph Firth, Josh A Firth, Brendon Stubbs, Davy Vancampfort, Felipe B Schuch, Mats Hallgren, Nicola Veronese, Alison R Yung, Jerome Sarris
Importance: Objective physical fitness measures, such as handgrip strength, are associated with physical, mental, and cognitive outcomes in the general population. Although people with mental illness experience reduced physical fitness and cognitive impairment, the association between muscular strength and cognition has not been examined to date. Objective: To determine associations between maximal handgrip strength and cognitive performance in people with major depression or bipolar disorder and in healthy controls...
April 18, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29705602/liraglutide-attenuates-the-depressive-and-anxiety-like-behaviour-in-the-corticosterone-induced-depression-model-via-improving-hippocampal-neural-plasticity
#8
Han Weina, Niu Yuhu, Holscher Christian, Li Birong, Shen Feiyu, Wang Le
Recent studies indicate that metabolic disorders such as diabetes and obesity are a major risk factor of psychiatric diseases. This relationship opens the opportunity to develop new antidepressant drugs by repurposing antidiabetic drugs. Previous research has demonstrated that GLP-1 analogs are neuroprotective in several neurological disease models including Alzheimer's disease (AD), Parkinson's disease (PD), and stroke. In addition, the GLP-1 analog liraglutide has been shown to promote neurogenesis, which is seen to play important roles in memory formation and cognitive and emotional processing...
April 26, 2018: Brain Research
https://www.readbyqxmd.com/read/29696602/translational-shifts-in-preclinical-models-of-depression-implications-for-biomarkers-for-improved-treatments
#9
Chloe Slaney, Justyna K Hinchcliffe, Emma S J Robinson
Understanding the neurobiology of major depressive disorder (MDD) remains one of the major challenges in neuroscience. The disease is heterogeneous in nature, and patients present with a varied symptom profile. Studies seeking to identify biomarkers for MDD diagnosis and treatment have not yet found any one candidate which achieves sufficient sensitivity and specificity. In this article, we consider whether neuropsychological impairments, specifically affective biases, could provide a behavioural biomarker...
April 26, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29691380/increased-functional-connectivity-of-the-posterior-cingulate-cortex-with-the-lateral-orbitofrontal-cortex-in-depression
#10
Wei Cheng, Edmund T Rolls, Jiang Qiu, Xiongfei Xie, Dongtao Wei, Chu-Chung Huang, Albert C Yang, Shih-Jen Tsai, Qi Li, Jie Meng, Ching-Po Lin, Peng Xie, Jianfeng Feng
To analyze the functioning of the posterior cingulate cortex (PCC) in depression, we performed the first fully voxel-level resting state functional-connectivity neuroimaging analysis of depression of the PCC, with 336 patients with major depressive disorder and 350 controls. Voxels in the PCC had significantly increased functional connectivity with the lateral orbitofrontal cortex, a region implicated in non-reward and which is thereby implicated in depression. In patients receiving medication, the functional connectivity between the lateral orbitofrontal cortex and PCC was decreased back towards that in the controls...
April 25, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29689517/neuropsychological-predictors-of-performance-based-measures-of-functional-capacity-and-social-skills-in-individuals-with-severe-mental-illness
#11
Zanjbeel Mahmood, Cynthia Z Burton, Lea Vella, Elizabeth W Twamley
Neuropsychological abilities may underlie successful performance of everyday functioning and social skills. We aimed to determine the strongest neuropsychological predictors of performance-based functional capacity and social skills performance across the spectrum of severe mental illness (SMI). Unemployed outpatients with SMI (schizophrenia, bipolar disorder, or major depression; n = 151) were administered neuropsychological (expanded MATRICS Consensus Cognitive Battery), functional capacity (UCSD Performance-Based Skills Assessment-Brief; UPSA-B), and social skills (Social Skills Performance Assessment; SSPA) assessments...
April 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29687527/amygdala-real-time-fmri-neurofeedback-for-major-depressive-disorder-a-review
#12
Kymberly D Young, Vadim Zotev, Raquel Phillips, Masaya Misaki, Wayne C Drevets, Jerzy Bodurka
Advances in imaging technologies have allowed for the analysis of fMRI data in real-time (rtfMRI), leading to the development of neurofeedback (nf) training. This rtfMRI-nf training utilizes fMRI tomographic localization capacity to allow a person to see and regulate the localized hemodynamic signal from his or her own brain. In this review, we summarize the results of several studies that have developed and applied neurofeedback training to healthy and depressed individuals with the amygdala as the neurofeedback target and the goal to increase the hemodynamic response during positive autobiographical memory recall...
April 23, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29684091/impaired-visual-working-and-verbal-memory-in-first-episode-drug-naive-patients-with-major-depressive-disorder-in-a-chinese-population
#13
Ce Chen, Wen-Hui Jiang, Wei Wang, Xian-Cang Ma, Ye Li, Jin Wu, Kenji Hashimoto, Cheng-Ge Gao
Cognitive impairment has been observed in patients with major depressive disorder (MDD). However, it remains unclear whether the deficits in specific cognitive domains are present in first-episode, drug-naïve patients or medicated patients. In the present study, using the CogState battery (CSB) Chinese language version, we evaluated the visual, working, and verbal memory in first-episode drug-naive patients and medicated patients with MDD in a Chinese population. We measured the cognitive function in first-episode drug-naïve patients (n = 36), medicated MDD patients (n = 71), and age- and sex-matched healthy control subjects (n = 59) in a Chinese population...
2018: PloS One
https://www.readbyqxmd.com/read/29680498/sleep-eeg-spectral-power-is-correlated-with-subjective-objective-discrepancy-of-sleep-onset-latency-in-major-depressive-disorder
#14
Seung-Gul Kang, Sara Mariani, Stephanie A Marvin, Kwang-Pil Ko, Susan Redline, John W Winkelman
We aimed to identify the sleep electroencephalography (EEG) spectral power correlates of the subjective-objective discrepancy (SOD) of sleep onset latency (SOL) in major depressive disorder (MDD), primary insomnia (PI), and normal sleeping control (NSC) groups. We examined relative power values in standard frequency bands of the EEG spectra during the first Non-Rapid Eye Movement (NREM) sleep period as correlates of SOD of SOL between sleep diary and polysomnography in MDD (n = 36), PI (n = 19), and NSC (n = 23) groups...
April 19, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29679991/empirical-evidence-for-discrete-neurocognitive-subgroups-in-patients-with-non-psychotic-major-depressive-disorder-clinical-implications
#15
Shenghong Pu, Takamasa Noda, Shiori Setoyama, Kazuyuki Nakagome
BACKGROUND: Neuropsychological deficits are present across various cognitive domains in major depressive disorder (MDD). However, a consistent and specific profile of neuropsychological abnormalities has not yet been established. METHODS: We assessed cognition in 170 patients with non-psychotic MDD using the Brief Assessment of Cognition in Schizophrenia and the scores were compared with those of 42 patients with schizophrenia as a reference for severity of cognitive impairment...
April 22, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29676230/insights-into-the-molecular-aspects-of-neuroprotective-bacoside-a-and-bacopaside-i
#16
Vini C Sekhar, Gayathri Viswanathan, Sabulal Baby
Bacopa monnieri, commonly known as Brahmi, has been extensively used as a neuromedicine for various disorders such as anxiety, depression and memory loss. Chemical characterization studies revealed the major active constituents of the herb as the triterpenoid saponins, bacosides. Bacoside A, the vital neuroprotective constituent, is composed of four constituents viz., bacoside A3, bacopaside II, jujubogenin isomer of bacopasaponin C (bacopaside X) and bacopasaponin C. B. monnieri extracts as well as bacosides successfully establish a healthy antioxidant environment in various tissues especially in liver and brain...
April 19, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29662202/stimulation-of-entorhinal-cortex-dentate-gyrus-circuitry-is-antidepressive
#17
Sanghee Yun, Ryan P Reynolds, Iraklis Petrof, Alicia White, Phillip D Rivera, Amir Segev, Adam D Gibson, Maiko Suarez, Matthew J DeSalle, Naoki Ito, Shibani Mukherjee, Devon R Richardson, Catherine E Kang, Rebecca C Ahrens-Nicklas, Ivan Soler, Dane M Chetkovich, Saïd Kourrich, Douglas A Coulter, Amelia J Eisch
Major depressive disorder (MDD) is considered a 'circuitopathy', and brain stimulation therapies hold promise for ameliorating MDD symptoms, including hippocampal dysfunction. It is unknown whether stimulation of upstream hippocampal circuitry, such as the entorhinal cortex (Ent), is antidepressive, although Ent stimulation improves learning and memory in mice and humans. Here we show that molecular targeting (Ent-specific knockdown of a psychosocial stress-induced protein) and chemogenetic stimulation of Ent neurons induce antidepressive-like effects in mice...
April 16, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29652529/neurocognitive-predictors-of-clinical-improvement-in-selective-serotonin-reuptake-inhibitor-treated-adolescents-with-major-depressive-disorder
#18
Fadi Maalouf, Rinad Bakhti, Hani Tamim, Safa Shehab, David Brent
OBJECTIVES: Numerous studies have suggested cognitive deficits as consistently associated with adolescent depression. No study to date, however, has assessed neurocognitive predictors of selective serotonin reuptake inhibitor (SSRI) treatment response in adolescents with depression. This study examined neurocognitive tasks at baseline as predictors of clinical improvement with SSRI treatment (fluoxetine) at week 6 and 12 in an adolescent population. METHODS: Adolescents with depression were recruited from a child and adolescent psychiatry outpatient clinic at a university medical center...
April 13, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29628068/negative-autobiographical-memory-in-depression-reflects-elevated-amygdala-hippocampal-reactivity-and-hippocampally-associated-emotion-regulation
#19
Bruce P Doré, Odile Rodrik, Chelsea Boccagno, Alexa Hubbard, Jochen Weber, Barbara Stanley, Maria A Oquendo, Jeffrey M Miller, M Elizabeth Sublette, J John Mann, Kevin N Ochsner
BACKGROUND: Dysregulated autobiographical recall is observed in major depressive disorder (MDD). However, it is unknown whether people with MDD show abnormalities in memory-, emotion-, and control-related brain systems during reactivity to and regulation of negative autobiographical memories. METHODS: We used functional magnetic resonance imaging to identify neural mechanisms underlying MDD-related emotional responses to negative autobiographical memories and the ability to downregulate these responses using a cognitive regulatory strategy known as reappraisal...
April 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29621842/repetitive-transcranial-magnetic-stimulation-in-the-treatment-of-depression
#20
Saxby Pridmore, William Pridmore
BACKGROUND: Transcranial magnetic stimulation (TMS)is a treatment for major depressive disorder that is otherwise resistant to treatment. Although world-leading research in TMS has been conducted in Australia, where it has had some availability for two decades, there is limited familiarity with the treatment in the general medical community. Availability, however, is increasing. OBJECTIVE: The aim of this article is to inform general practitioners of some scientific and practical aspects of TMS treatment...
March 2018: Australian journal of general practice
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