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https://www.readbyqxmd.com/read/28645775/altered-populations-of-natural-killer-cells-cytotoxic-t-lymphocytes-and-regulatory-t-cells-in-major-depressive-disorder-association-with-sleep-disturbance
#1
Hideo Suzuki, Jonathan Savitz, T Kent Teague, Siva K Gandhapudi, Chibing Tan, Masaya Misaki, Brett A McKinney, Michael R Irwin, Wayne C Drevets, Jerzy Bodurka
A subset of individuals with major depressive disorder (MDD) have impaired adaptive immunity characterized by a greater vulnerability to viral infection and a deficient response to vaccination along with a decrease in the number and/or activity of T cells and natural killer cells (NKC). Nevertheless, it remains unclear which specific subsets of lymphocytes are altered in MDD, a shortcoming we address here by utilizing an advanced fluorescence-activated cell sorting (FACS) method that allows for the differentiation of important functionally-distinct lymphocyte sub-populations...
June 20, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28634383/discrepancy-between-objective-and-subjective-cognition-in-adults-with-major-depressive-disorder
#2
Manit Srisurapanont, Sirijit Suttajit, Kanokkwan Eurviriyanukul, Prirada Varnado
This study aimed to determine: i) the correlation between objective and subjective cognition, ii) the correlates of objective and subjective cognition and iii) the predictors of discrepancy between objective and subjective cognition. Participants were non-elderly patients with major depressive disorder (MDD). We assessed subjective cognition using the Perceived Deficit Questionnaire for Depression (PDQ-D) and objective cognition using Face I and Face II tests of the Wechsler Memory Scale, 3rd edition and Digit Span and Matrix Reasoning tests of the Wechsler Intelligence Scale for Adults, 3rd edition...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629225/cortical-plasticity-in-depression
#3
Mariagiovanna Cantone, Alessia Bramanti, Giuseppe Lanza, Manuela Pennisi, Placido Bramanti, Giovanni Pennisi, Rita Bella
Neural plasticity is considered the neurophysiological correlate of learning and memory, although several studies have also noted that it plays crucial roles in a number of neurological and psychiatric diseases. Indeed, impaired brain plasticity may be one of the pathophysiological mechanisms that underlies both cognitive decline and major depression. Moreover, a degree of cognitive impairment is frequently observed throughout the clinical spectrum of mood disorders, and the relationship between depression and cognition is often bidirectional...
May 2017: ASN Neuro
https://www.readbyqxmd.com/read/28628764/psychiatric-disorders-moderate-the-relationship-between-insomnia-and-cognitive-problems-in-military-soldiers
#4
Janeese A Brownlow, Elizabeth A Klingaman, Elaine M Boland, Glenna S Brewster, Philip R Gehrman
BACKGROUND: There has been a great deal of research on the comorbidity of insomnia and psychiatric disorders, but much of the existing data is based on small samples and does not assess the full diagnostic criteria for each disorder. Further, the exact nature of the relationship between these conditions and their impact on cognitive problems are under-researched in military samples. METHOD: Data were collected from the All Army Study of the Army Study to Assess Risk and Resilience in Service members (unweighted N = 21, 449; weighted N = 674,335; 18-61 years; 13...
June 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28628388/coordination-of-ampa-receptor-trafficking-by-rab-small-gtpases
#5
Angelika Hausser, Katalin Schlett
Synaptic connections in the brain are continuously weakened or strengthened in response to changes in neuronal activity. This process, known as synaptic plasticity, is the cellular basis for learning and memory, and is thought to be altered in several neuronal disorders. An important aspect of synaptic plasticity is the tightly controlled trafficking and synaptic targeting of the AMPA-type glutamate receptors, which are the major mediators of fast excitatory transmission in the brain. This review addresses the role of Rab GTPases in AMPA receptor trafficking in neurons under basal conditions and during activity-induced synaptic plasticity, especially during long-term potentiation (LTP) and long-term depression (LTD)...
June 19, 2017: Small GTPases
https://www.readbyqxmd.com/read/28625940/prodromal-stage-of-disease-dementia-with-lewy-bodies-how-to-diagnose-in-practice
#6
Frédéric Blanc, Marc Verny
Disease with Lewy bodies or dementia with Lewy bodies (DLB), particularly at the prodromal stage, is a complex disease to diagnose because of different clinical beginnings and variable paths in terms of clinical expression. Thus DLB can be entcountered in different input modes: mild cognitive impairment, depression, acute behavioral disorders, confusion and delirium, or sleep disorders. In the aim to better diagnose the disease, should be sought obviously to search for the key symptoms: fluctuations, hallucinations, extra-pyramidal syndrome, and REM sleep behavior disorder...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28625590/intranasal-cotinine-improves-memory-and-reduces-depressive-like-behavior-and-gfap-cells-loss-induced-by-restraint-stress-in-mice
#7
Nelson Perez-Urrutia, Cristhian Mendoza, Nathalie Alvarez-Ricartes, Patricia Oliveros-Matus, Florencia Echeverria, J Alex Grizzell, George E Barreto, Alexandre Iarkov, Valentina Echeverria
Posttraumatic stress disorder (PTSD), chronic psychological stress, and major depressive disorder have been found to be associated with a significant decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus of rodents. Cotinine is an alkaloid that prevents memory impairment, depressive-like behavior and synaptic loss when co-administered during restraint stress, a model of PTSD and stress-induced depression, in mice. Here, we investigated the effects of post-treatment with intranasal cotinine on depressive- and anxiety-like behaviors, visual recognition memory as well as the number and morphology of GFAP+ immunoreactive cells, in the hippocampus and frontal cortex of mice subjected to prolonged restraint stress...
June 15, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28624581/polygenic-risk-for-depression-and-the-neural-correlates-of-working-memory-in-healthy-subjects
#8
Dilara Yüksel, Bruno Dietsche, Andreas J Forstner, Stephanie H Witt, Robert Maier, Marcella Rietschel, Carsten Konrad, Markus M Nöthen, Udo Dannlowski, Bernhard T Baune, Tilo Kircher, Axel Krug
INTRODUCTION: Major depressive disorder (MDD) patients show impairments of cognitive functioning such as working memory (WM), and furthermore alterations during WM-fMRI tasks especially in frontal and parietal brain regions. The calculation of a polygenic risk score (PRS) can be used to describe the genetic influence on MDD, hence imaging genetic studies aspire to combine both genetics and neuroimaging data to identify the influence of genetic factors on brain functioning. We aimed to detect the effect of MDD-PRS on brain activation during a WM task measured with fMRI and expect healthy individuals with a higher PRS to be more resembling to MDD patients...
June 15, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28617690/short-and-long-term-cognitive-outcomes-in-patients-with-major-depression-treated-with-electroconvulsive-therapy
#9
Megha M Vasavada, Amber M Leaver, Stephanie Njau, Shantanu H Joshi, Linda Ercoli, Gerhard Hellemann, Katherine L Narr, Randall Espinoza
OBJECTIVES: The risk of cognitive impairment is a concern for patients with major depressive disorder receiving electroconvulsive therapy (ECT). Here, we evaluate the acute, short-term and long-term effects of ECT on tests of processing speed, executive function, memory, and attention. METHODS: Forty-four patients with major depressive disorder receiving ECT (61% right unilateral, 39% mixed right unilateral-bitemporal, left unilateral, and/or bitemporal lead placement) underwent a cognitive battery prior to ECT (T1), after 2 sessions (T2), and at the end of the index (T3)...
June 14, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28607167/the-role-of-creb-srf-and-mef2-in-activity-dependent-neuronal-plasticity-in-the-visual-cortex
#10
Nisha S Pulimood, Rodrigues Wandilson Dos Santos, Devon A Atkinson, Sandra M Mooney, Alexandre E Medina
The transcription factors CREB (cAMP Response Element Binding factor), SRF (Serum Response Factor) and MEF2 (Myocyte Enhancer Factor 2) play critical roles in the mechanisms underlying neuronal plasticity. However, the role of the activation of these transcription factors in the different components of plasticity in vivo is not well known. In this study, we tested the role of CREB, SRF and MEF2 in ocular dominance plasticity (ODP), a paradigm of activity-dependent neuronal plasticity in the visual cortex. These three proteins bind to the Synaptic Activity Response Element (SARE), an enhancer sequence found upstream of many plasticity-related genes (Kawashima et al...
June 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28599834/effects-of-interleukin-1beta-polymorphisms-on-brain-function-and-behavior-in-healthy-and-psychiatric-disease-conditions
#11
REVIEW
Shih-Jen Tsai
A high level of Interleukin-1beta (IL1B), a key mediator of inflammation, is expressed in the brain, particularly in the hippocampus, which plays a pivotal role in memory and mood regulation. In the brain, IL1B exerts a myriad of effects such as neuronal proliferation, differentiation, apoptosis, and long-term potentiation. Considering its pleiotropic effects in the brain, IL1B has been implicated in the pathogenesis of various psychiatric disorders as well as cognitive function in normal individuals. Thus, IL1B has been considered a candidate gene for the study of psychiatric diseases as well as brain function in normal individuals...
June 3, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28599348/a-pilot-open-label-8-week-study-evaluating-the-efficacy-safety-and-tolerability-of-adjunctive-minocycline-for-the-treatment-of-bipolar-i-ii-depression
#12
Joanna K Soczynska, Sidney H Kennedy, Mohammad Alsuwaidan, Rodrigo B Mansur, Madeline Li, Mary Pat McAndrews, Elisa Brietzke, Hanna O Woldeyohannes, Valerie H Taylor, Roger S McIntyre
OBJECTIVES: The objectives of the study were to determine if adjunctive minocycline mitigates depressive symptom severity and improves cognitive function in individuals with bipolar I/II disorder (BD). The study also aimed to determine if changes in depressive and/or cognitive symptoms over the course of treatment were associated with changes in circulating inflammatory cytokine levels. METHODS: A total of 29 (intention-to-treat: n=27) adults meeting DSM-IV-TR criteria for a major depressive episode as part of bipolar I or II disorder (i...
May 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28546314/chronic-stress-induced-behavioral-changes-associated-with-subregion-selective-serotonin-cell-death-in-the-dorsal-raphe
#13
Reka Natarajan, Laura Forrester, Nicolas Chiaia, Bryan K Yamamoto
The current study examined the neurochemical mechanisms and neuroanatomical changes underlying co-existing behavioral effects associated with chronic stress-induced alterations in serotonin (5HT) neurons. Chronic unpredictable stress (CUS) to adult male rats produced depression-like changes with cognitive dysfunction and selective cell death in the interfascicular nucleus of the dorsal raphe (DRif) resulting in decreased 5HTergic innervation of medial prefrontal cortex (mPFC). Twenty-one days of CUS decreased basal plasma levels of corticosterone and produced a shorter latency to immobility and longer durations of immobility in the force-swim test that persisted for one month after CUS...
May 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28527907/behavioral-and-cognitive-impact-of-early-life-stress-insights-from-an-animal-model
#14
Hesong Liu, Fatin Atrooz, Ankita Salvi, Samina Salim
BACKGROUND: Children subjected to traumatic events during childhood are reported to exhibit behavioral and cognitive deficits later in life, often leading to post-traumatic stress disorder (PTSD) and major depression. Interestingly, some children continue to remain normal despite being exposed to the same risk factors. These trauma-related behavioral and cognitive profiles across different stages of life are not well understood. Animal studies can offer useful insights. OBJECTIVE: The goal of this study was to determine the impact of early life exposure to traumatic events on behavioral and cognitive profile in rats by tracking the behavior of each rat at different ages...
May 17, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28523217/relation-between-patterns-of-intrinsic-network-connectivity-cognitive-functioning-and-symptom-presentation-in-trauma-exposed-patients-with-major-depressive-disorder
#15
Melissa Parlar, Maria Densmore, Geoffrey B Hall, Paul A Frewen, Ruth A Lanius, Margaret C McKinnon
OBJECTIVE: The present study investigated resting fMRI connectivity within the default mode (DMN), salience (SN), and central executive (CEN) networks in relation to neurocognitive performance and symptom severity in trauma-exposed patients with major depressive disorder (MDD). METHOD: Group independent component analysis was conducted among patients with MDD (n = 21), examining DMN, SN, and CEN connectivity in relation to neurocognitive performance and symptom severity...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28499272/effects-of-cortisol-on-the-memory-bias-for-emotional-words-a-study-in-patients-with-depression-and-healthy-participants-using-the-directed-forgetting-task
#16
Linn K Kuehl, Oliver T Wolf, Martin Driessen, Nicole Schlosser, Silvia Carvalho Fernando, Katja Wingenfeld
Mood congruent alterations in information processing such as an impaired memory bias for emotional information and impaired inhibitory functions are prominent features of a major depressive disorder (MDD). Furthermore, in MDD patients hypothalamic-pituitary-adrenal axis dysfunctions are frequently found. Impairing effects of stress or cortisol administration on memory retrieval as well as impairing stress effects on cognitive inhibition are well documented in healthy participants. In MDD patients, no effect of acute cortisol administration on memory retrieval was found...
April 29, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28493605/adverse-effects-of-obesity-on-cognitive-functions-in-individuals-at-ultra-high-risk-for-bipolar-disorder-results-from-the-global-mood-and-brain-science-initiative
#17
Roger S McIntyre, Rodrigo B Mansur, Yena Lee, Letícia Japiassú, Kun Chen, Rui Lu, Weicong Lu, Xiaodong Chen, Ting Li, Guiyun Xu, Kangguang Lin
BACKGROUND: The burden of illness associated with bipolar disorder (BD) warrants early pre-emption/prevention. Prediction models limited to psychiatric phenomenology have insufficient predictive power. Herein, we aimed to evaluate whether the presence of overweight/obesity is associated with greater cognitive decline in individuals at high risk (HR) or ultra high risk (UHR) for BD. METHODS: We conducted a retrospective analysis to investigate the moderational role of body mass index (BMI) on measures of cognitive function...
March 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28476208/transcriptome-alterations-in-prefrontal-pyramidal-cells-distinguish-schizophrenia-from-bipolar-and-major-depressive-disorders
#18
Dominique Arion, Zhiguang Huo, John F Enwright, John P Corradi, George Tseng, David A Lewis
BACKGROUND: Impairments in certain cognitive processes (e.g., working memory) are typically most pronounced in schizophrenia (SZ), intermediate in bipolar disorder, and least in major depressive disorder. Given that working memory depends, in part, on neural circuitry that includes pyramidal cells in layer 3 (L3) and layer 5 (L5) of the dorsolateral prefrontal cortex (DLPFC), we sought to determine if transcriptome alterations in these neurons were shared or distinctive for each diagnosis...
April 4, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28476207/real-time-functional-magnetic-resonance-imaging-amygdala-neurofeedback-changes-positive-information-processing-in-major-depressive-disorder
#19
Kymberly D Young, Masaya Misaki, Catherine J Harmer, Teresa Victor, Vadim Zotev, Raquel Phillips, Greg J Siegle, Wayne C Drevets, Jerzy Bodurka
BACKGROUND: In participants with major depressive disorder who are trained to upregulate their amygdalar hemodynamic responses during positive autobiographical memory recall with real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) training, depressive symptoms diminish. This study tested whether amygdalar rtfMRI-nf also changes emotional processing of positive and negative stimuli in a variety of behavioral and imaging tasks. METHODS: Patients with major depressive disorder completed two rtfMRI-nf sessions (18 received amygdalar rtfMRI-nf, 16 received control parietal rtfMRI-nf)...
March 28, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28475603/the-impact-of-obesity-on-neuropsychological-functioning-in-adults-with-and-without-major-depressive-disorder
#20
Maria R Restivo, Margaret C McKinnon, Benicio N Frey, Geoffrey B Hall, Wasimuddin Syed, Valerie H Taylor
BACKGROUND: Evidence suggests obesity exerts a negative impact on cognition. Major Depressive Disorder (MDD) is also linked to problems in cognitive functioning. Obesity is highly prevalent in individuals with MDD and is linked to a failure to return to a full level of functioning. The study's objective was to investigate the effect of obesity on cognitive impairment in participants with MDD. METHODS: This study compared cognitive performance in obese individuals with MDD and two control populations (obese individuals without a psychiatric illness and non-obese controls)...
2017: PloS One
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