keyword
https://read.qxmd.com/read/37458464/altered-placental-ion-channel-gene-expression-in-preeclamptic-high-altitude-pregnancies
#1
JOURNAL ARTICLE
Colleen G Julian, Julie A Houck, Sahand Fallahi, Litzi Lazo-Vega, Christopher J Matarazzo, Breea Diamond, Valquiria Miranda-Garrido, Bernardo J Krause, Lorna G Moore, Jonathan A Shortt, Lilian Toledo-Jaldin, Ramón A Lorca
High-altitude (>2500 m) residence increases the risk of pregnancy vascular disorders such as fetal growth restriction and preeclampsia, each characterized by impaired placental function. Genetic attributes of highland ancestry confer relative protection against vascular disorders of pregnancy at high altitude. Although ion channels have been implicated in placental function regulation, neither their expression in high-altitude placentas nor their relationship to high-altitude preeclampsia has been determined...
July 17, 2023: Physiological Genomics
https://read.qxmd.com/read/36810326/glioblastoma-upregulates-sumoylation-of-hnrnp-a2-b1-to-eliminate-the-tumor-suppressor-mir-204-3p-accelerating-angiogenesis-under-hypoxia
#2
JOURNAL ARTICLE
Qindong Guo, Yang Fan, Qingtong Wang, Boyan Li, Wei Qiu, Yanhua Qi, Ziwen Pan, Shouji Zhang, Shulin Zhao, Kehui Yang, Hao Xu, Ming Li, Zijie Gao, Jianye Xu, Huizhi Wang, Shaobo Wang, Qilin Tang, Jiawei Qiu, Xing Guo, Lin Deng, Ping Zhang, Rongrong Zhao, Hao Xue, Chengwei Wang, Gang Li
Glioma is the most common malignant tumor of the central nervous system in adults. The tumor microenvironment (TME) is related to poor prognosis in glioma patients. Glioma cells could sort miRNA into exosomes to modify TME. And hypoxia played an important role in this sorting process, but the mechanism is not clear yet. Our study was to find miRNAs sorted into glioma exosomes and reveal the sorting process. Sequencing analysis of glioma patients cerebrospinal fluid (CSF) and tissue showed that miR-204-3p tends to be sorted into exosomes...
February 21, 2023: Cell Death & Disease
https://read.qxmd.com/read/35845495/anti-atherosclerotic-effects-of-genistein-in-preventing-ox-low-density-lipoprotein-induced-smooth-muscle-derived-foam-cell-formation-via-inhibiting-src-expression-and-l-ca-channel-currents
#3
JOURNAL ARTICLE
Wei Zhang, Liming Zhang, Xiaosi Zhang
BACKGROUND: Atherosclerosis (AS) is associated with inflammation and abnormal proliferation and migration of vascular smooth muscle cells (VSMCs). Genistein may curtail the migration of VSMCs. Therefore, explorations are required to determine the molecular mechanism of genistein in AS. In this context, animal and cell models were developed to ascertain mechanisms of genistein in AS by modulating VSMC activities. METHODS: Genistein treatment and ectopic expression of lectin-like oxidized LDL receptor-1 ( LOX-1 ) were conducted in high-fat diet-induced AS rats, followed by analyses of atherosclerotic plaque lesion areas and lipid deposition using Oil Red O and hematoxylin and eosin (HE) staining...
June 2022: Annals of Translational Medicine
https://read.qxmd.com/read/35711357/unveiling-the-role-of-dna-methylation-in-vascular-cacna1c-tissue-specific-expression
#4
JOURNAL ARTICLE
Meng Zhao, Ting Xu, Jiahui Lei, Bingyu Ji, Qinqin Gao
Objective: Calcium voltage-gated channel subunit alpha1 C (CACNA1C) plays a critical role in many vascular physiological and pathological processes. Determining its tissue-specific expression pattern and clarifying the underlying molecular mechanisms are necessary and meaningful. Methods: We selected several representative vessels from normal male Sprague-Dawley rats. Vessel tissue or primary vascular smooth muscle cells were isolated for vascular function, electrophysiology, gene expression and promoter methylation studies...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/34368236/lncrna-ensmust00000155383-is-involved-in-the-improvement-of-dpp-4-inhibitor-mk-626-on-vascular-endothelial-function-by-modulating-cacna1c-mediated-ca-2-influx-in-hypertensive-mice
#5
JOURNAL ARTICLE
Yi Zhang, Na Tan, Yi Zong, Li Li, Yan Zhang, Jian Liu, Xiaorui Wang, Wenwen Han, Limei Liu
Objective: This study investigated the protective effects of dipeptidyl peptidase-4 inhibitor MK-626 on vascular endothelial function by regulating lncRNAs in hypertensive vasculature. Methods: Angiotensin Ⅱ (Ang Ⅱ)-loaded osmotic pumps were implanted in mice with or without MK-626 administration. GLP-1 levels in plasma were measured by ELISA. Aortic rings were suspended in myograph for tension measurement. Microarray was performed to analyze lncRNA and mRNA expression profiles. Protein expression and phosphorylation were examined by Western blot...
2021: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/34116258/prenatal-exercise-reprograms-the-development-of-hypertension-progress-and-improves-vascular-health-in-shr-offspring
#6
JOURNAL ARTICLE
Shanshan Li, Yu Chen, Yanyan Zhang, Fang Qiu, Fanxing Zeng, Lijun Shi
BACKGROUND: Upregulation of L-type voltage-gated Ca2+ (CaV 1.2) channel in the arterial myocytes is a hallmark feature of hypertension. However, whether maternal exercise during pregnancy has a sustained beneficial effect on the offspring of spontaneously hypertensive rats (SHRs) through epigenetic regulation of CaV 1.2 channel is largely unknown. METHODS: Pregnant SHRs and Wistar-Kyoto rats were subjected to swimming and the vascular molecular and functional properties of male offspring were evaluated at embryonic (E) 20...
August 2021: Vascular Pharmacology
https://read.qxmd.com/read/32950876/vascular-kv7-channels-control-intracellular-ca-2-dynamics-in-smooth-muscle
#7
JOURNAL ARTICLE
Yuan-Ming Tsai, Frederick Jones, Pierce Mullen, Karen E Porter, Derek Steele, Chris Peers, Nikita Gamper
Voltage-gated Kv7 (or KCNQ) channels control activity of excitable cells, including vascular smooth muscle cells (VSMCs), by setting their resting membrane potential and controlling other excitability parameters. Excitation-contraction coupling in muscle cells is mediated by Ca2+ but until now, the exact role of Kv7 channels in cytosolic Ca2+ dynamics in VSMCs has not been fully elucidated. We utilised microfluorimetry to investigate the impact of Kv7 channel activity on intracellular Ca2+ levels and electrical activity of rat A7r5 VSMCs and primary human internal mammary artery (IMA) SMCs...
August 29, 2020: Cell Calcium
https://read.qxmd.com/read/31645420/network-based-functional-prediction-augments-genetic-association-to-predict-candidate-genes-for-histamine-hypersensitivity-in-mice
#8
JOURNAL ARTICLE
Anna L Tyler, Abbas Raza, Dimitry N Krementsov, Laure K Case, Rui Huang, Runlin Z Ma, Elizabeth P Blankenhorn, Cory Teuscher, J Matthew Mahoney
Genetic mapping is a primary tool of genetics in model organisms; however, many quantitative trait loci (QTL) contain tens or hundreds of positional candidate genes. Prioritizing these genes for validation is often ad hoc and biased by previous findings. Here we present a technique for prioritizing positional candidates based on computationally inferred gene function. Our method uses machine learning with functional genomic networks, whose links encode functional associations among genes, to identify network-based signatures of functional association to a trait of interest...
October 23, 2019: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/31211998/exercise-during-pregnancy-enhances-vascular-function-via-epigenetic-repression-of-ca-v-1-2-channel-in-offspring-of-hypertensive-rats
#9
JOURNAL ARTICLE
Shanshan Li, Yu Chen, Yanyan Zhang, Huirong Zhang, Ying Wu, Hui He, Lijing Gong, Fanxing Zeng, Lijun Shi
AIMS: Studies suggest that cardiovascular function in offspring can be epigenetically programmed by environmental changes during pregnancy. CaV 1.2 channel plays a major role in the regulation of the vascular tone. This study investigated the effects and underlying mechanisms of exercise during pregnancy on CaV 1.2 channel functional remodeling in hypertensive offspring. MAIN METHODS: Exercise groups were subjected to swimming at the first day of pregnancy and on a regular schedule thereafter for 3 weeks...
June 15, 2019: Life Sciences
https://read.qxmd.com/read/29467196/specific-activation-of-the-alternative-cardiac-promoter-of-cacna1c-by-the-mineralocorticoid-receptor
#10
JOURNAL ARTICLE
Thassio R Mesquita, Gaëlle Auguste, Débora Falcón, Gema Ruiz-Hurtado, Rogelio Salazar-Enciso, Jessica Sabourin, Florence Lefebvre, Say Viengchareun, Hussein Kobeissy, Patrick Lechène, Valérie Nicolas, Amaya Fernandez-Celis, Susana Gómez, Sandra Lauton Santos, Eric Morel, Angelica Rueda, Natalia López-Andrés, Ana Maria Gómez, Marc Lombès, Jean-Pierre Benitah
RATIONALE: The MR (mineralocorticoid receptor) antagonists belong to the current therapeutic armamentarium for the management of cardiovascular diseases, but the mechanisms conferring their beneficial effects are poorly understood. Part of the cardiovascular effects of MR is because of the regulation of L-type Cav 1.2 Ca2+ channel expression, which is generated by tissue-specific alternative promoters as a long cardiac or short vascular N-terminal transcripts. OBJECTIVE: To analyze the molecular mechanisms by which aldosterone, through MR, modulates Cav 1...
March 30, 2018: Circulation Research
https://read.qxmd.com/read/28439241/nifedipine-inhibition-of-high-voltage-activated-calcium-channel-currents-in-cerebral-artery-myocytes-is-influenced-by-extracellular-divalent-cations
#11
JOURNAL ARTICLE
Fei Wang, Masayo Koide, George C Wellman
Voltage-dependent calcium channels (VDCCs) play an essential role in regulating cerebral artery diameter and it is widely appreciated that the L-type VDCC, CaV 1.2, encoded by the CACNA1C gene, is a principal Ca2+ entry pathway in vascular myocytes. However, electrophysiological studies using 10 mM extracellular barium ([Ba2+ ]o ) as a charge carrier have shown that ~20% of VDCC currents in cerebral artery myocytes are insensitive to 1,4-dihydropyridine (1,4-DHP) L-type VDDC inhibitors such as nifedipine. Here, we investigated the hypothesis that the concentration of extracellular divalent cations can influence nifedipine inhibition of VDCC currents...
2017: Frontiers in Physiology
https://read.qxmd.com/read/27881847/epigenetic-regulation-of-l-type-voltage-gated-ca-2-channels-in-mesenteric-arteries-of-aging-hypertensive-rats
#12
JOURNAL ARTICLE
Jingwen Liao, Yanyan Zhang, Fang Ye, Lin Zhang, Yu Chen, Fanxing Zeng, Lijun Shi
Accumulating evidence has shown that epigenetic regulation is involved in hypertension and aging. L-type voltage-gated Ca2+ channels (LTCCs), the dominant channels in vascular myocytes, greatly contribute to arteriole contraction and blood pressure (BP) control. We investigated the dynamic changes and epigenetic regulation of LTCC in the mesenteric arteries of aging hypertensive rats. LTCC function was evaluated by using microvascular rings and whole-cell patch-clamp in the mesenteric arteries of male Wistar-Kyoto rats and spontaneously hypertensive rats at established hypertension (3 month old) and an aging stage (16 month old), respectively...
May 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/27349457/high-affinity-complexes-of-pannexin-channels-and-l-type-calcium-channel-splice-variants-in-human-lung-possible-role-in-clevidipine-induced-dyspnea-relief-in-acute-heart-failure
#13
JOURNAL ARTICLE
Gerhard P Dahl, Gregory E Conner, Feng Qiu, Junjie Wang, Edward Spindler, Jason A Campagna, H Peter Larsson
UNLABELLED: Clevidipine, a dihydropyridine (DHP) analogue, lowers blood pressure (BP) by inhibiting l-type calcium channels (CaV1.2; gene CACNA1C) predominantly located in vascular smooth muscle (VSM). However, clinical observations suggest that clevidipine acts by a more complex mechanism. Clevidipine more potently reduces pulmonary vascular resistance (PVR) than systemic vascular resistance and its spectrum of effects on PVR are not shared by other DHPs. Clevidipine has potent spasmolytic effects in peripheral arteries at doses that are sub-clinical for BP lowering and, in hypertensive acute heart failure, clevidipine, but not other DHPs, provides dyspnea relief, partially independent of BP reduction...
August 2016: EBioMedicine
https://read.qxmd.com/read/26840416/myocardial-structural-and-biological-anomalies-induced-by-high-fat-diet-in-psammomys-obesus-gerbils
#14
JOURNAL ARTICLE
Abdelhamid Sahraoui, Céline Dewachter, Geoffrey de Medina, Robert Naeije, Souhila Aouichat Bouguerra, Laurence Dewachter
BACKGROUND: Psammomys obesus gerbils are particularly prone to develop diabetes and obesity after brief period of abundant food intake. A hypercaloric high fat diet has been shown to affect cardiac function. Here, we sought to determine whether a short period of high fat feeding might alter myocardial structure and expression of calcium handling proteins in this particular strain of gerbils. METHODS: Twenty Psammomys obesus gerbils were randomly assigned to receive a normal plant diet (controls) or a high fat diet...
2016: PloS One
https://read.qxmd.com/read/25937960/cav1-2-cell-proliferation-and-new-target-in-atherosclerosis
#15
REVIEW
Nikolai M Soldatov
Cav1.2 calcium channels are the principal proteins involved in electrical, mechanical, and/or signaling functions of the cell. Cav1.2 couples membrane depolarization to the transient increase in intracellular Ca(2+) concentration that is a trigger for muscle contraction and CREB-dependent transcriptional activation. The CACNA1C gene coding for the Cav1.2 pore-forming α 1C subunit is subject to extensive alternative splicing. This review is the first attempt to follow the association between cell proliferation, Cav1...
2013: ISRN Biochemistry
https://read.qxmd.com/read/19011682/potential-relevance-of-alpha-1-adrenergic-receptor-autoantibodies-in-refractory-hypertension
#16
JOURNAL ARTICLE
Katrin Wenzel, Hannelore Haase, Gerd Wallukat, Wolfgang Derer, Sabine Bartel, Volker Homuth, Florian Herse, Norbert Hubner, Herbert Schulz, Marion Janczikowski, Carsten Lindschau, Christoph Schroeder, Stefan Verlohren, Ingo Morano, Dominik N Muller, Friedrich C Luft, Rainer Dietz, Ralf Dechend, Peter Karczewski
BACKGROUND: Agonistic autoantibodies directed at the alpha(1)-adrenergic receptor (alpha(1)-AAB) have been described in patients with hypertension. We implied earlier that alpha(1)-AAB might have a mechanistic role and could represent a therapeutic target. METHODOLOGY/PRINCIPAL FINDINGS: To pursue the issue, we performed clinical and basic studies. We observed that 41 of 81 patients with refractory hypertension had alpha(1)-AAB; after immunoadsorption blood pressure was significantly reduced in these patients...
2008: PloS One
https://read.qxmd.com/read/17699517/a-novel-ca-v-1-2-n-terminus-expressed-in-smooth-muscle-cells-of-resistance-size-arteries-modifies-channel-regulation-by-auxiliary-subunits
#17
JOURNAL ARTICLE
Xiaoyang Cheng, Jianxi Liu, Maria Asuncion-Chin, Eva Blaskova, John P Bannister, Alejandro M Dopico, Jonathan H Jaggar
Voltage-dependent L-type Ca(2+) (Ca(V)1.2) channels are the principal Ca(2+) entry pathway in arterial myocytes. Ca(V)1.2 channels regulate multiple vascular functions and are implicated in the pathogenesis of human disease, including hypertension. However, the molecular identity of Ca(V)1.2 channels expressed in myocytes of myogenic arteries that regulate vascular pressure and blood flow is unknown. Here, we cloned Ca(V)1.2 subunits from resistance size cerebral arteries and demonstrate that myocytes contain a novel, cysteine rich N terminus that is derived from exon 1 (termed "exon 1c"), which is located within CACNA1C, the Ca(V)1...
October 5, 2007: Journal of Biological Chemistry
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